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Key to Member Program Affiliation |
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CMI |
Cancer Metabolism and Immunology |
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Publication |
Member(s) Credited |
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Ghaddar B, Biswas A, Harris C, Omary MB, Carpizo DR, Blaser MJ, De S. Tumor microbiome links cellular programs and immunity in pancreatic cancer. Cancer Cell. 2022;40(10):1240-53.e5. doi: 10.1016/j.ccell.2022.09.009. PubMed PMID: 36220074; PMCID: PMC9556978. |
Blaser MJ (CMI), |
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Jankowski CSR, Rabinowitz JD. Selenium Modulates Cancer Cell Response to Pharmacologic Ascorbate. Cancer Res. 2022;82(19):3486-98. doi: 10.1158/0008-5472.Can-22-0408. PubMed PMID: 35916672; PMCID: PMC9532358. |
Rabinowitz JD (CMI) |
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Li ML, Ragupathi A, Patel N, Hernandez T, Magsino J, Werlen G, Brewer G, Jacinto E. The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane. J Biol Chem. 2022;298(10):102437. doi: 10.1016/j.jbc.2022.102437. PubMed PMID: 36041631; PMCID: PMC9513781. |
Brewer G (ZY), |
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Zeng X, Xing X, Gupta M, Keber FC, Lopez JG, Lee YJ, Roichman A, Wang L, Neinast MD, Donia MS, Wühr M, Jang C, Rabinowitz JD. Gut bacterial nutrient preferences quantified in vivo. Cell. 2022;185(18):3441-56.e19. doi: 10.1016/j.cell.2022.07.020. PubMed PMID: 36055202; PMCID: PMC9450212. |
Donia MS (CMI), |
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Peng J, Qin C, Ramatchandirin B, Pearah A, Guo S, Hussain M, Yu L, Wondisford FE, He L. Activation of the canonical ER stress IRE1-XBP1 pathway by insulin regulates glucose and lipid metabolism. J Biol Chem. 2022;298(9):102283. doi: 10.1016/j.jbc.2022.102283. PubMed PMID: 35863429; PMCID: PMC9396404. |
Wondisford FE (CMI) |
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Sharma S, Yang J, Doamekpor SK, Grudizen-Nogalska E, Tong L, Kiledjian M. Identification of a novel deFADding activity in human, yeast and bacterial 5' to 3' exoribonucleases. Nucleic Acids Res. 2022;50(15):8807-17. doi: 10.1093/nar/gkac617. PubMed PMID: 35904778; PMCID: PMC9410882. |
Kiledjian M (CMI) |
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Yin Z, Bird JG, Kaelber JT, Nickels BE, Ebright RH. In transcription antitermination by Qλ, NusA induces refolding of Qλ to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc Natl Acad Sci U S A. 2022;119(33):e2205278119. doi: 10.1073/pnas.2205278119. PubMed PMID: 35951650; PMCID: PMC9388147. |
Kaelber JT (CP), |
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Tomer D, Arriagada C, Munshi S, Alexander BE, French B, Vedula P, Caorsi V, House A, Guvendiren M, Kashina A, Schwarzbauer JE, Astrof S. A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy. J Cell Sci. 2022;135(16). doi: 10.1242/jcs.260120. PubMed PMID: 35851804; PMCID: PMC9481930. |
Schwarzbauer JE (CMI) |
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Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022;55(8):1370-85.e8. doi: 10.1016/j.immuni.2022.06.007. PubMed PMID: 35835107; PMCID: PMC9378606. |
Sampath H (CMI) |
