Cancer Pharmacology Selected Program-Related Publications

Lukasak BJ, Mitchener MM, Kong L, Dul BE, Lazarus CD, Ramakrishnan A, Ni J, Shen L, Maze I, Muir TW. TGM2-mediated histone transglutamination is dictated by steric accessibility. Proc Natl Acad Sci U S A. 2022;119(43):e2208672119. doi: 10.1073/pnas.2208672119. PubMed PMID: 36256821; PMCID: PMC9618071.

Muir TW (CP)

Hackl M, Contrada EV, Ash JE, Kulkarni A, Yoon J, Cho HY, Lee KB, Yarbrough JM, Lopez CA, Gnanakaran S, Chundawat SPS. Acoustic force spectroscopy reveals subtle differences in cellulose unbinding behavior of carbohydrate-binding modules. Proc Natl Acad Sci U S A. 2022;119(42):e2117467119. doi: 10.1073/pnas.2117467119. PubMed PMID: 36215467; PMCID: PMC9586272.

Lee KB (CP)

Shao C, Bittrich S, Wang S, Burley SK. Assessing PDB macromolecular crystal structure confidence at the individual amino acid residue level. Structure. 2022;30(10):1385-94 e3. doi: 10.1016/j.str.2022.08.004. PubMed PMID: 36049478; PMCID: PMC9547844.

Burley SK (CP)

Nguyen T, Costa EJ, Deibert T, Reyes J, Keber FC, Tomschik M, Stadlmeier M, Gupta M, Kumar CK, Cruz ER, Amodeo A, Gatlin JC, Wuhr M. Differential nuclear import sets the timing of protein access to the embryonic genome. Nat Commun. 2022;13(1):5887. doi: 10.1038/s41467-022-33429-z. PubMed PMID: 36202846; PMCID: PMC9537182.

Wühr M (CP)

Burley SK, Berman HM, Duarte JM, Feng Z, Flatt JW, Hudson BP, Lowe R, Peisach E, Piehl DW, Rose Y, Sali A, Sekharan M, Shao C, Vallat B, Voigt M, Westbrook JD, Young JY, Zardecki C. Protein Data Bank: A Comprehensive Review of 3D Structure Holdings and Worldwide Utilization by Researchers, Educators, and Students. Biomolecules. 2022;12(10). doi: 10.3390/biom12101425. PubMed PMID: 36291635; PMCID: PMC9599165.

Burley SK (CP),
Vallat B (CP),
Westbrook JD (CP)

De Pascali F, Ippolito M, Wolfe E, Komolov KE, Hopfinger N, Lemenze D, Kim N, Armen RS, An SS, Scott CP, Benovic JL. beta(2) -Adrenoceptor agonist profiling reveals biased signalling phenotypes for the beta(2) -adrenoceptor with possible implications for the treatment of asthma. Br J Pharmacol. 2022;179(19):4692-708. doi: 10.1111/bph.15900. PubMed PMID: 35732075; PMCID: PMC9474705.

An SS (CP)

Castellano GM, Zeeshan S, Garbuzenko OB, Sabaawy HE, Malhotra J, Minko T, Pine SR. Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma. Mol Cancer Ther. 2022;21(9):1381-92. doi: 10.1158/1535-7163.MCT-22-0053. PubMed PMID: 35732569; PMCID: PMC9452486.

Malhotra J (CIPT),
Minko T (CP),
Pine SR (GICG)

Zeng X, Xing X, Gupta M, Keber FC, Lopez JG, Lee YJ, Roichman A, Wang L, Neinast MD, Donia MS, Wuhr M, Jang C, Rabinowitz JD. Gut bacterial nutrient preferences quantified in vivo. Cell. 2022;185(18):3441-56 e19. doi: 10.1016/j.cell.2022.07.020. PubMed PMID: 36055202; PMCID: PMC9450212.

Donia MS (CMI),
Wühr M (CP),
Rabinowitz JD (CMI)

Goodsell DS, Dutta S, Voigt M, Zardecki C, Burley SK. Molecular explorations of cancer biology and therapeutics at PDB-101. Oncogene. 2022;41(38):4333-5. doi: 10.1038/s41388-022-02424-5. PubMed PMID: 35948649; PMCID: PMC9364277.

Goodsell DS (CP),
Dutta S (CP),
Burley SK (CP)

Huang CY, Oka SI, Xu X, Chen CF, Tung CY, Chang YY, Mourad Y, Vehra O, Ivessa A, Yehia G, Romanienko P, Hsu CP, Sadoshima J. PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARalpha and PGC-1alpha. Sci Rep. 2022;12(1):14576. doi: 10.1038/s41598-022-18885-3. PubMed PMID: 36028747; PMCID: PMC9418182.

Sadoshima J (CP)

Mitchener MM, Muir TW. Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation. Mol Cell. 2022;82(16):2925-38. doi: 10.1016/j.molcel.2022.07.008. PubMed PMID: 35985302; PMCID: PMC9482148.

Muir TW (CP)

Yin Z, Bird JG, Kaelber JT, Nickels BE, Ebright RH. In transcription antitermination by Qlambda, NusA induces refolding of Qlambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc Natl Acad Sci U S A. 2022;119(33):e2205278119. doi: 10.1073/pnas.2205278119. PubMed PMID: 35951650; PMCID: PMC9388147.

Kaelber JT (CP),
Nickels BE (CMI)

Jia X, Wen X, Russo DP, Aleksunes LM, Zhu H. Mechanism-driven modeling of chemical hepatotoxicity using structural alerts and an in vitro screening assay. J Hazard Mater. 2022;436:129193. doi: 10.1016/j.jhazmat.2022.129193. PubMed PMID: 35739723; PMCID: PMC9262097.

Aleksunes LM (CIPT),
Zhu H (CP)

Ashley BK, Sui J, Javanmard M, Hassan U. Antibody-functionalized aluminum oxide-coated particles targeting neutrophil receptors in a multifrequency microfluidic impedance cytometer. Lab Chip. 2022;22(16):3055-66. doi: 10.1039/d2lc00563h. PubMed PMID: 35851596; PMCID: PMC9378602.

Javanmard M (CP)

Cui C, Wu C, Shu P, Liu T, Li H, Beuve A. Soluble guanylyl cyclase mediates noncanonical nitric oxide signaling by nitrosothiol transfer under oxidative stress. Redox Biol. 2022;55:102425. doi: 10.1016/j.redox.2022.102425. PubMed PMID: 35961098; PMCID: PMC9372771.

Li H (CP)

Deeney BT, Cao G, Orfanos S, Lee J, Kan M, Himes BE, Parikh V, Koziol-White CJ, An SS, Panettieri RA, Jr. Epinephrine evokes shortening of human airway smooth muscle cells following beta(2) adrenergic receptor desensitization. Am J Physiol Lung Cell Mol Physiol. 2022;323(2):L142-L51. doi: 10.1152/ajplung.00444.2021. PubMed PMID: 35787178; PMCID: PMC9359643.

An SS (CP),
Panettieri RA (CIPT)

Sacco MD, Wang S, Adapa SR, Zhang X, Lewandowski EM, Gongora MV, Keramisanou D, Atlas ZD, Townsend JA, Gatdula JR, Morgan RT, Hammond LR, Marty MT, Wang J, Eswara PJ, Gelis I, Jiang RHY, Sun X, Chen Y. A unique class of Zn(2+)-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat Commun. 2022;13(1):4370. doi: 10.1038/s41467-022-32086-6. PubMed PMID: 35902581; PMCID: PMC9334274.

Wang J (CP)

Arguello AE, Li A, Sun X, Eggert TW, Mairhofer E, Kleiner RE. Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases. Nat Commun. 2022;13(1):4176. doi: 10.1038/s41467-022-31876-2. PubMed PMID: 35853884; PMCID: PMC9296451.

Kleiner RE (CP)

Tessier SN, de Vries RJ, Pendexter CA, Cronin SEJ, Ozer S, Hafiz EOA, Raigani S, Oliveira-Costa JP, Wilks BT, Lopera Higuita M, van Gulik TM, Usta OB, Stott SL, Yeh H, Yarmush ML, Uygun K, Toner M. Partial freezing of rat livers extends preservation time by 5-fold. Nat Commun. 2022;13(1):4008. doi: 10.1038/s41467-022-31490-2. PubMed PMID: 35840553; PMCID: PMC9287450.

Yarmush ML (CP)

Aggarwal T, Hansen WA, Hong J, Ganguly A, York DM, Khare SD, Izgu EC. Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign. ACS Chem Biol. 2022;17(7):1924-36. doi: 10.1021/acschembio.2c00373. PubMed PMID: 35776893; PMCID: PMC9442636.

