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Cancer Pharmacology Selected Program-Related Publications


Key to Member Program Affiliation
Cancer Metabolism and Growth
Genomic Instability and Cancer Genetics 
Cancer Pharmacology 
Clinical Investigations and Precision Therapeutics
Cancer Prevention and Control 

Publications with PMCID

Cancer Institute Member(s) Credited

Burley SK, Berman HM, Christie C, Duarte JM, Feng Z, Westbrook J, Young J, Zardecki C. RCSB Protein Data Bank: Sustaining a living digital data resource that enables breakthroughs in scientific research and biomedical education. Protein Sci. 2018 Jan;27(1):316-330. PMID: 29067736; PMCID: PMC5734314. Burley SK (CP)
Gore S, Sanz García E, Hendrickx PMS, Gutmanas A, Westbrook JD, Yang H, Feng Z, Baskaran K, Berrisford JM, Hudson BP, Ikegawa Y, Kobayashi N, Lawson CL, Mading S, Mak L, Mukhopadhyay A, Oldfield TJ, Patwardhan A, Peisach E, Sahni G, Sekharan MR, Sen S, Shao C, Smart OS, Ulrich EL, Yamashita R, Quesada M, Young JY, Nakamura H, Markley JL, Berman HM, Burley SK, Velankar S, Kleywegt GJ. Validation of Structures in the Protein Data Bank. Structure. 2017 Dec 05;25(12):1916-1927. PMID: 29174494; PMCID: PMC5718880. Burley SK (CP)
Morgan KM, Fischer BS, Lee FY, Shah JJ, Bertino JR, Rosenfeld J, Singh A, Khiabanian H, Pine SR. Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma. Mol. Cancer Ther. 2017 Dec;16(12):2759-2769. PMID: 28978720; PMCID: PMC5716926. Bertino JR (CP), Khiabanian H (GICG), Pine SR (GICG)
Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R. Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circ. Res. 2017 Oct 27;121(10):1182-1191. PMID: 28835357; PMCID: PMC5659937. Sadoshima J (CMG, CP)
Sadoshima J. Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School. Circ. Res. 2017 Oct 27;121(10):1127-1129. PMID: 29074531; PMCID: PMC5762121. Sadoshima J (CMG, CP)
Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc. Natl. Acad. Sci. U.S.A. 2017 Oct 24;114(43):11404-11409. PMID: 29073064; PMCID: PMC5664509. Gitai Z (CMG), Kim H (CP), Rabinowitz JD (CMG)
Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Nat. Chem. Biol. 2017 Oct;13(10):1081-1087. PMID: 28805803; PMCID: PMC5605442. Su X (CMG), Kang Y (CMG), Muir TW (CP), Rabinowitz JD (CMG)
Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S, Sadoshima J. Thioredoxin-1 maintains mTOR function during oxidative stress in cardiomyocytes. J. Biol. Chem. In process 2017 Sep 22. PMID: 28939765; PMCID: PMC5704480. Sadoshima J (CMG, CP)
Jiang C, Xu R, Li XX, Wang YY, Liang WQ, Zeng JD, Zhang SS, Xu XY, Yang Y, Zhang MY, Wang HY, Zheng XFS. p53R2 overexpression in cervical cancer promotes AKT signaling and EMT, and is correlated with tumor progression, metastasis and poor prognosis. Cell Cycle. 2017 Sep 17;16(18):1673-1682. PMID: 28841361; PMCID: PMC5602298. Zheng XFS (CP)
Hatefi A, Karjoo Z, Nomani A. Development of a Recombinant Multifunctional Biomacromolecule for Targeted Gene Transfer to Prostate Cancer Cells. Biomacromolecules. 2017 Sep 11;18(9):2799-2807. PMID: 28806522; PMCID: PMC5593778. Hatefi A (CP)
Stevens AJ, Sekar G, Shah NH, Mostafavi AZ, Cowburn D, Muir TW. A promiscuous split intein with expanded protein engineering applications. Proc. Natl. Acad. Sci. U.S.A. 2017 Aug 08;114(32):8538-8543. PMID: 28739907; PMCID: PMC5559002. Muir TW (CP)
Sadoshima J, Tomoike H. What Should We Learn From the Recent Decline of Basic Cardiovascular Science in Japan? Circ. Res. 2017 Aug 04;121(4):314-316. PMID: 28775005; PMCID: PMC5560069. Sadoshima J (CMG, CP)