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Xiao Q, Zhang X, Tu L, Cao J, Hinrichs CS, Su X. Size-dependent activation of CAR-T cells. Sci Immunol. 2022;7(74):eabl3995. doi: 10.1126/sciimmunol.abl3995. PubMed PMID: 35930653; PMCID: PMC9678385. |
Cao J (CMI), |
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Gomes MT, Palasiewicz K, Gadiyar V, Lahey K, Calianese D, Birge RB, Ucker DS. Phosphatidylserine externalization by apoptotic cells is dispensable for specific recognition leading to innate apoptotic immune responses. J Biol Chem. 2022;298(7):102034. doi: 10.1016/j.jbc.2022.102034. PubMed PMID: 35588784; PMCID: PMC9234239. |
Birge RB (CMI) |
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Jonsson WO, Mirek ET, Wek RC, Anthony TG. Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific. Faseb j. 2022;36(7):e22396. doi: 10.1096/fj.202200204RR. PubMed PMID: 35690926; PMCID: PMC9204950. |
Anthony TG (CMI) |
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Badeti S, Jiang Q, Naghizadeh A, Tseng HC, Bushkin Y, Marras SAE, Nisa A, Tyagi S, Chen F, Romanienko P, Yehia G, Evans D, Lopez-Gonzalez M, Alland D, Russo R, Gause W, Shi L, Liu D. Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection. Cell Biosci. 2022;12(1):88. doi: 10.1186/s13578-022-00822-6. PubMed PMID: 35690792; PMCID: PMC9187929. |
Tyagi S (CP), |
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Pukhrambam C, Molodtsov V, Kooshkbaghi M, Tareen A, Vu H, Skalenko KS, Su M, Yin Z, Winkelman JT, Kinney JB, Ebright RH, Nickels BE. Structural and mechanistic basis of σ-dependent transcriptional pausing. Proc Natl Acad Sci U S A. 2022;119(23):e2201301119. doi: 10.1073/pnas.2201301119. PubMed PMID: 35653571; PMCID: PMC9191641. |
Nickels BE (CMI) |
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Yang Y, Gomez M, Marsh T, Poillet-Perez L, Sawant A, Chen L, Park NR, Jackson SR, Hu Z, Alon N, Liu C, Debnath J, Guan JL, Davidson S, Verzi M, White E. Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival. Proc Natl Acad Sci U S A. 2022;119(21):e2202016119. doi: 10.1073/pnas.2202016119. PubMed PMID: 35537042; PMCID: PMC9173755. |
Liu C (CIPT), |
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Koch MD, Black ME, Han E, Shaevitz JW, Gitai Z. Pseudomonas aeruginosa distinguishes surfaces by stiffness using retraction of type IV pili. Proc Natl Acad Sci U S A. 2022;119(20):e2119434119. doi: 10.1073/pnas.2119434119. PubMed PMID: 35561220; PMCID: PMC9171759. |
Gitai Z (CMI) |
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Krzyzanowska AK, Haynes Ii RAH, Kovalovsky D, Lin HC, Osorio L, Edelblum KL, Corcoran LM, Rabson AB, Denzin LK, Sant'Angelo DB. Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis. Sci Immunol. 2022;7(71):eabf3717. doi: 10.1126/sciimmunol.abf3717. PubMed PMID: 35522722; PMCID: PMC9709958. |
Denzin LK (CMI), Sant'Angelo DB (CMI) |
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Shekhtman L, Cotler SJ, Ploss A, Dahari H. Mathematical modeling suggests that entry-inhibitor bulevirtide may interfere with hepatitis D virus clearance from circulation. J Hepatol. 2022;76(5):1229-31. doi: 10.1016/j.jhep.2021.12.030. PubMed PMID: 34995688; PMCID: PMC9018506. |
Ploss A (CMI) |
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Ebert SM, Rasmussen BB, Judge AR, Judge SM, Larsson L, Wek RC, Anthony TG, Marcotte GR, Miller MJ, Yorek MA, Vella A, Volpi E, Stern JI, Strub MD, Ryan Z, Talley JJ, Adams CM. Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. J Nutr. 2022;152(4):926-38. doi: 10.1093/jn/nxab440. PubMed PMID: 34958390; PMCID: PMC8970988. |
