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Cao Laboratory - Select Publications

Cao J, Yan, Q. Cancer epigenetics, tumor immunity, and immunotherapy. Trends in Cancer. Epub 2020 Mar 31.

Halaban R, Bacchiocchi A, Straub R, Cao J, Sznol M, Narayan D, Allam A, Krauthammer M, Mansour TS. A novel anti-melanoma SRC-family kinase inhibitor. Oncotarget. 2019 Mar 19;10(23):2237-2251. doi: 10.18632/oncotarget.26787. PMID: 31040916; PMCID: PMC6481345.

Gale M, Li Y, Cao J, Liu ZZ, Holmbeck MA, Zhang M, Lang SM, Wu L, Do Carmo M, Gupta S, Aoshima K, DiGiovanna MP, Stern DF, Rimm DL, Shadel GS, Chen X, Yan Q. Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition. Cancer Res. 2020 Feb 1;80(3):524-535. doi: 10.1158/0008-5472.CAN-18-3985. Epub 2019 Nov 5. PMID: 31690671; PMCID: PMC7002225.

Chen X, Kost J, Sulovari A, Wong N, Liang W, Cao J#, Li D#. A virome-wide clonal integration analysis platform for discovering cancer viral etiology. Genome Res. 2019 Mar 14. pii: gr.242529.118. PMID: 30872350. (#correspondence)

Cao J#, Xiao Q#, and Yan Q. The multiplexed CRISPR targeting platforms. Drug Discov Today Technol. 2018 Aug;28:53-61. PMID: 30205881. (#correspondence)

Wu L*, Cao J*, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS1, and Yan Q. KDM5 histone demethylases repress immune response via suppression of STING. PLoS Biol. 2018 Aug 6;16(8):e2006134. PMID: 12847236. (*equal contribution)

Cao J#, and Li D#. Searching for human oncoviruses: Histories, challenges, and opportunities. J Cell Biochem. 2018 Jun;119(6):4897-4906. PMID: 29377246. (#correspondence)

Blair LP, Liu Z, Labitigan RLD, Wu L, Zheng D, Xia Z, Pearson EL, Nazeer FI, Cao J, Lang SM, Rines RJ, Mackintosh SJ, Moore CL, Li W, Tian B, Tackett AJ, and Yan Q. KDM5 lysine demethylases are involved in maintenance of 3′UTR length. Science Advances. 2016 Nov 18;2(11):e1501662. PMID: 28138513.

Gale M, Sayegh J, Cao J, Norcia M, Gareiss P, Hoyer D, Merkel JS, and Yan Q. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944. PMID: 27224921.

Cao J, Wu L, Zhang SM, Lu M, Cheung WKC, Cai W, Gale M, Xu Q, and Yan Q. An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting. Nucleic Acids Research. 2016 Nov 2;44(19):e149. PMID: 27458201.

Zou MR, Cao J, Liu Z, Huh SJ, Polyak K, and Yan Q. Histone Demethylase Jumonji AT-Rich Interactive Domain 1B (JARID1B) Controls Mammary Gland Development by Regulating Key Developmental and Lineage Specification Genes. Journal of Biological Chemistry. 2014 Jun; 289(25):17620-33. PMID: 24802759.

Cao J, Liu Z, Cheung WKC, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q. Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Reports. 2014 Mar; 6(5):868-877. PMID: 24582965.

Cao J, Liu X, Han S, Zhang CK, Liu Z, Li D. Association of the HTR2A gene with alcohol and heroin abuse. Human Genetics. 2014 Mar;133(3):357-65. PMID: 24178752.

Cao J, Hudziak J, Li D. Multi-cultural Association of the Serotonin Transporter Gene (SLC6A4) with Substance Use Disorder. Neuropsychopharmacology. 2013 Aug;38(9):1737-47. PMID: 23518607.

Cao J and Yan Q. Histone demethylases set the stage for cancer metastasis. Science Signaling. 2013 Apr; 6(273):pe15. PMID: 23633674.

Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, and Yan Q. Identification of small molecule inhibitors of Jumonji AT-Rich Interactive Domain 1B (JARID1B) histone demethylase by a sensitive high-throughput screen. Journal of Biological Chemistry. 2013 Mar; 288(13):9408-17. PMID: 23408432.

Cao J, LaRocque E, Li D. Associations of the 5-hydroxytryptamine (Serotonin) Receptor 1B Gene (HTR1B) with Alcohol, Cocaine, and Heroin Abuse. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2013 Mar;162(2):169-76. PMID: 23335468.

Cao J*, and Yan Q*. Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer. Frontiers in Oncology. 2012 Mar 12;2:26. PMID: 22649782. (*correspondence)

Blair LP, Cao J, Zou MR, Sayegh J, and Yan Q. Epigenetic regulation by lysine demethylase 5 (KDM5) enzymes in cancer. Cancers. 2011 Mar; 3(1):1383-1404. PMID: 21544224.

Lin W*, Cao J*, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson JT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WJ, Jr., and Yan Q. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proceedings of the National Academy of Sciences USA. 2011 Aug; 108(33):13379-86. PMID: 21788502. (*equal contribution)

Ge L, Wang J, Qi W, Miao HH, Cao J, Qu YX, Li BL, and Song BL. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metabolism. 2008 Jun; 7(6): 508-519. PMID: 18522832.

Cao J, Wang J, Qi W, Miao HH, Wang J, Ge L, DeBose-Boyd RA, Tang JJ, Li BL, and Song BL. Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. Cell Metabolism. 2007 Aug; 6(2): 115-128. PMID: 17681147.

Yang Y, Cao J, Huang L, Fang HY, and Sheng HZ. Regulated expression of TATA-binding protein-related factor 3 (TRF3) during early embryogenesis. Cell Research. 2006 Jul; 16(7): 610-621. PMID: 16721357.