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Steven J. Brill, PhD

Selected Publications

  1. Chen, C-F. and Brill, S.J. (2014). Multimerization domains are associated with apparent strand exchange activity in BLM and WRN DNA helicases.  DNA Repair, In press.
  2. Glineburg, M.R., Chavez, A., Agrawal, V., Brill, S.J., and Johnson, F.B. (2013).  Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication. J. Biol. Chem. 288, 33193-33204.
  3. Mullen, J. R., Das, M., and Brill, S.J. (2011). Genetic evidence that poly-sumoylation bypasses the need for a SUMO-targeted Ub ligase.  Genetics 187, 73-87.
  4. Chen, C-F. and Brill, S.J. (2010). An essential DNA strand exchange activity is conserved in the divergent N-termini of BLM orthologs.  EMBO J. 29, 1713-25.  
  5. Mullen, J. R. and Brill, S.J. (2008).  Activation of the Slx5-Slx8 Ub ligase by poly-SUMO conjugates.  J. Biol. Chem. 283, 19912-19921. 
  6. Chen, C-F., and Brill, S.J.  (2007). Binding and activation of DNA topoisomerase III by the Rmi1 subunit.  J. Biol. Chem. 282, 28971-28979. 
  7. Mullen, J.R., Nallaseth, F. S., Lan, Y. Q., Slagle, C. E., and Brill, S.J. (2005). Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex.  Mol. Cell. Biol. 25, 4476-4487.
  8. Hollingsworth, N. M. and Brill, S. J.  (2004).  The Mus81 solution to resolution: Generating meiotic crossovers without Holliday junctions.  Genes Dev.  18, 117-125.
  9. Bastin-Shanower, S.A., Fricke, W.M., Mullen, J.R., and Brill, S.J.  (2003).  The mechanism of Mus81-Mms4 cleavage-site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol. Cell. Biol. 23, 3487-3496.
  10. Fricke, W.M. and Brill, S.J. (2003).  Slx1-Slx4 is a second structure-specific endonuclease that functionally overlaps with Sgs1-Top3. Genes Dev.  17, 1768-1778.
  11. Kaliraman, V., Mullen, J. R., Fricke, W. M., Bastin-Shanower, S.A., and Brill, S.J. (2001).  Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease.  Genes Dev.  15, 2730-2740.
  12. Fricke, W. M., Kaliraman, V., and Brill, S.J. (2001).  Mapping of the DNA topoisomerase III binding domain of the Sgs1 DNA helicase J. Biol. Chem. 276, 8848 - 8855.
  13. Kim, H.S. and Brill, S.J. (2001). Rfc4 Interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Mol. Cell Biol. 21, 3725-3737. 
  14. Bastin-Shanower, S.A. and Brill, S.J. (2001).  Functional analysis of the four DNA binding domains of Replication Protein A: the role of RPA2 in ssDNA binding. J. Biol. Chem. 276, 36446-36453.
  15. Mullen, J. R., Kaliraman, V., Ibrahim, S. S., and Brill, S.J. (2001).  Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase.  Genetics, 157, 103-118.