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Researcher Publications

Xiaoyang Su, PhD

Selected Publications

  1. X. Su, W. Lu, J.D. Rabinowitz, Metabolite Spectral Accuracy on Orbitraps, Anal. Chem. 89 (2017) 5940–5948. doi:10.1021/acs.analchem.7b00396.
  2. W. Lu, X. Su, M.S. Klein, I.A. Lewis, O. Fiehn, J.D. Rabinowitz, Metabolite Measurement: Pitfalls to Avoid and Practices to Follow, Annu. Rev. Biochem. 86 (2017) 277–304. doi:10.1146/annurev-biochem-061516-044952.
  3. Z. Zhang, L. Chen, L. Liu, X. Su, J.D. Rabinowitz, Chemical Basis for Deuterium Labeling of Fat and NADPH, J. Am. Chem. Soc. 139 (2017) 14368–14371. doi:10.1021/jacs.7b08012.
  4. R.C. Oslund, X. Su, M. Haugbro, J.M. Kee, M. Esposito, Y. David, B. Wang, E. Ge, D.H. Perlman, Y. Kang, T.W. Muir, J.D. Rabinowitz, Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate, Nat. Chem. Biol. 13 (2017) 1081–1087. doi:10.1038/nchembio.2453.
  5. L. Liu, X. Su, W.J. Quinn, S. Hui, K. Krukenberg, D.W. Frederick, P. Redpath, L. Zhan, K. Chellappa, E. White, M. Migaud, T.J. Mitchison, J.A. Baur, J.D. Rabinowitz, Quantitative Analysis of NAD Synthesis-Breakdown Fluxes, Cell Metab. 27 (2018) 1067-1080.e5. doi:10.1016/j.cmet.2018.03.018.
  6. L. Poillet-Perez, X. Xie, L. Zhan, Y. Yang, D.W. Sharp, Z.S. Hu, X. Su, A. Maganti, C. Jiang, W. Lu, H. Zheng, M.W. Bosenberg, J.M. Mehnert, J.Y. Guo, E. Lattime, J.D. Rabinowitz, E. White, Autophagy maintains tumour growth through circulating arginine, Nature. 563 (2018) 569–573. doi:10.1038/s41586-018-0697-7.
  7. J.G. Moloughney, N.M. Vega-Cotto, S. Liu, C. Patel, P.K. Kim, C.C. Wu, D. Albaciete, C. Magaway, A. Chang, S. Rajput, X. Su, G. Werlen, E. Jacinto, MTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation, J. Biol. Chem. 293 (2018) 16464–16478. doi:10.1074/jbc.RA118.003991.
  8. M. Dong, E.E. Dando, I. Kotliar, X. Su, B. Dzikovski, J.H. Freed, H. Lin, The asymmetric function of Dph1–Dph2 heterodimer in diphthamide biosynthesis, J. Biol. Inorg. Chem. 24 (2019) 777–782. doi:10.1007/s00775-019-01702-0.
  9. V. Bhatt, K. Khayati, Z.S. Hu, A. Lee, W. Kamran, X. Su, J.Y. Guo, Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient kras-driven lung tumorigenesis, Genes Dev. 33 (2019) 150–165. doi:10.1101/gad.320481.118.
  10. E. Chiles, Y. Wang, K.M. Kalemba, H. Kwon, F.E. Wondisford, X. Su, Fast LC-MS quantitation of glucose and glycerol via enzymatic derivatization, Anal. Biochem. 575 (2019) 40–43. doi:10.1016/j.ab.2019.03.020.
  11. D. Du, L. Tan, Y. Wang, B. Peng, J.N. Weinstein, F.E. Wondisford, X. Su, P.L. Lorenzi, ElemCor: Accurate data analysis and enrichment calculation for high-resolution LC-MS stable isotope labeling experiments, BMC Bioinformatics. 20 (2019) 1–9. doi:10.1186/s12859-019-2669-9.