Tsang AT, Dudgeon C, Yi L, Yu X, Goraczniak R, Donohue K, Kogan S, Brenneman MA, Ho ES, Gunderson SI, Carpizo DR. U1 Adaptors Suppress the KRAS-MYC Oncogenic Axis in Human Pancreatic Cancer Xenografts. Mol. Cancer Ther. 2017 Aug;16(8):1445-1455. PMID: 28377488; PMCID: PMC5544574. Gunderson SI (GICG), Carpizo DR (CIPT, CP)
Mizushima W, Sadoshima J. BAG3 plays a central role in proteostasis in the heart. J. Clin. Invest. 2017 Aug 01;127(8):2900-2903. PMID: 28737514; PMCID: PMC5531392. Sadoshima J (CMG, CP)
Winer BY, Huang TS, Pludwinski E, Heller B, Wojcik F, Lipkowitz GE, Parekh A, Cho C, Shrirao A, Muir TW, Novik E, Ploss A. Long-term hepatitis B infection in a scalable hepatic co-culture system. Nat Commun. 2017 07 25;8(1):125. PMID: 28743900; PMCID: PMC5527081. Muir TW (CP), Ploss A (CMG)
Zhao JY, Liang L, Gu X, Li Z, Wu S, Sun L, Atianjoh FE, Feng J, Mo K, Jia S, Lutz BM, Bekker A, Nestler EJ, Tao YX. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nat Commun. 2017 Mar 08;8:14712. PMID: 28270689; PMCID: PMC5344974. Tao YX (CP)
Saito T, Sadoshima J. Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System. Circ. Res. 2017 Feb 17;120(4):610-612. PMID: 28209790; PMCID: PMC5319734. Sadoshima J (CMG, CP)
Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn Ii GW, Sadoshima J, Ellisman MH, Gustafsson ÅB. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun. 2017 Jan 30;8:14050. PMID: 28134239; PMCID: PMC5290275. Li H (CP), Sadoshima J (CMG, CP)
Rose PW, Prlić A, Altunkaya A, Bi C, Bradley AR, Christie CH, Costanzo LD, Duarte JM, Dutta S, Feng Z, Green RK, Goodsell DS, Hudson B, Kalro T, Lowe R, Peisach E, Randle C, Rose AS, Shao C, Tao YP, Valasatava Y, Voigt M, Westbrook JD, Woo J, Yang H, Young JY, Zardecki C, Berman HM, Burley SK. The RCSB protein data bank: integrative view of protein, gene and 3D structural information. Nucleic Acids Res. 2017 Jan 04;45(D1):D271-D281. PMID: 27794042; PMCID: PMC5210513. Burley SK (CP)
Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife. 2016 12 19;5. PMID: 27991852; PMCID: PMC5218537. Ryazanov AG (CP)
Bansal N, Bartucci M, Yusuff S, Davis S, Flaherty K, Huselid E, Patrizii M, Jones D, Cao L, Sydorenko N, Moon YC, Zhong H, Medina DJ, Kerrigan J, Stein MN, Kim IY, Davis TW, DiPaola RS, Bertino JR, Sabaawy HE. BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer. Clin. Cancer Res. 2016 Dec 15;22(24):6176-6191. PMID: 27307599; PMCID: PMC5159329. Medina DJ (CIPT), Kim IY (CIPT), DiPaola RS (CIPT), Bertino JR (CP), Sabaawy HE (CP)
Salloum S, Holmes JA, Jindal R, Bale SS, Brisac C, Alatrakchi N, Lidofsky A, Kruger AJ, Fusco DN, Luther J, Schaefer EA, Lin W, Yarmush ML, Chung RT. Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types. Hepatology. 2016 Dec;64(6):1951-1968. PMID: 27531241; PMCID: PMC5116014. Yarmush ML (CP)
Cheng D, Wu R, Guo Y, Kong AN. Regulation of Keap1-Nrf2 signaling: The role of epigenetics. Curr Opin Toxicol. 2016 12;1:134-138. PMID: 29057383; PMCID: PMC5645054. Kong AN (CIPT, CP)
Yang XZ, Li XX, Zhang YJ, Rodriguez-Rodriguez L, Xiang MQ, Wang HY, Zheng XF. Rab1 in cell signaling, cancer and other diseases. Oncogene. 2016 Nov 03;35(44):5699-5704. PMID: 27041585; PMCID: PMC5396462. Rodriguez-Rodriguez L (CIPT), Zheng XF (CP)
Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016 Oct 14;44(18):8855-8869. PMID: 27566146; PMCID: PMC5062998. Bunting SF (GICG), Zheng XF (CP), Shen Z (GICG), Sabaawy HE (CP), Liu L (CP), Pine SR (GICG)
Berman HM, Burley SK, Kleywegt GJ, Markley JL, Nakamura H, Velankar S. The archiving and dissemination of biological structure data. Curr. Opin. Struct. Biol. 2016 Oct;40:17-22. PMID: 27450113; PMCID: PMC5161703. Burley SK (CP)
