New Brunswick, N.J. – An analysis of lymph node dissection in renal cell carcinoma (a type of kidney cancer) that has not spread to other organs (non-metastatic) indicates the procedure is often performed for stage 1 disease and shows no overall survival benefit. Investigators from Rutgers Cancer Institute of New Jersey presented the work as part of a poster presentation at the Annual Meeting of the American Urological Association taking place this week in San Francisco.
Practice guidelines from the American Urological Association recommend lymph node dissection in renal cell carcinoma if it is thought the cancer has spread to the lymph nodes. The aim is to determine disease staging and prognosis, however, whether there is a clinical benefit to this practice remains unclear.
Investigators examined information from the National Cancer Database on 110,963 patients with non-metastatic renal cell carcinoma who underwent surgery between 2010 and 2014 to either have full or partial removal of a kidney. Of those patients, 11,867 also underwent lymph node dissection at the same time. They found that out of the group that underwent concurrent lymph node dissection, 35.5 percent of the cases were stage 1 disease; 32.6 percent were stage 2; 26.7 percent were stage 3; and 5.2 percent were stage 4. There was no significant change in rate of lymph node dissection from 2010 to 2014.
A majority of the surgeries (57 percent) were performed through an open method, while 25 percent of the cases were conducted through a laparoscopic approach and 18 percent through robotic methods. Kaplan-Meier analysis did not show a significant improvement in mean overall survival for those patients who had lymph node dissection compared to those who did not (34.55 months versus 34.48 months respectively). Cox regression analysis showed lymph node dissection was not associated with an overall survival benefit.
“Our results demonstrate that among renal cell carcinoma patients, lymph node dissections are performed most often for those with stage 1 disease, which suggests that this procedure is potentially being over utilized,” explains Eric A. Singer, MD, MA, FACS urologic oncologist at Rutgers Cancer Institute and senior investigator of the work.
“With our work showing no overall survival benefit to any of the subgroups of patients who underwent lymph node dissection, including those thought to have cancer involving their lymph nodes, further research is warranted to determine which patient populations might benefit from this procedure alone or in combination with systemic therapy,” adds Dr. Singer, who is also director of the Kidney Cancer Program at Rutgers Cancer Institute and an assistant professor of surgery at Rutgers Robert Wood Johnson Medical School.
Along with Singer, other authors on the work are: Nicholas Farber, Rutgers Robert Wood Johnson Medical School; Zorimar Rivera-Nunez and Sinae Kim, Rutgers Cancer Institute of New Jersey; Kushan Radadia, Brian Shinder, Joshua Sterling and Parth K. Modi, Rutgers Robert Wood Johnson Medical School; Sharad Goyal, George Washington University School of Medicine and Health Sciences; Rahul Parikh, Robert Weiss, Isaac Y. Kim, Sammy E. Elsamra and Thomas L. Jang, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School.
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