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White Laboratory - Select Publications

Poillet-Perez L, Sharp DW, Yang Y, Laddha SV, Ibrahim M, Bommareddy PK, Hu Z, Vieth J, Haas M, Bosenberg MW, Rabinowitz JD, Cao J, Guan J, Ganesan S, Chan CS, Mehnert JM, Lattime EC, White E. Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune responseNature Cancer. 2020 Sep; 1:923-924.

Liu J, Zhang C, Wu H, Sun XX, Li Y, Huang S, Yue X, Lu SE, Shen Z, Su X, White E, Haffty BG, Hu W, Feng Z. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. J Clin Invest. 2020 Jun 1;130(6):3253-3269. doi: 10.1172/JCI132876. PubMed PMID: 32478681
Ghergurovich JM, Esposito M, Chen Z, Wang JZ, Bhatt V, Lan T, White E, Kang Y, Guo JY, Rabinowitz JD. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020 Sep 15;80(18):3820-3829. doi: 10.1158/0008-5472.CAN-19-2486. Epub 2020 Jul 13. PubMed PMID: 32661137

Yang Y, White E. Autophagy suppresses TRP53/p53 and oxidative stress to enable mammalian survival. Autophagy. 2020 May 23;:1-3. doi: 10.1080/15548627.2020.1765522. [Epub ahead of print] PubMed PMID: 32370647.
Yang L, Garcia Canaveras JC, Chen Z, Wang L, Liang L, Jang C, Mayr JA, Zhang Z, Ghergurovich JM, Zhan L, Joshi S, Hu Z, McReynolds MR, Su X, White E, Morscher RJ, Rabinowitz JD. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metab. 2020 Apr 7;31(4):809-821.e6. doi: 10.1016/j.cmet.2020.02.017. Epub 2020 Mar 17. PubMed PMID: 32187526.
Yang Y, Karsli-Uzunbas G, Poillet-Perez L, Sawant A, Hu ZS, Zhao Y, Moore D, Hu W, White E. Autophagy promotes mammalian survival by suppressing oxidative stress and p53. Genes Dev. 2020 May 1;34(9-10):688-700. doi: 10.1101/gad.335570.119. Epub 2020 Mar 19. PubMed PMID: 32193353.

White E. Blockade of RAF and autophagy is the one-two punch to take out Ras. Proc Natl Acad Sci U S A. 2019 doi: 10.1073/pnas.1900800116.  PubMed PMID: 30782814.

Wang Y, Xiong H, Liu D, Hill C, Ertay A, Li J, Zou Y, Miller P, White E, Downward J, Goldin RD, Yuan X, Lu X. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. 2019;15(5):886-99. doi: 10.1080/15548627.2019.1569912.  PubMed PMID: 30782064.

Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg MW, Mehnert JM, Guo JY, Lattime E, Rabinowitz JD, White E. Author Correction: Autophagy maintains tumour growth through circulating arginine. Nature. 2019;565(7737):E3. doi: 10.1038/s41586-018-0815-6.  PubMed PMID: 30523330.

Poillet-Perez L, White E. Role of tumor and host autophagy in cancer metabolism. Genes Dev. 2019;33(11-12):610-19. doi: 10.1101/gad.325514.119.  PubMed PMID: 31160394.

Neinast MD, Jang C, Hui S, Murashige DS, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z. Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell Metab. 2019;29(2):417-29 e4. doi: 10.1016/j.cmet.2018.10.013.  PubMed PMID: 30449684.

Tsang CK, Chen M, Cheng X, Qi Y, Chen Y, Das I, Li X, Vallat B, Fu LW, Qian CN, Wang HY, White E, Burley SK, Zheng XFS. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. Mol Cell. 2018;70(3):502-15 e8. doi: 10.1016/j.molcel.2018.03.029.  PubMed PMID: 29727620.

Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Syst. 2018;7(1):49-62 e8. doi: 10.1016/j.cels.2018.06.003.  PubMed PMID: 29960885.