De Gassart A, Demaria O, Panes R, Zaffalon L, Ryazanov AG, Gilliet M, Martinon F. Pharmacological eEF2K activation promotes cell death and inhibits cancer progression. EMBO Rep. 2016 10;17(10):1471-1484. PMID: 27572820; PMCID: PMC5048377. Ryazanov AG (CP)
Nah J, Fernández ÁF, Kitsis RN, Levine B, Sadoshima J. Does Autophagy Mediate Cardiac Myocyte Death During Stress? Circ. Res. 2016 Sep 30;119(8):893-5. PMID: 27688304; PMCID: PMC5161244. Sadoshima J (CMG, CP)
Cui L, Miao X, Liang L, Abdus-Saboor I, Olson W, Fleming MS, Ma M, Tao YX, Luo W. Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain. Neuron. 2016 Sep 07;91(5):1137-1153. PMID: 27545714; PMCID: PMC5017914. Tao YX (CP)
Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu CP, Li H, Tsutsui H, Sadoshima J. Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 2016 Sep 01;126(9):3403-16. PMID: 27525436; PMCID: PMC5004961. Li H (CP), Sadoshima J (CMG, CP)
Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park J, Hsu CP, Tian B, Pan D, Sadoshima J, Del Re DP. NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart. Circ. Res. 2016 Aug 19;119(5):596-606. PMID: 27402866; PMCID: PMC4992450. Tian B (GICG), Sadoshima J (CMG, CP)
Li Y, Tsang CK, Wang S, Li XX, Yang Y, Fu L, Huang W, Li M, Wang HY, Zheng XF. MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription. Hepatology. 2016 Jun;63(6):1928-42. PMID: 26910647; PMCID: PMC5021206. Zheng XF (CP)
McCarty WJ, Usta OB, Yarmush ML. A Microfabricated Platform for Generating Physiologically-Relevant Hepatocyte Zonation. Sci Rep. 2016 May 31;6:26868. PMID: 27240736; PMCID: PMC4886516. Yarmush ML (CP)
Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK, Sadoshima J. Aging and Autophagy in the Heart. Circ. Res. 2016 May 13;118(10):1563-76. PMID: 27174950; PMCID: PMC4869999. Sadoshima J (CMG, CP)
Ding R, Jin S, Pabon K, Scotto KW. A role for ABCG2 beyond drug transport: Regulation of autophagy. Autophagy. 2016 May 03;12(5):737-51. PMID: 26983466; PMCID: PMC4854550. Jin S (CP), Scotto KW (CP)
Zhang Y, Li Q, Welsh WJ, Moghe PV, Uhrich KE. Micellar and structural stability of nanoscale amphiphilic polymers: Implications for anti-atherosclerotic bioactivity. Biomaterials. 2016 Apr;84:230-40. PMID: 26828687; PMCID: PMC4755878. Welsh WJ (CP), Moghe PV (CP), Uhrich KE (CP)
Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure. Circulation. 2016 Mar 29;133(13):1249-63. PMID: 26915633; PMCID: PMC4811679. Sadoshima J (CMG, CP)
Carlson AL, Bennett NK, Francis NL, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang ZP, Moghe PV. Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds. Nat Commun. 2016 Mar 17;7:10862. PMID: 26983594; PMCID: PMC4800432. Hart RP (CMG), Kohn J (CP), Moghe PV (CP)
Tsang YH, Dogruluk T, Tedeschi PM, Wardwell-Ozgo J, Lu H, Espitia M, Nair N, Minelli R, Chong Z, Chen F, Chang QE, Dennison JB, Dogruluk A, Li M, Ying H, Bertino JR, Gingras MC, Ittmann M, Kerrigan J, Chen K, Creighton CJ, Eterovic K, Mills GB, Scott KL. Functional annotation of rare gene aberration drivers of pancreatic cancer. Nat Commun. 2016 Jan 25;7:10500. PMID: 26806015; PMCID: PMC4737758. Bertino JR (CP)
Che M, Wang R, Li X, Wang HY, Zheng XFS. Expanding roles of superoxide dismutases in cell regulation and cancer. Drug Discov. Today. 2016 Jan;21(1):143-149. PMID: 26475962; PMCID: PMC4724522. Zheng XFS (CP)
