Clinical Investigations and Precision Therapeutics Selected Program-Related Publications

Key to Member Program Affiliation

CMI
GICG
CP
CIPT
CPC

Cancer Metabolism and Immunology
Genomic Instability and Cancer Genetics
Cancer Pharmacology
Clinical Investigations and Precision Therapeutics
Cancer Prevention and Control

Publication

Member(s) Credited

Katugampola S, Wang J, Prasad A, Sofou S, Howell RW. Predicting response of micrometastases with MIRDcell V3: proof of principle with (225)Ac-DOTA encapsulating liposomes that produce different activity distributions in tumor spheroids. Eur J Nucl Med Mol Imaging. 2022;49(12):3989-99. doi: 10.1007/s00259-022-05878-7. PubMed PMID: 35802160; PMCID: PMC9529908.

Howell RW (CIPT)

Zingg D, Bhin J, Yemelyanenko J, Kas SM, Rolfs F, Lutz C, Lee JK, Klarenbeek S, Silverman IM, Annunziato S, Chan CS, Piersma SR, Eijkman T, Badoux M, Gogola E, Siteur B, Sprengers J, de Klein B, de Goeij-de Haas RR, Riedlinger GM, Ke H, Madison R, Drenth AP, van der Burg E, Schut E, Henneman L, van Miltenburg MH, Proost N, Zhen H, Wientjens E, et al. Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. Nature. 2022;608(7923):609-17. doi: 10.1038/s41586-022-05066-5. PubMed PMID: 35948633; PMCID: PMC9436779.

Chan CS (GICG),
Riedlinger GM (CIPT),
Ganesan S (CIPT)

Shaheen MF, Tse JY, Sokol ES, Masterson M, Bansal P, Rabinowitz I, Tarleton CA, Dobroff AS, Smith TL, Bocklage TJ, Mannakee BK, Gutenkunst RN, Bischoff J, Ness SA, Riedlinger GM, Groisberg R, Pasqualini R, Ganesan S, Arap W. Genomic landscape of lymphatic malformations: a case series and response to the PI3Kα inhibitor alpelisib in an N-of-1 clinical trial. Elife. 2022;11. doi: 10.7554/eLife.74510. PubMed PMID: 35787784; PMCID: PMC9255965.

Masterson M (CIPT),
Riedlinger GM (CIPT),
Groisberg R (CIPT),
Pasqualini R (CP),
Ganesan S (CIPT),
Arap W (CIPT)

Silk AW, Saraiya B, Groisberg R, Chan N, Spencer K, Girda E, Shih W, Palmeri M, Saunders T, Berman RM, Coric V, Chen S, Zloza A, Vieth J, Mehnert JM, Malhotra J. A phase Ib dose-escalation study of troriluzole (BHV-4157), an oral glutamatergic signaling modulator, in combination with nivolumab in patients with advanced solid tumors. Eur J Med Res. 2022;27(1):107. doi: 10.1186/s40001-022-00732-w. PubMed PMID: 35780243; PMCID: PMC9250196.

Silk AW (CIPT),
Saraiya B (CIPT),
Groisberg R (CIPT),
Chan N (CIPT),
Spencer K (CIPT),
Girda E (CIPT),
Shih W (CIPT),
Chen S (CP),
Zloza A (CIPT),
Mehnert JM (CIPT),
Malhotra J (CIPT)

Mondal A, Roberge J, Gilleran J, Peng Y, Jia D, Akel M, Patel Y, Zoltowski H, Doraiswamy A, Langenfeld J. Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells. Cell Commun Signal. 2022;20(1):99. doi: 10.1186/s12964-022-00905-4. PubMed PMID: 35761398; PMCID: PMC9238106.

Langenfeld J (CIPT)

Girda E, Hou J, Nelson D, Finlayson M, de Meritens AB, Chekmareiva M, Leiser A, Song M, Stephenson R, Chan N, Tergas AI, Vattakalam R, Wright JD, Yu H, Martincuks A, Kohut A, Palmer J, Rodriguez-Rodriguez L. Phase I trial of daily subcutaneous SPL-108 injections in combination with paclitaxel in patients with platinum resistant CD44+ advanced ovarian epithelial cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2022:ijgc-2021-003316. doi: 10.1136/ijgc-2021-003316. PubMed PMID: 35750354; PMCID: PMC9380511.

Girda E (CIPT),
Chan N (CIPT)

Palefsky JM, Lee JY, Jay N, Goldstone SE, Darragh TM, Dunlevy HA, Rosa-Cunha I, Arons A, Pugliese JC, Vena D, Sparano JA, Wilkin TJ, Bucher G, Stier EA, Tirado Gomez M, Flowers L, Barroso LF, Mitsuyasu RT, Lensing SY, Logan J, Aboulafia DM, Schouten JT, de la Ossa J, Levine R, Korman JD, Hagensee M, Atkinson TM, Einstein MH, Cracchiolo BM, Wiley D, et al. Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer. N Engl J Med. 2022;386(24):2273-82. doi: 10.1056/NEJMoa2201048. PubMed PMID: 35704479; PMCID: PMC9717677.