  12. A.J. Bott, J. Shen, C. Tonelli, L. Zhan, N. Sivaram, Y.P. Jiang, X. Yu, V. Bhatt, E. Chiles, H. Zhong, S. Maimouni, W. Dai, S. Velasquez, J.A. Pan, N. Muthalagu, J. Morton, T.G. Anthony, H. Feng, W.H. Lamers, D.J. Murphy, J.Y. Guo, J. Jin, H.C. Crawford, L. Zhang, E. White, R.Z. Lin, X. Su, D.A. Tuveson, W.X. Zong, Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism, Cell Rep. 29 (2019) 1287-1298.e6. doi:10.1016/j.celrep.2019.09.056.
  13. K.M. Kalemba, Y. Wang, H. Xu, E. Chiles, S.M. McMillin, H. Kwon, X. Su, F.E. Wondisford, Glycerol induces G6pc in primary mouse hepatocytes and is the preferred substrate for gluconeogenesis both in vitro and in vivo, J. Biol. Chem. 294 (2019) 18017–18028. doi:10.1074/jbc.RA119.011033.
  14. L. Wang, X. Xing, L. Chen, L. Yang, X. Su, H. Rabitz, W. Lu, J.D. Rabinowitz, Peak Annotation and Verification Engine for Untargeted LC-MS Metabolomics, Anal. Chem. 91 (2019). doi:10.1021/acs.analchem.8b03132.
  15. Y. Wang, H. Kwon, X. Su, F.E. Wondisford, Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting, Mol. Metab. 31 (2020) 36–44. doi:10.1016/j.molmet.2019.11.005.
  16. X. Su, E. Chiles, S. Maimouni, F.E. Wondisford, W.-X. Zong, C. Song, In-Source CID Ramping and Covariant Ion Analysis of Hydrophilic Interaction Chromatography Metabolomics, Anal. Chem. 14 (2020) 37. doi:10.1021/acs.analchem.9b04181.
  17. M. Dragan, M.U. Nguyen, S. Guzman, C. Goertzen, M. Brackstone, W.S. Dhillo, P.R. Bech, S. Clarke, A. Abbara, A.B. Tuck, D.A. Hess, S.R. Pine, W.X. Zong, F.E. Wondisford, X. Su, A. V Babwah, M. Bhattacharya, G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer, Cell Death Dis. 11 (2020). doi:10.1038/s41419-020-2305-7.
  18. L. Chen, R.P. Vasoya, N.H. Toke, A. Parthasarathy, S. Luo, E. Chiles, J. Flores, N. Gao, E.M. Bonder, X. Su, M.P. Verzi, HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice, Gastroenterology. 158 (2020) 985-999.e9. doi:10.1053/j.gastro.2019.11.031.
  19. L. Yang, J.C. Garcia Canaveras, Z. Chen, L. Wang, L. Liang, C. Jang, J.A. Mayr, Z. Zhang, J.M. Ghergurovich, L. Zhan, S. Joshi, Z. Hu, M.R. McReynolds, X. Su, E. White, R.J. Morscher, J.D. Rabinowitz, Serine Catabolism Feeds NADH when Respiration Is Impaired, Cell Metab. 31 (2020) 809-821.e6. doi:10.1016/j.cmet.2020.02.017.
  20. J. Liu, C. Zhang, H. Wu, X.-X. Sun, Y. Li, S. Huang, X. Yue, S.-E. Lu, Z. Shen, X. Su, E. White, B.G. Haffty, W. Hu, Z. Feng, Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression, J. Clin. Invest. 130 (2020) 3253–3269. doi:10.1172/JCI132876.
  21. S.A. Skubel, X. Su, A. Poulev, L.C. Foxcroft, V. Dushenkov, I. Raskin, Metabolomic differences between invasive alien plants from native and invaded habitats, Sci. Rep. 10 (2020) 1–9. doi:10.1038/s41598-020-66477-w.

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