Khare SD (CP)

Oliveros A, Yoo KH, Rashid MA, Corujo-Ramirez A, Hur B, Sung J, Liu Y, Hawse JR, Choi DS, Boison D, Jang MH. Adenosine A(2A) receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function. Proc Natl Acad Sci U S A. 2022;119(28):e2206415119. doi: 10.1073/pnas.2206415119. PubMed PMID: 35867768; PMCID: PMC9282426.

Jang MH (CP)

Shaheen MF, Tse JY, Sokol ES, Masterson M, Bansal P, Rabinowitz I, Tarleton CA, Dobroff AS, Smith TL, Bocklage TJ, Mannakee BK, Gutenkunst RN, Bischoff J, Ness SA, Riedlinger GM, Groisberg R, Pasqualini R, Ganesan S, Arap W. Genomic landscape of lymphatic malformations: a case series and response to the PI3Kalpha inhibitor alpelisib in an N-of-1 clinical trial. Elife. 2022;11. doi: 10.7554/eLife.74510. PubMed PMID: 35787784; PMCID: PMC9255965.

Masterson M (CIPT), Riedlinger GM (CIPT), Groisberg R (CIPT), Pasqualini R (CP),
Ganesan S (CIPT),
Arap W (CIPT)

Bulutoglu B, Acun A, Deng SL, Mert S, Lupon E, Lellouch AG, Cetrulo CL, Jr., Uygun BE, Yarmush ML. Combinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering. Adv Healthc Mater. 2022;11(13):e2102795. doi: 10.1002/adhm.202102795. PubMed PMID: 35373501; PMCID: PMC9262838.

Yarmush ML (CP)

Du S, Wu S, Feng X, Wang B, Xia S, Liang L, Zhang L, Govindarajalu G, Bunk A, Kadakia F, Mao Q, Guo X, Zhao H, Berkman T, Liu T, Li H, Stillman J, Bekker A, Davidson S, Tao YX. A nerve injury-specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression. J Clin Invest. 2022;132(13). doi: 10.1172/JCI153563. PubMed PMID: 35775484; PMCID: PMC9246381.

Li H (CP),
Tao YX (CP)

Tamasi MJ, Patel RA, Borca CH, Kosuri S, Mugnier H, Upadhya R, Murthy NS, Webb MA, Gormley AJ. Machine Learning on a Robotic Platform for the Design of Polymer-Protein Hybrids. Adv Mater. 2022;34(30):e2201809. doi: 10.1002/adma.202201809. PubMed PMID: 35593444; PMCID: PMC9339531.

Gormley AJ (CP)

Kim D, Tokmakova A, Woo JA, An SS, Goddard WA, 3rd, Liggett SB. Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development. Mol Diagn Ther. 2022;26(4):383-96. doi: 10.1007/s40291-022-00592-4. PubMed PMID: 35595932; PMCID: PMC9276727.

An SS (CP)

Badeti S, Jiang Q, Naghizadeh A, Tseng HC, Bushkin Y, Marras SAE, Nisa A, Tyagi S, Chen F, Romanienko P, Yehia G, Evans D, Lopez-Gonzalez M, Alland D, Russo R, Gause W, Shi L, Liu D. Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection. Cell Biosci. 2022;12(1):88. doi: 10.1186/s13578-022-00822-6. PubMed PMID: 35690792; PMCID: PMC9187929.

Tyagi S (CP),
Liu D (CMI)

Herranz D. INTERFERing with the progression of T-cell acute lymphoblastic leukemia: a multifaceted therapy. Haematologica. 2022;107(6):1232-4. doi: 10.3324/haematol.2021.279549. PubMed PMID: 34647445; PMCID: PMC9152966.

Herranz D (CP)

Baran N, Lodi A, Dhungana Y, Herbrich S, Collins M, Sweeney S, Pandey R, Skwarska A, Patel S, Tremblay M, Kuruvilla VM, Cavazos A, Kaplan M, Warmoes MO, Veiga DT, Furudate K, Rojas-Sutterin S, Haman A, Gareau Y, Marinier A, Ma H, Harutyunyan K, Daher M, Garcia LM, Al-Atrash G, Piya S, Ruvolo V, Yang W, Shanmugavelandy SS, Feng N, et al. Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia. Nat Commun. 2022;13(1):2801. doi: 10.1038/s41467-022-30396-3. PubMed PMID: 35589701; PMCID: PMC9120040.

Herranz D (CP)

Murari A, Goparaju NSV, Rhooms SK, Hossain KFB, Liang FG, Garcia CJ, Osei C, Liu T, Li H, Kitsis RN, Patel R, Owusu-Ansah E. IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system. Sci Adv. 2022;8(19):eabl8716. doi: 10.1126/sciadv.abl8716. PubMed PMID: 35544578; PMCID: PMC9094667.

Li H (CP)

Markosian C, Staquicini DI, Dogra P, Dodero-Rojas E, Lubin JH, Tang FHF, Smith TL, Contessoto VG, Libutti SK, Wang Z, Cristini V, Khare SD, Whitford PC, Burley SK, Onuchic JN, Pasqualini R, Arap W. Genetic and Structural Analysis of SARS-CoV-2 Spike Protein for Universal Epitope Selection. Mol Biol Evol. 2022;39(5). doi: 10.1093/molbev/msac091. PubMed PMID: 35511693; PMCID: PMC9129195.

Libutti SK (CIPT, GICG), Khare SD (CP),
Burley SK (CP),
Pasqualini R (CP),
Arap W (CIPT)

Ren QN, Zhang H, Sun CY, Zhou YF, Yang XF, Long JW, Li XX, Mai SJ, Zhang MY, Zhang HZ, Mai HQ, Chen MS, Zheng XFS, Wang HY. Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis. Hepatology. 2022;75(5):1123-38. doi: 10.1002/hep.32120. PubMed PMID: 34435708; PMCID: PMC9300126.

Zheng XFS (CP)

Badeti S, Jiang Q, Naghizadeh A, Tseng HC, Bushkin Y, Marras SAE, Nisa A, Tyagi S, Chen F, Romanienko P, Yehia G, Evans D, Lopez-Gonzalez M, Alland D, Russo R, Gause W, Shi L, Liu D. Development of a Novel Human CD147 Knock-in NSG Mouse Model to Test SARS-CoV-2 Viral Infection. Res Sq. 2022. doi: 10.21203/rs.3.rs-1431484/v1. PubMed PMID: 35475172; PMCID: PMC9040682.

Tyagi S (CP),
Liu D (CMI)

Yachnin BJ, Azouz LR, White RE, 3rd, Minetti C, Remeta DP, Tan VM, Drake JM, Khare SD. Massively parallel, computationally guided design of a proenzyme. Proc Natl Acad Sci U S A. 2022;119(15):e2116097119. doi: 10.1073/pnas.2116097119. PubMed PMID: 35377786; PMCID: PMC9169645.

Khare SD (CP)

Yang L, Patel KD, Rathnam C, Thangam R, Hou Y, Kang H, Lee KB. Harnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials. Small. 2022;18(13):e2104783. doi: 10.1002/smll.202104783. PubMed PMID: 35132796; PMCID: PMC9344859.

Lee KB (CP)

Wang S, Yang L, Cai B, Liu F, Hou Y, Zheng H, Cheng F, Zhang H, Wang L, Wang X, Lv Q, Kong L, Lee KB, Zhang Q. Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair. Natl Sci Rev. 2022;9(4):nwac037. doi: 10.1093/nsr/nwac037. PubMed PMID: 35419207; PMCID: PMC8998491.

Lee KB (CP)

Wang J, Li H. Editorial of Special Column on Antiviral Drug Discovery and Pharmacology. Acta Pharm Sin B. 2022;12(4):1540-1. doi: 10.1016/j.apsb.2022.03.005. PubMed PMID: 35474901; PMCID: PMC9023784.

Wang J (CP)

Kashihara T, Mukai R, Oka SI, Zhai P, Nakada Y, Yang Z, Mizushima W, Nakahara T, Warren JS, Abdellatif M, Sadoshima J. YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload. J Clin Invest. 2022;132(6). doi: 10.1172/JCI150595. PubMed PMID: 35133975; PMCID: PMC8920343.

Sadoshima J (CP)

Lukasak BJ, Thompson RE, Mitchener MM, Feng VJ, Bagert JD, Muir TW. A Genetically Encoded Approach for Breaking Chromatin Symmetry. ACS Cent Sci. 2022;8(2):176-83. doi: 10.1021/acscentsci.1c01332. PubMed PMID: 35233450; PMCID: PMC8875426.