Anthony TG (CMI) |
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Wang R, Suzuki S, Guest JD, Heller B, Almeda M, Andrianov AK, Marin A, Mariuzza RA, Keck ZY, Foung SKH, Yunus AS, Pierce BG, Toth EA, Ploss A, Fuerst TR. Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate. Proc Natl Acad Sci U S A. 2022;119(11):e2112008119. doi: 10.1073/pnas.2112008119. PubMed PMID: 35263223; PMCID: PMC8931252. |
Ploss A (CMI) |
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Lin X, Liu H, Wei Z, Roy SB, Gao N. An active learning approach for clustering single-cell RNA-seq data. Lab Invest. 2022;102(3):227-35. doi: 10.1038/s41374-021-00639-w. PubMed PMID: 34244616; PMCID: PMC8742847. |
Gao N (CMI) |
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Ravindran PT, McFann S, Thornton RH, Toettcher JE. A synthetic gene circuit for imaging-free detection of signaling pulses. Cell Syst. 2022;13(2):131-42.e13. doi: 10.1016/j.cels.2021.10.002. PubMed PMID: 34739875; PMCID: PMC8857027. |
Toettcher JE (CMI) |
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Farahani PE, Nelson CM. Revealing epithelial morphogenetic mechanisms through live imaging. Curr Opin Genet Dev. 2022;72:61-8. doi: 10.1016/j.gde.2021.10.007. PubMed PMID: 34864332; PMCID: PMC8860867. |
Nelson CM (CMI) |
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Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, et al. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022;139(4):538-53. doi: 10.1182/blood.2021012081. PubMed PMID: 34624079; PMCID: PMC8938936. |
Kim H (CP), |
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Jaslove JM, Goodwin K, Sundarakrishnan A, Spurlin JW, Mao S, Košmrlj A, Nelson CM. Transmural pressure signals through retinoic acid to regulate lung branching. Development. 2022;149(2). doi: 10.1242/dev.199726. PubMed PMID: 35051272; PMCID: PMC8917413. |
Nelson CM (CMI) |
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Martinez W, Zhang Q, Linden MA, Schacher N, Darvish S, Mirek ET, Levy JL, Jonsson WO, Anthony TG, Hamilton KL. Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction. Front Aging. 2022;3:975129. doi: 10.3389/fragi.2022.975129. PubMed PMID: 36091469; PMCID: PMC9450999. |
Anthony TG (CMI) |
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Kong B, Rizzolo D, Taylor RE, Guo GL. Bile Acid Profiling in Mouse Biofluids and Tissues. Methods Mol Biol. 2022;2455:305-18. doi: 10.1007/978-1-0716-2128-8_23. PubMed PMID: 35213003; PMCID: PMC8922367. |
Guo GL (CMI) |
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Kumar S, Gao N. A Scalable Human Intestinal Planar Culture Offers Opportunities for High-throughput Drug Testing. Cell Mol Gastroenterol Hepatol. 2022;14(2):407-8. doi: 10.1016/j.jcmgh.2022.05.001. PubMed PMID: 35640717; PMCID: PMC9305003. |
Gao N (CMI) |
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Hill KE, Lovett BM, Schwarzbauer JE. Heparan sulfate is necessary for the early formation of nascent fibronectin and collagen I fibrils at matrix assembly sites. J Biol Chem. 2022;298(1):101479. doi: 10.1016/j.jbc.2021.101479. PubMed PMID: 34890641; PMCID: PMC8801470. |
Schwarzbauer JE (CMI) |
