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Cancer Metabolism and Growth Selected Program-Related Publications


Key to Member Program Affiliation
Cancer Metabolism and Growth
Genomic Instability and Cancer Genetics 
Cancer Pharmacology 
Clinical Investigations and Precision Therapeutics
Cancer Prevention and Control 

Publications with PMCID

Cancer Institute Member(s) Credited

Heck BW, Devenport D. Trans-endocytosis of Planar Cell Polarity Complexes during Cell Division. Curr. Biol. 2017 Dec 04;27(23):3725-3733.e4. PMID: 29174888; PMCID: PMC5728440. Devenport D (CMG)
Lu Y, Xie S, Zhang W, Zhang C, Gao C, Sun Q, Cai Y, Xu Z, Xiao M, Xu Y, Huang X, Wu X, Liu W, Wang F, Kang Y, Zhou T. Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Res. 2017 Dec;27(12):1422-1440. PMID: 28829046; PMCID: PMC5717399. Kang Y (CMG)
Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, Gatza ML, Xia D, Gao J, White E, Haffty BG, Hu W, Feng Z. Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. Nat Commun. 2017 Nov 28;8(1):1823. PMID: 29180628; PMCID: PMC5703960. Gatza ML (GICG), White E (CMG), Haffty BG (CIPT), Hu W (GICG), Feng Z (GICG)
Donovan J, Rath S, Kolet-Mandrikov D, Korennykh A. Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery. RNA. 2017 11;23(11):1660-1671. PMID: 28808124; PMCID: PMC5648034. Korennykh A (CMG)
Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc. Natl. Acad. Sci. U.S.A. 2017 Oct 24;114(43):11404-11409. PMID: 29073064; PMCID: PMC5664509. Gitai Z (CMG), Kim H (CP), Rabinowitz JD (CMG)
Zhang Z, Chen L, Liu L, Su X, Rabinowitz JD. Chemical Basis for Deuterium Labeling of Fat and NADPH. J. Am. Chem. Soc. 2017 Oct 18;139(41):14368-14371. PMID: 28911221; PMCID: PMC5748894. Su X (CMG), Rabinowitz JD (CMG)
Lue HW, Podolak J, Kolahi K, Cheng L, Rao S, Garg D, Xue CH, Rantala JK, Tyner JW, Thornburg KL, Martinez-Acevedo A, Liu JJ, Amling CL, Truillet C, Louie SM, Anderson KE, Evans MJ, O'Donnell VB, Nomura DK, Drake JM, Ritz A, Thomas GV. Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade. Genes Dev. 2017 Oct 15;31(20):2067-2084. PMID: 29138276; PMCID: PMC5733498. Drake JM (CMG)
Sánchez-Cid L, Pons M, Lozano JJ, Rubio N, Guerra-Rebollo M, Soriano A, Paris-Coderch L, Segura MF, Fueyo R, Arguimbau J, Zodda E, Bermudo R, Alonso I, Caparrós X, Cascante M, Rafii A, Kang Y, Martínez-Balbás M, Weiss SJ, Blanco J, Muñoz M, Fernández PL, Thomson TM. MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells. Oncotarget. 2017 Oct 13;8(48):83384-83406. PMID: 29137351; PMCID: PMC5663523. Kang Y (CMG)
Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Nat. Chem. Biol. 2017 Oct;13(10):1081-1087. PMID: 28805803; PMCID: PMC5605442. Su X (CMG), Kang Y (CMG), Muir TW (CP), Rabinowitz JD (CMG)
Nofal M, Zhang K, Han S, Rabinowitz JD. mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein. Mol. Cell. 2017 Sep 21;67(6):936-946.e5. PMID: 28918901; PMCID: PMC5612669. Rabinowitz JD (CMG)
Liu DD, Kang Y. Ets2 anchors the prometastatic function of mutant p53 in osteosarcoma. Genes Dev. 2017 Sep 15;31(18):1823-1824. PMID: 29051386; PMCID: PMC5695082. Kang Y (CMG)
Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ. Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017 Sep 11;32(3):377-391.e9. PMID: 28898698; PMCID: PMC5751418. Rabinowitz JD (CMG)
Lu Y, Zhang X, Bouladoux N, Kaul SN, Jin K, Sant'Angelo D, Belkaid Y, Kovalovsky D. Zbtb1 controls NKp46+ ROR-gamma-T+ innate lymphoid cell (ILC3) development. Oncotarget. 2017 Aug 22;8(34):55877-55888. PMID: 28915559; PMCID: PMC5593530. Sant'Angelo D (CMG)
Shi J, Feng J, Xie J, Mei Z, Shi T, Wang S, Du Y, Yang G, Wu Y, Cheng X, Li S, Zhu L, Yang CS, Tu S, Jie Z. Targeted blockade of TGF-β and IL-6/JAK2/STAT3 pathways inhibits lung cancer growth promoted by bone marrow-derived myofibroblasts. Sci Rep. 2017 Aug 17;7(1):8660. PMID: 28819126; PMCID: PMC5561133. Yang CS (CMG)
Denzin LK, Khan AA, Virdis F, Wilks J, Kane M, Beilinson HA, Dikiy S, Case LK, Roopenian D, Witkowski M, Chervonsky AV, Golovkina TV. Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob. Immunity. 2017 Aug 15;47(2):310-322.e7. PMID: 28813660; PMCID: PMC5568092. Denzin LK (CMG)
Yue X, Zhang C, Zhao Y, Liu J, Lin AW, Tan VM, Drake JM, Liu L, Boateng MN, Li J, Feng Z, Hu W. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev. 2017 Aug 15;31(16):1641-1654. PMID: 28947497; PMCID: PMC5647935. Drake JM (CMG), Feng Z (GICG), Hu W (GICG)
Massa CB, Groves AM, Jaggernauth SU, Laskin DL, Gow AJ. Histologic and biochemical alterations predict pulmonary mechanical dysfunction in aging mice with chronic lung inflammation. PLoS Comput. Biol. 2017 Aug;13(8):e1005570. PMID: 28837561; PMCID: PMC5570219. Laskin DL (CMG)
Winer BY, Huang TS, Pludwinski E, Heller B, Wojcik F, Lipkowitz GE, Parekh A, Cho C, Shrirao A, Muir TW, Novik E, Ploss A. Long-term hepatitis B infection in a scalable hepatic co-culture system. Nat Commun. 2017 07 25;8(1):125. PMID: 28743900; PMCID: PMC5527081. Muir TW (CP), Ploss A (CMG)
Thapa P, Romero Arocha S, Chung JY, Sant'Angelo DB, Shapiro VS. Histone deacetylase 3 is required for iNKT cell development. Sci Rep. 2017 Jul 19;7(1):5784. PMID: 28724935; PMCID: PMC5517478. Sant'Angelo DB (CMG)
Yang S, Jan YH, Mishin V, Heck DE, Laskin DL, Laskin JD. Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. Chem. Res. Toxicol. 2017 Jul 17;30(7):1406-1418. PMID: 28595002; PMCID: PMC5708134. Laskin DL (CMG), Laskin JD (ZY)
Alečković M, Wei Y, LeRoy G, Sidoli S, Liu DD, Garcia BA, Kang Y. Identification of Nidogen 1 as a lung metastasis protein through secretome analysis. Genes Dev. 2017 Jul 15;31(14):1439-1455. PMID: 28827399; PMCID: PMC5588926. Garcia BA (GICG), Kang Y (CMG)
Guo Y, Su ZY, Zhang C, Gaspar JM, Wang R, Hart RP, Verzi MP, Kong AN. Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq. Biochem. Pharmacol. 2017 07 01;135:22-34. PMID: 28267439; PMCID: PMC5541256. Guo Y (CMG), Hart RP (CMG), Verzi MP (GICG), Kong AN (CIPT, CP)
