Researcher Directory

Academic Appointment

Professor
Coriell Institute for Medical Research

Research Interests

• Elucidate the molecular mechanisms and functional role of Hippo/YAP/TAZ in mediating CSCs traits, therapy resistance and metastases in gastroesophageal cancers
• Elucidate HippoYAP/SOXs/CSCs mediated tumor immunosuppressive microenvironment and the interaction among tumor cells, macrophage, cancer associated fibroblast (CAFs) and T cells for novel therapeutic strategies.
• Exploring novel immune checkpoints from patients derived metastatic cells/tissues and identify the effective target and immune combination therapies using syngenetic and genetic mouse models
• Building strong translational GI programs (PDXs, organoids etc) and facilitate novel discoveries from patients’