Zevon M, Ganapathy V, Kantamneni H, Mingozzi M, Kim P, Adler D, Sheng Y, Tan MC, Pierce M, Riman RE, Roth CM, Moghe PV. CXCR-4 Targeted, Short Wave Infrared (SWIR) Emitting Nanoprobes for Enhanced Deep Tissue Imaging and Micrometastatic Cancer Lesion Detection. Small. 2015 Dec 16;11(47):6347-57. PMID: 26514367; PMCID: PMC4763715. Pierce M (CIPT), Roth CM (CP), Moghe PV (CP)
Zhang Y, Wang X, Qin X, Wang X, Liu F, White E, Zheng XF. PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. EBioMedicine. 2015 Dec;2(12):1944-56. PMID: 26844273; PMCID: PMC4703732. White E (CMG), Zheng XF (CP)
Blanden AR, Yu X, Loh SN, Levine AJ, Carpizo DR. Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer. Drug Discov. Today. 2015 Nov;20(11):1391-7. PMID: 26205328; PMCID: PMC4922747. Levine AJ (GICG), Carpizo DR (CIPT, CP)
Yang Y, Del Re DP, Nakano N, Sciarretta S, Zhai P, Park J, Sayed D, Shirakabe A, Matsushima S, Park Y, Tian B, Abdellatif M, Sadoshima J. miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. Circ. Res. 2015 Oct 23;117(10):891-904. PMID: 26333362; PMCID: PMC4747867. Tian B (GICG), Sadoshima J (CMG, CP)
Tedeschi PM, Lin H, Gounder M, Kerrigan JE, Abali EE, Scotto K, Bertino JR. Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy. Mol. Pharmacol. 2015 Oct;88(4):720-7. PMID: 26219913; PMCID: PMC4576680. Scotto K (CP), Bertino JR (CP)
Winkelmann DA, Forgacs E, Miller MT, Stock AM. Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity. Nat Commun. 2015 Aug 06;6:7974. PMID: 26246073; PMCID: PMC4918383. Stock AM (CP)
Abdelhamid DS, Zhang Y, Lewis DR, Moghe PV, Welsh WJ, Uhrich KE. Tartaric acid-based amphiphilic macromolecules with ether linkages exhibit enhanced repression of oxidized low density lipoprotein uptake. Biomaterials. 2015 Jun;53:32-9. PMID: 25890704; PMCID: PMC4405674. Moghe PV (CP), Welsh WJ (CP), Uhrich KE (CP)
Mehta M, Khan A, Danish S, Haffty BG, Sabaawy HE. Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition. Mol. Cancer Ther. 2015 May;14(5):1171-80. PMID: 25695954; PMCID: PMC4425617. Khan A (CIPT), Haffty BG (CIPT), Sabaawy HE (CP)
Blanden AR, Yu X, Wolfe AJ, Gilleran JA, Augeri DJ, O'Dell RS, Olson EC, Kimball SD, Emge TJ, Movileanu L, Carpizo DR, Loh SN. Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore. Mol. Pharmacol. 2015 May;87(5):825-31. PMID: 25710967; PMCID: PMC4407733. Augeri DJ (CP), Carpizo DR (CIPT, CP)
Goodsell DS, Dutta S, Zardecki C, Voigt M, Berman HM, Burley SK. The RCSB PDB "Molecule of the Month": Inspiring a Molecular View of Biology. PLoS Biol. 2015 May;13(5):e1002140. PMID: 25942442; PMCID: PMC4420264. Burley SK (CP)
Wu TJ, Wang X, Zhang Y, Meng L, Kerrigan JE, Burley SK, Zheng XF. Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase. Cell Rep. 2015 Apr 21;11(3):446-59. PMID: 25865887; PMCID: PMC4761412. Burley SK (CP), Zheng XF (CP)
Saito T, Sadoshima J. Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circ. Res. 2015 Apr 10;116(8):1477-90. PMID: 25858070; PMCID: PMC4419704. Sadoshima J (CMG, CP)
Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H, Sadoshima J. mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep. 2015 Apr 07;11(1):125-36. PMID: 25843706; PMCID: PMC4417361. Li H (CP), Sadoshima J (CMG, CP)
Bruinsma BG, Berendsen TA, Izamis ML, Yeh H, Yarmush ML, Uygun K. Supercooling preservation and transplantation of the rat liver. Nat Protoc. 2015 Mar;10(3):484-94. PMID: 25692985; PMCID: PMC4494653. Yarmush ML (CP)
Bruinsma BG, Uygun K, Yarmush ML, Saeidi N. Surgical models of Roux-en-Y gastric bypass surgery and sleeve gastrectomy in rats and mice. Nat Protoc. 2015 Mar;10(3):495-507. PMID: 25719268; PMCID: PMC4476550. Yarmush ML (CP)
Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature. 2015 Jan 22;517(7535):497-500. PMID: 25383520; PMCID: PMC4304784. Ryazanov AG (CP)