Perekatt AO, Shah PP, Cheung S, Jariwala N, Wu A, Gandhi V, Kumar N, Feng Q, Patel N, Chen L, Joshi S, Zhou A, Taketo MM, Xing J, White E, Gao N, Gatza ML, Verzi MP. SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium. Cancer Res. 2018;78(17):4878-90. doi: 10.1158/0008-5472.CAN-18-0043.  PubMed PMID: 29986996.

Liu L, Su X, Quinn WJ, 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metab. 2018;27(5):1067-80 e5. doi: 10.1016/j.cmet.2018.03.018.  PubMed PMID: 29685734.

Panda A, Mehnert JM, Hirshfield KM, Riedlinger G, Damare S, Saunders T, Kane M, Sokol L, Stein MN, Poplin E, Rodriguez-Rodriguez L, Silk AW, Aisner J, Chan N, Malhotra J, Frankel M, Kaufman HL, Ali S, Ross JS, White EP, Bhanot G, Ganesan S. Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer. J Natl Cancer Inst. 2017 doi: 10.1093/jnci/djx213.  PubMed PMID: 29155997;  PMCID.

Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, Gatza ML, Xia D, Gao J, White E, Haffty BG, Hu W, Feng Z. Parkin targets HIF-1alpha for ubiquitination and degradation to inhibit breast tumor progression. Nat Commun. 2017;8(1):1823. doi: 10.1038/s41467-017-01947-w.  PubMed PMID: 29180628;  PMCID: PMC5703960.

Kulkarni A, Al-Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine SR, Jeyamohan C, Sokol L, Ali SM, Teo ML, White E, Rodriguez-Rodriguez L, Mehnert JM, Ganesan S. BRAF fusion as a novel mechanism of acquired resistance to vemurafenib in BRAF V600E mutant melanoma. Clin Cancer Res. 2017 doi: 10.1158/1078-0432.CCR-16-0758.  PubMed PMID: 28539463;  PMCID.

Kimmelman AC, White E. Autophagy and Tumor Metabolism. Cell Metab. 2017;25(5):1037-43. doi: 10.1016/j.cmet.2017.04.004.  PubMed PMID: 28467923;  PMCID.

Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Z, Yanxiang Guo J, White E, Rabinowitz JD. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017;551(7678):115-18. doi: 10.1038/nature24057.  PubMed PMID: 29045397;  PMCID.

Huhn SC, Liu J, Ye C, Lu H, Jiang X, Feng X, Ganesan S, White E, Shen Z. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017 doi: 10.1038/onc.2017.92.  PubMed PMID: 28394342;  PMCID.

Guo JY, White E. Autophagy, Metabolism, and Cancer. Cold Spring Harb Symp Quant Biol. 2017 doi: 10.1101/sqb.2016.81.030981.  PubMed PMID: 28209717;  PMCID.

Zong WX, Rabinowitz JD, White E. Mitochondria and Cancer. Mol Cell. 2016;61(5):667-76. doi: 10.1016/j.molcel.2016.02.011.  PubMed PMID: 26942671;  PMCID: PMC4779192.

White E. Women in Metabolism: Part IV. Cell Metab. 2016;24(6):767-70. doi: 10.1016/j.cmet.2016.11.014.  PubMed PMID: 27974174;  PMCID.

White E. Autophagy and p53. Cold Spring Harb Perspect Med. 2016;6(4):a026120. doi: 10.1101/cshperspect.a026120.  PubMed PMID: 27037419;  PMCID.

Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL. Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. J Cell Biol. 2016;212(5):545-60. doi: 10.1083/jcb.201507023.  PubMed PMID: 26929451;  PMCID: PMC4772497.

Santanam U, Banach-Petrosky W, Abate-Shen C, Shen MM, White E, DiPaola RS. Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. Genes Dev. 2016;30(4):399-407. doi: 10.1101/gad.274134.115.  PubMed PMID: 26883359;  PMCID: PMC4762425.