Muir TW (CP)

Xu J, Su X, Burley SK, Zheng XFS. Nuclear SOD1 in Growth Control, Oxidative Stress Response, Amyotrophic Lateral Sclerosis, and Cancer. Antioxidants (Basel). 2022;11(2). doi: 10.3390/antiox11020427. PubMed PMID: 35204309; PMCID: PMC8869091.

Su X (CMI),
Burley SK (CP),
Zheng XFS (CP)

Nofal M, Wang T, Yang L, Jankowski CSR, Hsin-Jung Li S, Han S, Parsons L, Frese AN, Gitai Z, Anthony TG, Wuhr M, Sabatini DM, Rabinowitz JD. GCN2 adapts protein synthesis to scavenging-dependent growth. Cell Syst. 2022;13(2):158-72 e9. doi: 10.1016/j.cels.2021.09.014. PubMed PMID: 34706266; PMCID: PMC8961722.

Gitai Z (CMI),
Anthony TG (CMI),
Wühr M (CP),
Rabinowitz JD (CMI)

Nam D, Tinoco A, Shen Z, Adukure RD, Sreenilayam G, Khare SD, Fasan R. Enantioselective Synthesis of alpha-Trifluoromethyl Amines via Biocatalytic N-H Bond Insertion with Acceptor-Acceptor Carbene Donors. J Am Chem Soc. 2022;144(6):2590-602. doi: 10.1021/jacs.1c10750. PubMed PMID: 35107997; PMCID: PMC8855427.

Khare SD (CP)

Dao HT, Liu H, Mashtalir N, Kadoch C, Muir TW. Synthesis of Oriented Hexasomes and Asymmetric Nucleosomes Using a Template Editing Process. J Am Chem Soc. 2022;144(5):2284-91. doi: 10.1021/jacs.1c12420. PubMed PMID: 35081309; PMCID: PMC8935522.

Muir TW (CP)

Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, Haupl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schnutgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, et al. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022;139(4):538-53. doi: 10.1182/blood.2021012081. PubMed PMID: 34624079; PMCID: PMC8938936.

Kim H (CP),
Rabinowitz JD (CMI)

Lazofsky A, Doherty C, Szary P, Buckley B. A surface sampling and liquid chromatography mass spectrometry method for the analysis of quaternary ammonium compounds collected from public transportation buses in New Jersey. Emerg Contam. 2022;8:318-28. doi: 10.1016/j.emcon.2022.06.005. PubMed PMID: 35791422; PMCID: PMC9247117.

Buckley B (CP)

Ferrer A, Kenfack Y, Petryna A, Arap W, Pasqualini R, Rameshwar P. Leveraging the scientific findings to develop therapeutic strategies for dormant breast cancer cells. Oncoscience. 2022;9:42-8. doi: 10.18632/oncoscience.562. PubMed PMID: 36110329; PMCID: PMC9469806.

Arap W (CIPT),
Pasqualini R (CP), Rameshwar P (CP)

Zhang H, Su X, Burley SK, Zheng XFS. mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma. Theranostics. 2022;12(7):3518-33. doi: 10.7150/thno.72581. PubMed PMID: 35547764; PMCID: PMC9065186.

Su X (CMI),
Burley SK (CP),
Zheng XFS (CP)

Shen M, Wei Y, Kim H, Wan L, Jiang YZ, Hang X, Raba M, Remiszewski S, Rowicki M, Wu CG, Wu S, Zhang L, Lu X, Yuan M, Smith HA, Zheng A, Bertino J, Jin JF, Xing Y, Shao ZM, Kang Y. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer. 2022;3(1):43-59. doi: 10.1038/s43018-021-00279-5. PubMed PMID: 35121987; PMCID: PMC8818087.

Kim H (CP),
Zhang L (CIPT),
Bertino J (CP),
Kang Y (CMI)

Xirouchaki CE, Jia Y, McGrath MJ, Greatorex S, Tran M, Merry TL, Hong D, Eramo MJ, Broome SC, Woodhead JST, D'Souza R F, Gallagher J, Salimova E, Huang C, Schittenhelm RB, Sadoshima J, Watt MJ, Mitchell CA, Tiganis T. Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance. Sci Adv. 2021;7(51):eabl4988. doi: 10.1126/sciadv.abl4988. PubMed PMID: 34910515; PMCID: PMC8673768.

Sadoshima J (CP)

Kim D, Tokmakova A, Lujan LK, Strzelinski HR, Kim N, Najari Beidokhti M, Giulianotti MA, Mafi A, Woo JA, An SS, Goddard WA, 3rd, Liggett SB. Identification and characterization of an atypical Galphas-biased beta(2)AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis. Proc Natl Acad Sci U S A. 2021;118(49). doi: 10.1073/pnas.2026668118. PubMed PMID: 34857633; PMCID: PMC8670521.

An SS (CP)

Ma L, Yu L, Jiang BC, Wang J, Guo X, Huang Y, Ren J, Sun N, Gao DS, Ding H, Lu J, Zhou H, Zou L, Gao Y, Wang L, Sun K, Ming Y, Meng Z, Tao YX, Yan M. ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons. J Exp Med. 2021;218(12). doi: 10.1084/jem.20210920. PubMed PMID: 34762123; PMCID: PMC8590274.

Tao YX (CP)

Koehler Leman J, Lyskov S, Lewis SM, Adolf-Bryfogle J, Alford RF, Barlow K, Ben-Aharon Z, Farrell D, Fell J, Hansen WA, Harmalkar A, Jeliazkov J, Kuenze G, Krys JD, Ljubetic A, Loshbaugh AL, Maguire J, Moretti R, Mulligan VK, Nance ML, Nguyen PT, S OC, Roy Burman SS, Samanta R, Smith ST, Teets F, Tiemann JKS, Watkins A, Woods H, Yachnin BJ, et al. Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks. Nat Commun. 2021;12(1):6947. doi: 10.1038/s41467-021-27222-7. PubMed PMID: 34845212; PMCID: PMC8630030.

Khare SD (CP)

Zhang S, Zhou YF, Cao J, Burley SK, Wang HY, Zheng XFS. mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma. Cancer Res. 2021;81(22):5652-65. doi: 10.1158/0008-5472.CAN-21-0206. PubMed PMID: 34429326; PMCID: PMC8595749.

Cao J (CMI),
Burley SK (CP),
Zheng XFS (CP)

Dai W, Li A, Yu NJ, Nguyen T, Leach RW, Wuhr M, Kleiner RE. Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation. Nat Chem Biol. 2021;17(11):1178-87. doi: 10.1038/s41589-021-00874-8. PubMed PMID: 34556860; PMCID: PMC8551019.

Wühr M (CP),
Kleiner RE (CP)

Yi SA, Zhang Y, Rathnam C, Pongkulapa T, Lee KB. Bioengineering Approaches for the Advanced Organoid Research. Adv Mater. 2021;33(45):e2007949. doi: 10.1002/adma.202007949. PubMed PMID: 34561899; PMCID: PMC8682947.

Lee KB (CP)

Fraser LCR, Dikdan RJ, Dey S, Singh A, Tyagi S. Reduction in gene expression noise by targeted increase in accessibility at gene loci. Proc Natl Acad Sci U S A. 2021;118(42). doi: 10.1073/pnas.2018640118. PubMed PMID: 34625470; PMCID: PMC8545487.

Tyagi S (CP)

da Silva-Diz V, Cao B, Lancho O, Chiles E, Alasadi A, Aleksandrova M, Luo S, Singh A, Tao H, Augeri D, Minuzzo S, Indraccolo S, Khiabanian H, Su X, Jin S, Herranz D. A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia. Blood. 2021;138(15):1317-30. doi: 10.1182/blood.2020008955. PubMed PMID: 33876224; PMCID: PMC8525334.

Khiabanian H (GICG),
Su X (CMI),
Jin S (CP),
Herranz D (CP)

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jaattela M, Johansen T, Juhasz G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, et al. Autophagy in major human diseases. EMBO J. 2021;40(19):e108863. doi: 10.15252/embj.2021108863. PubMed PMID: 34459017; PMCID: PMC8488577.

Sadoshima J (CP)

Foo TK, Vincelli G, Huselid E, Her J, Zheng H, Simhadri S, Wang M, Huo Y, Li T, Yu X, Li H, Zhao W, Bunting SF, Xia B. ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G(2)-M Checkpoint Maintenance. Cancer Res. 2021;81(18):4676-84. doi: 10.1158/0008-5472.CAN-20-2723. PubMed PMID: 34301763; PMCID: PMC8448966.