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Zhang S, Zhou YF, Cao J, Burley SK, Wang HY, Zheng XFS. mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma. Cancer Res. 2021;81(22):5652-65. doi: 10.1158/0008-5472.Can-21-0206. PubMed PMID: 34429326; PMCID: PMC8595749. |
Cao J (CMI), |
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da Silva-Diz V, Cao B, Lancho O, Chiles E, Alasadi A, Aleksandrova M, Luo S, Singh A, Tao H, Augeri D, Minuzzo S, Indraccolo S, Khiabanian H, Su X, Jin S, Herranz D. A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia. Blood. 2021;138(15):1317-30. doi: 10.1182/blood.2020008955. PubMed PMID: 33876224; PMCID: PMC8525334. |
Khiabanian H (GICG), |
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Barth VC, Chauhan U, Zeng J, Su X, Zheng H, Husson RN, Woychik NA. Mycobacterium tuberculosis VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response. Proc Natl Acad Sci U S A. 2021;118(32). doi: 10.1073/pnas.2022136118. PubMed PMID: 34362841; PMCID: PMC8364209. |
Su X (CMI), |
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Hou K, Shen J, Yan J, Zhai C, Zhang J, Pan JA, Zhang Y, Jiang Y, Wang Y, Lin RZ, Cong H, Gao S, Zong WX. Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. EBioMedicine. 2021;69:103456. doi: 10.1016/j.ebiom.2021.103456. PubMed PMID: 34233258; PMCID: PMC8261003. |
Zong WX (CMI) |
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Yang M, Hu X, Bao W, Zhang X, Lin Y, Stanton S, Haffty B, Hu W, Kang Y, Wei S, Zhang L. Changing trends and disparities in 5-year overall survival of women with invasive breast cancer in the United States, 1975-2015. Am J Cancer Res. 2021;11(6):3201-11. PubMed PMID: 34249455; PMCID: PMC8263668. |
Lin Y (CPC), |
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Scheffler RJ, Sugimoto Y, Bratton BP, Ellison CK, Koch MD, Donia MS, Gitai Z. Pseudomonas aeruginosa detachment from surfaces via a self-made small molecule. J Biol Chem. 2021;296:100279. doi: 10.1016/j.jbc.2021.100279. PubMed PMID: 33450229; PMCID: PMC7949062. |
Donia MS (CMI), |
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Liu Y, Gokhale S, Jung J, Zhu S, Luo C, Saha D, Guo JY, Zhang H, Kyin S, Zong WX, White E, Xie P. Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes. Front Immunol. 2021;12:670338. doi: 10.3389/fimmu.2021.670338. PubMed PMID: 34745083; PMCID: PMC8564014. |
Guo JY (CMI), |
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Ye C, Liu B, Lu H, Liu J, Rabson AB, Jacinto E, Pestov DG, Shen Z. BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis. Nucleic Acids Res. 2020;48(22):12817-32. doi: 10.1093/nar/gkaa1114. PubMed PMID: 33245766; PMCID: PMC7736804. |
Jacinto E (CMI), |
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Zheng Y, Chen Z, Han Y, Han L, Zou X, Zhou B, Hu R, Hao J, Bai S, Xiao H, Li WV, Bueker A, Ma Y, Xie G, Yang J, Chen S, Li H, Cao J, Shen L. Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment. Nat Commun. 2020;11(1):6268. doi: 10.1038/s41467-020-20019-0. PubMed PMID: 33293583; PMCID: PMC7722722. |
Li WV (GICG), |
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Pham K, Huynh D, Le L, Delitto D, Yang L, Huang J, Kang Y, Steinberg MB, Li J, Zhang L, Liu D, Tang MS, Liu C, Wang H. E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1. Cancer Lett. 2020;491:132-45. doi: 10.1016/j.canlet.2020.08.010. PubMed PMID: 32829009; PMCID: PMC9703643. |