Mehnert JM, Panda A, Zhong H, Hirshfield K, Damare S, Lane K, Sokol L, Stein MN, Rodriguez-Rodriquez L, Kaufman HL, Ali S, Ross JS, Pavlick DC, Bhanot G, White EP, DiPaola RS, Lovell A, Cheng J, Ganesan S. Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer. J Clin Invest. 2016;126(6):2334-40. doi: 10.1172/JCI84940.  PubMed PMID: 27159395;  PMCID: PMC4887167.

Liao Y, Chu HP, Hu Z, Merkin JJ, Chen J, Liu Z, Degenhardt K, White E, Ryazanov AG. Paradoxical roles of elongation factor-2 kinase in stem cell survival. J Biol Chem. 2016 doi: 10.1074/jbc.M116.724856.  PubMed PMID: 27466362;  PMCID.

Lashinger LM, O'Flanagan CH, Dunlap SM, Rasmussen AJ, Sweeney S, Guo JY, Lodi A, Tiziani S, White E, Hursting SD. Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors. Cancer Metab. 2016;4:18. doi: 10.1186/s40170-016-0158-4.  PubMed PMID: 27651895;  PMCID: PMC5025535.

Kumar N, Srivillibhuthur M, Joshi S, Walton KD, Zhou A, Faller WJ, Perekatt AO, Sansom OJ, Gumucio DL, Xing J, Bonder EM, Gao N, White E, Verzi MP. A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016;143(20):3711-22. doi: 10.1242/dev.137992.  PubMed PMID: 27802136;  PMCID: PMC5087649.

Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.  PubMed PMID: 26799652;  PMCID: PMC4835977.

Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016;30(15):1704-17. doi: 10.1101/gad.283416.116.  PubMed PMID: 27516533;  PMCID: PMC5002976.

Amaravadi R, Kimmelman AC, White E. Recent insights into the function of autophagy in cancer. Genes Dev. 2016;30(17):1913-30. doi: 10.1101/gad.287524.116.  PubMed PMID: 27664235;  PMCID: PMC5066235.

Zhang Y, Wang X, Qin X, Wang X, Liu F, White E, Zheng XF. PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. EBioMedicine. 2015;2(12):1944-56. doi: 10.1016/j.ebiom.2015.11.031.  PubMed PMID: 26844273;  PMCID: PMC4703732.

Xie X, Koh JY, Price S, White E, Mehnert JM. Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. Cancer Discov. 2015;5(4):410-23. doi: 10.1158/2159-8290.CD-14-1473.  PubMed PMID: 25673642;  PMCID: 4390491.

White E, Mehnert JM, Chan CS. Autophagy, Metabolism, and Cancer. Clin Cancer Res. 2015;21(22):5037-46. doi: 10.1158/1078-0432.CCR-15-0490.  PubMed PMID: 26567363;  PMCID: PMC4646728.

White E. The role for autophagy in cancer. J Clin Invest. 2015;125(1):42-6. doi: 10.1172/JCI73941.  PubMed PMID: 25654549;  PMCID: PMC4382247.

Strohecker AM, Joshi S, Possemato R, Abraham RT, Sabatini DM, White E. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene. 2015 doi: 10.1038/onc.2015.23.  PubMed PMID: 25772235;  PMCID: 4573377.

Santaguida S, Vasile E, White E, Amon A. Aneuploidy-induced cellular stresses limit autophagic degradation. Genes Dev. 2015;29(19):2010-21. doi: 10.1101/gad.269118.115.  PubMed PMID: 26404941;  PMCID: PMC4604343.

Mathew R, White E. Eat this, not that! How selective autophagy helps cancer cells survive. Mol Cell Oncol. 2015;2(2):e975638. doi: 10.4161/23723556.2014.975638.  PubMed PMID: 27308434;  PMCID: PMC4904891.

Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, Hsieh JJ, Ganesan S, Chan CS, White E. The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. Cell Rep. 2015;13(9):1895-908. doi: 10.1016/j.celrep.2015.10.059.  PubMed PMID: 26655904;  PMCID: PMC4779191.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, Lopez-Otin C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Munoz-Pinedo C, Nunez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015;22(1):58-73. doi: 10.1038/cdd.2014.137.  PubMed PMID: 25236395;  PMCID: 4262782.

White E. Q&A: targeting autophagy in cancer-a new therapeutic? Cancer Metab. 2014;2:14. doi: 10.1186/2049-3002-2-14.  PubMed PMID: 25215185;  PMCID: 4160717.

Autophagy coverStrohecker AM, White E. Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism. Autophagy. 2014;10(2):384-5. doi: 10.4161/auto.27320.  PubMed PMID: 24362353;  PMCID.

Strohecker AM, White E. Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers. Cancer Discov. 2014;4(7):766-72. doi: 10.1158/2159-8290.CD-14-0196.  PubMed PMID: 24860158;  PMCID: 4090279.

Cancer Discovery coverShim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, Kho EY, Ghosh AP, Kirkman R, Velu S, Dutta S, Chenna B, Rea SL, Mishur RJ, Li Q, Johnson-Pais TL, Guo L, Bae S, Wei S, Block K, Sudarshan S. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014;4(11):1290-8. doi: 10.1158/2159-8290.CD-13-0696.  PubMed PMID: 25182153;  PMCID: PMC4286872.

Michaud M, Xie X, Bravo-San Pedro JM, Zitvogel L, White E, Kroemer G. An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy. Oncoimmunology. 2014;3(7):e944047. doi: 10.4161/21624011.2014.944047.  PubMed PMID: 25610726;  PMCID: 4292732.

Mathew R, Khor S, Hackett SR, Rabinowitz JD, Perlman DH, White E. Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Mol Cell. 2014;55(6):916-30. doi: 10.1016/j.molcel.2014.07.019.  PubMed PMID: 25175026;  PMCID: 4169768.

Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zhou J, Sun Y, Ruan K, Cheng S, Komatsu M, White E, Li L, Ji H, Finley D, Hu R. Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. Cancer Cell. 2014;26(1):106-20. doi: 10.1016/j.ccr.2014.05.015.  PubMed PMID: 25026213;  PMCID: 4166492.

Laddha SV, Ganesan S, Chan CS, White E. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Mol Cancer Res. 2014;12(4):485-90. doi: 10.1158/1541-7786.MCR-13-0614.  PubMed PMID: 24478461;  PMCID: 3989371.

Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov. 2014;4(8):914-27. doi: 10.1158/2159-8290.CD-14-0363.  PubMed PMID: 24875857;  PMCID: 4125614.

Andrianasolo EH, Haramaty L, White E, Lutz R, Falkowski P. Mode of action of diterpene and characterization of related metabolites from the soft coral, Xenia elongata. Mar Drugs. 2014;12(2):1102-15. doi: 10.3390/md12021102.  PubMed PMID: 24562393;  PMCID: 3944532.

Xie X, White EP, Mehnert JM. Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma. PLoS One. 2013;8(1):e55096. doi: 10.1371/journal.pone.0055096.  PubMed PMID: 23383069;  PMCID: 3559441.

White E. Exploiting the bad eating habits of Ras-driven cancers. Genes Dev. 2013;27(19):2065-71. doi: 10.1101/gad.228122.113.  PubMed PMID: 24115766;  PMCID: 3850091.

Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov. 2013;3(11):1272-85. doi: 10.1158/2159-8290.CD-13-0397.  PubMed PMID: 23965987;  PMCID: 3823822.

Martovetsky G, Tee JB, Nigam SK. Hepatocyte nuclear factors 4alpha and 1alpha regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters. Mol Pharmacol. 2013;84(6):808-23. doi: 10.1124/mol.113.088229.  PubMed PMID: 24038112;  PMCID: PMC3834141.

