Shen Laboratory - Select Publications

  1. Ma H, Kang Z, Foo TK, Shen Z, Xia B. Disrupted BRCA1-PALB2 interaction induces tumor immunosuppression and T-lymphocyte infiltration in HCC through cGAS-STING pathway. Hepatology. 2023 Jan 1;77(1):33-47. doi: 10.1002/hep.32335. Epub 2022 Feb 15. PubMed PMID: 35006619; PubMed Central PMCID: PMC9271123.
  2. Wang Y, Shen Z. Unmasking the mammalian SET domain-containing protein 4. NAR Cancer. 2022 Sep;4(3):zcac021. doi: 10.1093/narcan/zcac021. eCollection 2022 Sep. PubMed PMID: 35854936; PubMed Central PMCID: PMC9277757.
  3. Wang Y, Liu B, Lu H, Liu J, Romanienko PJ, Montelione GT, Shen Z. SETD4-mediated KU70 methylation suppresses apoptosis. Cell Rep. 2022 May 10;39(6):110794. doi: 10.1016/j.celrep.2022.110794. PubMed PMID: 35545041; PubMed Central PMCID: PMC9201767.
  4. Kang Z, Fu P, Alcivar AL, Fu H, Redon C, Foo TK, Zuo Y, Ye C, Baxley R, Madireddy A, Buisson R, Bielinsky AK, Zou L, Shen Z, Aladjem MI, Xia B. BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage. Nat Commun. 2021 Oct 13;12(1):5966. doi: 10.1038/s41467-021-26227-6. PubMed PMID: 34645815; PubMed Central PMCID: PMC8514439.
  5. Choi WS, Liu B, Shen Z, Yang W. Structure of human BCCIP and implications for binding and modification of partner proteins. Protein Sci. 2021 Mar;30(3):693-699. doi: 10.1002/pro.4026. Epub 2021 Jan 29. PubMed PMID: 33452718; PubMed Central PMCID: PMC7888581. 
  6. Lu H, Ye C, Liu J, Rabson AB, Verzi M, De S, Shen Z. Requirement of Bccip for the Regeneration of Intestinal Progenitors. Am J Pathol. 2021 Jan;191(1):66-78. doi: 10.1016/j.ajpath.2020.09.009. Epub 2020 Oct 9. PubMed PMID: 33039352; PubMed Central PMCID: PMC7857062. 
  7. Ye C, Liu B, Lu H, Liu J, Rabson AB, Jacinto E, Pestov DG, Shen Z. BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis. Nucleic Acids Res. 2020 Dec 16;48(22):12817-12832. doi: 10.1093/nar/gkaa1114. PubMed PMID: 33245766; PubMed Central PMCID: PMC7736804.
  8. Feng X, Lu H, Yue J, Shettigar M, Liu J, Denzin LK, Shen Z. Deletion of Mouse Setd4 Promotes the Recovery of Hematopoietic Failure. Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):779-792. doi: 10.1016/j.ijrobp.2020.03.026. Epub 2020 Apr 4. PubMed PMID: 32259569; PubMed Central PMCID: PMC7321877.
  9. Lu H, Ye C, Feng X, Liu J, Bhaumik M, Xia B, Liu C, Shen Z. Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice. Am J Pathol. 2020 Jun;190(6):1175-1187. doi: 10.1016/j.ajpath.2020.01.020. Epub 2020 Mar 20. PubMed PMID: 32201259; PubMed Central PMCID: PMC7280756.
  10. Feng X, Lu H, Yue J, Schneider N, Liu J, Denzin LK, Chan CS, De S, Shen Z. Loss of Setd4 delays radiation-induced thymic lymphoma in mice. DNA Repair (Amst). 2020 Feb;86:102754. doi: 10.1016/j.dnarep.2019.102754. Epub 2019 Nov 25. PubMed PMID: 31794893; PubMed Central PMCID: PMC6960333.
  11. Roberto Droz-Rosario, Huimei Lu, Jingmei Liu, NingAng Liu, Shridar Ganesan, Bing Xia, Bruce G. Haffty, and Zhiyuan Shen. Roles of BCCIP deficiency in mammary tumorigenesis. Breast Cancer Research 2017, 19:115.
  12. Huhn SC, Liu J, Ye C, Lu H, Jiang X, Feng X, Ganesan S, White E, Shen Z. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene 2017 Apr 10.; doi: 10.1038/onc.2017.92.