Bak MJ, Das Gupta S, Wahler J, Lee HJ, Li X, Lee MJ, Yang CS, Suh N. Inhibitory Effects of γ- and δ-Tocopherols on Estrogen-Stimulated Breast Cancer In Vitro and In Vivo. Cancer Prev Res (Phila). 2017 Mar;10(3):188-197. PMID: 28096236; PMCID: PMC5337152. Yang CS (CMG), Suh N (CIPT)
Goyal Y, Jindal GA, Pelliccia JL, Yamaya K, Yeung E, Futran AS, Burdine RD, Schüpbach T, Shvartsman SY. Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nat. Genet. 2017 Mar;49(3):465-469. PMID: 28166211; PMCID: PMC5621734. Schüpbach T (CMG)
Melentijevic I, Toth ML, Arnold ML, Guasp RJ, Harinath G, Nguyen KC, Taub D, Parker JA, Neri C, Gabel CV, Hall DH, Driscoll M. C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. Nature. 2017 02 16;542(7641):367-371. PMID: 28178240; PMCID: PMC5336134. Driscoll M (CMG)
Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat. Med. 2017 Feb;23(2):235-241. PMID: 28024083; PMCID: PMC5407288. Rabinowitz JD (CMG)
Jindal GA, Goyal Y, Yamaya K, Futran AS, Kountouridis I, Balgobin CA, Schüpbach T, Burdine RD, Shvartsman SY. In vivo severity ranking of Ras pathway mutations associated with developmental disorders. Proc. Natl. Acad. Sci. U.S.A. 2017 Jan 17;114(3):510-515. PMID: 28049852; PMCID: PMC5255624. Schüpbach T (CMG)
Norris A, Tammineni P, Wang S, Gerdes J, Murr A, Kwan KY, Cai Q, Grant BD. SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes. Proc. Natl. Acad. Sci. U.S.A. 2017 Jan 17;114(3):E307-E316. PMID: 28053230; PMCID: PMC5255583. Cai Q (CMG)
Ducker GS, Rabinowitz JD. One-Carbon Metabolism in Health and Disease. Cell Metab. 2017 Jan 10;25(1):27-42. PMID: 27641100; PMCID: PMC5353360. Rabinowitz JD (CMG)
Geng K, Kumar S, Kimani SG, Kholodovych V, Kasikara C, Mizuno K, Sandiford O, Rameshwar P, Kotenko SV, Birge RB. Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6. Front Immunol. 2017;8:1521. PMID: 29176978; PMCID: PMC5686386. Kotenko SV (CMG), Birge RB (CMG)
Shou P, Chen Q, Jiang J, Xu C, Zhang J, Zheng C, Jiang M, Velletri T, Cao W, Huang Y, Yang Q, Han X, Zhang L, Wei L, Rabson AB, Chin YE, Wang Y, Shi Y. Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells. Oncogene. 2016 Nov 17;35(46):5953-5962. PMID: 27109100; PMCID: PMC5079855. Rabson AB (CMG), Shi Y (CMG)
Pan Y, Heemskerk I, Ibar C, Shraiman BI, Irvine KD. Differential growth triggers mechanical feedback that elevates Hippo signaling. Proc. Natl. Acad. Sci. U.S.A. In process 2016 Oct 26. PMID: 27791172; PMCID: PMC5111668. Irvine KD (CMG)
Kohlhapp FJ, Huelsmann EJ, Lacek AT, Schenkel JM, Lusciks J, Broucek JR, Goldufsky JW, Hughes T, Zayas JP, Dolubizno H, Sowell RT, Kühner R, Burd S, Kubasiak JC, Nabatiyan A, Marshall S, Bommareddy PK, Li S, Newman JH, Monken CE, Shafikhani SH, Marzo AL, Guevara-Patino JA, Lasfar A, Thomas PG, Lattime EC, Kaufman HL, Zloza A. Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death. Cell Rep. 2016 10 18;17(4):957-965. PMID: 27760326; PMCID: PMC5589518. Li S (CMG), Lattime EC (CMG), Kaufman HL (CIPT), Zloza A (CIPT)