Martino JJ, Wall BA, Mastrantoni E, Wilimczyk BJ, La Cava SN, Degenhardt K, White E, Chen S. Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene. 2013;32(37):4366-76. doi: 10.1038/onc.2012.471.  PubMed PMID: 23085756;  PMCID: PMC3910169.

Lau A, Zheng Y, Tao S, Wang H, Whitman SA, White E, Zhang DD. Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. Mol Cell Biol. 2013;33(12):2436-46. doi: 10.1128/MCB.01748-12.  PubMed PMID: 23589329;  PMCID: 3700105.

Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A. 2013;110(22):8882-7. doi: 10.1073/pnas.1307237110.  PubMed PMID: 23671091;  PMCID: 3670379.

Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E, Xia B. Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov. 2013;3(8):894-907. doi: 10.1158/2159-8290.CD-13-0011.  PubMed PMID: 23650262;  PMCID: 3740014.

Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell. 2013;155(6):1216-9. doi: 10.1016/j.cell.2013.11.019.  PubMed PMID: 24315093;  PMCID: 3987898.

Guo JY, White E. Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors. Autophagy. 2013;9(10):1636-8. doi: 10.4161/auto.26123.  PubMed PMID: 23959381;  PMCID.

Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, White E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 2013;27(13):1447-61. doi: 10.1101/gad.219642.113.  PubMed PMID: 23824538;  PMCID: 3713426.

Fan J, Kamphorst JJ, Mathew R, Chung MK, White E, Shlomi T, Rabinowitz JD. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol. 2013;9:712. doi: 10.1038/msb.2013.65.  PubMed PMID: 24301801;  PMCID: PMC3882799.

White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer. 2012;12(6):401-10. doi: 10.1038/nrc3262.  PubMed PMID: 22534666;  PMCID: 3664381.

White E. Q&A: Eileen White on understanding autophagy. Cancer Discov. 2012;2(10):863. doi: 10.1158/2159-8290.CD-ND2012-036.  PubMed PMID: 23071017;  PMCID.

Sulzmaier FJ, Valmiki MK, Nelson DA, Caliva MJ, Geerts D, Matter ML, White EP, Ramos JW. PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene. 2012;31(30):3547-60. doi: 10.1038/onc.2011.514.  PubMed PMID: 22105357;  PMCID: PMC3295902.

Saleem A, Dvorzhinski D, Santanam U, Mathew R, Bray K, Stein M, White E, DiPaola RS. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate. 2012;72(12):1374-81. doi: 10.1002/pros.22487.  PubMed PMID: 22241682;  PMCID: 3840901.

Lin CS, Sharpley MS, Fan W, Waymire KG, Sadun AA, Carelli V, Ross-Cisneros FN, Baciu P, Sung E, McManus MJ, Pan BX, Gil DW, Macgregor GR, Wallace DC. Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc Natl Acad Sci U S A. 2012;109(49):20065-70. doi: 10.1073/pnas.1217113109.  PubMed PMID: 23129651;  PMCID: PMC3523873.

Ladoire S, Chaba K, Martins I, Sukkurwala AQ, Adjemian S, Michaud M, Poirier-Colame V, Andreiuolo F, Galluzzi L, White E, Rosenfeldt M, Ryan KM, Zitvogel L, Kroemer G. Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy. 2012;8(8):1175-84. doi: 10.4161/auto.20353.  PubMed PMID: 22647537;  PMCID: 3973657.

Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR, Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni W, Mehlen P, Nunez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU, Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012;19(1):107-20. doi: 10.1038/cdd.2011.96.  PubMed PMID: 21760595;  PMCID: 3252826.

Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One. 2012;7(7):e41831. doi: 10.1371/journal.pone.0041831.  PubMed PMID: 22848625;  PMCID: 3406086.

Andrianasolo EH, Haramaty L, Rosario-Passapera R, Vetriani C, Falkowski P, White E, Lutz R. Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans. Mar Drugs. 2012;10(10):2300-11. doi: 10.3390/md10102300.  PubMed PMID: 23170085;  PMCID: 3497024.