Li H (CP),
Bunting SF (GICG),
Xia B (GICG)

Nomani A, Li G, Yousefi S, Wu S, Malekshah OM, Nikkhoi SK, Pourfathi M, Rizi R, Hatefi A. Gadolinium-labeled affibody-XTEN recombinant vector for detection of HER2+ lesions of ovarian cancer lung metastasis using quantitative MRI. J Control Release. 2021;337:132-43. doi: 10.1016/j.jconrel.2021.07.022. PubMed PMID: 34284047; PMCID: PMC8440463.

Hatefi A (CP)

Daquinag AC, Gao Z, Fussell C, Immaraj L, Pasqualini R, Arap W, Akimzhanov AM, Febbraio M, Kolonin MG. Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking. JCI Insight. 2021;6(17). doi: 10.1172/jci.insight.147057. PubMed PMID: 34314388; PMCID: PMC8492349.

Pasqualini R (CP),
Arap W (CIPT)

Mitchener MM, Muir TW. Janus Bioparticles: Asymmetric Nucleosomes and Their Preparation Using Chemical Biology Approaches. Acc Chem Res. 2021;54(16):3215-27. doi: 10.1021/acs.accounts.1c00313. PubMed PMID: 34319695; PMCID: PMC8411803.

Muir TW (CP)

Ciallella HL, Russo DP, Aleksunes LM, Grimm FA, Zhu H. Revealing Adverse Outcome Pathways from Public High-Throughput Screening Data to Evaluate New Toxicants by a Knowledge-Based Deep Neural Network Approach. Environ Sci Technol. 2021;55(15):10875-87. doi: 10.1021/acs.est.1c02656. PubMed PMID: 34304572; PMCID: PMC8713073.

Aleksunes LM (CIPT),
Zhu H (CP)

Gormley AJ, Webb MA. Machine learning in combinatorial polymer chemistry. Nat Rev Mater. 2021;6:642-4. doi: 10.1038/s41578-021-00282-3. PubMed PMID: 34394961; PMCID: PMC8356908.

Gormley AJ (CP)

Huang H, He X, Yarmush ML. Advanced technologies for the preservation of mammalian biospecimens. Nat Biomed Eng. 2021;5(8):793-804. doi: 10.1038/s41551-021-00784-z. PubMed PMID: 34426675; PMCID: PMC8765766.

Yarmush ML (CP)

Sillerud LO, Neuwelt AJ, Staquicini FI, Arap W, Pasqualini R. Repurposing Ferumoxytol as a Breast Cancer-Associated Macrophage Tracer with Five-Dimensional Quantitative [Fe]MRI of SPION Dynamics. Cancers (Basel). 2021;13(15). doi: 10.3390/cancers13153802. PubMed PMID: 34359704; PMCID: PMC8345165.

Staquicini FI (CP),
Arap W (CIPT),
Pasqualini R (CP)

Staquicini DI, Tang FHF, Markosian C, Yao VJ, Staquicini FI, Dodero-Rojas E, Contessoto VG, Davis D, O'Brien P, Habib N, Smith TL, Bruiners N, Sidman RL, Gennaro ML, Lattime EC, Libutti SK, Whitford PC, Burley SK, Onuchic JN, Arap W, Pasqualini R. Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain. Proc Natl Acad Sci U S A. 2021;118(30). doi: 10.1073/pnas.2105739118. PubMed PMID: 34234013; PMCID: PMC8325333.

Staquicini FI (CP),
Gennaro ML (CMI),
Lattime EC (CMI),
Libutti SK (CIPT, GICG), Burley SK (CP),
Arap W (CIPT),
Pasqualini R (CP)

Mashtalir N, Dao HT, Sankar A, Liu H, Corin AJ, Bagert JD, Ge EJ, D'Avino AR, Filipovski M, Michel BC, Dann GP, Muir TW, Kadoch C. Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes. Science. 2021;373(6552):306-15. doi: 10.1126/science.abf8705. PubMed PMID: 34437148; PMCID: PMC8390793.

Muir TW (CP)

Wu A, Zhi J, Tian T, Cihan A, Cevher MA, Liu Z, David Y, Muir TW, Roeder RG, Yu M. DOT1L complex regulates transcriptional initiation in human erythroleukemic cells. Proc Natl Acad Sci U S A. 2021;118(27). doi: 10.1073/pnas.2106148118. PubMed PMID: 34187895; PMCID: PMC8271641.

Muir TW (CP)

Pan Z, Du S, Wang K, Guo X, Mao Q, Feng X, Huang L, Wu S, Hou B, Chang YJ, Liu T, Chen T, Li H, Bachmann T, Bekker A, Hu H, Tao YX. Downregulation of a Dorsal Root Ganglion-Specifically Enriched Long Noncoding RNA is Required for Neuropathic Pain by Negatively Regulating RALY-Triggered Ehmt2 Expression. Adv Sci (Weinh). 2021;8(13):e2004515. doi: 10.1002/advs.202004515. PubMed PMID: 34383386; PMCID: PMC8356248.

Li H (CP),
Tao YX (CP)

Song H, Burton AJ, Shirran SL, Fahrig-Kamarauskaite J, Kaspar H, Muir TW, Kunzler M, Naismith JH. Engineering of a Peptide alpha-N-Methyltransferase to Methylate Non-Proteinogenic Amino Acids. Angew Chem Int Ed Engl. 2021;60(26):14319-23. doi: 10.1002/anie.202100818. PubMed PMID: 33856715; PMCID: PMC8251615.

Muir TW (CP)

Bagert JD, Muir TW. Molecular Epigenetics: Chemical Biology Tools Come of Age. Annu Rev Biochem. 2021;90:287-320. doi: 10.1146/annurev-biochem-080120-021109. PubMed PMID: 34153213; PMCID: PMC8284505.

Muir TW (CP)

Johnson A, Stadlmeier M, Wuhr M. TMTpro Complementary Ion Quantification Increases Plexing and Sensitivity for Accurate Multiplexed Proteomics at the MS2 Level. J Proteome Res. 2021;20(6):3043-52. doi: 10.1021/acs.jproteome.0c00813. PubMed PMID: 33929851; PMCID: PMC8330405.

Wühr M (CP)

Mahmoodi SR, Xie P, Zachs DP, Peterson EJ, Graham RS, Kaiser CRW, Lim HH, Allen MG, Javanmard M. Single-step label-free nanowell immunoassay accurately quantifies serum stress hormones within minutes. Sci Adv. 2021;7(27). doi: 10.1126/sciadv.abf4401. PubMed PMID: 34193414; PMCID: PMC8245048.

Javanmard M (CP)

Staquicini FI, Hajitou A, Driessen WH, Proneth B, Cardo-Vila M, Staquicini DI, Markosian C, Hoh M, Cortez M, Hooda-Nehra A, Jaloudi M, Silva IT, Buttura J, Nunes DN, Dias-Neto E, Eckhardt B, Ruiz-Ramirez J, Dogra P, Wang Z, Cristini V, Trepel M, Anderson R, Sidman RL, Gelovani JG, Cristofanilli M, Hortobagyi GN, Bhujwalla ZM, Burley SK, Arap W, Pasqualini R. Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer. Elife. 2021;10. doi: 10.7554/eLife.65145. PubMed PMID: 34060472; PMCID: PMC8169110.

Staquicini FI (CP),
Burley S (CP),
Arap W (CIPT),
Pasqualini R (CP)

Sandhu SK, Kumar S, Raut J, Singh M, Kaur S, Sharma G, Roldan TL, Trehan S, Holloway J, Wahler G, Laskin JD, Sinko PJ, Berthiaume F, Michniak-Kohn B, Rishi P, Ganesh N, Kaur IP. Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing. Antioxidants (Basel). 2021;10(5). doi: 10.3390/antiox10050725. PubMed PMID: 34063003; PMCID: PMC8148018.

Laskin JD (CP),
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Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12(1):2259. doi: 10.1038/s41467-021-22480-x. PubMed PMID: 33859191; PMCID: PMC8050259.

Guo JY (CMI),
Pine S (GICG),
Li H (CP),
White E (CMI),
Liu C (CIPT),
Kiledjian M (CMI),
Pestov DG (GICG),
Steven Zheng XF (CP)

Upadhya R, Kosuri S, Tamasi M, Meyer TA, Atta S, Webb MA, Gormley AJ. Automation and data-driven design of polymer therapeutics. Adv Drug Deliv Rev. 2021;171:1-28. doi: 10.1016/j.addr.2020.11.009. PubMed PMID: 33242537; PMCID: PMC8127395.

Gormley AJ (CP)

Bagert JD, Mitchener MM, Patriotis AL, Dul BE, Wojcik F, Nacev BA, Feng L, Allis CD, Muir TW. Oncohistone mutations enhance chromatin remodeling and alter cell fates. Nat Chem Biol. 2021;17(4):403-11. doi: 10.1038/s41589-021-00738-1. PubMed PMID: 33649601; PMCID: PMC8174649.

