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Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification And Intensification Clinical Trial Evaluation.
Protocol: 082201Principal Investigator:
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Lara Hathout
Applicable Disease Sites: Prostate -
A Phase 2 Study of Bevacizumab, Erlotinib and Atezolizumab in Subjects with Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Associated or Sporadic Papillary Renal Cell Cancer.
Protocol: 082203Principal Investigator:
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Ryan Stephenson
Applicable Disease Sites: Kidney -
A Phase II/III Trial of MEDI4736 (Durvalumab) and Chemotherapy for Patients with High Grade Upper Tract Urothelial Cancer Prior to Nephroureterectomy.
Protocol: 082210Principal Investigator:
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Saum Ghodoussipour
Applicable Disease Sites: Other Female Genital
Other Male Genital
Urinary Bladder -
International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study).
Protocol: 082212Principal Investigator:
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Thomas Jang
Applicable Disease Sites: Other Male Genital -
A Randomized Phase III Trial oflntravesical BCG veRsus Intravesical Docetaxel and GEmcitabine Treatment in BCG Naive High Grade Non-Muscle Invasive Bladder Cancer (BRIDGE).
Protocol: 082303Principal Investigator:
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Saum Ghodoussipour
Applicable Disease Sites: Urinary Bladder -
Randomized Study of ONC-392 plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) who Progressed on Androgen Receptor (AR) Pathway Inhibition
Protocol: 082304Principal Investigator:
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Biren Saraiya
Applicable Disease Sites: Prostate -
NRG-GU012: Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Study (SAMURAI)
Protocol: 082305Principal Investigator:
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Lara Hathout
Applicable Disease Sites: Kidney -
A032103: MODERN: An Integrated Phase 2/3 and Phase 3 Trial of MRD-Based Optimization of ADjuvant ThErapy in URothelial CaNcer
Protocol: 082401Principal Investigator:
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Biren Saraiya
Applicable Disease Sites: Urinary Bladder -
A Phase 3, Randomized Study Evaluating the Efficacy and Safety of TAR-210 Erdafitinib
Intravesical Delivery System Versus Single Agent Intravesical Chemotherapy in Participants With Intermediate-risk Non-muscle Invasive Bladder Cancer (IR-NMIBC) and Susceptible FGFR Alterations
Protocol: 082404Principal Investigator:
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Saum Ghodoussipour
Applicable Disease Sites: Urinary Bladder -
Melanoma Margins Trial (MelMarT): A Phase III, Multi-Centre, Multi-National Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma.
Protocol: 092202Principal Investigator:
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Adam Berger
Applicable Disease Sites: Melanoma, Skin -
Phase 2/3 Randomized Study of Tebentafusp as Monotherapy and in Combination with Pembrolizumab Versus Investigator's Choice in HLAA*02:01-Positive Participants with Previously Treated Advanced Melanoma.
Protocol: 092203Principal Investigator:
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Ryan Stephenson
Applicable Disease Sites: Melanoma, Skin -
A Phase I Study to Evaluate the Safety of Naltrexone and Propranolol in Combination with Standard of Care Ipilimumab and Nivolumab in Patients with Advanced Melanoma.
Protocol: 092302Principal Investigator:
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Ryan Stephenson
Applicable Disease Sites: Melanoma, Skin -
NCI 10204 - A Phase 1b Study of Nivolumab in Patients with Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)
Protocol: 092305Principal Investigator:
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Sarah Weiss
Applicable Disease Sites: Melanoma, Skin -
A Randomized Phase III Study of Neoadjuvant Chemotherapy followed by Surgery versus Surgery Alone for Patients with High Risk RetroPeritoneal Sarcoma (STRASS 2).
Protocol: 092401Principal Investigator:
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Vadim Koshenkov
Applicable Disease Sites: Other Skin -
Assessment of Carboplatin Clearance Predictors: A PK Study on NCI-Sponsored Clinical Trials or Standard of Care Treatments Using Carboplatin.
Protocol: 102003Principal Investigator:
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Eugenia Girda
Applicable Disease Sites: Any Site -
A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer Among BRC1 Carriers.
Protocol: 102005Principal Investigator:
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Eugenia Girda
Applicable Disease Sites: Ovary