Einstein MH (CIPT)

Evens AM, Brandt JS, Peer CJ, Yin T, Schaar D, Farooq F, Mozarsky B, Figg WD, Sharon E. Checkpoint inhibitor immunotherapy during pregnancy for relapsed-refractory Hodgkin lymphoma. Am J Hematol. 2022;97(6):833-8. doi: 10.1002/ajh.26527. PubMed PMID: 35285979; PMCID: PMC9314600.

Evens AM (CIPT),
Schaar D (CIPT)

Buhtoiarov IN, Mba NI, Santos CDL, McCarten KM, Metzger ML, Pei Q, Bush R, Baker K, Kelly KM, Cole PD. Durable remission for four pediatric patients with high-risk relapsed classical Hodgkin lymphoma treated with brentuximab vedotin plus gemcitabine but without autologous stem cell transplantation: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2022;69(6):e29649. doi: 10.1002/pbc.29649. PubMed PMID: 35338689; PMCID: PMC9465975.

Cole PD (CIPT)

Rousseau B, Murugan S, Palagani A, Sarkar DK. Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling. Breast Cancer Res. 2022;24(1):33. doi: 10.1186/s13058-022-01526-y. PubMed PMID: 35568869; PMCID: PMC9107672.

Sarkar DK (CIPT)

Evens AM, Connors JM, Younes A, Ansell SM, Kim WS, Radford J, Feldman T, Tuscano J, Savage KJ, Oki Y, Grigg A, Pocock C, Dlugosz-Danecka M, Fenton K, Forero-Torres A, Liu R, Jolin H, Gautam A, Gallamini A. Older patients (aged ≥60 years) with previously untreated advanced-stage classical Hodgkin lymphoma: a detailed analysis from the phase III ECHELON-1 study. Haematologica. 2022;107(5):1086-94. doi: 10.3324/haematol.2021.278438. PubMed PMID: 34162178; PMCID: PMC9052913.

Evens AM (CIPT)

Madison RW, Hu X, Ramanan V, Xu Z, Huang RSP, Sokol ES, Frampton GM, Schrock AB, Ali SM, Ganesan S, De S. Clustered 8-Oxo-Guanine Mutations and Oncogenic Gene Fusions in Microsatellite-Unstable Colorectal Cancer. JCO Precis Oncol. 2022;6:e2100477. doi: 10.1200/po.21.00477. PubMed PMID: 35584350; PMCID: PMC9200390.

Ganesan S (CIPT),
De S (GICG)

Delnevo CD, Jeong M, Teotia A, Bover Manderski MM, Singh B, Hrywna M, Wackowski OA, Steinberg MB. Communication Between US Physicians and Patients Regarding Electronic Cigarette Use. JAMA Netw Open. 2022;5(4):e226692. doi: 10.1001/jamanetworkopen.2022.6692. PubMed PMID: 35426926; PMCID: PMC9012960.

Delnevo CD (CPC),
Jeong M (CPC),
Bover Manderski MM (CPC),
Hrywna M (CPC),
Wackowski OA (CPC),
Steinberg MB (CIPT)

Mehnert JM, Mitchell TC, Huang AC, Aleman TS, Kim BJ, Schuchter LM, Linette GP, Karakousis GC, Mitnick S, Giles L, Carberry M, Frey N, Kossenkov A, Groisberg R, Hernandez-Aya LF, Ansstas G, Silk AW, Chandra S, Sosman JA, Gimotty PA, Mick R, Amaravadi RK. BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma. Clin Cancer Res. 2022;28(6):1098-106. doi: 10.1158/1078-0432.Ccr-21-3382. PubMed PMID: 35022320; PMCID: PMC8923957.

Mehnert JM (CIPT), Groisberg R (CIPT),
Silk AW (CIPT)

Palmeri M, Mehnert J, Silk AW, Jabbour SK, Ganesan S, Popli P, Riedlinger G, Stephenson R, de Meritens AB, Leiser A, Mayer T, Chan N, Spencer K, Girda E, Malhotra J, Chan T, Subbiah V, Groisberg R. Real-world application of tumor mutational burden-high (TMB-high) and microsatellite instability (MSI) confirms their utility as immunotherapy biomarkers. ESMO Open. 2022;7(1):100336. doi: 10.1016/j.esmoop.2021.100336. PubMed PMID: 34953399; PMCID: PMC8717431.

Ganesan S (CIPT),
Riedlinger G (CIPT),
Mayer T (CIPT),
Chan N (CIPT),
Spencer K (CIPT),
Girda E (CIPT),
Malhotra J (CIPT),
Groisberg R (CIPT)

Steinberg MB, Bover Manderski MT, Wackowski OA, Singh B, Strasser AA, Delnevo CD. Nicotine Risk Misperception Among US Physicians. J Gen Intern Med. 2021;36(12):3888-90. doi: 10.1007/s11606-020-06172-8. PubMed PMID: 32875504; PMCID: PMC8642586.

