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Zheng Laboratory - Select Publications

View Dr. Zheng’s Complete List of Published Work in MyBibliography

  1. Ren QN, Zhang H, Sun CY, Zhou YF, Yang XF, Long JW, Li XX, Mai SJ, Zhang MY, Zhang HZ, Mai HQ, Chen MS, Zheng XFS, Wang HY. Phosphorylation of Androgen Receptor by mTORC1 Promotes Liver Steatosis and Tumorigenesis. Hepatology. 2021. Epub 2021/08/27. doi: 10.1002/hep.32120. PubMed PMID: 34435708.
  2. Zhang S, Zhou YF, Cao J, Burley SK, Wang HY, Zheng XFS. mTORC1 Promotes ARID1A Degradation and Oncogenic Chromatin Remodeling in Hepatocellular Carcinoma. Cancer Res. 2021. Epub 2021/08/26. doi: 10.1158/0008-5472.CAN-21-0206. PubMed PMID: 34429326.
  3. Zhang H, Spencer K, Burley SK, Zheng XFS. Toward improving androgen receptor-targeted therapies in male-dominant hepatocellular carcinoma. Drug Discov Today. 2021;26(6):1539-46. Epub 2021/02/10. doi: 10.1016/j.drudis.2021.02.001. PubMed PMID: 33561464; PMCID: PMC8222101.
  4. Wang X*, Zhang H*, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG#, Zheng XFS#. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12(1):2259. Epub 2021/04/17. doi: 10.1038/s41467-021-22480-x. PubMed PMID: 33859191; PMCID: PMC8050259. (*co-first authors, #corresponding authors)
  5. Zhang X, Wang X, Yuan Z, Radford SJ, Liu C, Libutti SK, Zheng XFS. Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis. Cell Rep. 2021;34(11):108830. Epub 2021/03/18. doi: 10.1016/j.celrep.2021.108830. PubMed PMID: 33730578; PMCID: PMC8062038.
  6. Zhang H, Li XX, Yang Y, Zhang Y, Wang HY, Zheng XFS. Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross-talk in hepatocellular carcinoma. Hepatology. 2018;67(6):2271-86. Epub 2017/12/09. doi: 10.1002/hep.29715. PubMed PMID: 29220539; PMCID: PMC6106789.
  7. Tsang CK, Chen M, Cheng X, Qi Y, Chen Y, Das I, Li X, Vallat B, Fu LW, Qian CN, Wang HY, White E, Burley SK, Zheng XFS. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. Mol Cell. 2018;70(3):502-15 e8. Epub 2018/05/05. doi: 10.1016/j.molcel.2018.03.029. PubMed PMID: 29727620; PMCID: PMC6108545.
  8. Wu TJ, Wang X, Zhang Y, Meng L, Kerrigan JE, Burley SK, Zheng XF. Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase. Cell Rep. 2015;11(3):446-59. Epub 2015/04/14. doi: 10.1016/j.celrep.2015.03.040. PubMed PMID: 25865887; PMCID: PMC4761412.
  9. Thomas JD*, Zhang YJ*, Wei YH, Cho JH, Morris LE, Wang HY, Zheng XF. Rab1A is an mTORC1 activator and a colorectal oncogene. Cancer Cell. 2014;26(5):754-69. Epub 2014/12/03. doi: 10.1016/j.ccell.2014.09.008. PubMed PMID: 25446900; PMCID: PMC4288827. (*co-first authors)
    This paper was featured in: Preview by Cancer Cell 26:601–602; Research Watch by Cancer Discovery4:1366
  10. Tsang CK, Liu Y, Thomas J, Zhang Y, Zheng XF. Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance. Nat Commun. 2014;5:3446. Epub 2014/03/22. doi: 10.1038/ncomms4446. PubMed PMID: 24647101; PMCID: PMC4678626.
  11. Wei Y, Tsang CK, Zheng XF. Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1. EMBO J. 2009;28(15):2220-30. Epub 2009/07/04. doi: 10.1038/emboj.2009.179. PubMed PMID: 19574957; PMCID: PMC2726700.
  12. Tsang CK, Qi H, Liu LF, Zheng XF. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today. 2007;12(3-4):112-24. Epub 2007/02/06. doi: 10.1016/j.drudis.2006.12.008. PubMed PMID: 17275731.
  13. Tsang CK, Li H, Zheng XS. Nutrient starvation promotes condensin loading to maintain rDNA stability. EMBO J. 2007;26(2):448-58. Epub 2007/01/05. doi: 10.1038/sj.emboj.7601488. PubMed PMID: 17203076; PMCID: PMC1783468.
    This paper was featured in: EMBO Journal Online, 2007
  14. Li H, Tsang CK, Watkins M, Bertram PG, Zheng XF. Nutrient regulates Tor1 nuclear localization and association with rDNA promoter. Nature. 2006;442(7106):1058-61. Epub 2006/08/11. doi: 10.1038/nature05020. PubMed PMID: 16900101.
    This paper was featured in: Science’s STKE Vol. 2006, Issue 351, pp. tw302, 5 September 2006; Cell Metabolism 2006, 4:259-260
  15. Tsang CK, Bertram PG, Ai W, Drenan R, Zheng XF. Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR. EMBO J. 2003;22(22):6045-56. Epub 2003/11/12. doi: 10.1093/emboj/cdg578. PubMed PMID: 14609951; PMCID: PMC275436.
  16. Ai W, Bertram PG, Tsang CK, Chan TF, Zheng XF. Regulation of subtelomeric silencing during stress response. Mol Cell. 2002;10(6):1295-305. Epub 2002/12/31. doi: 10.1016/s1097-2765(02)00695-0. PubMed PMID: 12504006.
  17. Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. EMBO Rep. 2002;3(10):988-94. Epub 2002/09/17. doi: 10.1093/embo-reports/kvf197. PubMed PMID: 12231510; PMCID: PMC1307618.
  18. Chan TF, Carvalho J, Riles L, Zheng XF. A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR). Proc Natl Acad Sci U S A. 2000;97(24):13227-32. Epub 2000/11/15. doi: 10.1073/pnas.240444197. PubMed PMID: 11078525; PMCID: PMC27207.
  19. Choi JH, Adames NR, Chan TF, Zeng C, Cooper JA, Zheng XF. TOR signaling regulates microtubule structure and function. Curr Biol. 2000;10(14):861-4. Epub 2000/07/19. doi: 10.1016/s0960-9822(00)00599-6. PubMed PMID: 10899009.