Organoid Development

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Mission

Rutgers Cancer Institute is excited to announce a new organoid development shared resource (ODSR) that is being operationalized under the leadership of Faculty Director Michael Verzi.

Patient-derived organoids better represent the complexity and heterogeneity of tumor biology than cell lines and are becoming the preferred in vitro model for cancer research. The mission of the ODSR is to offer Rutgers Cancer Institute researchers advanced cancer models of tumor initiation and growth utilizing three-dimensional culture techniques, to maintain and bank patient-derived cells, and perform drug testing studies in optimized protocols for basic researchers. The ODSR team can work with investigators in grant writing, experimental design, data acquisition, and figure preparation.

The ODSR effort is facilitated by a top-of-the-line imaging instrument (Cytation 7 Biospa) equipped with an upright microscope with a finder scope, an inverted fluorescence microscope with a wide field of view camera and up to 60x magnification, image stitching and z-projection capabilities, and automated incubator with 8-plate capacity, incubation to 45 C, and CO2/O2 control and monitoring for hypoxia experiments

Personnel

Michael Verzi, PhD, leads the development of the ODSR. Dr. Verzi is a Professor with the Department of Genetics of the Rutgers School of Arts and Sciences. His research focuses on the growth and maturation of the intestinal epithelium in normal health and disease, focusing on colon cancer.

Geuntaek Lee, PhD, serves as the managing director and has years of experience in organoid biology. To enquire about services, please email Dr. Verzi at verzi@dls.rutgers.edu and Dr. Lee at leege@cinj.rutgers.edu


Publication Acknowledgment

"Services, results, and/or products supporting the research project were generated by the Rutgers Cancer Institute Organoid Development Shared Resource, supported, in part, with funding from NCI-CCSG P30CA072720-6852."

Please consider including the names of individuals from the shared resource if they provided any intellectual input or additional effort.

NIH Public Access Policy: Publications resulting from services provided by this Shared Resource must comply with the NIH Public Access policy by submitting your paper to PubMed Central. Go to https://publicaccess.nih.gov/submit_process.htm for PubMed Central's submission instructions. 

If you need additional guidance on properly acknowledging a single shared resource or multiple shared resources, you can contact Janet Bandoy, Shared Resources Coordinator.