Rose PW, Prlić A, Bi C, Bluhm WF, Christie CH, Dutta S, Green RK, Goodsell DS, Westbrook JD, Woo J, Young J, Zardecki C, Berman HM, Bourne PE, Burley SK. The RCSB Protein Data Bank: views of structural biology for basic and applied research and education. Nucleic Acids Res. 2015 Jan;43(Database issue):D345-56. PMID: 25428375; PMCID: PMC4383988. Burley SK (CP)
Nikonorova IA, Kornakov NV, Dmitriev SE, Vassilenko KS, Ryazanov AG. Identification of a Mg2+-sensitive ORF in the 5'-leader of TRPM7 magnesium channel mRNA. Nucleic Acids Res. 2014 Nov 10;42(20):12779-88. PMID: 25326319; PMCID: PMC4227784. Ryazanov AG (CP)
Thomas JD, Zhang YJ, Wei YH, Cho JH, Morris LE, Wang HY, Zheng XF. Rab1A is an mTORC1 activator and a colorectal oncogene. Cancer Cell. 2014 Nov 10;26(5):754-69. PMID: 25446900; PMCID: PMC4288827. Zheng XF (CP)
Tao H, Zhang Y, Zeng X, Shulman GI, Jin S. Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nat. Med. 2014 Nov;20(11):1263-9. PMID: 25282357; PMCID: PMC4299950. Jin S (CP)
Das K, Martinez SE, Bandwar RP, Arnold E. Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage. Nucleic Acids Res. 2014 Jul;42(12):8125-37. PMID: 24880687; PMCID: PMC4081091. Arnold E (CP)
Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat. Med. 2014 Jul;20(7):790-3. PMID: 24973919; PMCID: PMC4141719. Yarmush ML (CP)
Odokonyero D, Sakai A, Patskovsky Y, Malashkevich VN, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Agarwal R, Wang C, Ozerova ND, Yew WS, Sauder JM, Swaminathan S, Burley SK, Almo SC, Glasner ME. Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family. Proc. Natl. Acad. Sci. U.S.A. 2014 Jun 10;111(23):8535-40. PMID: 24872444; PMCID: PMC4060685. Burley SK (CP)
Wen Y, Li J, Koo J, Shin SS, Lin Y, Jeong BS, Mehnert JM, Chen S, Cohen-Sola KA, Goydos JS. Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression. Cancer Res. 2014 May 01;74(9):2499-509. PMID: 24491800; PMCID: PMC4008638. Mehnert JM (CIPT), Chen S (CP), Goydos JS (CIPT)
Degen D, Feng Y, Zhang Y, Ebright KY, Ebright YW, Gigliotti M, Vahedian-Movahed H, Mandal S, Talaue M, Connell N, Arnold E, Fenical W, Ebright RH. Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife. 2014 Apr 30;3:e02451. PMID: 24843001; PMCID: PMC4029172. Arnold E (CP)
Zhang Y, Degen D, Ho MX, Sineva E, Ebright KY, Ebright YW, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright RH. GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife. 2014 Apr 22;3:e02450. PMID: 24755292; PMCID: PMC3994528. Arnold E (CP)
Tsang CK, Liu Y, Thomas J, Zhang Y, Zheng XF. Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance. Nat Commun. 2014 Mar 19;5:3446. PMID: 24647101; PMCID: PMC4678626. Zheng XF (CP)
Chu HP, Liao Y, Novak JS, Hu Z, Merkin JJ, Shymkiv Y, Braeckman BP, Dorovkov MV, Nguyen A, Clifford PM, Nagele RG, Harrison DE, Ellis RE, Ryazanov AG. Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev. Cell. 2014 Mar 10;28(5):561-572. PMID: 24582807; PMCID: PMC4712648. Ryazanov AG (CP)
Shao D, Oka S, Liu T, Zhai P, Ago T, Sciarretta S, Li H, Sadoshima J. A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. Cell Metab. 2014 Feb 04;19(2):232-45. PMID: 24506865; PMCID: PMC3937768. Li H (CP), Sadoshima J (CMG, CP)
Nativ NI, Yarmush G, Chen A, Dong D, Henry SD, Guarrera JV, Klein KM, Maguire T, Schloss R, Berthiaume F, Yarmush ML. Rat hepatocyte culture model of macrosteatosis: effect of macrosteatosis induction and reversal on viability and liver-specific function. J. Hepatol. 2013 Dec;59(6):1307-14. PMID: 23872604; PMCID: PMC3899833. Yarmush ML (CP)