Kumar N, Srivillibhuthur M, Joshi S, Walton KD, Zhou A, Faller WJ, Perekatt AO, Sansom OJ, Gumucio DL, Xing J, Bonder EM, Gao N, White E, Verzi MP. A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016 10 15;143(20):3711-3722. PMID: 27802136; PMCID: PMC5087649. Gao N (CMG), White E (CMG), Verzi MP (GICG)
Moloughney JG, Kim PK, Vega-Cotto NM, Wu CC, Zhang S, Adlam M, Lynch T, Chou PC, Rabinowitz JD, Werlen G, Jacinto E. mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Mol. Cell. 2016 Sep 01;63(5):811-26. PMID: 27570073; PMCID: PMC5006067. Rabinowitz JD (CMG), Jacinto E (CMG)
Amaravadi R, Kimmelman AC, White E. Recent insights into the function of autophagy in cancer. Genes Dev. 2016 Sep 01;30(17):1913-30. PMID: 27664235; PMCID: PMC5066235. White E (CMG)
Aw WY, Heck BW, Joyce B, Devenport D. Transient Tissue-Scale Deformation Coordinates Alignment of Planar Cell Polarity Junctions in the Mammalian Skin. Curr. Biol. 2016 Aug 22;26(16):2090-100. PMID: 27451904; PMCID: PMC5005808. Devenport D (CMG)
Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park J, Hsu CP, Tian B, Pan D, Sadoshima J, Del Re DP. NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart. Circ. Res. 2016 Aug 19;119(5):596-606. PMID: 27402866; PMCID: PMC4992450. Tian B (GICG), Sadoshima J (CMG, CP)
Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, Stoyanova T, Faltermeier CM, Uzunangelov V, Carlin DE, Fleming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, Huang J, Wohlschlegel JA, Graeber TG, Witte ON, Stuart JM. Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. 2016 Aug 11;166(4):1041-1054. PMID: 27499020; PMCID: PMC4985183. Drake JM (CMG)
Frederick DW, Loro E, Liu L, Davila A, Chellappa K, Silverman IM, Quinn WJ, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016 Aug 09;24(2):269-82. PMID: 27508874; PMCID: PMC4985182. Liu L (CP), Rabinowitz JD (CMG)
Cui R, Yue W, Lattime EC, Stein MN, Xu Q, Tan XL. Targeting tumor-associated macrophages to combat pancreatic cancer. Oncotarget. 2016 Aug 02;7(31):50735-50754. PMID: 27191744; PMCID: PMC5226617. Lattime EC (CMG), Tan XL (CPC)
Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016 Aug 01;30(15):1704-17. PMID: 27516533; PMCID: PMC5002976. Guo JY (CMG), Chan CS (GICG), Rabinowitz JD (CMG), White E (CMG)
Bird JG, Zhang Y, Tian Y, Panova N, Barvík I, Greene L, Liu M, Buckley B, Krásný L, Lee JK, Kaplan CD, Ebright RH, Nickels BE. The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA. Nature. 2016 07 21;535(7612):444-7. PMID: 27383794; PMCID: PMC4961592. Nickels BE (CMG)
Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab. 2016 Jun 14;23(6):1140-1153. PMID: 27211901; PMCID: PMC4909566. Kang Y (CMG), Rabinowitz JD (CMG)
Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, Barcinski M, Brekken RA, Huang X, Hutchins JT, Freimark B, Empig C, Mercer J, Schroit AJ, Schett G, Herrmann M. Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer. Cell Death Differ. 2016 Jun;23(6):962-78. PMID: 26915293; PMCID: PMC4987730. Birge RB (CMG)
