Payne Laboratory - Publications

  1. Kumari R, Hosseini ES, Warrington KE, Milonas T, Payne KK. Butyrophilins: Dynamic Regulators of Protective T Cell Immunity in Cancer. Int J Mol Sci. 2023 May 13;24(10):8722. doi: 10.3390/ijms24108722.
  2. Martin AL, Anadon CM, Biswas S, Mine JA, Handley KF, Payne KK, Mandal G, Chaurio RA, Powers JJ, Sprenger KB, Rigolizzo KE, Innamarato P, Harro CM, Mehta S, Perez BA, Wenham RM, Conejo-Garcia JR. Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors. Mol Cancer Ther. 2022 Jul 5;21(7):1184-1194. doi: 10.1158/1535-7163.MCT-21-0872.
  3. Anadon CM, Yu X, Hänggi K, Biswas S, Chaurio RA, Martin A, Payne KK, Mandal G, Innamarato P, Harro CM, Mine JA, Sprenger KB, Cortina C, Powers JJ, Costich TL, Perez BA, Gatenbee CD, Prabhakaran S, Marchion D, Heemskerk MHM, Curiel TJ, Anderson AR, Wenham RM, Rodriguez PC, Conejo-Garcia JR. Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells. Cancer Cell. 2022 May 9;40(5):545-557.e13. doi: 0.1016/j.ccell.2022.03.008.
  4. Chaurio RA, Anadon CM, Lee Costich T, Payne KK, Biswas S, Harro CM, Moran C, Ortiz AC, Cortina C, Rigolizzo KE, Sprenger KB, Mine JA, Innamarato P, Mandal G, Powers JJ, Martin A, Wang Z, Mehta S, Perez BA, Li R, Robinson J, Kroeger JL, Curiel TJ, Yu X, Rodriguez PC, Conejo-Garcia JR. TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures. Immunity. 2022 Jan 11;55(1):115-128.e9. doi: 10.1016/j.immuni.2021.12.007.
  5. Mandal G, Biswas S, Anadon CM, Yu X, Gatenbee CD, Prabhakaran S, Payne KK, Chaurio RA, Martin A, Innamarato P, Moran C, Powers JJ, Harro CM, Mine JA, Sprenger KB, Rigolizzo KE, Wang X, Curiel TJ, Rodriguez PC, Anderson AR, Saglam O, Conejo-Garcia JR. IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer. Cancer Res. 2022 Mar 1;82(5):859-871. doi: 10.1158/0008-5472.CAN-21-2376.
  6. Payne KK. Cellular stress responses and metabolic reprogramming in cancer progression and dormancy. Semin Cancer Biol. 2022 Jan;78:45-48. doi: 10.1016/j.semcancer.2021.06.004.
  7. Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, Mine JA, Trillo-Tinoco J, Sasamoto N, Terry KL, Marchion D, Buras A, Wehham RM, Yu X, Townsend MK, Tworoger SS, Rodriguez PC, Anderson AR, Conejo-Garcia JR. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature. 2021 Feb 3. doi: 10.1038/s41586-020-03144-0.
  8. Harro CM, Perez-Sanz J, Costich TL, Payne KK, Anadon Galindo CM, Chaurio RA, Biswas S, Mandal G, Rigolizzo KE, Sprenger KB, Mine JA, Showe L, Yu X, Liu K, Rodriguez PC, Pinilla-Ibarz J, Sokol L, Conejo-Garcia JR. Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice. J Clin Invest. 2020 Dec 3;135711. doi: 10.1172/JCI135711.
  9. Payne KK, Mine JA, Biswas S, Chaurio RA, Perales-Puchalt A, Anadon CM, Costich TL, Harro CM, Walrath J, Qianqian M, Tcyganov E, Buras AL, Rigolizzo KE, Mandal G, Lajoie J, Ophir M, Tchou J, Marchion D, Luca VC, Bobrowicz P, McLaughlin B, Eskiocak U, Schmidt M, Cubillos-Ruiz JR, Rodriguez PC, Gabrilovich DI, Conejo-Garcia JR. BTN3A1 governs antitumor responses by coordinating ab and gd T cells. Science. 2020 Aug 21; 369(6506):942-949. doi: 10.1126/science.aay2767.
  10. Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, de Mingo Pulido A, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hänggi K, Anadon CM, Flores ER, Haura EB, Mehrotra S, Pilon-Thomas S, Ruffell B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC. The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020 Apr 14;52(4):668-682.e7.
  11. Biswas S, Mandal G, Roy Chowdhury S, Purohit S, Payne KK, Anadon C, Gupta A, Swanson P, Yu X, Conejo-Garcia JR, Bhattacharyya A. Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer. J Immunol. 2019 Dec 15;203(12):3447-3460.
  12. Song M, Sandoval TA, Chae CS, Chopra S, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, Bettigole SE, Shin HR, Crowley MJ, Cerliani JP, Kossenkov AV, Motorykin I, Zhang S, Manfredi G, Zamarin D, Holcomb K, Rodreguez PC, Rabinovich GA, Conejo-Garcia JR, Glimcher LH, Cubillos-Ruiz J. IRE1a-XBP1 signaling promotes T cell metabolic dysfunction in ovarian cancer by limiting glutamine influx. Nature. 2018 Oct;562(7727):423-428.