  13. Ba Q, Li X, Huang C, Li J, Fu Y, Chen P, Duan J, Hao M, Zhang Y, Li J, Sun C, Ying H, Song H, Zhang R, Shen Z, Wang H. BCCIPbeta modulates the ribosomal and extraribosomal function of S7 through a direct interaction. Journal of molecular cell biology 2017;9:209-19
  14. Anantha RW, Simhadri S, Foo TK, Miao S, Liu J, Shen Z, Ganesan S, Xia B. Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance. Elife 2017;6
  15. Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes & development 2016;30:1956-70
  16. Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic acids research 2016;44:8855-69
  17. Wei L, Nakajima S, Bohm S, Bernstein KA, Shen Z, Tsang M, Levine AS, Lan L. DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination. Proceedings of the National Academy of Sciences of the United States of America 2015;112:E3495-504
  18. Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, Liu Z, Lin K, Xu-Monette ZY, Young KH, Liu J, Shen Z, Feng Z, Hu W. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nature communications 2014;5:5218
  19. Yue J, Lu H, Lan S, Liu J, Stein MN, Haffty BG, Shen Z. Identification of the DNA repair defects in a case of Dubowitz syndrome. PLoS One 2013;8:e54389 
  20. Yue J, Huhn S, Shen Z. Complex roles of filamin-A mediated cytoskeleton network in cancer progression. Cell Biosci 2013;3:7 
  21. Shen Z, Huhn SC, Haffty BG. Escaping death to quiescence: Avoiding mitotic catastrophe after DNA damage. Cell Cycle 2013;12
  22. Shen Z, Huhn S. PTEN sumo-wrestles human RAD52 to mystery land. Cell Cycle 2013;12:3585
  23. Shen Z. Cancer biomarkers and targeted therapies. Cell Biosci 2013;3:6  
  24. Jiang X, Yue J, Lu H, Campbell N, Yang Q, Lan S, Haffty BG, Yuan C, Shen Z. Inhibition of filamin-a reduces cancer metastatic potential. Int J Biol Sci 2013;9:67-77 
  25. Huang YY, Dai L, Gaines D, Droz-Rosario R, Lu H, Liu J, Shen Z. BCCIP Suppresses Tumor Initiation but Is Required for Tumor Progression. Cancer Res 2013;73:7122-33 
  26. Yue J, Lu H, Liu J, Berwick M, Shen Z. Filamin-A as a marker and target for DNA damage based cancer therapy. DNA Repair (Amst)2012;11:192-200 
  27. Yue J, Lan S, Yuan C, Shen Z. Prognostic values of filamin-A status for topoisomerase II poison chemotherapy. Int J Biol Sci 2012;8:442-50 http://www.ijbs.com/v08p0442.pdf
  28. Huang YY, Lu H, Liu S, Droz-Rosario R, Shen Z. Requirement of mouse BCCIP for neural development and progenitor proliferation. PLoS One 2012;7:e30638 
  29. Shen Z. Genomic instability and cancer: an introduction. Journal of molecular cell biology 2011;3:1-3 https://academic.oup.com/jmcb/article/3/1/1/910971
  30. Lu H, Huang YY, Mehrotra S, Droz-Rosario R, Liu J, Bhaumik M, White E, Shen Z. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet 2011;7:e1002291
  31. Zhu H, Yue J, Pan Z, Wu H, Cheng Y, Lu H, Ren X, Yao M, Shen Z, Yang JM. Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination and non-homologous end joining. PLoS One 2010;5:e12055
  32. Yue J, Wang Q, Lu H, Brenneman M, Fan F, Shen Z. The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repair. Cancer Res 2009;69:7978-85
  33. Rewari A, Lu H, Parikh R, Yang Q, Shen Z, Haffty BG. BCCIP as a prognostic marker for radiotherapy of laryngeal cancer. Radiother Oncol 2009;90:183-8 
  34. Sayar H, Shen Z, Lee SJ, Royce M, Rabinowitz I, Lee F, Smith H, Eberhardt S, Maestas A, Lu H, Verschraegen C. Phase I study of capecitabine in combination with cisplatin and irinotecan in patients with advanced solid malignancies. Invest New Drugs 2009;27:153-8
  35. Liu J, Lu H, Ohgaki H, Merlo A, Shen Z. Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas. BMC Cancer2009;9:268 
  36. Fan J, Wray J, Meng X, Shen Z. BCCIP is required for the nuclear localization of the p21 protein. Cell Cycle 2009;8:3019-24 
  37. Du Y, Zhou J, Fan J, Shen Z, Chen X. Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex. J Proteome Res 2009;8:2211-7
  38. Wray J, Liu J, Nickoloff JA, Shen Z. Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress. Cancer Res 2008;68:2699-707 
  39. Shen Z, Nickoloff JA. Mammalian Homologous Recombination Repair and Cancer Intervention. In: Wei Q, Li L, Chen DJ, editors. DNA Repair, Genetic Instability, and Cancer. Singapore: World Scientific Publishing Co. Pte. Ltd., ; 2007. p 119-56.
  40. Meng X, Yue J, Liu Z, Shen Z. Abrogation of the transactivation activity of p53 by BCCIP down-regulation. J Biol Chem 2007;282:1570-6 
  41. Meng X, Fan J, Shen Z. Roles of BCCIP in chromosome stability and cytokinesis. Oncogene 2007;26:6253-60   https://www.nature.com/onc/journal/v26/n43/pdf/1210460a.pdf
  42. Lu H, Yue J, Meng X, Nickoloff JA, Shen Z. BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. Nucleic acids research 2007;35:7160-70  
  43. Lu H, Guo X, Meng X, Liu J, Allen C, Wray J, Nickoloff JA, Shen Z. The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Mol Cell Biol 2005;25:1949-57 

A complete list of publications by Dr. Zhiyuan Shen can be found here.