Muir TW (CP)

Zhen G, Guo Q, Li Y, Wu C, Zhu S, Wang R, Guo XE, Kim BC, Huang J, Hu Y, Dan Y, Wan M, Ha T, An S, Cao X. Mechanical stress determines the configuration of TGFbeta activation in articular cartilage. Nat Commun. 2021;12(1):1706. doi: 10.1038/s41467-021-21948-0. PubMed PMID: 33731712; PMCID: PMC7969741.

An S (CP)

Zhang X, Wang X, Yuan Z, Radford SJ, Liu C, Libutti SK, Zheng XFS. Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis. Cell Rep. 2021;34(11):108830. doi: 10.1016/j.celrep.2021.108830. PubMed PMID: 33730578; PMCID: PMC8062038.

Liu C (CIPT),
Libutti SK (CIPT, GICG), Zheng XFS (CP)

Murphy SA, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen P, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C. PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. Nat Commun. 2021;12(1):1648. doi: 10.1038/s41467-021-21957-z. PubMed PMID: 33712605; PMCID: PMC7955035.

An SS (CP)

Kan L, Ott S, Joseph B, Park ES, Dai W, Kleiner RE, Claridge-Chang A, Lai EC. A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila. Nat Commun. 2021;12(1):1458. doi: 10.1038/s41467-021-21537-1. PubMed PMID: 33674589; PMCID: PMC7935873.

Kleiner RE (CP)

Ikeda S, Nah J, Shirakabe A, Zhai P, Oka SI, Sciarretta S, Guan KL, Shimokawa H, Sadoshima J. YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases. J Clin Invest. 2021;131(5). doi: 10.1172/JCI143173. PubMed PMID: 33373332; PMCID: PMC7919732.

Sadoshima J (CP)

George B, Pillai PM, Paul AM, Amjesh R, Leitzel K, Ali SM, Sandiford O, Lipton A, Rameshwar P, Hortobagyi GN, Pillai MR, Kumar R. Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics. Cells. 2021;10(2). doi: 10.3390/cells10020433. PubMed PMID: 33670680; PMCID: PMC7921985.

Rameshwar P (CP)

Zhao S, Chuh KN, Zhang B, Dul BE, Thompson RE, Farrelly LA, Liu X, Xu N, Xue Y, Roeder RG, Maze I, Muir TW, Li H. Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout. Proc Natl Acad Sci U S A. 2021;118(6). doi: 10.1073/pnas.2016742118. PubMed PMID: 33526675; PMCID: PMC8017887.

Muir TW (CP)

Garcia-Canaveras JC, Lancho O, Ducker GS, Ghergurovich JM, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz JD. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021;35(2):377-88. doi: 10.1038/s41375-020-0845-6. PubMed PMID: 32382081; PMCID: PMC7647950.

Kim H (CP),
Herranz D (CP),
Rabinowitz JD (CMI)

Yang L, Kim TH, Cho HY, Luo J, Lee JM, Chueng SD, Hou Y, Yin PT, Han J, Kim JH, Chung BG, Choi JW, Lee KB. Hybrid Graphene-Gold Nanoparticle-based Nucleic Acid Conjugates for Cancer-Specific Multimodal Imaging and Combined Therapeutics. Adv Funct Mater. 2021;31(5). doi: 10.1002/adfm.202006918. PubMed PMID: 33776614; PMCID: PMC7996391.

Lee KB (CP)

Anaya DA, Dogra P, Wang Z, Haider M, Ehab J, Jeong DK, Ghayouri M, Lauwers GY, Thomas K, Kim R, Butner JD, Nizzero S, Ramirez JR, Plodinec M, Sidman RL, Cavenee WK, Pasqualini R, Arap W, Fleming JB, Cristini V. A Mathematical Model to Estimate Chemotherapy Concentration at the Tumor-Site and Predict Therapy Response in Colorectal Cancer Patients with Liver Metastases. Cancers (Basel). 2021;13(3). doi: 10.3390/cancers13030444. PubMed PMID: 33503971; PMCID: PMC7866038.

Pasqualini R (CP),
Arap W (CIPT)

Lebeau PF, Wassef H, Byun JH, Platko K, Ason B, Jackson S, Dobroff J, Shetterly S, Richards WG, Al-Hashimi AA, Won KD, Mbikay M, Prat A, Tang A, Pare G, Pasqualini R, Seidah NG, Arap W, Chretien M, Austin RC. The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury. J Clin Invest. 2021;131(2). doi: 10.1172/JCI128650. PubMed PMID: 33211673; PMCID: PMC7810474.

Pasqualini R (CP),
Arap W (CIPT)

Burley SK, Bhikadiya C, Bi C, Bittrich S, Chen L, Crichlow GV, Christie CH, Dalenberg K, Di Costanzo L, Duarte JM, Dutta S, Feng Z, Ganesan S, Goodsell DS, Ghosh S, Green RK, Guranovic V, Guzenko D, Hudson BP, Lawson CL, Liang Y, Lowe R, Namkoong H, Peisach E, Persikova I, Randle C, Rose A, Rose Y, Sali A, Segura J, et al. RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences. Nucleic Acids Res. 2021;49(D1):D437-D51. doi: 10.1093/nar/gkaa1038. PubMed PMID: 33211854; PMCID: PMC7779003.

Burley SK (CP),
Dutta S (CP),
Goodsell DS (CP), Westbrook JD (CP)

Xiong H, Mancini M, Gobert M, Shen S, Furtado GC, Lira SA, Parkhurst CN, Garambois V, Brengues M, Tadokoro CE, Trimarchi T, Gomez-Lopez G, Singh A, Khiabanian H, Minuzzo S, Indraccolo S, Lobry C, Aifantis I, Herranz D, Lafaille JJ, Maraver A. Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia. Theranostics. 2021;11(4):1594-608. doi: 10.7150/thno.48067. PubMed PMID: 33408769; PMCID: PMC7778594.

Khiabanian H (GICG), Herranz D (CP)

Prokopi A, Tripp CH, Tummers B, Hornsteiner F, Spoeck S, Crawford JC, Clements DR, Efremova M, Hutter K, Bellmann L, Cappellano G, Cadilha BL, Kobold S, Boon L, Ortner D, Trajanoski Z, Chen S, de Gruijl TD, Idoyaga J, Green DR, Stoitzner P. Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy. J Immunother Cancer. 2021;9(1). doi: 10.1136/jitc-2020-000832. PubMed PMID: 33408092; PMCID: PMC7789456.

Chen S (CP)

Stebbing J, Sanchez Nievas G, Falcone M, Youhanna S, Richardson P, Ottaviani S, Shen JX, Sommerauer C, Tiseo G, Ghiadoni L, Virdis A, Monzani F, Rizos LR, Forfori F, Avendano Cespedes A, De Marco S, Carrozzi L, Lena F, Sanchez-Jurado PM, Lacerenza LG, Cesira N, Caldevilla Bernardo D, Perrella A, Niccoli L, Mendez LS, Matarrese D, Goletti D, Tan YJ, Monteil V, Dranitsaris G, et al. JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Sci Adv. 2021;7(1). doi: 10.1126/sciadv.abe4724. PubMed PMID: 33187978; PMCID: PMC7775747.

Dutta S (CP),
Burley SK (CP)

Zhang J, Wang H, Fan Y, Yu Z, You G. Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination. Pharmacol Ther. 2021;217:107647. doi: 10.1016/j.pharmthera.2020.107647. PubMed PMID: 32758646; PMCID: PMC7770002.

You G (CP)

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy. 2021;17(1):1-382. doi: 10.1080/15548627.2020.1797280. PubMed PMID: 33634751; PMCID: PMC7996087.

Sadoshima J (CP),
Scotto KW (CP),
Zong WX (CMI)

Timmins LM, Burr AM, Carroll K, Keefe R, Teryek M, Cantolupo LJ, van der Loo JCM, Heathman TRJ, Gormley A, Smith D, Parekkadan B. Selecting a Cell Engineering Methodology During Cell Therapy Product Development. Cell Transplant. 2021;30:9636897211003022. doi: 10.1177/09636897211003022. PubMed PMID: 34013781; PMCID: PMC8145581.

Gormley A (CP), Parekkadan B (CMI)

Leicher R, Ge EJ, Lin X, Reynolds MJ, Xie W, Walz T, Zhang B, Muir TW, Liu S. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020;117(48):30465-75. doi: 10.1073/pnas.2003395117. PubMed PMID: 33208532; PMCID: PMC7720148.