  13. Perales-Puchalt A, Svoronos N, Villarreal DO, Zankharia U, Reuschel E, Wojtak K, Payne KK, Duperret EK, Muthumani K, Conejo-Garcia JR, Weiner DB. IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment. Oncoimmunology. 2019;8(1):e1515058.
  14. Payne KK, Aqbi HF, Butler SE, Graham L, Keim RC, Wan W, Idowu MO, Bear HD, Wang XY, Manjili MH. Gr1-/low CD11b-/low MHCII+ myeloid cells boost T cell anti-tumor efficacy. J Leukoc Biol. 2018 Dec;104(6):1215-1228.
  15. Aqbi HF, Tyutyunyk-Massey L, Keim RC, Joshi S, Butler SE, Smith TM, Bandyopadhyay D, Idowu MO, Bear HD, Payne KK, Gewirtz DA, Manjili MH. Autophagy-deficient breast cancer shows early recurrence following chemotherapy. Oncotarget. 2018 Apr 24;9(31):22113-22122.
  16. Perales-Puchalt A, Perez Sanz J, Payne KK, Svoronos N, Allegrezza MJ, Chaurio RA, Anadon C, Calmette J, Mine JA, Costich TL, Nickels L, Wickramasinghe J, Rutkowski MR, Conejo-Garcia JR. Microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol. 2018 May;103(5):799-805.
  17. Stephen TL*, Payne KK*, Chaurio RA, Allegrezza MJ, Zhu H, Perez-Sanz J, Perales-Puchalt A, Nguyen JM, Vara-Ailor AE, Eruslanov EB, Borowsky ME, Zhang R, Laufer TM, Conejo-Garcia JR. Satb1 expression governs epigenetic repression of PD-1 in tumor-reactive T cells. Immunity. 2017 Jan 17;46(1):51-64. *equal contribution
  18. Perales-Puchalt A, Svoronos N, Rutkowski MR, Allegrezza MJ, Tesone AJ, Payne KK, Wickramasinge J, Nguyen JM, O’Brien SW, Gumireddy K, Huang Q, Cadungog MG, Connolly DC, Tchou J, Curiel TJ, Conejo-Garcia JR. Follicle-Stimulating Hormone Receptor is expressed my most ovarian cancer subtypes and is a safe and effective immunotherapeutic target. Clin Cancer Res. 2017 Jan 15;23(2):441-453.
  19. Svoronos N, Perales-Puchalt A, Allegrezza MJ, Rutkowski MR, Payne KK, Nguyen JM, Tesone AJ, Nguyen JM, Curiel TJ, Cadungog MG, Singhal S, Eruslanov EB, Zhang P, Tchou J, Zhang R, Conejo-Garcia JR. Tumor cell-independent estrogen signaling drives malignant progression through MDSC mobilization. Cancer Discov. 2017 Jan;7(1):72-85
  20. Zou P, Liu L, Zheng LD, Payne KK, Manjili MH, Idowu MO, Zhang J, Schmelz EM, Cheng Z. Coordinated upregulation of mitochondrial biogenesis and autophagy in breast cancer cells: The role of dynamin related protein-1 and implication for breast cancer treatment. Oxid Med Cell Longev. 2016;2016:4085727.
  21. Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Perales-Puchalt A, Nguyen JM, Payne KK, Singhal S, Eruslanov EB, Tchou J, Conejo-Garcia JR. Trametinib Drives T-Cell-Dependent Control of Kras-Mutated Tumors by Inhibiting Pathological Myelopoiesis. Cancer Res. 2016 Nov 1;76(21):6253-6265.
  22. Terracina KP, Graham LJ, Payne KK, Manjili MH, Baek A, Damle SR, Bear HD. DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer. Cancer Immunol Immunother. 2016 Sep;65(9):1061-73.
  23. Payne KK, Keim RC, Graham L, Idowu MO, Wan W, Wang XY, Toor AA, Bear HD, Manjili MH. Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells. J Leukoc Biol. 2016 Sep;100(3):625-35
  24. Tesone AJ, Rutkowski MR, Brencicova E, Svoronos N, Perales-Puchalt A, Stephen TL, Allegrezza MJ, Payne KK, Nguyen JM, Wickramasinghe J, Tchou J, Borowsky ME, Rabinovich GA, Kossenkov AV, Conejo-Garcia JR. Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. Cell Rep. 2016 Feb 23;14(7):1774-86.
