Researcher Profiles

Return to member profile

Virginia A. Zakian, PhD

Selected Publications

  1. Bochman ML, Paeschke K, Chan A, Zakian VA. Hrq1, a Homolog of the Human RecQ4 Helicase, Acts Catalytically and Structurally to Promote Genome Integrity. Cell Rep, In process, 2014.
  2. Zhou R, Zhang J, Bochman ML, Zakian VA, Ha T. Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA. Elife, 3:e02190, 2014.
  3. Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature, 497:458-462, 2013.
  4. Webb CJ, Wu Y, Zakian VA. DNA repair at telomeres: keeping the ends intact. Cold Spring Harb Perspect Biol, In process, 2013.
  5. Wu Y, Dimaggio PA, Perlman DH, Zakian V, Garcia BA. Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation. J Proteome Res, 12:316-327, 2013.
  6. Bochman ML, Paeschke K, Zakian VA. DNA secondary structures: stability and function of G-quadruplex structures. Nat Rev Genet, 13:770-780, 2012.
  7. Chisholm KM, Aubert SD, Freese KP, Zakian VA, King MC, Welcsh PL. A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1. PLoS One, 7:e30748, 2012.
  8. Sabouri N, McDonald KR, Webb CJ, Cristea IM, Zakian VA. DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Genes Dev, 26:581-593, 2012.
  9. Webb CJ, Zakian VA. Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association. Genes Dev, 26:82-91, 2012.
  10. Wellinger RJ, Zakian VA. Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End. Genetics, 191:1073-1105, 2012.
  11. Zakian VA. Telomeres: the beginnings and ends of eukaryotic chromosomes. Exp Cell Res, 318:1456-1460, 2012.
  12. Bochman ML, Judge CP, Zakian VA. The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? Mol Biol Cell, 22:1955-1959, 2011.
  13. Paeschke K, Capra JA, Zakian VA. DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell, 145:678-691, 2011.
  14. Tuzon CT, Wu Y, Chan A, Zakian VA. The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro. PLoS Genet, 7:e1002060, 2011.
  15. Wu Y, Zakian VA. The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro. Proc Natl Acad Sci U S A, 108:20362-20369, 2011.