Kang Y (CMI), |
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Tseng HC, Xiong W, Badeti S, Yang Y, Ma M, Liu T, Ramos CA, Dotti G, Fritzky L, Jiang JG, Yi Q, Guarrera J, Zong WX, Liu C, Liu D. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11(1):4810. doi: 10.1038/s41467-020-18444-2. PubMed PMID: 32968061; PMCID: PMC7511348. |
Zong WX (CMI), |
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Poillet-Perez L, Sharp DW, Yang Y, Laddha SV, Ibrahim M, Bommareddy PK, Hu ZS, Vieth J, Haas M, Bosenberg MW, Rabinowitz JD, Cao J, Guan JL, Ganesan S, Chan CS, Mehnert JM, Lattime EC, White E. Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nat Cancer. 2020;1(9):923-34. doi: 10.1038/s43018-020-00110-7. PubMed PMID: 34476408; PMCID: PMC8409526. |
Rabinowitz JD (CMI), |
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Wang H, Wang J, Zhao Y, Zhang X, Liu J, Zhang C, Haffty B, Verzi M, Zhang L, Gao N, Feng Z, Hu W. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death Dis. 2020;11(7):588. doi: 10.1038/s41419-020-02790-6. PubMed PMID: 32719388; PMCID: PMC7385639. |
Haffty B (CIPT), |
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Portal DE, Weiss RE, Wojtowicz M, Mansour A, Monken C, Mehnert JM, Aisner JA, Kane M, Nishioka J, Aisner S, Peters S, Stein MN, Kim IY, Mayer TM, Shih W, Gulley J, Streicher H, Singer EA, Lattime EC. Phase I neoadjuvant study of intravesical recombinant fowlpox-GM-CSF (rF-GM-CSF) or fowlpox-TRICOM (rF-TRICOM) in patients with bladder carcinoma. Cancer Gene Ther. 2020;27(6):438-47. doi: 10.1038/s41417-019-0112-z. PubMed PMID: 31222182; PMCID: PMC6923616. |
Mehnert JM (CIPT), |
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Dragan M, Nguyen MU, Guzman S, Goertzen C, Brackstone M, Dhillo WS, Bech PR, Clarke S, Abbara A, Tuck AB, Hess DA, Pine SR, Zong WX, Wondisford FE, Su X, Babwah AV, Bhattacharya M. G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer. Cell Death Dis. 2020;11(2):106. doi: 10.1038/s41419-020-2305-7. PubMed PMID: 32034133; PMCID: PMC7005685. |
Pine SR (GICG), |
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Newman JH, Chesson CB, Herzog NL, Bommareddy PK, Aspromonte SM, Pepe R, Estupinian R, Aboelatta MM, Buddhadev S, Tarabichi S, Lee M, Li S, Medina DJ, Giurini EF, Gupta KH, Guevara-Aleman G, Rossi M, Nowicki C, Abed A, Goldufsky JW, Broucek JR, Redondo RE, Rotter D, Jhawar SR, Wang SJ, Kohlhapp FJ, Kaufman HL, Thomas PG, Gupta V, Kuzel TM, et al. Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer. Proc Natl Acad Sci U S A. 2020;117(2):1119-28. doi: 10.1073/pnas.1904022116. PubMed PMID: 31888983; PMCID: PMC6969546. |
Medina DJ (CIPT), |
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Kalemba KM, Wang Y, Xu H, Chiles E, McMillin SM, Kwon H, Su X, Wondisford FE. Glycerol induces G6pc in primary mouse hepatocytes and is the preferred substrate for gluconeogenesis both in vitro and in vivo. J Biol Chem. 2019;294(48):18017-28. doi: 10.1074/jbc.RA119.011033. PubMed PMID: 31645433; PMCID: PMC6885632. |
Su X (CMI), |
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Nikonorova IA, Zhu Q, Signore CC, Mirek ET, Jonsson WO, Kong B, Guo GL, Belden WJ, Anthony TG. Age modulates liver responses to asparaginase-induced amino acid stress in mice. J Biol Chem. 2019;294(38):13864-75. doi: 10.1074/jbc.RA119.009864. PubMed PMID: 31413113; PMCID: PMC6755797. |