Mehnert JM, Tan AR, Moss R, Poplin E, Stein MN, Sovak M, Levinson K, Lin H, Kane M, Gounder M, Lin Y, Shih WJ, White E, Rubin EH, Karantza V. Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach. Mol Cancer Ther. 2011;10(8):1509-19. doi: 10.1158/1535-7163.MCT-10-0944.  PubMed PMID: 21680752;  PMCID: 3155243.

Mathew R, White E. Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev. 2011;21(1):113-9. doi: 10.1016/j.gde.2010.12.008.  PubMed PMID: 21255998;  PMCID: 3039840.

Mathew R, White E. Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger. Cold Spring Harb Symp Quant Biol. 2011;76:389-96. doi: 10.1101/sqb.2012.76.011015.  PubMed PMID: 22442109;  PMCID.

Lu H, Huang YY, Mehrotra S, Droz-Rosario R, Liu J, Bhaumik M, White E, Shen Z. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet. 2011;7(9):e1002291. doi: 10.1371/journal.pgen.1002291.  PubMed PMID: 21966279;  PMCID: PMC3178617.

Kamphorst JJ, Fan J, Lu W, White E, Rabinowitz JD. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal Chem. 2011;83(23):9114-22. doi: 10.1021/ac202220b.  PubMed PMID: 22004349;  PMCID: PMC3230881.Genes and Development cover

Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011;25(5):460-70. doi: 10.1101/gad.2016311.  PubMed PMID: 21317241;  PMCID: 3049287.

Chen HY, White E. Role of autophagy in cancer prevention. Cancer Prev Res (Phila). 2011;4(7):973-83. doi: 10.1158/1940-6207.CAPR-10-0387.  PubMed PMID: 21733821;  PMCID: 3136921.

Cancer Prevention ResearchAndrianasolo EH, Haramaty L, McPhail KL, White E, Vetriani C, Falkowski P, Lutz R. Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus. J Nat Prod. 2011;74(4):842-6. doi: 10.1021/np100601w.  PubMed PMID: 21222464;  PMCID: 3081957.

Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res. 2011;17(4):654-66. doi: 10.1158/1078-0432.CCR-10-2634.  PubMed PMID: 21325294;  PMCID: 3075808.

White E, Karp C, Strohecker AM, Guo Y, Mathew R. Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol. 2010;22(2):212-7. doi: 10.1016/  PubMed PMID: 20056400;  PMCID: 2857707.

Stein M, Lin H, Jeyamohan C, Dvorzhinski D, Gounder M, Bray K, Eddy S, Goodin S, White E, Dipaola RS. Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies. Prostate. 2010;70(13):1388-94. doi: 10.1002/pros.21172.  PubMed PMID: 20687211;  PMCID: 4142700.

Singh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, Ponpuak M, Master S, Pilli M, White E, Komatsu M, Deretic V. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol. 2010;12(12):1154-65. doi: 10.1038/ncb2119.  PubMed PMID: 21102437;  PMCID: 2996476.

Rabinowitz JD, White E. Autophagy and metabolism. Science. 2010;330(6009):1344-8. doi: 10.1126/science.1193497.  PubMed PMID: 21127245;  PMCID: 3010857.

Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010;30(13):3275-85. doi: 10.1128/MCB.00248-10.  PubMed PMID: 20421418;  PMCID: 2897585.

Kroemer G, White E. Autophagy for the avoidance of degenerative, inflammatory, infectious, and neoplastic disease. Curr Opin Cell Biol. 2010;22(2):121-3. doi: 10.1016/  PubMed PMID: 20202808;  PMCID: 2854209.

Kongara S, Kravchuk O, Teplova I, Lozy F, Schulte J, Moore D, Barnard N, Neumann CA, White E, Karantza V. Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors. Mol Cancer Res. 2010;8(6):873-84. doi: 10.1158/1541-7786.MCR-09-0494.  PubMed PMID: 20530580;  PMCID: 2891319.