Muir TW (CP)

Kantamneni H, Barkund S, Donzanti M, Martin D, Zhao X, He S, Riman RE, Tan MC, Pierce MC, Roth CM, Ganapathy V, Moghe PV. Shortwave infrared emitting multicolored nanoprobes for biomarker-specific cancer imaging in vivo. BMC Cancer. 2020;20(1):1082. doi: 10.1186/s12885-020-07604-8. PubMed PMID: 33172421; PMCID: PMC7654009.

Pierce MC (CIPT),
Moghe PV (CP)

Shen AM, Minko T. Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery. J Control Release. 2020;326:222-44. doi: 10.1016/j.jconrel.2020.07.011. PubMed PMID: 32681948; PMCID: PMC7501141.

Minko T (CP)

Yang C, Luo J, Polunas M, Bosnjak N, Chueng SD, Chadwick M, Sabaawy HE, Chester SA, Lee KB, Lee H. 4D-Printed Transformable Tube Array for High-Throughput 3D Cell Culture and Histology. Adv Mater. 2020;32(40):e2004285. doi: 10.1002/adma.202004285. PubMed PMID: 32864842; PMCID: PMC7603422.

Sabaawy HE (CIPT),
Lee KB (CP)

Goodsell DS, Burley SK. RCSB Protein Data Bank tools for 3D structure-guided cancer research: human papillomavirus (HPV) case study. Oncogene. 2020;39(43):6623-32. doi: 10.1038/s41388-020-01461-2. PubMed PMID: 32939013; PMCID: PMC7581513.

Goodsell DS (CP),
Burley SK (CP)

Skupin-Mrugalska P, Minko T. Development of Liposomal Vesicles for Osimertinib Delivery to EGFR Mutation-Positive Lung Cancer Cells. Pharmaceutics. 2020;12(10). doi: 10.3390/pharmaceutics12100939. PubMed PMID: 33008019; PMCID: PMC7599969.

Minko T (CP)

Shah R, Chen S. Metabolic Signaling Cascades Prompted by Glutaminolysis in Cancer. Cancers (Basel). 2020;12(9). doi: 10.3390/cancers12092624. PubMed PMID: 32937954; PMCID: PMC7565600.

Chen S (CP)

Oka SI, Chin A, Park JY, Ikeda S, Mizushima W, Ralda G, Zhai P, Tong M, Byun J, Tang F, Einaga Y, Huang CY, Kashihara T, Zhao M, Nah J, Tian B, Hirabayashi Y, Yodoi J, Sadoshima J. Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart. Cardiovasc Res. 2020;116(10):1742-55. doi: 10.1093/cvr/cvz251. PubMed PMID: 31584633; PMCID: PMC7825501.

Tian B (GICG),
Sadoshima J (CP)

Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020;217(7). doi: 10.1084/jem.20190745. PubMed PMID: 32441762; PMCID: PMC7336299.

Sadoshima J (CP)

Leman JK, Weitzner BD, Lewis SM, Adolf-Bryfogle J, Alam N, Alford RF, Aprahamian M, Baker D, Barlow KA, Barth P, Basanta B, Bender BJ, Blacklock K, Bonet J, Boyken SE, Bradley P, Bystroff C, Conway P, Cooper S, Correia BE, Coventry B, Das R, De Jong RM, DiMaio F, Dsilva L, Dunbrack R, Ford AS, Frenz B, Fu DY, Geniesse C, et al. Macromolecular modeling and design in Rosetta: recent methods and frameworks. Nat Methods. 2020;17(7):665-80. doi: 10.1038/s41592-020-0848-2. PubMed PMID: 32483333; PMCID: PMC7603796.

Khare SD (CP)

Ghergurovich JM, Garcia-Canaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731-9. doi: 10.1038/s41589-020-0533-x. PubMed PMID: 32393898; PMCID: PMC7311271.

Kim H (CP),
Rabinowitz JD (CMI)

Li Y, Guo X, Sun L, Xiao J, Su S, Du S, Li Z, Wu S, Liu W, Mo K, Xia S, Chang YJ, Denis D, Tao YX. N(6)-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons. Adv Sci (Weinh). 2020;7(13):1902402. doi: 10.1002/advs.201902402. PubMed PMID: 32670741; PMCID: PMC7341103.

Tao YX (CP)

He L, Han G, Wu S, Du S, Zhang Y, Liu W, Jiang B, Zhang L, Xia S, Jia S, Hannaford S, Xu Y, Tao YX. Toll-like receptor 7 contributes to neuropathic pain by activating NF-kappaB in primary sensory neurons. Brain Behav Immun. 2020;87:840-51. doi: 10.1016/j.bbi.2020.03.019. PubMed PMID: 32205121; PMCID: PMC7316623.

Tao YX (CP)

Martin JK, 2nd, Sheehan JP, Bratton BP, Moore GM, Mateus A, Li SH, Kim H, Rabinowitz JD, Typas A, Savitski MM, Wilson MZ, Gitai Z. A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance. Cell. 2020;181(7):1518-32 e14. doi: 10.1016/j.cell.2020.05.005. PubMed PMID: 32497502; PMCID: PMC7780349.

Kim H (CP),
Rabinowitz JD (CMI),
Gitai Z (CMI)

Kwon M, Park K, Hyun K, Lee JH, Zhou L, Cho YW, Ge K, Skalnik DG, Muir TW, Kim J. H2B ubiquitylation enhances H3K4 methylation activities of human KMT2 family complexes. Nucleic Acids Res. 2020;48(10):5442-56. doi: 10.1093/nar/gkaa317. PubMed PMID: 32365172; PMCID: PMC7261165.

Muir TW (CP)

Burton AJ, Haugbro M, Parisi E, Muir TW. Live-cell protein engineering with an ultra-short split intein. Proc Natl Acad Sci U S A. 2020;117(22):12041-9. doi: 10.1073/pnas.2003613117. PubMed PMID: 32424098; PMCID: PMC7275667.

Diehl KL, Muir TW. Chromatin as a key consumer in the metabolite economy. Nat Chem Biol. 2020;16(6):620-9. doi: 10.1038/s41589-020-0517-x. PubMed PMID: 32444835; PMCID: PMC7258299.

Muir TW (CP)

Burton AJ, Haugbro M, Gates LA, Bagert JD, Allis CD, Muir TW. In situ chromatin interactomics using a chemical bait and trap approach. Nat Chem. 2020;12(6):520-7. doi: 10.1038/s41557-020-0474-8. PubMed PMID: 32472103; PMCID: PMC7331920.

Muir TW (CP)

Westbrook JD, Soskind R, Hudson BP, Burley SK. Impact of the Protein Data Bank on antineoplastic approvals. Drug Discov Today. 2020;25(5):837-50. doi: 10.1016/j.drudis.2020.02.002. PubMed PMID: 32068073; PMCID: PMC7305983.

Westbrook JD (CP),
Burley SK (CP)

Butner JD, Elganainy D, Wang CX, Wang Z, Chen SH, Esnaola NF, Pasqualini R, Arap W, Hong DS, Welsh J, Koay EJ, Cristini V. Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy. Sci Adv. 2020;6(18):eaay6298. doi: 10.1126/sciadv.aay6298. PubMed PMID: 32426472; PMCID: PMC7190324.

Pasqualini R (CP),
Arap W (CIPT)

Thompson RE, Muir TW. Chemoenzymatic Semisynthesis of Proteins. Chem Rev. 2020;120(6):3051-126. doi: 10.1021/acs.chemrev.9b00450. PubMed PMID: 31774265; PMCID: PMC7101271.

Muir TW (CP)

Murawska M, Schauer T, Matsuda A, Wilson MD, Pysik T, Wojcik F, Muir TW, Hiraoka Y, Straub T, Ladurner AG. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Mol Cell. 2020;77(3):501-13 e7. doi: 10.1016/j.molcel.2019.11.016. PubMed PMID: 31837996; PMCID: PMC7007867.

Muir TW (CP)

Nechay M, Kleiner RE. High-throughput approaches to profile RNA-protein interactions. Curr Opin Chem Biol. 2020;54:37-44. doi: 10.1016/j.cbpa.2019.11.002. PubMed PMID: 31812895; PMCID: PMC7131871.

Kleiner RE (CP)

Andres J, Smith LC, Murray A, Jin Y, Businaro R, Laskin JD, Laskin DL. Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants. Cytokine Growth Factor Rev. 2020;51:12-8. doi: 10.1016/j.cytogfr.2019.12.001. PubMed PMID: 31901309; PMCID: PMC7052797.

Laskin JD (CP),
Laskin DL (CMI)

Dao HT, Dul BE, Dann GP, Liszczak GP, Muir TW. A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing. Nat Chem Biol. 2020;16(2):134-42. doi: 10.1038/s41589-019-0413-4. PubMed PMID: 31819269; PMCID: PMC6982587.