  25. Kmieciak M, Payne KK, Wang XY, Manjili MH. IFN-γ Rα is a key determinant of CD8+ T cell-mediated tumor elimination or tumor escape and relapse in the FVB mouse. PLoS One. 2013 Dec 6;8(12):e82544
  26. Gowda M, Payne KK, Godder K, Manjili MH. HLA-DR expression on myeloid cells can be a potential prognostic factor in patients with high risk Neuroblastoma. Oncoimmunology. 2013 Oct 1;2(10):e26616
  27. Payne KK, Zoon CK, Wan W, Marlar K, Borelli CA, Keim RC, Kenari MN, Kazim AL, Bear HD, Manjili MH. Peripheral blood mononuclear cells of patients with breast cancer can be reprogrammed to enhance anti-HER-2/neu reactivity and overcome myeloid-derived suppressor cells. Breast Cancer Res Treat. 2013 Nov;142(1):45-57
  28. Ascierto ML, Idowu MO, Zhao Y, Khalak H, Payne KK, Wang XY, Dumur CI, Bedognetti D, Tomei S, Ascierto PA, Shanker A, Bear HD, Wang E, Marincola FM, De Maria A, Manjili MH. Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients. J Transl Med. 2013 Nov;142(1):45-57.
  29. Meier JM, Roberts C, Avent K, Hazlett AF, Berrie J, Payne KK, Hamm D, Chung HM, Desmarais C, Hogan KT, Archer KJ, Manjili MH, Toor AA. (2013). Fractal Organization of the Human T Cell Repertoire in Health and Following Stem Cell Transplantation. Biol Blood Marrow Transplant. 2013 Mar;19(3):366-77.
  30. Toor AA, Payne KK, Chung HM, Hazlett AF, Sabo RT, Clark WB, Kmieciak M, Anderson J, Buskey A, Roseff S, Williams DC, Roberts C, McCarty J, Manjili MH. Epigenetic Induction of Adaptive Immune Response in Multiple Myeloma: Sequential Azacitidine and Lenalidomide to Generate Cancer Testis Antigen Specific Cellular Immunity. Br J Haematol. 2012 Sep; 158(6):700-11
  31. Kmieciak M*, Basu D*, Payne KK*, Toor A, Yacoub A, Graham L, Sale L, Bear HD, Manjili MH. Activated NK T cells and NK cells render T cells resistant to MDSC and result in an effective adoptive cellular therapy against breast cancer in the FVBN202 transgenic mouse. J Immunol. 2011 Jul 15:187; 708-717 *Equal Contribution
  32. Kmieciak M, Payne KK, Idowu MO, Grimes MM, Graham L, Ascierto ML, Wang E, Bear HD, Manjili MH. Tumor escape and progression of HER-2/neu negative breast cancer under immune pressure. J Transl Med. 2011 Mar 31;9:35
  33. Sumpter TL, Payne KK, Wilkes DS. Regulation of the NFAT pathway discriminates CD4+CD25+ regulatory T cells from CD4+CD25- helper T cells. J Leukoc Bio. 2008 Mar;83(3): 708-717.
  34. Smith GN, Mickler EA, Payne KK, Lee J, Duncan M, Reynolds J, Foresman B, Wilkes DS. Lung transplant metalloproteinase levels are elevated prior to bronchiolitis obliterans syndrome. Am J Transplant, 2007 Jul;7(7):1856-61 Review Articles:
  35. Payne KK. Cellular stress responses and metabolic reprogramming in cancer progression and dormancy. Semin Cancer Biol. 2021 June 4;S1044-579X(21)00172-3.
  36. Aqbi HF, Wallace M, Sappal S, Payne KK, Manjili MH. IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape and progression. J Leukoc Biol. 2018 Feb 22;10.1002/JLB.5MIR0917-351R.
  37. Benson Z, Manjili SH, Habibi M, Guruli G, Toor AA, Payne KK, Manjili MH. Conditioning neoadjuvant therapies for improved immunotherapy of cancer. Biochem Pharmacol. 2017 Dec 1;145:12-17.
  38. Conejo-Garcia JR, Payne KK, Svoronos N. Estrogens drive myeloid-derived suppressor cell accumulation. Oncoscience. 2017 Feb 24;4(1-2);5-6.
  39. Payne KK. Lymphocyte-mediated immune regulation in health and disease: The Treg and γδ T cell co-conspiracy. Immunol Invest. 2016 Nov;45(8):767-775
  40. Manjili MH, Payne KK. Prospects in cancer immunotherapy: treating advanced stage disease or preventing tumor recurrence? Discov. Med.. 2015 19(107):427-31.
  41. Payne KK, Bear HD, Manjili MH. Adoptive cellular therapy of cancer: exploring innate and adaptive cellular crosstalk to improve anti-tumor efficacy. Future Oncol. 2014 Aug;10(10): 1779-94.
  42. Payne KK, Toor AA, Wang XY, Manjili MH. Immunotherapy of cancer: re-programming tumor-immune crosstalk. Clin Dev Immunol. 2012;2012:760965
  43. Payne KK, Manjili MH. Adaptive immune responses associated with breast cancer relapse. Arch. Immunol. Ther. Exp. 2012 Oct;60(5):345–350 Manjili MH, Payne KK. Cancer immunotherapy: re-programming cells of the innate and adaptive immune systems. Oncoimmunology, 2012 Mar 1;1(2): 201-204