Steinberg MB (CIPT),
Bover Manderski MT (CPC),
Wackowski OA (CPC),
Delnevo CD (CPC)

Neibart SS, Mamidanna S, Chundury A, Sayan M, Alexander HR, August DA, Berim LD, Boland PM, Grandhi MS, Gulhati P, Hochster HS, Langan RC, Spencer KR, Kennedy TJ, Deek MP, Jabbour SK. Outcomes of patients with borderline resectable and resectable pancreatic adenocarcinoma treated with neoadjuvant three-week course chemoradiotherapy using capecitabine-based versus gemcitabine-based concurrent chemotherapy. Journal of gastrointestinal oncology. 2021;12(6):2557-66. doi: 10.21037/jgo-21-503. PubMed PMID: 35070387; PMCID: PMC8748032.

Alexander HR (CIPT),
Boland PM (CIPT),
Hochster HS (CIPT), Spencer KR (CIPT),
Deek MP (CIPT),
Jabbour SK (CIPT)

Panda A, Bhanot G, Ganesan S, Bajpai M. Gene Expression in Barrett's Esophagus Cell Lines Resemble Esophageal Squamous Cell Carcinoma Instead of Esophageal Adenocarcinoma. Cancers (Basel). 2021;13(23). doi: 10.3390/cancers13235971. PubMed PMID: 34885081; PMCID: PMC8656995.

Bhanot G (GICG),
Ganesan S (CIPT)

Butner JD, Martin GV, Wang Z, Corradetti B, Ferrari M, Esnaola N, Chung C, Hong DS, Welsh JW, Hasegawa N, Mittendorf EA, Curley SA, Chen SH, Pan PY, Libutti SK, Ganesan S, Sidman RL, Pasqualini R, Arap W, Koay EJ, Cristini V. Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling. Elife. 2021;10. doi: 10.7554/eLife.70130. PubMed PMID: 34749885; PMCID: PMC8629426.

Libutti SK (CIPT, GICG),
Ganesan S (CIPT),
Pasqualini R (CP),
Arap W (CIPT)

Kwon M, Rubio G, Nolan N, Auteri P, Volmar JA, Adem A, Javidian P, Zhou Z, Verzi MP, Pine SR, Libutti SK. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Cancer Res. 2021;81(21):5523-39. doi: 10.1158/0008-5472.Can-21-0897. PubMed PMID: 34417201; PMCID: PMC8563430.

Zhou Z (GICG),
Verzi MP (GICG),
Pine SR (GICG),
Libutti SK (CIPT, GICG)

Canter BS, Leung CN, Fritton JC, Bäck T, Rajon D, Azzam EI, Howell RW. Radium-223-Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow. Mol Cancer Res. 2021;19(10):1739-50. doi: 10.1158/1541-7786.Mcr-21-0005. PubMed PMID: 34039648; PMCID: PMC8492514.

Azzam EI (GICG),
Howell RW (CIPT)

Rodday AM, Hahn T, Kumar AJ, Lindenauer PK, Friedberg JW, Evens AM, Parsons SK. Association of Treatment Intensity With Survival in Older Patients With Hodgkin Lymphoma. JAMA Netw Open. 2021;4(10):e2128373. doi: 10.1001/jamanetworkopen.2021.28373. PubMed PMID: 34673965; PMCID: PMC8531990.

Evens AM (CIPT)

Murugan S, Rousseau B, Sarkar DK. Beta 2 Adrenergic Receptor Antagonist Propranolol and Opioidergic Receptor Antagonist Naltrexone Produce Synergistic Effects on Breast Cancer Growth Prevention by Acting on Cancer Cells and Immune Environment in a Preclinical Model of Breast Cancer. Cancers (Basel). 2021;13(19). doi: 10.3390/cancers13194858. PubMed PMID: 34638341; PMCID: PMC8508249.

Sarkar DK (CIPT)

Sillerud LO, Neuwelt AJ, Staquicini FI, Arap W, Pasqualini R. Repurposing Ferumoxytol as a Breast Cancer-Associated Macrophage Tracer with Five-Dimensional Quantitative [Fe]MRI of SPION Dynamics. Cancers (Basel). 2021;13(15). doi: 10.3390/cancers13153802. PubMed PMID: 34359704; PMCID: PMC8345165.

Staquicini FI (CP),
Arap W (CIPT),
Pasqualini R (CP)

Staquicini DI, Tang FHF, Markosian C, Yao VJ, Staquicini FI, Dodero-Rojas E, Contessoto VG, Davis D, O'Brien P, Habib N, Smith TL, Bruiners N, Sidman RL, Gennaro ML, Lattime EC, Libutti SK, Whitford PC, Burley SK, Onuchic JN, Arap W, Pasqualini R. Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain. Proc Natl Acad Sci U S A. 2021;118(30). doi: 10.1073/pnas.2105739118. PubMed PMID: 34234013; PMCID: PMC8325333.

