White Laboratory - Select Publications

Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease
P Liu, A Anandhan, J Chen, A Shakya, M Dodson, A Ooi, E Chapman, ...
Redox Biology 59, 102570

2023

Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors
V Bhatt, T Lan, W Wang, J Kong, EC Lopes, J Wang, K Khayati, A Raju, ...
Cell Death & Disease 14 (1), 61

2023

Abstract IA020: Increased mitochondrial DNA mutation burden with age limits lung cancer
E White
Cancer Research 83 (2_Supplement_1), IA020-IA020

2023

Functional cooperation between ATG7/autophagy and the PALB2 tumor suppressor in mitochondrial regulation, redox homeostasis, and neuronal health
Y Huo, A Sawant, E White, B Xia
Autophagy Reports 1 (1), 234-237

2022

Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer
K Khayati, V Bhatt, T Lan, F Alogaili, W Wang, E Lopez, ZS Hu, S Gokhale, ...
Cancer Research 82 (23), 4429-4443

2022

Autophagy in PDGFRA+ mesenchymal cells is required for intestinal homeostasis and mammalian survival
Y Yang, E White
Autophagy, 1-3

2022

Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival
Y Yang, M Gomez, T Marsh, L Poillet-Perez, A Sawant, L Chen, NR Park, ...
Proceedings of the National Academy of Sciences 119 (21), e2202016119

2022

Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration
Y Huo, A Sawant, Y Tan, AH Mahdi, T Li, H Ma, V Bhatt, R Yan, ...
PLoS genetics 18 (4), e1010138

2022

Mitochondrial fission factor is a novel interacting protein of the critical B cell survival regulator TRAF3 in B lymphocytes
Y Liu, S Gokhale, J Jung, S Zhu, C Luo, D Saha, JY Guo, H Zhang, S Kyin, ...
Frontiers in immunology 12, 670338

2021

Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
L Poillet-Perez, DW Sharp, Y Yang, SV Laddha, M Ibrahim, ...
Nature cancer 2 (9), 994

2021

Breakthroughs and bottlenecks in autophagy research
N Mizushima, E White, DC Rubinsztein
Trends in Molecular Medicine 27 (9), 835-838

2021

Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism
P Liu, M Dodson, H Li, CJ Schmidlin, A Shakya, Y Wei, JGN Garcia, ...
Molecular Metabolism 51, 101243

2021

Autophagy regulates stress responses, metabolism, and anticancer immunity
E White, EC Lattime, JY Guo
Trends in cancer 7 (8), 778-789

2021

MDVs to the rescue: How autophagy-deficient cancer cells adapt to defective mitophagy
L Poillet-Perez, E White
Developmental Cell 56 (14), 2010-2012

2021

Autophagy inhibition sensitizes liver kinase b1 (LKB1)-deficient kras-driven lung tumors to MEK inhibitor trametinib
VD Bhatt, T Lan, W Wang, K Khayati, E Cararo-Lopes, J Wang, J Kong, ...
Cancer Research 81 (13_Supplement), 88-88

2021

PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7 to suppress p53 dependent neurodegeneration
Y Huo, A Sawant, Y Tan, AH Mahdi, T Li, H Ma, V Bhatt, R Yan, ...
bioRxiv, 2021.06. 07.447248

2021

SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
X Wang, H Zhang, R Sapio, J Yang, J Wong, X Zhang, JY Guo, S Pine, ...
Nature communications 12 (1), 2259

2021

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382

2021

Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or MetastasisG6PD Is Not Essential for K-Ras Tumor Growth or Metastasis
JM Ghergurovich, M Esposito, Z Chen, JZ Wang, V Bhatt, T Lan, E White, ...
Cancer research 80 (18), 3820-3829

2020

Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
L Poillet-Perez, DW Sharp, Y Yang, SV Laddha, M Ibrahim, ...
Nature cancer 1 (9), 923-934

2020

Autophagy suppresses TRP53/p53 and oxidative stress to enable mammalian survival
Y Yang, E White
Autophagy 16 (7), 1355-1357

2020

Role of autophagy in cancer metabolism.
EP White
CANCER RESEARCH 80 (11), 21-21

2020

Abstract IA19: Role of autophagy in cancer metabolism
EP White
Cancer Research 80 (11_Supplement), IA19-IA19

2020

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression
J Liu, C Zhang, H Wu, XX Sun, Y Li, S Huang, X Yue, SE Lu, Z Shen, X Su, ...
The Journal of clinical investigation 130 (6), 3253-3269

2020

Autophagy promotes mammalian survival by suppressing oxidative stress and p53
Y Yang, G Karsli-Uzunbas, L Poillet-Perez, A Sawant, ZS Hu, Y Zhao, ...
Genes & Development 34 (9-10), 688-700

2020

Serine catabolism feeds NADH when respiration is impaired
L Yang, JCG Canaveras, Z Chen, L Wang, L Liang, C Jang, JA Mayr, ...
Cell metabolism 31 (4), 809-821. e6

2020

Ceramide derivatives as anticancer agents
R Lutz, E Andrianasolo, P Falkowski, E White, L Haramaty
US Patent 10,537,545

2020

Beth Levine in memoriam
Z An, A Ballabi, L Bennett, P Boya, F Cecconi, WC Chiang, P Codogno, ...
Landes Bioscience

2020

Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism
AJ Bott, J Shen, C Tonelli, L Zhan, N Sivaram, YP Jiang, X Yu, V Bhatt, ...
Cell reports 29 (5), 1287-1298. e6

2019

A phase I trial of MK-2206 and hydroxychloroquine in patients with advanced solid tumors
JM Mehnert, AD Kaveney, J Malhotra, K Spencer, D Portal, S Goodin, ...
Cancer chemotherapy and pharmacology 84, 899-907

2019

Role of tumor and host autophagy in cancer metabolism
L Poillet-Perez, E White
Genes & development 33 (11-12), 610-619

2019

Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells
Y Wang, H Xiong, D Liu, C Hill, A Ertay, J Li, Y Zou, P Miller, E White, ...
Autophagy 15 (5), 886-899

2019

Blockade of RAF and autophagy is the one-two punch to take out Ras
E White
Proceedings of the National Academy of Sciences 116 (10), 3965-3967

2019

Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids
MD Neinast, C Jang, S Hui, DS Murashige, Q Chu, RJ Morscher, X Li, ...
Cell metabolism 29 (2), 417-429. e4

2019

Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC)
J Malhotra, S Jabbour, M Orlick, G Riedlinger, Y Guo, E White, J Aisner
Cancer treatment and research communications 21, 100158

2019

Author Correction: Autophagy maintains tumour growth through circulating arginine.
L Poillet-Perez, X Xie, L Zhan, Y Yang, DW Sharp, ZS Hu, X Su, A Maganti, ...
Nature 565 (7737), E3-E3

2019