Guo GL (CMI), |
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Zhang S, Vieth JA, Krzyzanowska A, Henry EK, Denzin LK, Siracusa MC, Sant'Angelo DB. The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils. J Immunol. 2019;203(5):1230-41. doi: 10.4049/jimmunol.1900068. PubMed PMID: 31366712; PMCID: PMC9710206. |
Denzin LK (CMI), Sant'Angelo DB (CMI) |
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D'Agostino L, Nie Y, Goswami S, Tong K, Yu S, Bandyopadhyay S, Flores J, Zhang X, Balasubramanian I, Joseph I, Sakamori R, Farrell V, Li Q, Yang CS, Gao B, Ferraris RP, Yehia G, Bonder EM, Goldenring JR, Verzi MP, Zhang L, Ip YT, Gao N. Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling. Cancer Res. 2019;79(16):4099-112. doi: 10.1158/0008-5472.Can-18-4075. PubMed PMID: 31239271; PMCID: PMC6726494. |
Verzi MP (GICG), |
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Darcy PW, Jin K, Osorio L, Denzin LK, Sant'Angelo DB. Coexpression of YY1 Is Required to Elaborate the Effector Functions Controlled by PLZF in NKT Cells. J Immunol. 2019;203(3):627-38. doi: 10.4049/jimmunol.1900055. PubMed PMID: 31227579; PMCID: PMC9710202. |
Denzin LK (CMI), Sant'Angelo DB (CMI) |
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Rizzolo D, Buckley K, Kong B, Zhan L, Shen J, Stofan M, Brinker A, Goedken M, Buckley B, Guo GL. Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model. Hepatology. 2019;70(1):389-402. doi: 10.1002/hep.30612. PubMed PMID: 30864232; PMCID: PMC7893641. |
Buckley B (CP), |
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Wang L, Xing X, Chen L, Yang L, Su X, Rabitz H, Lu W, Rabinowitz JD. Peak Annotation and Verification Engine for Untargeted LC-MS Metabolomics. Anal Chem. 2019;91(3):1838-46. doi: 10.1021/acs.analchem.8b03132. PubMed PMID: 30586294; PMCID: PMC6501219. |
Su X (CMI), |
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Silk AW, Kaufman HL, Curti B, Mehnert JM, Margolin K, McDermott D, Clark J, Newman J, Bommareddy PK, Denzin L, Najmi S, Haider A, Shih W, Kane MP, Zloza A. High-Dose Ipilimumab and High-Dose Interleukin-2 for Patients With Advanced Melanoma. Front Oncol. 2019;9:1483. doi: 10.3389/fonc.2019.01483. PubMed PMID: 31998643; PMCID: PMC6965158. |
Silk AW (CIPT), |
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Douam F, Ziegler CGK, Hrebikova G, Fant B, Leach R, Parsons L, Wang W, Gaska JM, Winer BY, Heller B, Shalek AK, Ploss A. Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses. Nat Commun. 2018;9(1):5031. doi: 10.1038/s41467-018-07478-2. PubMed PMID: 30487575; PMCID: PMC6262001. |
Ploss A (CMI) |
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Obr AE, Kumar S, Chang YJ, Bulatowicz JJ, Barnes BJ, Birge RB, Lazzarino DA, Gallagher E, LeRoith D, Wood TL. Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment. Breast Cancer Res. 2018;20(1):138. doi: 10.1186/s13058-018-1063-2. PubMed PMID: 30458886; PMCID: PMC6245538. |
Birge RB (CMI), |
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Fröhlich KS, Förstner KU, Gitai Z. Post-transcriptional gene regulation by an Hfq-independent small RNA in Caulobacter crescentus. Nucleic Acids Res. 2018;46(20):10969-82. doi: 10.1093/nar/gky765. PubMed PMID: 30165530; PMCID: PMC6237742. |
Gitai Z (CMI) |