Staquicini FI (CP),
Gennaro ML (CMI),
Lattime EC (CMI),
Libutti SK (CIPT, GICG),
Burley SK (CP),
Arap W (CIPT),
Pasqualini R (CP)

Zayac AS, Evens AM, Danilov A, Smith SD, Jagadeesh D, Leslie LA, Wei C, Kim SH, Naik S, Sundaram S, Reddy N, Farooq U, Kenkre VP, Epperla N, Blum KA, Khan N, Singh D, Alderuccio JP, Godara A, Yazdy MS, Diefenbach C, Rabinovich E, Varma G, Karmali R, Shao Y, Trabolsi A, Burkart M, Martin P, Stettner S, Chauhan A, et al. Outcomes of Burkitt lymphoma with central nervous system involvement: evidence from a large multicenter cohort study. Haematologica. 2021;106(7):1932-42. doi: 10.3324/haematol.2020.270876. PubMed PMID: 33538152; PMCID: PMC8252937.

Evens AM (CIPT),
David KA (CIPT)

Jabbour SK, Lee KH, Frost N, Breder V, Kowalski DM, Pollock T, Levchenko E, Reguart N, Martinez-Marti A, Houghton B, Paoli JB, Safina S, Park K, Komiya T, Sanford A, Boolell V, Liu H, Samkari A, Keller SM, Reck M. Pembrolizumab Plus Concurrent Chemoradiation Therapy in Patients With Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer: The Phase 2 KEYNOTE-799 Nonrandomized Trial. JAMA Oncol. 2021;7(9):1-9. doi: 10.1001/jamaoncol.2021.2301. PubMed PMID: 34086039; PMCID: PMC8446818.

Jabbour SK (CIPT)

Staquicini FI, Hajitou A, Driessen WH, Proneth B, Cardó-Vila M, Staquicini DI, Markosian C, Hoh M, Cortez M, Hooda-Nehra A, Jaloudi M, Silva IT, Buttura J, Nunes DN, Dias-Neto E, Eckhardt B, Ruiz-Ramírez J, Dogra P, Wang Z, Cristini V, Trepel M, Anderson R, Sidman RL, Gelovani JG, Cristofanilli M, Hortobagyi GN, Bhujwalla ZM, Burley SK, Arap W, Pasqualini R. Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer. Elife. 2021;10. doi: 10.7554/eLife.65145. PubMed PMID: 34060472; PMCID: PMC8169110.

Staquicini FI (CP),
Burley S (CP),
Arap W (CIPT),
Pasqualini R (CP)

Shah MR, Jan I, Johns J, Singh K, Kumar P, Belarmino N, Saggiomo KJ, Hayes C, Washington K, Toppmeyer DL, Haffty BG, Libutti SK, Evens AM. SARS-CoV-2 nosocomial infection: Real-world results of environmental surface testing from a large tertiary cancer center. Cancer. 2021;127(11):1926-32. doi: 10.1002/cncr.33453. PubMed PMID: 33599303; PMCID: PMC8014051.

Toppmeyer DL (CIPT),
Haffty BG (CIPT),
Libutti SK (CIPT, GICG),
Evens AM (CIPT)

Srivastava A, Patel HV, Kim S, Shinder B, Sterling J, Tabakin AL, Polotti CF, Saraiya B, Mayer T, Kim IY, Ghodoussipour S, Patel HD, Jang TL, Singer EA. Delaying surgery for clinical T1b-T2bN0M0 renal cell carcinoma: Oncologic implications in the COVID-19 era and beyond. Urol Oncol. 2021;39(5):247-57. doi: 10.1016/j.urolonc.2020.10.012. PubMed PMID: 33223368; PMCID: PMC7574787.

Saraiya B (CIPT),
Mayer T (CIPT),
Kim IY (CIPT), Ghodoussipour S (CIPT),
Jang TL (CPC),
Singer EA (CIPT)

Cecchini M, Kortmansky JS, Cui C, Wei W, Thumar JR, Uboha NV, Hafez N, Lacy J, Fischbach NA, Sabbath KD, Gomez CM, Sporn JR, Stein S, Hochster HS. A phase 1b expansion study of TAS-102 with oxaliplatin for refractory metastatic colorectal cancer. Cancer. 2021;127(9):1417-24. doi: 10.1002/cncr.33379. PubMed PMID: 33351187; PMCID: PMC8085021.

Hochster HS (CIPT)

Nagarsheth NB, Norberg SM, Sinkoe AL, Adhikary S, Meyer TJ, Lack JB, Warner AC, Schweitzer C, Doran SL, Korrapati S, Stevanović S, Trimble CL, Kanakry JA, Bagheri MH, Ferraro E, Astrow SH, Bot A, Faquin WC, Stroncek D, Gkitsas N, Highfill S, Hinrichs CS. TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers. Nat Med. 2021;27(3):419-25. doi: 10.1038/s41591-020-01225-1. PubMed PMID: 33558725; PMCID: PMC9620481.

