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Collection of Pediatric and Adult Research Specimens for CNS Malignancies

Objectives:

1. To make available acquired specimens to clinically validate Real-time PCR assays that identify somatic mutations in circulating tumor DNA (ctDNA) using SuperSelective primers.

2. Evaluate the use of blood-based biomarker panels and facilitate real-time diagnosis, therapeutic responses, disease progression, and potentially identifying available targeted therapeutics.

3. Clinically correlate the results of the blood-based biomarker panels with clinical presentation at baseline and each available timepoint. Clinical patient profiles will include, but not be limited to, baseline tumor tissue mutation analysis, key laboratory evaluations, radiographic assessments, treatment responses, and disease progression/recurrence.

4. Feasibility of collecting biological specimens in pediatric and adult patients with CNS malignancies. These biospecimen will include blood and, when available, cerebrospinal fluid.

5. Quality of life of pediatric patients with CNS malignancies using the Pediatric Quality of Life Inventory (PedsQL) core module. This aim will be limited to the pediatric portion of this study

Protocol Number: 112503
Phase: N/A
Applicable Disease Sites: Brain and Nervous System
Principal Investigator: Nehal Parikh
Scope: Local
Participating Institutions:
  • RWJBarnabas Health
    • Cooperman Barnabas, Livingston
    • Newark Beth Israel Medical Center
  • Rutgers University

For further information about clinical trials, please contact us at 732-235-7356.