Muir TW (CP)

Sharma G, Hu C, Staquicini DI, Brigman JL, Liu M, Mauvais-Jarvis F, Pasqualini R, Arap W, Arterburn JB, Hathaway HJ, Prossnitz ER. Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes. Sci Transl Med. 2020;12(528). doi: 10.1126/scitranslmed.aau5956. PubMed PMID: 31996464; PMCID: PMC7083206.

Pasqualini R (CP),
Arap W (CIPT)

Wan L, Chong S, Xuan F, Liang A, Cui X, Gates L, Carroll TS, Li Y, Feng L, Chen G, Wang SP, Ortiz MV, Daley SK, Wang X, Xuan H, Kentsis A, Muir TW, Roeder RG, Li H, Li W, Tjian R, Wen H, Allis CD. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature. 2020;577(7788):121-6. doi: 10.1038/s41586-019-1842-7. PubMed PMID: 31853060; PMCID: PMC7061414.

Muir TW (CP)

Tong M, Sadoshima J. Nuclear miR-320 Controls Lipotoxicity. Circ Res. 2019;125(12):1121-3. doi: 10.1161/CIRCRESAHA.119.316199. PubMed PMID: 31804912; PMCID: PMC8514138.

Sadoshima J (CP)

Belver L, Yang AY, Albero R, Herranz D, Brundu FG, Quinn SA, Perez-Duran P, Alvarez S, Gianni F, Rashkovan M, Gurung D, Rocha PP, Raviram R, Reglero C, Cortes JR, Cooke AJ, Wendorff AA, Cordo V, Meijerink JP, Rabadan R, Ferrando AA. GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia. Cancer Discov. 2019;9(12):1774-91. doi: 10.1158/2159-8290.CD-19-0471. PubMed PMID: 31519704; PMCID: PMC6891196.

Herranz D (CP)

Valencia AM, Collings CK, Dao HT, St Pierre R, Cheng YC, Huang J, Sun ZY, Seo HS, Mashtalir N, Comstock DE, Bolonduro O, Vangos NE, Yeoh ZC, Dornon MK, Hermawan C, Barrett L, Dhe-Paganon S, Woolf CJ, Muir TW, Kadoch C. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. 2019;179(6):1342-56 e23. doi: 10.1016/j.cell.2019.10.044. PubMed PMID: 31759698; PMCID: PMC7175411.

Muir TW (CP)

Albig C, Wang C, Dann GP, Wojcik F, Schauer T, Krause S, Maenner S, Cai W, Li Y, Girton J, Muir TW, Johansen J, Johansen KM, Becker PB, Regnard C. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Nat Commun. 2019;10(1):5343. doi: 10.1038/s41467-019-13174-6. PubMed PMID: 31767855; PMCID: PMC6877644.

Muir TW (CP)

Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer SJ, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O, Kroemer G. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019;11(11):e10469. doi: 10.15252/emmm.201910469. PubMed PMID: 31609086; PMCID: PMC6835206.

Sadoshima J (CP)

Castellano GM, Aisner J, Burley SK, Vallat B, Yu HA, Pine SR, Ganesan S. A Novel Acquired Exon 20 EGFR M766Q Mutation in Lung Adenocarcinoma Mediates Osimertinib Resistance but is Sensitive to Neratinib and Poziotinib. J Thorac Oncol. 2019;14(11):1982-8. doi: 10.1016/j.jtho.2019.06.015. PubMed PMID: 31254668; PMCID: PMC8080261.

Aisner J (CIPT),
Burley SK (CP),
Vallat B (CP),
Pine SR (GICG),
Ganesan S (CIPT)

Diehl KL, Ge EJ, Weinberg DN, Jani KS, Allis CD, Muir TW. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proc Natl Acad Sci U S A. 2019;116(44):22152-7. doi: 10.1073/pnas.1911775116. PubMed PMID: 31611394; PMCID: PMC6825254.

Muir TW (CP)

Malekshah OM, Sarkar S, Nomani A, Patel N, Javidian P, Goedken M, Polunas M, Louro P, Hatefi A. Bioengineered adipose-derived stem cells for targeted enzyme-prodrug therapy of ovarian cancer intraperitoneal metastasis. J Control Release. 2019;311-312:273-87. doi: 10.1016/j.jconrel.2019.09.006. PubMed PMID: 31499084; PMCID: PMC6884134.

Hatefi A (CP)

Ge EJ, Jani KS, Diehl KL, Muller MM, Muir TW. Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2. J Am Chem Soc. 2019;141(38):15029-39. doi: 10.1021/jacs.9b02321. PubMed PMID: 31479253; PMCID: PMC6941475.

Muir TW (CP)

Yin Z, Kaelber JT, Ebright RH. Structural basis of Q-dependent antitermination. Proc Natl Acad Sci U S A. 2019;116(37):18384-90. doi: 10.1073/pnas.1909801116. PubMed PMID: 31455742; PMCID: PMC6744881.

Kaelber JT (CP)

Suwan K, Yata T, Waramit S, Przystal JM, Stoneham CA, Bentayebi K, Asavarut P, Chongchai A, Pothachareon P, Lee KY, Topanurak S, Smith TL, Gelovani JG, Sidman RL, Pasqualini R, Arap W, Hajitou A. Next-generation of targeted AAVP vectors for systemic transgene delivery against cancer. Proc Natl Acad Sci U S A. 2019;116(37):18571-7. doi: 10.1073/pnas.1906653116. PubMed PMID: 31375630; PMCID: PMC6744886.

Pasqualini R (CP),
Arap W (CIPT)

Gramespacher JA, Burton AJ, Guerra LF, Muir TW. Proximity Induced Splicing Utilizing Caged Split Inteins. J Am Chem Soc. 2019;141(35):13708-12. doi: 10.1021/jacs.9b05721. PubMed PMID: 31418547; PMCID: PMC6903685.

Muir TW (CP)

Marras SAE, Bushkin Y, Tyagi S. High-fidelity amplified FISH for the detection and allelic discrimination of single mRNA molecules. Proc Natl Acad Sci U S A. 2019;116(28):13921-6. doi: 10.1073/pnas.1814463116. PubMed PMID: 31221755; PMCID: PMC6628817.

Tyagi S (CP)

Rizzolo D, Buckley K, Kong B, Zhan L, Shen J, Stofan M, Brinker A, Goedken M, Buckley B, Guo GL. Bile Acid Homeostasis in a Cholesterol 7alpha-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model. Hepatology. 2019;70(1):389-402. doi: 10.1002/hep.30612. PubMed PMID: 30864232; PMCID: PMC7893641.

Buckley B (CP),
Guo GL (CMI)

Thomas WC, Brooks FP, 3rd, Burnim AA, Bacik JP, Stubbe J, Kaelber JT, Chen JZ, Ando N. Convergent allostery in ribonucleotide reductase. Nat Commun. 2019;10(1):2653. doi: 10.1038/s41467-019-10568-4. PubMed PMID: 31201319; PMCID: PMC6572854.

Kaelber JT (CP)

Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF. Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization. Cell. 2019;177(7):1781-96 e25. doi: 10.1016/j.cell.2019.04.028. PubMed PMID: 31104845; PMCID: PMC6570567.

Muir TW (CP)

Zang X, Lee JB, Deshpande K, Garbuzenko OB, Minko T, Kagan L. Prevention of paclitaxel-induced neuropathy by formulation approach. J Control Release. 2019;303:109-16. doi: 10.1016/j.jconrel.2019.04.013. PubMed PMID: 30981814; PMCID: PMC6708409.

Minko T (CP),
Kagan L (CP)

Stein MN, Malhotra J, Tarapore RS, Malhotra U, Silk AW, Chan N, Rodriguez L, Aisner J, Aiken RD, Mayer T, Haffty BG, Newman JH, Aspromonte SM, Bommareddy PK, Estupinian R, Chesson CB, Sadimin ET, Li S, Medina DJ, Saunders T, Frankel M, Kareddula A, Damare S, Wesolowsky E, Gabel C, El-Deiry WS, Prabhu VV, Allen JE, Stogniew M, Oster W, et al. Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration. J Immunother Cancer. 2019;7(1):136. doi: 10.1186/s40425-019-0599-8. PubMed PMID: 31118108; PMCID: PMC6532211.