Hinrichs CS (CIPT, CMI)

Yuan Z, Gardiner JC, Maggi EC, Huang S, Adem A, Bagdasarov S, Li G, Lee S, Slegowski D, Exarchakis A, Howe JR, Lattime EC, Zang X, Libutti SK. B7 immune-checkpoints as targets for the treatment of neuroendocrine tumors. Endocr Relat Cancer. 2021;28(2):135-49. doi: 10.1530/erc-20-0337. PubMed PMID: 33410766; PMCID: PMC8486311.

Lattime EC (CMI),
Libutti SK (CIPT, GICG)

Kopetz S, Guthrie KA, Morris VK, Lenz HJ, Magliocco AM, Maru D, Yan Y, Lanman R, Manyam G, Hong DS, Sorokin A, Atreya CE, Diaz LA, Allegra C, Raghav KP, Wang SE, Lieu CH, McDonough SL, Philip PA, Hochster HS. Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406). J Clin Oncol. 2021;39(4):285-94. doi: 10.1200/jco.20.01994. PubMed PMID: 33356422; PMCID: PMC8462593.

Hochster HS (CIPT)

Evens AM, Danilov A, Jagadeesh D, Sperling A, Kim SH, Vaca R, Wei C, Rector D, Sundaram S, Reddy N, Lin Y, Farooq U, D'Angelo C, Bond DA, Berg S, Churnetski MC, Godara A, Khan N, Choi YK, Yazdy M, Rabinovich E, Varma G, Karmali R, Mian A, Savani M, Burkart M, Martin P, Ren A, Chauhan A, Diefenbach C, et al. Burkitt lymphoma in the modern era: real-world outcomes and prognostication across 30 US cancer centers. Blood. 2021;137(3):374-86. doi: 10.1182/blood.2020006926. PubMed PMID: 32663292; PMCID: PMC8765121.

Evens AM (CIPT),
Lin Y (CPC),
David KA (CIPT)

Riedlinger GM, Joshi S, Hirshfield KM, Barnard N, Ganesan S. Targetable alterations in invasive pleomorphic lobular carcinoma of the breast. Breast Cancer Res. 2021;23(1):7. doi: 10.1186/s13058-020-01385-5. PubMed PMID: 33441174; PMCID: PMC7805167.

Riedlinger GM (CIPT), Hirshfield KM (GICG), Ganesan S (CIPT)

Panda A, Ganesan S. Genomic and Immunologic Correlates of Indoleamine 2,3-Dioxygenase Pathway Expression in Cancer. Front Genet. 2021;12:706435. doi: 10.3389/fgene.2021.706435. PubMed PMID: 34367262; PMCID: PMC8340027.

Ganesan S (CIPT)

Leung CN, Howell DM, Howell RW. Radium-223 dichloride causes transient changes in natural killer cell population and cytotoxic function. Int J Radiat Biol. 2021;97(10):1417-24. doi: 10.1080/09553002.2021.1956002. PubMed PMID: 34264175; PMCID: PMC8580662.

Howell RW (CIPT)

Chang GJ, You YNY, Russell CA, Tierno MB, Turner M, Bennett JP, Lau A, Hochster HS. Young-Onset Colon Cancer and Recurrence Risk by Gene Expression. J Natl Cancer Inst. 2020;112(11):1170-3. doi: 10.1093/jnci/djaa019. PubMed PMID: 32040172; PMCID: PMC7669228.

Hochster HS (CIPT)

Gulhati P, Yin J, Pederson L, Schmoll HJ, Hoff P, Douillard JY, Hecht JR, Tournigand C, Tebbut N, Chibaudel B, Gramont A, Shi Q, Overman MJ. Threshold Change in CEA as a Predictor of Non-Progression to First-Line Systemic Therapy in Metastatic Colorectal Cancer Patients With Elevated CEA. J Natl Cancer Inst. 2020;112(11):1127-36. doi: 10.1093/jnci/djaa020. PubMed PMID: 32191317; PMCID: PMC7669230.

Gulhati P (CIPT)

Wang SJ, Khullar K, Kim S, Yegya-Raman N, Malhotra J, Groisberg R, Crayton SH, Silk AW, Nosher JL, Gentile MA, Mehnert JM, Jabbour SK. Effect of cyclo-oxygenase inhibitor use during checkpoint blockade immunotherapy in patients with metastatic melanoma and non-small cell lung cancer. J Immunother Cancer. 2020;8(2). doi: 10.1136/jitc-2020-000889. PubMed PMID: 33020239; PMCID: PMC7537331.

Malhotra J (CIPT), Groisberg R (CIPT), Mehnert JM (CIPT), Jabbour SK (CIPT)

Jan I, Chen K, Sayan M, Uprety P, Laumbach RJ, Ennis RD, Haffty BG. Prevalence of Surface Contamination With SARS-CoV-2 in a Radiation Oncology Clinic. JAMA Oncol. 2020;6(10):1632-4. doi: 10.1001/jamaoncol.2020.3552. PubMed PMID: 32852509; PMCID: PMC7453342.