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Kong B, Sun R, Huang M, Chow MD, Zhong XB, Xie W, Lee YH, Guo GL. Fibroblast Growth Factor 15-Dependent and Bile Acid-Independent Promotion of Liver Regeneration in Mice. Hepatology. 2018;68(5):1961-76. doi: 10.1002/hep.30041. PubMed PMID: 29672888; PMCID: PMC6195490. |
Guo GL (CMI) |
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Moloughney JG, Vega-Cotto NM, Liu S, Patel C, Kim PK, Wu CC, Albaciete D, Magaway C, Chang A, Rajput S, Su X, Werlen G, Jacinto E. mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation. J Biol Chem. 2018;293(42):16464-78. doi: 10.1074/jbc.RA118.003991. PubMed PMID: 30201609; PMCID: PMC6200946. |
Su X (CMI), |
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Perekatt AO, Shah PP, Cheung S, Jariwala N, Wu A, Gandhi V, Kumar N, Feng Q, Patel N, Chen L, Joshi S, Zhou A, Taketo MM, Xing J, White E, Gao N, Gatza ML, Verzi MP. SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium. Cancer Res. 2018;78(17):4878-90. doi: 10.1158/0008-5472.Can-18-0043. PubMed PMID: 29986996; PMCID: PMC6125228. |
Perekatt AO (GICG), |
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Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Syst. 2018;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. PubMed PMID: 29960885; PMCID: PMC6062487. |
White E (CMI), |
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Yu S, Tong K, Zhao Y, Balasubramanian I, Yap GS, Ferraris RP, Bonder EM, Verzi MP, Gao N. Paneth Cell Multipotency Induced by Notch Activation following Injury. Cell Stem Cell. 2018;23(1):46-59.e5. doi: 10.1016/j.stem.2018.05.002. PubMed PMID: 29887318; PMCID: PMC6035085. |
Verzi MP (GICG), |
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Chakrabarti R, Celià-Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, Hwang J, Peng J, Nixon B, Grady JJ, DeCoste C, Gao J, van Es JH, Li MO, Aifantis I, Clevers H, Kang Y. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science. 2018;360(6396). doi: 10.1126/science.aan4153. PubMed PMID: 29773667; PMCID: PMC7881440. |
Kang Y (CMI) |
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Aijaz A, Li M, Smith D, Khong D, LeBlon C, Fenton OS, Olabisi RM, Libutti S, Tischfield J, Maus MV, Deans R, Barcia RN, Anderson DG, Ritz J, Preti R, Parekkadan B. Biomanufacturing for clinically advanced cell therapies. Nat Biomed Eng. 2018;2(6):362-76. doi: 10.1038/s41551-018-0246-6. PubMed PMID: 31011198; PMCID: PMC6594100. |
Libutti S (CIPT, GICG), Tischfield J (GICG), Parekkadan B (CMI) |
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Tsang CK, Chen M, Cheng X, Qi Y, Chen Y, Das I, Li X, Vallat B, Fu LW, Qian CN, Wang HY, White E, Burley SK, Zheng XFS. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. Mol Cell. 2018;70(3):502-15.e8. doi: 10.1016/j.molcel.2018.03.029. PubMed PMID: 29727620; PMCID: PMC6108545. |
Vallat B (CP), |
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Vvedenskaya IO, Bird JG, Zhang Y, Zhang Y, Jiao X, Barvík I, Krásný L, Kiledjian M, Taylor DM, Ebright RH, Nickels BE. CapZyme-Seq Comprehensively Defines Promoter-Sequence Determinants for RNA 5' Capping with NAD<sup/>. Mol Cell. 2018;70(3):553-64.e9. doi: 10.1016/j.molcel.2018.03.014. PubMed PMID: 29681497; PMCID: PMC5935523. |
Kiledjian M (CMI), |