Malhotra J (CIPT),
Malhotra U (CIPT),
Silk AW (CIPT),
Chan N (CIPT),
Rodriguez L (CIPT),
Aisner J (CIPT),
Aiken RD (CIPT),
Mayer T (CIPT),
Haffty BG (CIPT),
Medina DJ (CIPT),
Bertino JR (CP),
Libutti SK (CIPT, GICG), Mehnert JM (CIPT),
Zloza A (CIPT)

Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019;10(1):2146. doi: 10.1038/s41467-019-09981-6. PubMed PMID: 31086175; PMCID: PMC6513997.

Muir TW (CP)

Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J. Glycogen Synthase Kinase-3alpha Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab. 2019;29(5):1119-34 e12. doi: 10.1016/j.cmet.2019.01.005. PubMed PMID: 30745182; PMCID: PMC6677269.

Tian B (GICG),
Li H (CP),
Sadoshima J (CP)

Calizo RC, Bhattacharya S, van Hasselt JGC, Wei C, Wong JS, Wiener RJ, Ge X, Wong NJ, Lee JJ, Cuttitta CM, Jayaraman G, Au VH, Janssen W, Liu T, Li H, Salem F, Jaimes EA, Murphy B, Campbell KN, Azeloglu EU. Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity. Nat Commun. 2019;10(1):2061. doi: 10.1038/s41467-019-09936-x. PubMed PMID: 31053734; PMCID: PMC6499885.

Li H (CP)

Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J. Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy. Circ Res. 2019;124(9):1360-71. doi: 10.1161/CIRCRESAHA.118.314607. PubMed PMID: 30786833; PMCID: PMC6483841.

Sadoshima J (CP)

Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Muller MM, Lewis PW, Muir TW. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proc Natl Acad Sci U S A. 2019;116(17):8295-300. doi: 10.1073/pnas.1819029116. PubMed PMID: 30967505; PMCID: PMC6486736.

Muir TW (CP)

Khan AJ, LaCava S, Mehta M, Schiff D, Thandoni A, Jhawar S, Danish S, Haffty BG, Chen S. The glutamate release inhibitor riluzole increases DNA damage and enhances cytotoxicity in human glioma cells, in vitro and in vivo. Oncotarget. 2019;10(29):2824-34. doi: 10.18632/oncotarget.26854. PubMed PMID: 31073373; PMCID: PMC6497458.

Haffty BG (CIPT),
Chen S (CP)

Shah R, Singh SJ, Eddy K, Filipp FV, Chen S. Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1(+) Melanoma. Cancer Res. 2019;79(8):1799-809. doi: 10.1158/0008-5472.CAN-18-1500. PubMed PMID: 30987979; PMCID: PMC6469683.

Chen S (CP)

Russo DP, Strickland J, Karmaus AL, Wang W, Shende S, Hartung T, Aleksunes LM, Zhu H. Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across. Environ Health Perspect. 2019;127(4):47001. doi: 10.1289/EHP3614. PubMed PMID: 30933541; PMCID: PMC6785238.

Aleksunes LM (CIPT),
Zhu H (CP)

Rameshwar P. Cancer stem cell gene profile getting closer to the clinic to enhance precise treatment. EBioMedicine. 2019;42:22-3. doi: 10.1016/j.ebiom.2019.03.036. PubMed PMID: 30904608; PMCID: PMC6491416.

Rameshwar P (CP)

Majumder J, Taratula O, Minko T. Nanocarrier-based systems for targeted and site specific therapeutic delivery. Adv Drug Deliv Rev. 2019;144:57-77. doi: 10.1016/j.addr.2019.07.010. PubMed PMID: 31400350; PMCID: PMC6748653.

Minko T (CP)

Liszczak G, Muir TW. Nucleic Acid-Barcoding Technologies: Converting DNA Sequencing into a Broad-Spectrum Molecular Counter. Angew Chem Int Ed Engl. 2019;58(13):4144-62. doi: 10.1002/anie.201808956. PubMed PMID: 30153374; PMCID: PMC6748390.

Muir TW (CP)

Brocato TA, Brown-Glaberman U, Wang Z, Selwyn RG, Wilson CM, Wyckoff EF, Lomo LC, Saline JL, Hooda-Nehra A, Pasqualini R, Arap W, Brinker CJ, Cristini V. Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies. JCI Insight. 2019;5(8). doi: 10.1172/jci.insight.126518. PubMed PMID: 30835256; PMCID: PMC6538356.

Pasqualini R (CP),
Arap W (CIPT)

Szilagyi JT, Composto-Wahler GM, Joseph LB, Wang B, Rosen T, Laskin JD, Aleksunes LM. Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis. Pharmacol Res. 2019;141:331-42. doi: 10.1016/j.phrs.2019.01.002. PubMed PMID: 30610963; PMCID: PMC6391190.

Laskin JD (CP),
Aleksunes LM (CIPT)

Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H, 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567(7749):535-9. doi: 10.1038/s41586-019-1024-7. PubMed PMID: 30867594; PMCID: PMC6557285.

Muir TW (CP)

Nacev BA, Feng L, Bagert JD, Lemiesz AE, Gao J, Soshnev AA, Kundra R, Schultz N, Muir TW, Allis CD. The expanding landscape of 'oncohistone' mutations in human cancers. Nature. 2019;567(7749):473-8. doi: 10.1038/s41586-019-1038-1. PubMed PMID: 30894748; PMCID: PMC6512987.

Muir TW (CP)

Tang FHF, Staquicini FI, Teixeira AAR, Michaloski JS, Namiyama GM, Taniwaki NN, Setubal JC, da Silva AM, Sidman RL, Pasqualini R, Arap W, Giordano RJ. A ligand motif enables differential vascular targeting of endothelial junctions between brain and retina. Proc Natl Acad Sci U S A. 2019;116(6):2300-5. doi: 10.1073/pnas.1809483116. PubMed PMID: 30670660; PMCID: PMC6369793.

Staquicini FI (CP),
Pasqualini R (CP),
Arap W (CIPT)

Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, Baljinnyam E, Fraidenraich D, Fritzky L, Zhai P, Ichinose S, Isobe M, Hsu CP, Kundu M, Sadoshima J. An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. J Clin Invest. 2019;129(2):802-19. doi: 10.1172/JCI122035. PubMed PMID: 30511961; PMCID: PMC6355232.

Li H (CP),
Sadoshima J (CP)

Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circ Res. 2019;124(2):292-305. doi: 10.1161/CIRCRESAHA.118.314048. PubMed PMID: 30582455; PMCID: PMC6645688.

Tian B (GICG),
Sadoshima J (CP)

Burley SK, Berman HM, Bhikadiya C, Bi C, Chen L, Di Costanzo L, Christie C, Dalenberg K, Duarte JM, Dutta S, Feng Z, Ghosh S, Goodsell DS, Green RK, Guranovic V, Guzenko D, Hudson BP, Kalro T, Liang Y, Lowe R, Namkoong H, Peisach E, Periskova I, Prlic A, Randle C, Rose A, Rose P, Sala R, Sekharan M, Shao C, et al. RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy. Nucleic Acids Res. 2019;47(D1):D464-D74. doi: 10.1093/nar/gky1004. PubMed PMID: 30357411; PMCID: PMC6324064.

Burley SK (CP),
Dutta S (CP),
Goodsell DS (CP), Westbrook J (CP)

Rather GM, Lin SY, Lin H, Szekely Z, Bertino JR. A Novel Antibody-Toxin Conjugate to Treat Mantle Cell Lymphoma. Front Oncol. 2019;9:258. doi: 10.3389/fonc.2019.00258. PubMed PMID: 31024856; PMCID: PMC6467949.

Szekely Z (CP),
Bertino JR (CP)

Ahuja K, Rather GM, Lin Z, Sui J, Xie P, Le T, Bertino JR, Javanmard M. Toward point-of-care assessment of patient response: a portable tool for rapidly assessing cancer drug efficacy using multifrequency impedance cytometry and supervised machine learning. Microsyst Nanoeng. 2019;5:34. doi: 10.1038/s41378-019-0073-2. PubMed PMID: 31645995; PMCID: PMC6799891.

Bertino JR (CP),
Javanmard M (CP)

Garbuzenko OB, Kuzmov A, Taratula O, Pine SR, Minko T. Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy. Theranostics. 2019;9(26):8362-76. doi: 10.7150/thno.39816. PubMed PMID: 31754402; PMCID: PMC6857061.

Pine SR (GICG),
Minko T (CP)

Tsang CK, Chen M, Cheng X, Qi Y, Chen Y, Das I, Li X, Vallat B, Fu LW, Qian CN, Wang HY, White E, Burley SK, Zheng XFS. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. Mol Cell. 2018;70(3):502-15 e8. doi: 10.1016/j.molcel.2018.03.029. PubMed PMID: 29727620; PMCID: PMC6108545.

Vallat B (CP),
White E (CMI),
Burley SK (CP),
Zheng XFS (CP)