Mehnert JM, Panda A, Zhong H, Hirshfield K, Damare S, Lane K, Sokol L, Stein MN, Rodriguez-Rodriquez L, Kaufman HL, Ali S, Ross JS, Pavlick DC, Bhanot G, White EP, DiPaola RS, Lovell A, Cheng J, Ganesan S. Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer. J. Clin. Invest. 2016 Jun 01;126(6):2334-40. PMID: 27159395; PMCID: PMC4887167. Mehnert JM (CIPT), Hirshfield K (GICG), Rodriguez-Rodriquez L (CIPT), Kaufman HL (CIPT), Bhanot G (GICG), White EP (CMG), DiPaola RS (CIPT), Ganesan S (CIPT)
He L, Chang E, Peng J, An H, McMillin SM, Radovick S, Stratakis CA, Wondisford FE. Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production. J. Biol. Chem. 2016 May 13;291(20):10562-70. PMID: 27002150; PMCID: PMC4865906. Radovick S (CMG), Wondisford FE (CMG)
Zong WX, Rabinowitz JD, White E. Mitochondria and Cancer. Mol. Cell. 2016 Mar 03;61(5):667-676. PMID: 26942671; PMCID: PMC4779192. Zong WX (CMG), Rabinowitz JD (CMG), White E (CMG)
Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, Zong WX. TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Mol. Cell. 2016 Mar 03;61(5):720-733. PMID: 26942676; PMCID: PMC4779181. Zong WX (CMG)
Santanam U, Banach-Petrosky W, Abate-Shen C, Shen MM, White E, DiPaola RS. Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. Genes Dev. 2016 Feb 15;30(4):399-407. PMID: 26883359; PMCID: PMC4762425. White E (CMG), DiPaola RS (CIPT)
Weng M, Wieschaus E. Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly. J. Cell Biol. 2016 Jan 18;212(2):219-29. PMID: 26754645; PMCID: PMC4738385. Wieschaus E (CMG)
Faltermeier CM, Drake JM, Clark PM, Smith BA, Zong Y, Volpe C, Mathis C, Morrissey C, Castor B, Huang J, Witte ON. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proc. Natl. Acad. Sci. U.S.A. 2016 Jan 12;113(2):E172-81. PMID: 26621741; PMCID: PMC4720329. Drake JM (CMG)
Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, Wu H, Blanco F, Li S, Bhanot G, Haffty BG, Hu W, Feng Z. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife. 2016 Jan 11;5:e10727. PMID: 26751560; PMCID: PMC4749555. Li S (CMG), Bhanot G (GICG), Haffty BG (CIPT), Hu W (GICG), Feng Z (GICG)
Bott AJ, Peng IC, Fan Y, Faubert B, Zhao L, Li J, Neidler S, Sun Y, Jaber N, Krokowski D, Lu W, Pan JA, Powers S, Rabinowitz J, Hatzoglou M, Murphy DJ, Jones R, Wu S, Girnun G, Zong WX. Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metab. 2015 Dec 01;22(6):1068-77. PMID: 26603296; PMCID: PMC4670565. Rabinowitz J (CMG), Zong WX (CMG)
Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, Hsieh JJ, Ganesan S, Chan CS, White E. The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. Cell Rep. 2015 Dec 01;13(9):1895-908. PMID: 26655904; PMCID: PMC4779191. Ganesan S (CIPT), Chan CS (GICG), White E (CMG)
Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D. Tumour exosome integrins determine organotropic metastasis. Nature. 2015 Nov 19;527(7578):329-35. PMID: 26524530; PMCID: PMC4788391. Garcia BA (GICG), Kang Y (CMG)
White E, Mehnert JM, Chan CS. Autophagy, Metabolism, and Cancer. Clin. Cancer Res. 2015 Nov 15;21(22):5037-46. PMID: 26567363; PMCID: PMC4646728. White E (CMG), Mehnert JM (CIPT), Chan CS (GICG)