Laumbach RJ (CPC),
Haffty BG (CIPT)

Rodday AM, Hahn T, Kumar AJ, Lindenauer PK, Friedberg JW, Evens AM, Parsons SK. First-line treatment in older patients with Hodgkin lymphoma: a Surveillance, Epidemiology, and End Results (SEER)-Medicare population-based study. Br J Haematol. 2020;190(2):222-35. doi: 10.1111/bjh.16525. PubMed PMID: 32090325; PMCID: PMC7368808.

Evens AM (CIPT)

Jabbour SK, Berman AT, Decker RH, Lin Y, Feigenberg SJ, Gettinger SN, Aggarwal C, Langer CJ, Simone CB, 2nd, Bradley JD, Aisner J, Malhotra J. Phase 1 Trial of Pembrolizumab Administered Concurrently With Chemoradiotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Nonrandomized Controlled Trial. JAMA Oncol. 2020;6(6):848-55. doi: 10.1001/jamaoncol.2019.6731. PubMed PMID: 32077891; PMCID: PMC7042914.

Jabbour SK (CIPT),
Lin Y (CPC),
Aisner J (CIPT),
Malhotra J (CIPT)

Panda A, Rosenfeld JA, Singer EA, Bhanot G, Ganesan S. Genomic and immunologic correlates of LAG-3 expression in cancer. Oncoimmunology. 2020;9(1):1756116. doi: 10.1080/2162402x.2020.1756116. PubMed PMID: 32923111; PMCID: PMC7458666.

Singer EA (CIPT),
Bhanot G (GICG),
Ganesan S (CIPT)

Ravi D, Sarkar S, Purvey S, Passero F, Beheshti A, Chen Y, Mokhtar M, David K, Konry T, Evens AM. Interaction kinetics with transcriptomic and secretory responses of CD19-CAR natural killer-cell therapy in CD20 resistant non-hodgkin lymphoma. Leukemia. 2020;34(5):1291-304. doi: 10.1038/s41375-019-0663-x. PubMed PMID: 31772298; PMCID: PMC7196029.

David K (CIPT),
Evens AM (CIPT)

Staquicini FI, Smith TL, Tang FHF, Gelovani JG, Giordano RJ, Libutti SK, Sidman RL, Cavenee WK, Arap W, Pasqualini R. Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies. Cancer Gene Ther. 2020;27(5):301-10. doi: 10.1038/s41417-019-0101-2. PubMed PMID: 31130731; PMCID: PMC6879804.

Staquicini FI (CP),
Libutti SK (CIPT, GICG),
Arap W (CIPT),
Pasqualini R (CP)

Sparano JA, Gray RJ, Makower DF, Albain KS, Saphner TJ, Badve SS, Wagner LI, Kaklamani VG, Keane MM, Gomez HL, Reddy PS, Goggins TF, Mayer IA, Toppmeyer DL, Brufsky AM, Goetz MP, Berenberg JL, Mahalcioiu C, Desbiens C, Hayes DF, Dees EC, Geyer CE, Jr., Olson JA, Jr., Wood WC, Lively T, Paik S, Ellis MJ, Abrams J, Sledge GW, Jr. Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial. JAMA Oncol. 2020;6(3):367-74. doi: 10.1001/jamaoncol.2019.4794. PubMed PMID: 31566680; PMCID: PMC6777230.

Toppmeyer DL (CIPT)

Iqbal S, McDonough S, Lenz HJ, Ilson D, Burtness B, Nangia CS, Barzi A, Schneider CJ, Liu JJ, Dotan E, Guthrie KA, Hochster HS. Randomized, Phase II Study Prospectively Evaluating Treatment of Metastatic Esophageal, Gastric, or Gastroesophageal Cancer by Gene Expression of ERCC1: SWOG S1201. J Clin Oncol. 2020;38(5):472-9. doi: 10.1200/jco.19.00925. PubMed PMID: 31815582; PMCID: PMC7007287.

Hochster HS (CIPT)

Omene C, Ma L, Moore J, Ouyang H, Illa-Bochaca I, Chou W, Patel MS, Sebastiano C, Demaria S, Mao JH, Karagoz K, Gatza ML, Barcellos-Hoff MH. Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can Be Prevented by Dietary Intervention. Cancer Immunol Res. 2020;8(2):217-29. doi: 10.1158/2326-6066.Cir-19-0253. PubMed PMID: 31831632; PMCID: PMC7002223.

Omene C (CIPT),
Gatza ML (GICG)

Sokol ES, Pavlick D, Khiabanian H, Frampton GM, Ross JS, Gregg JP, Lara PN, Oesterreich S, Agarwal N, Necchi A, Miller VA, Alexander B, Ali SM, Ganesan S, Chung JH. Pan-Cancer Analysis of BRCA1 and BRCA2 Genomic Alterations and Their Association With Genomic Instability as Measured by Genome-Wide Loss of Heterozygosity. JCO Precis Oncol. 2020;4:442-65. doi: 10.1200/po.19.00345. PubMed PMID: 32903788; PMCID: PMC7446440.

Khiabanian H (GICG),
Ganesan S (CIPT)

Malhotra J, Jabbour SK, Pine S. Impact of surveillance frequency on survival in non-small cell lung cancer (NSCLC) survivors. Translational lung cancer research. 2019;8(Suppl 4):S347-S50. doi: 10.21037/tlcr.2019.05.04. PubMed PMID: 32038912; PMCID: PMC6987361.

Malhotra J (CIPT),
Jabbour SK (CIPT),
Pine S (GICG)

NeMoyer R, Mondal A, Vora M, Langenfeld E, Glover D, Scott M, Lairson L, Rongo C, Augeri DJ, Peng Y, Jabbour SK, Langenfeld J. Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein. Cell Commun Signal. 2019;17(1):150. doi: 10.1186/s12964-019-0469-5. PubMed PMID: 31744505; PMCID: PMC6862756.

Augeri DJ (CP),
Jabbour SK (CIPT),
Langenfeld J (CIPT)

Castellano GM, Aisner J, Burley SK, Vallat B, Yu HA, Pine SR, Ganesan S. A Novel Acquired Exon 20 EGFR M766Q Mutation in Lung Adenocarcinoma Mediates Osimertinib Resistance but is Sensitive to Neratinib and Poziotinib. J Thorac Oncol. 2019;14(11):1982-8. doi: 10.1016/j.jtho.2019.06.015. PubMed PMID: 31254668; PMCID: PMC8080261.

Aisner J (CIPT),
Burley SK (CP),
Vallat B (CP),
Pine SR (GICG),
Ganesan S (CIPT)

Suwan K, Yata T, Waramit S, Przystal JM, Stoneham CA, Bentayebi K, Asavarut P, Chongchai A, Pothachareon P, Lee KY, Topanurak S, Smith TL, Gelovani JG, Sidman RL, Pasqualini R, Arap W, Hajitou A. Next-generation of targeted AAVP vectors for systemic transgene delivery against cancer. Proc Natl Acad Sci U S A. 2019;116(37):18571-7. doi: 10.1073/pnas.1906653116. PubMed PMID: 31375630; PMCID: PMC6744886.

Pasqualini R (CP),
Arap W (CIPT)

Haffty BG, McCall LM, Ballman KV, Buchholz TA, Hunt KK, Boughey JC. Impact of Radiation on Locoregional Control in Women with Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy and Axillary Lymph Node Dissection: Results from ACOSOG Z1071 Clinical Trial. Int J Radiat Oncol Biol Phys. 2019;105(1):174-82. doi: 10.1016/j.ijrobp.2019.04.038. PubMed PMID: 31085287; PMCID: PMC6699883.

Haffty BG (CIPT)

Lenz HJ, Ou FS, Venook AP, Hochster HS, Niedzwiecki D, Goldberg RM, Mayer RJ, Bertagnolli MM, Blanke CD, Zemla T, Qu X, Wirapati P, Tejpar S, Innocenti F, Kabbarah O. Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance). J Clin Oncol. 2019;37(22):1876-85. doi: 10.1200/jco.18.02258. PubMed PMID: 31042420; PMCID: PMC6675593.

Hochster HS (CIPT)

Kim IE, Jr., Kim S, Srivastava A, Saraiya B, Mayer T, Kim WJ, Kim IY. Similar incidence of DNA damage response pathway alterations between clinically localized and metastatic prostate cancer. BMC Urol. 2019;19(1):33. doi: 10.1186/s12894-019-0453-9. PubMed PMID: 31060606; PMCID: PMC6501301.

Saraiya B (CIPT),
Mayer T (CIPT),
Kim IY (CIPT)

Ramanathan RK, McDonough SL, Philip PA, Hingorani SR, Lacy J, Kortmansky JS, Thumar J, Chiorean EG, Shields AF, Behl D, Mehan PT, Gaur R, Seery T, Guthrie KA, Hochster HS. Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313. J Clin Oncol. 2019;37(13):1062-9. doi: 10.1200/jco.18.01295. PubMed PMID: 30817250; PMCID: PMC6494359.

Hochster HS (CIPT)

Jhawar SR, Rivera-Núñez Z, Drachtman R, Cole PD, Hoppe BS, Parikh RR. Association of Combined Modality Therapy vs Chemotherapy Alone With Overall Survival in Early-Stage Pediatric Hodgkin Lymphoma. JAMA Oncol. 2019;5(5):689-95. doi: 10.1001/jamaoncol.2018.5911. PubMed PMID: 30605220; PMCID: PMC6512456.

Drachtman R (CIPT),
Cole PD (CIPT),
Parikh RR (CIPT)

Khan AJ, LaCava S, Mehta M, Schiff D, Thandoni A, Jhawar S, Danish S, Haffty BG, Chen S. The glutamate release inhibitor riluzole increases DNA damage and enhances cytotoxicity in human glioma cells, in vitro and in vivo. Oncotarget. 2019;10(29):2824-34. doi: 10.18632/oncotarget.26854. PubMed PMID: 31073373; PMCID: PMC6497458.

Haffty BG (CIPT),
Chen S (CP)

Einstein MH, Ndlovu N, Lee J, Stier EA, Kotzen J, Garg M, Whitney K, Lensing SY, Tunmer M, Kadzatsa W, Palefsky J, Krown SE. Cisplatin and radiation therapy in HIV-positive women with locally advanced cervical cancer in sub-Saharan Africa: A phase II study of the AIDS malignancy consortium. Gynecol Oncol. 2019;153(1):20-5. doi: 10.1016/j.ygyno.2019.01.023. PubMed PMID: 30773222; PMCID: PMC6430646.

Einstein MH (CIPT)

Riedlinger G, Hadigol M, Khiabanian H, Ganesan S. Association of JAK2-V617F Mutations Detected by Solid Tumor Sequencing With Coexistent Myeloproliferative Neoplasms. JAMA Oncol. 2019;5(2):265-7. doi: 10.1001/jamaoncol.2018.6286. PubMed PMID: 30605212; PMCID: PMC6439565.

Riedlinger G (CIPT), Khiabanian H (GICG), Ganesan S (CIPT)

Sayan M, Yegya-Raman N, Greco SH, Gui B, Zhang A, Chundury A, Grandhi MS, Hochster HS, Kennedy TJ, Langan RC, Malhotra U, Rustgi VK, Shah MM, Spencer KR, Carpizo DR, Nosher JL, Jabbour SK. Rethinking the Role of Radiation Therapy in the Treatment of Unresectable Hepatocellular Carcinoma: A Data Driven Treatment Algorithm for Optimizing Outcomes. Front Oncol. 2019;9:345. doi: 10.3389/fonc.2019.00345. PubMed PMID: 31275846; PMCID: PMC6591511.

Hochster HS (CIPT),
Spencer KR (CIPT),
Carpizo DR (CIPT),
Jabbour SK (CIPT)

Na B, Yu X, Withers T, Gilleran J, Yao M, Foo TK, Chen C, Moore D, Lin Y, Kimball SD, Xia B, Ganesan S, Carpizo DR. Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation. NPJ Breast Cancer. 2019;5:14. doi: 10.1038/s41523-019-0110-1. PubMed PMID: 30993195; PMCID: PMC6465291.

Moore D (CPC),
Lin Y (CPC),
Xia B (GICG),
Ganesan S (CIPT),
Carpizo DR (CIPT)

Yegya-Raman N, Aisner J, Kim S, Sayan M, Li D, Langenfeld J, Patel M, Malhotra J, Jabbour SK. Synchronous Oligometastatic Non-small Cell Lung Cancer Managed with Curative-Intent Chemoradiation Therapy: Long-term Outcomes from a Single Institution. Adv Radiat Oncol. 2019;4(3):541-50. doi: 10.1016/j.adro.2019.03.005. PubMed PMID: 31360811; PMCID: PMC6639751.

Aisner J (CIPT),
Langenfeld J (CIPT),
Malhotra J (CIPT),
Jabbour SK (CIPT)

Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg MW, Mehnert JM, Guo JY, Lattime E, Rabinowitz JD, White E. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563(7732):569-73. doi: 10.1038/s41586-018-0697-7. PubMed PMID: 30429607; PMCID: PMC6287937.

Su X (CMI),
Mehnert JM (CIPT),
Guo JY (CMI),
Lattime E (CMI),
Rabinowitz JD (CMI),
White E (CMI)

Smith CC, Beckermann KE, Bortone DS, De Cubas AA, Bixby LM, Lee SJ, Panda A, Ganesan S, Bhanot G, Wallen EM, Milowsky MI, Kim WY, Rathmell WK, Swanstrom R, Parker JS, Serody JS, Selitsky SR, Vincent BG. Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma. J Clin Invest. 2018;128(11):4804-20. doi: 10.1172/jci121476. PubMed PMID: 30137025; PMCID: PMC6205406.

Ganesan S (CIPT),
Bhanot G (GICG)

Parsons SK, Kelly MJ, Cohen JT, Castellino SM, Henderson TO, Kelly KM, Keller FG, Henzer TJ, Kumar AJ, Johnson P, Meyer RM, Radford J, Raemaekers J, Hodgson DC, Evens AM. Early-stage Hodgkin lymphoma in the modern era: simulation modelling to delineate long-term patient outcomes. Br J Haematol. 2018;182(2):212-21. doi: 10.1111/bjh.15255. PubMed PMID: 29707774; PMCID: PMC6055753.

Evens AM (CIPT)

Dinizo M, Shih W, Kwon YS, Eun D, Reese A, Giusto L, Trabulsi EJ, Yuh B, Ruel N, Marchalik D, Hwang J, Kundu SD, Eggener S, Kim IY. Multi-institution analysis of racial disparity among African-American men eligible for prostate cancer active surveillance. Oncotarget. 2018;9(30):21359-65. doi: 10.18632/oncotarget.25103. PubMed PMID: 29765545; PMCID: PMC5940363.

Shih W (CIPT),
Kim IY (CIPT)