Cole Laboratory - Publications

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  1. Athale UH, Flamand Y, Blonquist T, Steveson KE, Spira M, Asselin BL, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc J-M, Michon B, Schorin MA, Welch JJG, Harris MH, Neuberg DS, Sallan SE, Silverman LB. Predictors of thrombosis in children receiving therapy for acute lymphoblastic leukemia (ALL): Results from Dana-Farber Cancer Institute (DFCI) ALL Consortium trial 05-001. Pediatric Blood & Cancer. 2022; 69: 00e29581.
  2. Wen J, Patel C, Diglio F, Baker K, Marshall G, Li S, Cole PD.  Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate. Neuropharmacology. 2022 Jan 2:108939. Available online January 2, 2022.
  3. Williams AM and Cole PD. Biomarkers of Cognitive Impairment in Pediatric Cancer Survivors. Journal of Clinical Oncology. 2021; Published online April 22, 2021. DOI: 10.1200/JCO.20.02436. PMID: 33886369.
  4. Song Y, Zhu Q, Cole PD, Stevenson K, Harris M, Schultz E, Kahn JM, Ladas EJ, Athale UH, Clavell L, Laverdiere C, Leclerc J-M, Michon B, Welch JJG, Sallan SE, Silverman LB, Kelly K. Genetic Ancestry and Skeletal Toxicities among Childhood Acute Lymphoblastic Leukemia Patients in the DFCI 05-001 Cohort. Blood Advances 2020; 5(2):451-8.
  5. Ladas EJ, Blonquist TM, Puligandla M, Orjuela M, Stevenson K, Cole PD, Athale UH, Clavell LA, Leclerc J-M, Laverdiere C, Michon B, Schorin MA, Welch JG, Asselin BL, Sallan SE, Silverman LB, Kelly KM. The protective effects of dietary intake of antioxidants and treatment-related toxicity in childhood leukemia: A Report from the DALLT Cohort. Journal of Clinical Oncology, 2020; 38(19): 2151-2159. PMID: 32330103
  6. Brace K, Lee W, Cole PD, Sussman E. (2019). Childhood leukemia survivors exhibit deficiencies in sensory and cognitive processes, as reflected by event-related brain potentials after completion of curative chemotherapy: A preliminary investigation. Journal of Clinical and Experimental Neuropsychology; 2019 Oct;41(8):814-831. DOI: 10.1080/13803395.2019.1623865. PMID: 31156064
  7. Ladas EJ, Orjuela M, Stevenson K, Cole PD, Lin M, Athale UH, Clavell LA, Leclerc JM, Laverdiere C, Michon B, Schorin MA. Fluctuations in Dietary Intake During Treatment for Childhood Leukemia: A Report from the DALLT Cohort. Clinical Nutrition. 2019;38(6):2866-2874
  8. Wen J, Maxwell RR, Wolf AJ, Spira M, Gulinello ME, Cole PD. Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model. Neuropharmacology. 2018; 139:76-84. PMID: 29990472
  9. Cole PD, McCarten KM, Pei Q, Spira M, Metzger ML, Drachtman RA, Horton TM, Bush R, Blaney SM, Weigel BJ, Kelly KM. Brentuximab vedotin with Gemcitabine for Pediatric and Young Adult Patients with Relapsed or Refractory Hodgkin Lymphoma: A Children’s Oncology Group, Single-arm, Phase 1 / 2 Trial. The Lancet
  10. Thomsen AM, Gulinello ME, Vijayanathan V, Wen J, Schmiegelow K, Cole PD. Liposomal Cytarabine Induces Less Neurocognitive Dysfunction than Intrathecal Methotrexate in an Animal Model. Journal of Pediatric Hematology / Oncology. 2018; 40 (2), e91-e96; published online July 17 2017. PMID: 28654460.