Kanazawa T, Konno A, Hashimoto Y, Kon Y. Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney. Dev Dyn. 2010;239(4):1145-54. doi: 10.1002/dvdy.22276.  PubMed PMID: 20235219;  PMCID.

Jiang H, Martin V, Gomez-Manzano C, Johnson DG, Alonso M, White E, Xu J, McDonnell TJ, Shinojima N, Fueyo J. The RB-E2F1 pathway regulates autophagy. Cancer Res. 2010;70(20):7882-93. doi: 10.1158/0008-5472.CAN-10-1604.  PubMed PMID: 20807803;  PMCID: 3104680.

Fan G, Simmons MJ, Ge S, Dutta-Simmons J, Kucharczak J, Ron Y, Weissmann D, Chen CC, Mukherjee C, White E, Gelinas C. Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. Blood. 2010;115(17):3559-69. doi: 10.1182/blood-2009-08-236760.  PubMed PMID: 20185581;  PMCID: 2867266.

Eng CH, Yu K, Lucas J, White E, Abraham RT. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal. 2010;3(119):ra31. doi: 10.1126/scisignal.2000911.  PubMed PMID: 20424262;  PMCID.

DiPaola RS, Chen YH, Stein M, Vaughn D, Patrick-Miller L, Carducci M, Roth B, White E, Wilding G. A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899. J Transl Med. 2010;8:20. doi: 10.1186/1479-5876-8-20.  PubMed PMID: 20178647;  PMCID: PMC2837641.

White E, Lowe SW. Eating to exit: autophagy-enabled senescence revealed. Genes Dev. 2009;23(7):784-7. doi: 10.1101/gad.1795309.  PubMed PMID: 19339684;  PMCID.

White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res. 2009;15(17):5308-16. doi: 10.1158/1078-0432.CCR-07-5023.  PubMed PMID: 19706824;  PMCID: 2737083.

Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, Dipaola RS, Karantza-Wadsworth V, White E. Autophagy suppresses tumorigenesis through elimination of p62. Cell. 2009;137(6):1062-75. doi: 10.1016/j.cell.2009.03.048.  PubMed PMID: 19524509;  PMCID: 2802318.

Mathew R, Karantza-Wadsworth V, White E. Assessing metabolic stress and autophagy status in epithelial tumors. Methods Enzymol. 2009;453:53-81. doi: 10.1016/S0076-6879(08)04004-4.  PubMed PMID: 19216902;  PMCID: 2857509.

Mao L, Tang Y, Vaiphei ST, Shimazu T, Kim SG, Mani R, Fakhoury E, White E, Montelione GT, Inouye M. Production of membrane proteins for NMR studies using the condensed single protein (cSPP) production system. J Struct Funct Genomics. 2009;10(4):281-9. doi: 10.1007/s10969-009-9072-0.  PubMed PMID: 19856129;  PMCID: PMC2923930.

Fu J, Jiang J, Li J, Wang S, Shi G, Feng Q, White E, Qin J, Wong J. Deleted in breast cancer 1, a novel androgen receptor (AR) coactivator that promotes AR DNA-binding activity. J Biol Chem. 2009;284(11):6832-40. doi: 10.1074/jbc.M808988200.  PubMed PMID: 19126541;  PMCID: PMC2652261.

Bray K, Chen HY, Karp CM, May M, Ganesan S, Karantza-Wadsworth V, DiPaola RS, White E. Bcl-2 modulation to activate apoptosis in prostate cancer. Mol Cancer Res. 2009;7(9):1487-96. doi: 10.1158/1541-7786.MCR-09-0166.  PubMed PMID: 19737977;  PMCID: 2855683.

Andrianasolo EH, Haramaty L, Rosario-Passapera R, Bidle K, White E, Vetriani C, Falkowski P, Lutz R. Ammonificins A and B, hydroxyethylamine chroman derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans. J Nat Prod. 2009;72(6):1216-9. doi: 10.1021/np800726d.  PubMed PMID: 19507867;  PMCID: 2880718.