Shah V, Taratula O, Garbuzenko OB, Taratula OR, Rodriguez-Rodriguez L, Minko T. Targeted nanomedicine for suppression of CD44 and simultaneous cell death induction in ovarian cancer: an optimal delivery of siRNA and anticancer drug. Clin. Cancer Res. 2013 Nov 15;19(22):6193-204. PMID: 24036854; PMCID: PMC3846837. Rodriguez-Rodriguez L (CIPT), Minko T (CP)
Tedeschi PM, Markert EK, Gounder M, Lin H, Dvorzhinski D, Dolfi SC, Chan LL, Qiu J, DiPaola RS, Hirshfield KM, Boros LG, Bertino JR, Oltvai ZN, Vazquez A. Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell Death Dis. 2013 Oct 24;4:e877. PMID: 24157871; PMCID: PMC3920946. Markert EK (CIPT), DiPaola RS (CIPT), Hirshfield KM (GICG), Bertino JR (CP), Vazquez A (GICG)
Lewis DR, Kholodovych V, Tomasini MD, Abdelhamid D, Petersen LK, Welsh WJ, Uhrich KE, Moghe PV. In silico design of anti-atherogenic biomaterials. Biomaterials. 2013 Oct;34(32):7950-9. PMID: 23891521; PMCID: PMC3880781. Welsh WJ (CP), Uhrich KE (CP)
Martino JJ, Wall BA, Mastrantoni E, Wilimczyk BJ, La Cava SN, Degenhardt K, White E, Chen S. Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene. 2013 Sep 12;32(37):4366-76. PMID: 23085756; PMCID: PMC3910169. White E (CMG), Chen S (CP)
Saeidi N, Meoli L, Nestoridi E, Gupta NK, Kvas S, Kucharczyk J, Bonab AA, Fischman AJ, Yarmush ML, Stylopoulos N. Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. Science. 2013 Jul 26;341(6144):406-10. PMID: 23888041; PMCID: PMC4068965. Yarmush ML (CP)
Almo SC, Garforth SJ, Hillerich BS, Love JD, Seidel RD, Burley SK. Protein production from the structural genomics perspective: achievements and future needs. Curr. Opin. Struct. Biol. 2013 Jun;23(3):335-44. PMID: 23642905; PMCID: PMC4163025. Burley SK (CP)
Kuroda DG, Bauman JD, Challa JR, Patel D, Troxler T, Das K, Arnold E, Hochstrasser RM. Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase. Nat Chem. 2013 Mar;5(3):174-81. PMID: 23422558; PMCID: PMC3607437. Arnold E (CP)
Hsieh YC, Tedeschi P, Adebisi Lawal R, Banerjee D, Scotto K, Kerrigan JE, Lee KC, Johnson-Farley N, Bertino JR, Abali EE. Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs. Mol. Pharmacol. 2013 Feb;83(2):339-53. PMID: 23197646; PMCID: PMC3558814. Scotto K (CP), Bertino JR (CP)
Kim JH, Yu S, Chen JD, Kong AN. The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains. Oncogene. 2013 Jan 24;32(4):514-27. PMID: 22370642; PMCID: PMC3538952. Kong AN (CIPT, CP)
Vazquez A, Tedeschi PM, Bertino JR. Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors. Cancer Res. 2013 Jan 15;73(2):478-82. PMID: 23135910; PMCID: PMC4083755. Vazquez A (GICG), Bertino JR (CP)
Gao R, Stock AM. Probing kinase and phosphatase activities of two-component systems in vivo with concentration-dependent phosphorylation profiling. Proc. Natl. Acad. Sci. U.S.A. 2013 Jan 08;110(2):672-7. PMID: 23267085; PMCID: PMC3545780. Stock AM (CP)
Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. Construction of human activity-based phosphorylation networks. Mol. Syst. Biol. 2013;9:655. PMID: 23549483; PMCID: PMC3658267. Ryazanov AG (CP)
Naczynski DJ, Tan MC, Zevon M, Wall B, Kohl J, Kulesa A, Chen S, Roth CM, Riman RE, Moghe PV. Rare-earth-doped biological composites as in vivo shortwave infrared reporters. Nat Commun. 2013;4:2199. PMID: 23873342; PMCID: PMC3736359. Chen S (CP), Roth CM (CP), Moghe PV (CP)
Kaul M, Parhi AK, Zhang Y, LaVoie EJ, Tuske S, Arnold E, Kerrigan JE, Pilch DS. A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization. J. Med. Chem. 2012 Nov 26;55(22):10160-76. PMID: 23050700; PMCID: PMC3969268. LaVoie EJ (CP), Arnold E (CP), Pilch DS (CP)