Kim HY, Pang MF, Varner VD, Kojima L, Miller E, Radisky DC, Nelson CM. Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung. Dev. Cell. 2015 Sep 28;34(6):719-26. PMID: 26387457; PMCID: PMC4589145. Nelson CM (CMG)
Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03;525(7567):109-13. PMID: 26258302; PMCID: PMC4720389. Irvine KD (CMG)
DiPaola RS, Chen YH, Bubley GJ, Stein MN, Hahn NM, Carducci MA, Lattime EC, Gulley JL, Arlen PM, Butterfield LH, Wilding G. A national multicenter phase 2 study of prostate-specific antigen (PSA) pox virus vaccine with sequential androgen ablation therapy in patients with PSA progression: ECOG 9802. Eur. Urol. 2015 Sep;68(3):365-71. PMID: 25533418; PMCID: PMC4472612. DiPaola RS (CIPT), Lattime EC (CMG)
Das Gupta S, Sae-tan S, Wahler J, So JY, Bak MJ, Cheng LC, Lee MJ, Lin Y, Shih WJ, Shull JD, Safe S, Yang CS, Suh N. Dietary γ-Tocopherol-Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response, and PPARγ. Cancer Prev Res (Phila). 2015 Sep;8(9):807-16. PMID: 26130252; PMCID: PMC4560648. Shih WJ (CIPT), Yang CS (CMG), Suh N (CIPT)
Yue W, Zheng X, Lin Y, Yang CS, Xu Q, Carpizo D, Huang H, DiPaola RS, Tan XL. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget. 2015 Aug 28;6(25):21208-24. PMID: 26056043; PMCID: PMC4673260. Zheng X (CIPT), Yang CS (CMG), Carpizo D (CIPT, CP), DiPaola RS (CIPT), Tan XL (CPC)
Wu A, Zhang Q, Lambert G, Khin Z, Gatenby RA, Kim HJ, Pourmand N, Bussey K, Davies PC, Sturm JC, Austin RH. Ancient hot and cold genes and chemotherapy resistance emergence. Proc. Natl. Acad. Sci. U.S.A. 2015 Aug 18;112(33):10467-72. PMID: 26240372; PMCID: PMC4547268. Austin RH (CMG)
Varner VD, Gleghorn JP, Miller E, Radisky DC, Nelson CM. Mechanically patterning the embryonic airway epithelium. Proc. Natl. Acad. Sci. U.S.A. 2015 Jul 28;112(30):9230-5. PMID: 26170292; PMCID: PMC4522767. Nelson CM (CMG)
Gjorevski N, Piotrowski AS, Varner VD, Nelson CM. Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices. Sci Rep. 2015 Jul 13;5:11458. PMID: 26165921; PMCID: PMC4499882. Nelson CM (CMG)
Shrestha R, Little KA, Tamayo JV, Li W, Perlman DH, Devenport D. Mitotic Control of Planar Cell Polarity by Polo-like Kinase 1. Dev. Cell. 2015 Jun 08;33(5):522-34. PMID: 26004507; PMCID: PMC4464975. Devenport D (CMG)
Cheng XT, Zhou B, Lin MY, Cai Q, Sheng ZH. Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes. J. Cell Biol. 2015 May 11;209(3):377-86. PMID: 25940348; PMCID: PMC4427784. Cai Q (CMG)
Xie X, Koh JY, Price S, White E, Mehnert JM. Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. Cancer Discov. 2015 Apr;5(4):410-23. PMID: 25673642; PMCID: PMC4390491. White E (CMG), Mehnert JM (CIPT)
Wang K, Yan R, Cooper KF, Strich R. Cyclin C mediates stress-induced mitochondrial fission and apoptosis. Mol. Biol. Cell. 2015 Mar 15;26(6):1030-43. PMID: 25609094; PMCID: PMC4357504. Strich R (CMG)
Blythe SA, Wieschaus EF. Zygotic genome activation triggers the DNA replication checkpoint at the midblastula transition. Cell. 2015 Mar 12;160(6):1169-81. PMID: 25748651; PMCID: PMC4359640. Wieschaus EF (CMG)
Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res. 2015 Feb 01;75(3):544-53. PMID: 25644265; PMCID: PMC4316379. Rabinowitz JD (CMG)
Lalani AI, Moore CR, Luo C, Kreider BZ, Liu Y, Morse HC, Xie P. Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice. J. Immunol. 2015 Jan 01;194(1):334-48. PMID: 25422508; PMCID: PMC4272913. Xie P (CMG)
Olayanju B, Hampsey JJ, Hampsey M. Genetic analysis of the Warburg effect in yeast. Adv Biol Regul. 2015 Jan;57:185-92. PMID: 25446884; PMCID: PMC5399883. Hampsey M (CMG)
White E. The role for autophagy in cancer. J. Clin. Invest. 2015 Jan;125(1):42-6. PMID: 25654549; PMCID: PMC4382247. White E (CMG)
Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, Thompson CB. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov. 2014 Dec;4(12):1406-17. PMID: 25186948; PMCID: PMC4258153. Rabinowitz JD (CMG)
Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res. 2014 Oct 01;74(19):5480-92. PMID: 25113996; PMCID: PMC4184946. Yang CS (CMG), Verzi MP (GICG), Gao N (CMG)
Chakrabarti R, Wei Y, Hwang J, Hang X, Andres Blanco M, Choudhury A, Tiede B, Romano RA, DeCoste C, Mercatali L, Ibrahim T, Amadori D, Kannan N, Eaves CJ, Sinha S, Kang Y. ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat. Cell Biol. 2014 Oct;16(10):1004-15, 1-13. PMID: 25241036; PMCID: PMC4183725. Kang Y (CMG)
Mathew R, Khor S, Hackett SR, Rabinowitz JD, Perlman DH, White E. Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Mol. Cell. 2014 Sep 18;55(6):916-930. PMID: 25175026; PMCID: PMC4169768. Rabinowitz JD (CMG), White E (CMG)
Tsou WI, Nguyen KQ, Calarese DA, Garforth SJ, Antes AL, Smirnov SV, Almo SC, Birge RB, Kotenko SV. Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation. J. Biol. Chem. 2014 Sep 12;289(37):25750-63. PMID: 25074926; PMCID: PMC4162177. Birge RB (CMG), Kotenko SV (CMG)
Nguyen KQ, Tsou WI, Calarese DA, Kimani SG, Singh S, Hsieh S, Liu Y, Lu B, Wu Y, Garforth SJ, Almo SC, Kotenko SV, Birge RB. Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity. J. Biol. Chem. 2014 Sep 12;289(37):25737-49. PMID: 25074939; PMCID: PMC4162176. Kotenko SV (CMG), Birge RB (CMG)
Codelia VA, Sun G, Irvine KD. Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr. Biol. 2014 Sep 08;24(17):2012-7. PMID: 25127217; PMCID: PMC4160395. Irvine KD (CMG)
Zheng H, Shen M, Zha YL, Li W, Wei Y, Blanco MA, Ren G, Zhou T, Storz P, Wang HY, Kang Y. PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. Cancer Cell. 2014 Sep 08;26(3):358-373. PMID: 25203322; PMCID: PMC4159622. Kang Y (CMG)
Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov. 2014 Aug;4(8):914-27. PMID: 24875857; PMCID: PMC4125614. Guo JY (CMG), Chan CS (GICG), Rabinowitz JD (CMG), White E (CMG)
Oh H, Slattery M, Ma L, White KP, Mann RS, Irvine KD. Yorkie promotes transcription by recruiting a histone methyltransferase complex. Cell Rep. 2014 Jul 24;8(2):449-59. PMID: 25017066; PMCID: PMC4152371. Irvine KD (CMG)
Zakaria S, Mao Y, Kuta A, de Sousa CF, Gaufo GO, McNeill H, Hindges R, