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Phase 3 Randomized, Double-Blind, Placebo-controlled Studies Assessing Ziftomenib in Combination with Either Standard of Care Nonintensive (Venetoclax + Azacitidine) or Intensive (7+3) Therapy in Patients with Untreated NPM1 Mutated or KMT2A Rearranged Acute Myeloid Leukemia.
Protocol: 022501Principal Investigator:
- Xiaoyi Chen
Applicable Disease Sites: Myeloid and Monocytic Leukemia -
A Phase I Study Evaluating the Safety of Cirtuvivint as Monotherapy and in Combination with ASTX727 in Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Protocol: 022503Principal Investigator:
- Neil Palmisiano
Applicable Disease Sites: Leukemia, other
Myeloid and Monocytic Leukemia -
A Phase I Study of Autophagy Inhibition with Hydroxychloroquine and Oral Decitabine with Venetoclax after Hypomethylating Agent and Venetoclax Failure in Acute Myeloid Leukemia.
Protocol: 022601Principal Investigator:
- Neil Palmisiano
Applicable Disease Sites: Leukemia, not otherwise specified
Leukemia, other -
A Phase I Study of Autophagy Inhibition with Hydroxychloroquine and Oral Decitabine with Venetoclax after Hypomethylating Agent and Venetoclax Failure in Acute Myeloid Leukemia.
Protocol: 022601Principal Investigator:
- Neil Palmisiano
Applicable Disease Sites: Leukemia, not otherwise specified
Leukemia, other -
A Phase II De-Escalation Study of Metronomic Decitabine/Cedazuridine Plus Venetoclax in Acute Myeloid Leukemia Maintenance.
Protocol: 022604Principal Investigator:
- Xiaoyi Chen
Applicable Disease Sites: Myeloid and Monocytic Leukemia -
A Phase II De-Escalation Study of Metronomic Decitabine/Cedazuridine Plus Venetoclax in Acute Myeloid Leukemia Maintenance.
Protocol: 022604Principal Investigator:
- Xiaoyi Chen
Applicable Disease Sites: Myeloid and Monocytic Leukemia -
A Randomized Phase II Trial of Adjuvant Pembrolizumab versus Observation Following Curative Resection for Stage I Non-Small Cell Lung Cancer (NSCLC) with Primary Tumors between 1-4 cm.
Protocol: 032006Principal Investigator:
- Missak Haigentz
Applicable Disease Sites: Lung -
Alternating Treatment Plans for Patients with Advanced Thoracic/HN Cancers (ATATcH).
Protocol: 032201Principal Investigator:
- Missak Haigentz
Applicable Disease Sites: Lung -
A Randomized Phase II Trial of Adjuvant Pembrolizumab versus Observation Following Curative Resection for Stage I Non-Small Cell Lung Cancer (NSCLC) with Primary Tumors between 1-4 cm.
Protocol: 032006Principal Investigator:
- Missak Haigentz
Applicable Disease Sites: Lung -
Phase 1/1b Study of AKT Inhibitor Ipatasertib with Chemoradiation for Locally Advanced Head and Neck Cancer.
Protocol: 032204Applicable Disease Sites: Larynx
Lip, Oral Cavity and Pharynx -
Alternating Treatment Plans for Patients with Advanced Thoracic/HN Cancers (ATATcH).
Protocol: 032201Principal Investigator:
- Missak Haigentz
Applicable Disease Sites: Lung -
Phase 1/1b Study of AKT Inhibitor Ipatasertib with Chemoradiation for Locally Advanced Head and Neck Cancer.
Protocol: 032204Applicable Disease Sites: Larynx
Lip, Oral Cavity and Pharynx -
An Open-label, Multi-center, Global Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX43 (Anti-PD-L1 ADC) in Subjects with Advanced Non-small Cell Lung Cancer (NSCLC)
Protocol: 032506Applicable Disease Sites: Lung
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An Open-label, Multi-center, Global Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX43 (Anti-PD-L1 ADC) in Subjects with Advanced Non-small Cell Lung Cancer (NSCLC)
Protocol: 032506Applicable Disease Sites: Lung
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Phase II Dose Optimization Study of Platinum/Etoposide Plus Ivonescimab (CEI) as First-Line Treatment of Extensive-Stage Small Cell Lung Cancer.
Protocol: 032509Principal Investigator:
- Missak Haigentz
Applicable Disease Sites: Lung -
Phase II Dose Optimization Study of Platinum/Etoposide Plus Ivonescimab (CEI) as First-Line Treatment of Extensive-Stage Small Cell Lung Cancer.
Protocol: 032509Principal Investigator:
- Missak Haigentz
Applicable Disease Sites: Lung