Zhang Y, Feng Y, Chatterjee S, Tuske S, Ho MX, Arnold E, Ebright RH. Structural basis of transcription initiation. Science. 2012 Nov 23;338(6110):1076-80. PMID: 23086998; PMCID: PMC3593053. Arnold E (CP)
Wangari-Talbot J, Wall BA, Goydos JS, Chen S. Functional effects of GRM1 suppression in human melanoma cells. Mol. Cancer Res. 2012 Nov;10(11):1440-50. PMID: 22798429; PMCID: PMC3501593. Goydos JS (CIPT), Chen S (CP)
Taylor R, Chen PH, Chou CC, Patel J, Jin SV. KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formation. Autophagy. 2012 Sep;8(9):1300-11. PMID: 22889849; PMCID: PMC3442877. Jin SV (CP)
Yu X, Vazquez A, Levine AJ, Carpizo DR. Allele-specific p53 mutant reactivation. Cancer Cell. 2012 May 15;21(5):614-25. PMID: 22624712; PMCID: PMC3366694. Vazquez A (GICG), Levine AJ (GICG), Carpizo DR (CIPT, CP)
Ding R, Shi J, Pabon K, Scotto KW. Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance. Mol. Pharmacol. 2012 Mar;81(3):328-37. PMID: 22113078; PMCID: PMC3286305. Scotto KW (CP)
Zhang Y, Zheng XF. mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors. Cell Cycle. 2012 Feb 01;11(3):594-603. PMID: 22262166; PMCID: PMC3315097. Zheng XF (CP)
Das K, Martinez SE, Bauman JD, Arnold E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat. Struct. Mol. Biol. 2012 Jan 22;19(2):253-9. PMID: 22266819; PMCID: PMC3359132. Arnold E (CP)
Moloughney JG, Monken CE, Tao H, Zhang H, Thomas JD, Lattime EC, Jin S. Vaccinia virus leads to ATG12–ATG3 conjugation and deficiency in autophagosome formation. Autophagy. 2011 Dec;7(12):1434-47. PMID: 22024753; PMCID: PMC3327614. Lattime EC (CMG), Jin S (CP)
Lee HJ, Wall BA, Wangari-Talbot J, Shin SS, Rosenberg S, Chan JL, Namkoong J, Goydos JS, Chen S. Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies. Clin. Cancer Res. 2011 Nov 15;17(22):7080-92. PMID: 21844014; PMCID: PMC3218300. Goydos JS (CIPT), Chen S (CP)
Gocek E, Wang X, Liu X, Liu CG, Studzinski GP. MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis. Cancer Res. 2011 Oct 01;71(19):6230-9. PMID: 21816906; PMCID: PMC5572464. Studzinski GP (CP)


Publications without PMCID

Cancer Institute Member(s) Credited

Masia R, McCarty WJ, Lahmann C, Luther J, Chung RT, Yarmush ML, Yellen G. Live cell imaging of cytosolic NADH/NAD+ ratio in hepatocytes and liver slices. Am. J. Physiol. Gastrointest. Liver Physiol. In process 2017 Oct 12;ajpgi.00093.2017. PMID: 29025729. Yarmush ML (CP)
Burley SK, Kurisu G, Markley JL, Nakamura H, Velankar S, Berman HM, Sali A, Schwede T, Trewhella J. PDB-Dev: a Prototype System for Depositing Integrative/Hybrid Structural Models. Structure. 2017 Sep 05;25(9):1317-1318. PMID: 28877501. Burley SK (CP)
Dann GP, Liszczak GP, Bagert JD, Müller MM, Nguyen UTT, Wojcik F, Brown ZZ, Bos J, Panchenko T, Pihl R, Pollock SB, Diehl KL, Allis CD, Muir TW. ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference. Nature. 2017 08 31;548(7669):607-611. PMID: 28767641. Muir TW (CP)
Guo J, Tao H, Alasadi A, Huang Q, Jin S. Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice. Eat Weight Disord. In process 2017 Aug 05. PMID: 28780747. Guo J (CMG), Jin S (CP)
Stein MN, Bertino JR, Kaufman HL, Mayer T, Moss R, Silk A, Chan N, Malhotra J, Rodriguez L, Aisner J, Aiken RD, Haffty BG, DiPaola RS, Saunders T, Zloza A, Damare S, Beckett Y, Yu B, Najmi S, Gabel C, Dickerson S, Zheng L, El-Deiry WS, Allen JE, Stogniew M, Oster W, Mehnert JM. First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors. Clin. Cancer Res. 2017 Aug 01;23(15):4163-4169. PMID: 28331050. Bertino JR (CP), Kaufman HL (CIPT), Mayer T (CIPT), Moss R (CIPT), Silk A (CIPT), Chan N (CIPT), Malhotra J (CIPT), Rodriguez L (CIPT), Aisner J (CIPT), Aiken RD (CIPT), Haffty BG (CIPT), DiPaola RS (CIPT), Zloza A (CIPT), Mehnert JM (CIPT)
