Contessa Laboratory Select Publications

Complete list of Dr. Contessa’s publications

  1. Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty D, Rinis N, Charest J, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden J, Contessa JN, Oligosaccharyltransferase Inhibition Induces Senescence in RTK-Driven Tumor Cells, Nature Chemical Biology. 2016 Dec;12(12):1023-1030.
  2. Rinis N, Golden J, Carette J, Gilmore R, Contessa JN. Editing of N-Linked Glycan Site Occupancy with Small Molecule Oligosacharyltransferase (OST) inhibitors, Cell Chemical Biology. 2018 Jul 24. pii: S2451-9456(18)30232-0
  3. Baro M, Lopez-Sambrooks C, King AR, Saltzman WM, Contessa JN. Oligosaccharyltransferase inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity, Clinical Cancer Research, 2019 Jan 15;25(2):784-795.
  4. Lopez-Sambrooks C, Baro M, King AR, NarayanA, Cui W, Greninger P, Egan R, Patel A, Benes CH, Saltzman WM, Contessa JN.Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors. Cancer Research. 2018 Sep 1;78(17):5094-5106
  5. Baro M, Lopez Sambrooks C, Burtness BA, Lemmon MA, Contessa JN. Neuregulin Signaling Is a Mechanism of TherapeuticResistance in Head and Neck Squamous Cell Carcinoma. Molecular Cancer Therapeutics. 2019 Nov;18(11):2124-2134.
  6. Phoomak C, Cui W, Hayman TJ, Yu SH, Zhao P, Wells L, Steet R, Contessa JN. The translocon- associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress. Science Advances. 2021 Jan 15;7(3): eabc6364.
  7. Hayman T, Baro M, MacNeil T, Phoomak C, Cui W, Sandoval-Schaefer T, Burtness B, Rimm D, Contessa JN. STING EnhancesCell Death Through Regulation of Reactive Oxygen Species and DNA Damage. Nature Communications. 2021 Apr 19; 12(1):2327
  8. Phoomak C, Rinis N, Baro M, Shrimal S, Bennett D, Shaffer S, Lehrman M, Gilmore R, Contessa JN. Signal recognition particle receptor-B coordinates co-translational N-glycosylation. Science Advances 2023 Mar 17;9(11):eade8079. PMID: 36921042
  9. Lampson BL, Ramίrez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH,He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Positive selection CRISPR screens revea la druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB. Cell. 2024Apr 25;187(9):2209-2223. PMID: 38670073
  10. Dominguez-Vigil I, Banik K, Baro M, Contessa JN, Hayman T. PLK4 inhibition as a strategy to enhance non-small cell lungcancer radiosensitivity. Mol. Cancer Ther. 2025 Sep 2;24(9):1350-1361. doi: 10.1158/1535-7163.MCT-24-0978. PMID: 40296663
  11. Baro M, Lee H, Kelley V, Lou R, Phoomak C, Politi K, Zeiss CJ, Van Zandt M, Contessa JN. OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation. Cell Chemical Biology. 2025 Jun 19;32(6):839-853.e6. doi: 10.1016/j.chembiol.2025.05.005. Epub 2025 Jun 9. PMID: 40494352
  12. MacNeil T, Hayman TJ, Li S, Moutafi M, Martinez-Morilla S, Vathiotis IA, Hu R, Harari PM, Burtness B, Liu H, Kimple RJ, Rimm DL, Contessa JN. STING predicts patterns of failure in locally advanced head and neck squamous cell carcinoma. JNCI Cancer Spectr. 2026;10(2):pkaf126. doi:10.1093/jncics/pkaf126. PMID: 41569294
  13. Kelley VM, Baro M, Gasperi WE, Ader NR, Lea H, Lee H, Phoomak C, Kabeche L, King MC, Contessa JN. Loss of JAK1 function causes G2–M cell-cycle defects vulnerable to KIF18A inhibition. Cancer Res. 2026;86(9):2301-2317. doi:10.1158/0008-5472.CAN-25-1423. PMID: 41591363