  11. Finkelstein Y, Blonquist TM, Vijayanathan V, Stevenson KE, Neuberg DS, Silverman LB, Vrooman LM, Sallan SE, Cole PD. A Thymidylate Synthase Polymorphism is Associated with Increased Risk for Bone Toxicity Among Children Treated for Acute Lymphoblastic Leukemia. Pediatric Blood & Cancer. 2017; 64(7): e26393; Published online 13 Dec. 2016. PMID: 27957785
  12. Sands SA, Harel BT, Savone M, Kelly K, Vijayanathan V, Welch JG, Vrooman L, Silverman LB, Cole PD. Feasibility of Baseline Neurocognitive Assessment using Cogstate During the First Month of Therapy for Childhood Leukemia. Supportive Care in Cancer. 2016; published online October 12. PMID: 27726029
  13. Cole PD, Finkelstein Y, Stevenson KE, Blonquist TM, Vijayanathan V, Silverman LB, et al. Polymorphisms in Genes Related to Oxidative Stress Are Associated with Inferior Cognitive Function after Therapy for Childhood Acute Lymphoblastic Leukemia. Journal of Clinical Oncology. 2015; 33(19):2205-11. PMID: 25987702
  14. Kim S-E, Hinoue T, Kim MS, Sohn K-J, Cho RC, Cole PD, Weisberger DJ, Laird PW, Kim YI. g-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells. Genes and Nutrition, 2015; 10(1): 444. PMID: 25502219
  15. Kim S-E, Cole PD, Cho R, Ly A, Ishiguro L, Sohn K-J, Croxford R, Kamen B, Kim Y-I. γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate. British Journal of Cancer 2013; 109: 2175-88. PMID: 24045662
  16. Cole PD, Vijayanathan V, Ali NF, Wagshul ME, Tanenbaum EJ, Price J, Dalal V, Gulinello ME. “Memantine protects rats treated with intrathecal methotrexate from developing spatial memory deficits,” Clinical Cancer Research 2013: 19(16):4446-54. PMID: 23833301.
  17. Vijayanathan V, Ali N, Gulinello M, Cole PD. Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist. Behavioural Brain Research. 2011;225(2):491-7.
  18. Li Y, Vijayanathan V, Gulinello M, Cole PD. Intrathecal Methotrexate Induces Focal Cognitive Deficits and Increases Cerebrospinal Fluid Homocysteine. Pharmacology, Biochemistry and Behavior;2010; 95 (4): 428-33.
  19. Li Y, Vijayanathan V, Gulinello ME, Cole PD. Systemic Methotrexate Induces Spatial Memory Deficits and Depletes Cerebrospinal Fluid Folate in Rats. Pharmacology, Biochemistry and Behavior 2010: 94(3):454-63.
  20. Cole PD, Beckwith KA, Vijayanathan V, Roychowdhury S, Smith AK, Kamen BA. CSF Folate Homeostasis During Therapy for Acute Lymphoblastic Leukemia. Pediatric Neurology 2009; 40(1): 34-41.
  21. Wollack JB, Makori B, Ahlawat S, Koneru R, Picinich S, Smith AK, Goldman ID, Qiu A, Cole PD, Glod J, Kamen BA.  Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model. Journal of Neurochemistry, 2008; 104(6): 1494-503.
  22. Cho RC, Cole PD, Sohn KJ, Gaisano G, Croxford R, Kamen BA, Kim YI.  Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells.  Molecular Cancer Therapeutics, 2007; 6(11): 2909-20.
  23. Vijayanathan V. Smith AK, Zebala JA, Kamen BA, Cole PD. HPLC Separation of Aminopterin Polyglutamates Within Red Blood Cells of Children Treated for Acute Lymphoblastic Leukemia. Translational Research, 2007; 150(6) 367-73.
  24. Li WW, Su D, Mizobuchi H, Martin DS, Gu B, Gorlick R, Cole P, and Bertino JR. Status of methylthioadenosine phosphorylase and its impact on cellular response to l-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells. Oncology Research, 2004; 14: 373-379.
  25. Kaufman Y, Drori S, Cole PD, Kamen BA, Sirota J, Ifergan I, Ben Arush MW, Elhasid R, Sahar D, Kaspers GJL, Jansen G, Matherly LH, Rechavi G, Toren A, Assaraf YG.  Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia. Cancer. 2004; 100(4): 773-82.
  26. Cole PD, Smith AK, Kamen BA. Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.  Cancer Chemotherapy and Pharmacology 2002; 50(2): 111-6.
  27. Cole PD, Gorlick R, Banerjee D, Magill L, Smith A, Kamen BA, Bertino JR. Effects Of Overexpression Of g-Glutamyl Hydrolase (GGH) On Methotrexate Metabolism And Resistance.  Cancer Research, 2001; 61(11): 4599-4604.