You G. Preface: Molecular Mechanisms, Novel Modes of Regulation, and Therapeutic Strategies. Adv. Drug Deliv. Rev. 2017 Jul 01;116:1-2. PMID: 28882217. You G (CP)
Yarmush ML, D'Alessandro M, Saeidi N. Regulation of Energy Homeostasis After Gastric Bypass Surgery. Annu Rev Biomed Eng. 2017 Jun 21;19:459-484. PMID: 28633561. Yarmush ML (CP)
Lu ZR, Minko T. Molecular imaging for precision medicine. Adv. Drug Deliv. Rev. 2017 Apr;113:1-2. PMID: 28821310. Minko T (CP)
Cheng Y, Ren X, Yuan Y, Shan Y, Li L, Chen X, Zhang L, Takahashi Y, Yang JW, Han B, Liao J, Li Y, Harvey H, Ryazanov A, Robertson GP, Wan G, Liu D, Chen AF, Tao Y, Yang JM. eEF-2 kinase is a critical regulator of Warburg effect through controlling PP2A-A synthesis. Oncogene. 2016 Dec 08;35(49):6293-6308. PMID: 27181208. Ryazanov A (CP)
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat. Med. 2016 Dec;22(12):1428-1438. PMID: 27841876. Sadoshima J (CMG, CP)
Tedeschi PM, Bansal N, Kerrigan JE, Abali EE, Scotto KW, Bertino JR. NAD+ Kinase as a Therapeutic Target in Cancer. Clin. Cancer Res. 2016 Nov 01;22(21):5189-5195. PMID: 27582489. Scotto KW (CP), Bertino JR (CP)
Bertino JR. Landmark Study: The Relation of Solar Radiation to Cancer Mortality in North America. Cancer Res. 2016 Jan 15;76(2):185. PMID: 26773094. Bertino JR (CP)
Das K, Arnold E. Negative-Strand RNA Virus L Proteins: One Machine, Many Activities. Cell. 2015 Jul 16;162(2):239-241. PMID: 26186183. Arnold E (CP)
Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ. Res. 2015 Jan 16;116(2):264-78. PMID: 25332205. Sadoshima J (CMG, CP)
Bansal N, Farley NJ, Wu L, Lewis J, Youssoufian H, Bertino JR. Darinaparsin inhibits prostate tumor-initiating cells and Du145 xenografts and is an inhibitor of hedgehog signaling. Mol. Cancer Ther. 2015 Jan;14(1):23-30. PMID: 25381261. Bertino JR (CP)
Munoz JL, Rodriguez-Cruz V, Greco SJ, Nagula V, Scotto KW, Rameshwar P. Temozolomide induces the production of epidermal growth factor to regulate MDR1 expression in glioblastoma cells. Mol. Cancer Ther. 2014 Oct;13(10):2399-411. PMID: 25053824. Scotto KW (CP)
Yarmush ML, Golberg A, Serša G, Kotnik T, Miklavčič D. Electroporation-based technologies for medicine: principles, applications, and challenges. Annu Rev Biomed Eng. 2014 Jul 11;16:295-320. PMID: 24905876. Yarmush ML (CP)
Das K, Sarafianos SG, Arnold E. Structural requirements for RNA degradation by HIV-1 reverse transcriptase. Nat. Struct. Mol. Biol. 2013 Dec;20(12):1341-2. PMID: 24304910. Arnold E (CP)
Minko T, Rodriguez-Rodriguez L, Pozharov V. Nanotechnology approaches for personalized treatment of multidrug resistant cancers. Adv. Drug Deliv. Rev. 2013 Nov;65(13-14):1880-95. PMID: 24120655. Minko T (CP), Rodriguez-Rodriguez L (CIPT)
Wei R, Huang GL, Zhang MY, Li BK, Zhang HZ, Shi M, Chen XQ, Huang L, Zhou QM, Jia WH, Zheng XF, Yuan YF, Wang HY. Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma. Clin. Cancer Res. 2013 Sep 01;19(17):4780-91. PMID: 23812667. Zheng XF (CP)
Knapp S, Arruda P, Blagg J, Burley S, Drewry DH, Edwards A, Fabbro D, Gillespie P, Gray NS, Kuster B, Lackey KE, Mazzafera P, Tomkinson NC, Willson TM, Workman P, Zuercher WJ. A public-private partnership to unlock the untargeted kinome. Nat. Chem. Biol. 2013 Jan;9(1):3-6. PMID: 23238671. Burley S (CP)
Jin S. Mitochondrial complex III: Tuner of autophagy. Chem. Biol. 2011 Nov 23;18(11):1348-9. PMID: 22118666. Jin S (CP)