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Chan Laboratory - Select Publications

  1. Feng X, Lu H, Yue J, Schneider N, Liu J, Denzin LK, Chan CS, De S, Shen Z. Loss of Setd4 delays radiation-induced thymic lymphoma in mice. DNA Repair. 2020 Feb;86:102754.
  2. Laddha SV, da Silva EM, Robzyk K, Untch BR, Ke H, Rekhtman N, Poirier JT, Travis WD, Tang LH, Chan CS. Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids. Cancer Res. 2019 Sep 1;79(17):4339-4347.
  3. Choi S, Wang D, Chen X, Tang LH, Verma A, Chen Z, Kim BJ, Selesner L, Robzyk K, Zhang G, Pang S, Han T, Chan CS, Fahey TJ 3rd, Elemento O, Du YN. Function and clinical relevance of RHAMM isoforms in pancreatic tumor progression. Mol Cancer. 2019 May 9;18(1):92.
  4. Chan CS*, Laddha S, Lewis P, Koletsky M, Robzyk K, da Silva E, Torres P, Untch B, Li J, Bose P, Chan T, Klimstra D, Allis C, and Tang L*. ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup. Nat Commun. 2018 Oct 12;9(1):4158. *co-corresponding author.
  5. Yu X, Kogan S, Chen Y, Tsang A, Withers T, Lin H, Gilleran J, Buckley B, Moore D, Bertino J, Chan C, Kimball SD, Loh S, and Carpizo D. Zinc metallochaperones reactivate mutant p53 using an on/off switch mechanism: a new paradigm in cancer therapeutics. Clin Cancer Res. 2018 Sep 15;24(18):4505-4517.
  6. Baugh EH, Ke H, Levine AJ, Bonneau RA, and Chan CS. Why are there hot spot mutations in the p53 gene in human cancers? Cell Death Differ. 2018 Jan;25(1):154-160.
  7. Hirshfield KM, Tolkunov D, Zhong H, Ali SM, Stein MN, Murphy S, Vig H, Vazquez A, Glod J, Moss RA, Belyi V, Chan CS, Chen S, Goodell L, Foran D, Yelensky R, Palma NA, Sun JX, Miller VA, Stephens PJ, Ross JS, Kaufman H, Poplin E, Mehnert J, Tan AR, Bertino JR, Aisner J, DiPaola RS, Rodriguez-Rodriguez L, Ganesan S. Clinical actionability of comprehensive genomic profiling for management of rare or refractory cancers. 2016 Aug 26.
  8. Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016 Aug 1;30(15):1704-17.
  9. Contractor T, Kobayashi S, da Silva E, Clausen R, Chan C, Vosburgh E, Tang LH, Levine AJ, Harris CR. Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5. 2016 May 24;7(21):30585-96.
  10. Zhang C, Liu J, Tan C, Yue X, Zhao Y, Peng J, Wang X, Laddha SV, Chan CS, Zheng S, Hu W, Feng Z. microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. 2016 Feb 23;7(8):8783-96.
  11. Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, Hsieh JJ, Ganesan S, Chan CS*, White E*. The Genomic landscape of renal oncocytoma identifies a metabolic barrier to tumorigenesis. Cell Rep. 2015 Dec 1;13(9):1895-908. *co-corresponding author.
  12. White E, Mehnert JM, Chan CS. Autophagy, Metabolism, and Cancer. Clin Cancer Res. 2015 Nov 15;21(22):5037-46.
  13. Puzio-Kuter AM, Laddha SV, Castillo-Martin M, Sun Y, Cordon-Cardo C, Chan CS, Levine AJ. Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell Death Differ. 2015 Nov;22(11):1785-91.
  14. Ariffin H, Hainaut P, Puzio-Kuter A, Choong SS, Chan A, Tolkunov D, Rajagopal G, Kang W, Lim L, KrishnanS, Chen KS, Achatz MI, Karsal M, Shamsani J, Levine A, Chan CS. Whole genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome. PNAS, 111(43):15497-501, 2014.
  15. Dudgeon C*Chan CS*, Kang W, Sun Y, Emerson R, Robins H, Levine A. The evolution of thymic lymphomas in p53 knock-out mice. Genes Dev, 28(23):2613-20, 2014. *co-first author.
  16. Zhang C, Liu J, Wang X, Wu R, Lin M, Laddha S, Young KH, Chan CS, Feng Z. MicroRNA-339 inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling. Oncotarget, 5(19):9106-17, 2014.
  17. Wong C, Laddha SV, Tang L, Vosburgh E, Levine AJ, Normant E, Sandy P, Harris C, Chan CS, Xu EY. The Bromodomain and Extra-terminal Inhibitor CPI203 Enhances the Anti-proliferative Effects of Rapamycin on Human Neuroendocrine Tumors. Cell Death Dis, 5:e1450, 2014.
  18. Zhang C, Liu J, Wu R, Liang Y, Lin M, Liu J, Chan CS, Hu W, Feng Z. Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD. Oncotarget, 5(14):5535-46, 2014.
  19. Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalanny NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov., 4(8):914-27, 2014.
  20. Laddha SV, Ganesan S, Chan CS*, White E*. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Mol Cancer Res., 12(4):485-90, 2014. *co-corresponding author.
  21. Sagne C, Marcel V, Bota M, Martel-Planche G, Nobrega A, Palmero E, Perriaud L, Boniol M, Vagner S, Cox D, Chan CS, Mergny JL, Olivier M, Prolla P, Hall J, Hainaut P, Achatz M. Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures. Carcinogenesis, 35(4):807-15, 2014.
  22. Hu W, Chan CS, Zhang C., Sun Y., Song J.S., Levine A.J., Feng Z. Negative Regulation of Tumor Suppressor p53 by microRNA miR-504. Molecular Cell, 38:689-699, 2010.
  23. Chan C.S., Song J.S. CTCF Confines the Distal Action of Estrogen Receptor. Cancer Research, 68(21): 9041-9049, 2008.
  24. Chan C.S., Elemento O., Tavazoie S. Revealing Post-transcriptional Regulatory Networks in Complex Genomes. PLoS Computational Biology, 1(7): e69, 2005.