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Cetera M, Leybova L, Joyce B, Devenport D. Counter-rotational cell flows drive morphological and cell fate asymmetries in mammalian hair follicles. Nat Cell Biol. 2018;20(5):541-52. doi: 10.1038/s41556-018-0082-7. PubMed PMID: 29662173; PMCID: PMC6065250. |
Devenport D (CMI) |
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Liu L, Su X, Quinn WJ, 3rd, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metab. 2018;27(5):1067-80.e5. doi: 10.1016/j.cmet.2018.03.018. PubMed PMID: 29685734; PMCID: PMC5932087. |
Su X (CMI), |
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Simi AK, Anlaş AA, Stallings-Mann M, Zhang S, Hsia T, Cichon M, Radisky DC, Nelson CM. A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail. Cancer Res. 2018;78(9):2277-89. doi: 10.1158/0008-5472.Can-17-2899. PubMed PMID: 29483094; PMCID: PMC5932229. |
Nelson CM (CMI) |
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Raitman I, Huang ML, Williams SA, Friedman B, Godula K, Schwarzbauer JE. Heparin-fibronectin interactions in the development of extracellular matrix insolubility. Matrix Biol. 2018;67:107-22. doi: 10.1016/j.matbio.2017.11.012. PubMed PMID: 29223498; PMCID: PMC5910196. |
Schwarzbauer JE (CMI) |
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Panda A, Mehnert JM, Hirshfield KM, Riedlinger G, Damare S, Saunders T, Kane M, Sokol L, Stein MN, Poplin E, Rodriguez-Rodriguez L, Silk AW, Aisner J, Chan N, Malhotra J, Frankel M, Kaufman HL, Ali S, Ross JS, White EP, Bhanot G, Ganesan S. Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer. J Natl Cancer Inst. 2018;110(3):316-20. doi: 10.1093/jnci/djx213. PubMed PMID: 29155997; PMCID: PMC6658862. |
Mehnert JM (CIPT), Hirshfield KM (GICG), Riedlinger G (CIPT), Rodriguez-Rodriguez L (CIPT), |
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Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018;27(2):351-61.e3. doi: 10.1016/j.cmet.2017.12.016. PubMed PMID: 29414685; PMCID: PMC6032988. |
Rabinowitz JD (CMI) |
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Arrigucci R, Lakehal K, Vir P, Handler D, Davidow AL, Herrera R, Estrada-Guzmán JD, Bushkin Y, Tyagi S, Lardizabal AA, Gennaro ML. Active Tuberculosis Is Characterized by Highly Differentiated Effector Memory Th1 Cells. Front Immunol. 2018;9:2127. doi: 10.3389/fimmu.2018.02127. PubMed PMID: 30283456; PMCID: PMC6156157. |
Tyagi S (CP), |
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Zheng H, Bae Y, Kasimir-Bauer S, Tang R, Chen J, Ren G, Yuan M, Esposito M, Li W, Wei Y, Shen M, Zhang L, Tupitsyn N, Pantel K, King C, Sun J, Moriguchi J, Jun HT, Coxon A, Lee B, Kang Y. Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy. Cancer Cell. 2017;32(6):731-47.e6. doi: 10.1016/j.ccell.2017.11.002. PubMed PMID: 29232552; PMCID: PMC5729937. |
Zhang L (CIPT), |
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Cheng LC, Tan VM, Ganesan S, Drake JM. Integrating phosphoproteomics into the clinical management of prostate cancer. Clinical and translational medicine. 2017;6(1):9. doi: 10.1186/s40169-017-0138-5. PubMed PMID: 28197968; PMCID: PMC5309189. |
Ganesan S (CIPT), |
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Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, Gatza ML, Xia D, Gao J, White E, Haffty BG, Hu W, Feng Z. Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. Nat Commun. 2017;8(1):1823. doi: 10.1038/s41467-017-01947-w. PubMed PMID: 29180628; PMCID: PMC5703960. |
Gatza ML (GICG), |