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XiangLin Tan, MD, PhD

Selected Publications

Yue, W., Yang, C.S., DiPaola, R.S., Tan, X.L. (2014). Repurposing of metformin and aspirin by targeting AMPK-mTOR signaling and inflammation for pancreatic cancer prevention and treatment. Cancer Prev Res (Phila), 7(4):388-97. PMID:24520038

Tan, X.L., Bhattacharyya K., Dutta S.K., Bamlet W.R., Rabe K.G., Wang E., Smyrk T.C., Oberg A.L., Petersen G.M., Mukhopadhyay D. (2014). Metformin suppresses pancreatic tumor growth with inhibition of NF?B/STAT3 inflammatory signaling. Pancreas, (In Press)

Fridley, B.L., Abo, R., Tan, X.L., Jenkins, G.D., Batzler, A., Moyer, A.M., Biernacka, J.M., Wang, L. (2014). Integrative gene set analysis: application to platinum pharmacogenomics. OMICS,18(1):34-41. PMID:24199607; PMCID:PMC3903166

Jansen, R.J., Robinson, D.P., Stolzenberg-Solomon, R.Z., Bamlet, W.R., Tan, X.L.,Cunningham, J.M., Li, Y., Rider, D.N., Oberg, A.L., Rabe, K.G., Anderson, K.E., Sinha, R., Petersen, G.M. (2013). Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk. Pancreas, 42(7):1043-53. PMID:24051964; PMCID:PMC3779344

Tan, X.L., Marquardt, G., Massimi, A., Shi, M., Han, W., Spivack, S.D. (2012) High-throughput library screening identifies two novel NQO1 inducers in human lung cells. Am J Respir Cell Mol Biol, 46(3), 365-371. PMID:22021338; PMCID: PMC3326428

Tan, X.L., Moyer, A.M.,  Fridley, B.L., Schaid, D.J., Niu, N., Batzler, A.J., Jenkins, G.D., Abo, R.P., Li, L., Cunningham, J.M., Sun, Z., Yang, P., Wang, L. (2011). Genetic variations predicting cisplatin cytotoxicity associated with the overall survival in lung cancer patients receiving platinum-based chemotherapy. Clin Cancer Res, 17(17), 5801-5811. PMID:21775533, PMCID: PMC3167019

Tan, X.L., Reid-Lombardo, K.M., Bamlet, W.R., Oberg, A.L., Robinson, D.P., Anderson, K.E., Petersen, G.M. (2011). Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and risk of pancreatic cancer. Cancer Prev Res (Phila), 4(11), 1835-1841. PMID:21803981; PMCID: PMC3208748

Tan, X.L., Shi, M., Tang, H., Han, W., Spivack, S.D. (2010). Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells. J Nutr, 140(8), 1404-1410. PMID:20554899; PMCID: PMC2903300

Tan, X.L., Moslehi, R., Han, W., Spivack, S.D. (2009). Haplotype tagging single nucleotide polymorphisms in the GSTP1 gene promoter, and susceptibility to lung cancer. Cancer Detect Prev, 32(5-6), 403-15. PMID:19282111; PMCID: PMC3730463

Tan, X.L., Spivack, S.D. (2009). Dietary chemoprevention of lung cancer by modification of phase II metabolism: a review. Lung Cancer, 65(2), 129-137. PMID: 19185948; PMCID: PMC3730487

Tan, X.L., Wang, T., Xiong, S., Kumar, S.V., Han, W., Spivack, S.D. (2009). Smoking-related gene expression in laser capture microdissected human lung. Clin Cancer Res, 15(24), 7562-7570. PMID:19996203; PMCID – Pending.

Tan, X.L., Nieters, A., Hoffmeister, M., Beckmann, L., Brenner, H., Chang-Claude, J. (2008). The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer: a German population-based case control study and meta-analysis. Int. J. Cancer, 122(11):2573-80. PMID:18196581

Tan, X.L., Nieters, A., Hoffmeister, M., Beckmann, L., Brenner, H., Chang-Claude, J. (2007). Genetic Polymorphisms in TP53, Nonsteroidal Anti-inflammatory Drugs and the Risk of Colorectal Cancer: Evidence for Gene – Environment Interaction? Pharmacogenet. Genomics, 17(8), 639-645. PMID:17622940

Tan, X.L., Popanda, O., Ambrosone, C.B., Kropp, S., Helmbold, I., von Fournier, D., Haase, W., Sautter-Bihl, M.L., Wenz, F., Schmezer, P., Chang-Claude, J. (2006). Association between polymorphisms in TP53 and p21 and acute side effects of radiotherapy in breast cancer patients. Breast Cancer Res Treat, 97(3), 255-262. PMID:16331344

Popanda, O., Tan, X.L., Ambrosone, C.B., Kropp, S., Helmbold, I., von Fournier, D., Haase, W., Sautter-Bihl, M.L., Wenz, F., Schmezer, P., Chang-Claude, J. (2006). Genetic polymorphisms in the DNA double-strand break repair genes XRCC3, XRCC2 and NBS1 are not associated with acute side effects of radiotherapy in breast cancer patients. Ca Epidemiol Biomarkers Prev, 15(5), 1048-1050. PMID:16702393

Chang-Claude, J., Popanda, O., Tan, X.L., Kropp, S., Helmbold, I., von Fournier, D., Haase, W., Sautter-Bihl, M.L., Wenz, F., Schmezer, P., Ambrosone, C.B. (2005). Association between polymorphisms in the DNA repair genes, XRCC1, APE1 and XPD, and acute side effects of radiotherapy in breast cancer patients. Clin Cancer Res, 11(13), 4802-4809. PMID:16000577

Schluesener, H.J., Tan, X.L. . Selecting the peptides binding to pathological endothelia cells in glioblastoma in-VIVO phage display. J Neurol Sci, 224(1-2):77-82. PMID:15450774

Zhang, Z.R., Xu, S.Q., Sun, X., Xu, Y.J., Cai, X.K., Liu, Z.W., Tan, X.L., Zhou, Y.K., Zhang, J.U., Yan, H. (2003). Characteristics and application of established luciferase hepatoma cell line that responds to dioxin-like chemicals. World J Gastroenterol, 9(7):1460-4.

Tan, X.L., Xu, S.Q., Chen, J., Wang, H., Liu, D.B. (2002). Detect the level of people’s DNA adduct in the perilymphatic cells by bioluminescence. Zhonghua Yu Fang Yi Xue Za Zhi, 36(6):363-5. PMID:12641968

Xu, S.Q., He, M., Yu, H.P., Wang, X.Y., Tan, X.L., Lu, B., Sun, X., Zhou, Y.K., Yao, Q.F., Xu, Y.J., Zhang, Z.R. (2002). Bioluminescent method for detecting telomerase activity. Clin Chem, 48(7), 1016-1020. PMID:12089169

Zhang, Z.R., Xu, S.Q., Zhou, Y.K., Xu, Y.J., Liu, Z.W., Cai, X.K., Tan, X.L. (2002). Improvement of chemically-activated luciferase gene expression bioassay for detection of dioxin-like chemicals. Biomed Environ Sci, 15(1):58-66. PMID:12046549