Researcher Profile

Gary A. Brewer, PhD

Interim Chair and Professor of Biochemistry and Molecular Biology
Robert Wood Johnson Medical School
Rutgers, The State University of New Jersey

RWJMS Research Tower
675 Hoes Lane West, Room 735
Piscataway, NJ 08854

Phone: (732) 235-3473
Email: brewerga@rwjms.rutgers.edu

Research Program Alignment

  • Non-Programmatically Aligned

Membership Type: Full


Research Interests

  • Regulation of gene expression
  • Genomics

Selected Publications

Sirenko, O., Lofquist, A., DeMaria, C.T., Morris, J., Brewer, G., and Haskill, J.S. Regulation of an AU-rich element binding activity associated with AUF1. 1997. Mol Cell Biol., 17:3898-3906.

Laroia, G., Cuesta, R., Brewer, G., and Schneider, R.J. 1999.  Control of cytokine mRNA decay by the heat shock-ubiquitin-proteasome pathway.  Science 284:499-502.

Lasa, M., Mahtani, K.R., Finch, A., Brewer, G., Saklatvala, J., and Clark, A.R. 2000. Regulation of cyclooxygenase-2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade.  Mol Cell Biol.  20:4265-4274.

Wilson, G.M., Lu, J., Sutphen, K., Sun, Y., Huynh, Y., and Brewer, G. Regulation of ARE-directed mRNA turnover involving reversible phosphorylation of AUF1.  2003. J Biol Chem. 278: 33029-33038.

Wilson, G.M., Lu, J., Sutphen, K., Suarez, Y., Sinha, S., Brewer, B., Villanueva-Feliciano, E., Ysla, R.M., Charles, S., and Brewer, G. Phosphorylation of p40AUF1 regulates binding to AU-rich mRNA-destabilizing elements and protein-induced changes in ribonucleoprotein structure. 2003.  J Biol Chem. 278:33039-33048.

Sinsimer, K.S., Gratacos, F.M., Knapinska, A.M., Lu, J., Krause, C.D., Wierzbowski. A.V., Maher, L.R., Scrudato, S., Rivera, Y.M., Gupta, S., Turrin, D.K., De La Cruz, M.P., Pestka, S., and Brewer, G.  2008. Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay.  Mol. Cell Biol. 28: 5223-5237.

Sarkar, S., Sinsimer, K.S., Foster, R.L., Brewer, G., and Pestka, S. 2008. AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes. J Interferon Cytokine Res. 28: 679-692.

Sarkar, S., Han, J., Sinsimer, K.S., Liao, B., Foster, R.L., Brewer, G., and Pestka, S. 2011. RNA-binding protein AUF1 regulates LPS-induced IL10 expression by activating IκB kinase complex in monocytes.  Mol. Cell. Biol. 31: 602-615. 

Knapinska, A.M., Gratacós, F.M., Krause, C.D., Hernandez, K., Jensen, A.G., Bradley, J., Pestka, S. and Brewer, G. 2011.  Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation.  Mol. Cell. Biol. 31: 1419-1431.

Qi, M-Y., Wang, Z-Z., Zhang, Z., Shao, Q., Zeng, A., Li, X-Q., Li, W-Q., Wang, C., Tian, F-J., Li, Q., Zou, J., Qin, Y-W., Brewer, G., Huang, S. and Jing, Q. 2012.  AU-rich element-dependent translation repression requires the cooperation of Tristetraprolin and RCK/p54.  Mol. Cell. Biol. 32: 913-928.

Wu, X. and Brewer, G. 2012. Regulation of mRNA degradation in mammalian cells: 2.0. Gene, 500: 10-21.

Zhang, Z., Qin, Y-W., Brewer, G. and Jing, Q. 2012. MicroRNA degradation and turnover: Regulating the regulators.  Wiley Interdiscip. Rev. RNA 3: 593-600.

The content for this Research Profile is maintained by Paul Novembre (novembre@cinj.rutgers.edu)