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A Phase 1 Study of SynKIR-310, Autologous T Cells Transduced With CD19 KIR-CAR, in Participants With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma.

Primary:
- To evaluate the safety of a single IV infusion of SynKIR-310 in participants with relapsed/refractory B cell Non- Hodgkin Lymphoma (B-NHL).

- To determine the recommended Phase 2 dose (RP2D) of SynKIR-310 in participants with relapsed/refractory B-NHL.

Secondary:
- To evaluate feasibility of administering a single IV infusion of SynKIR-310 in participants with relapsed/refractory B cell Non-Hodgkin Lymphoma (B-NHL).

- To evaluate preliminary efficacy measures of SynKIR-310 in participants with relapsed/refractory B-NHL.

Protocol Number: 012504
Phase: Phase I
Applicable Disease Sites: Non-Hodgkin's Lymphoma
Drugs Involved: SynKIR-310
Principal Investigator: Matthew Matasar
Scope: National
Therapies Involved: Chemotherapy single agent systemic
Participating Institutions:
  • Rutgers University
Inclusion & Exclusion Criteria

Please note that we have obtained the inclusion and exclusion criteria information from the National Institutes of Health’s clinical trials web site ClinicalTrials.gov. The listed criteria may not necessarily reflect recent amendments to the protocol and the current criteria.

For further information about clinical trials, please contact us at 732-235-7356.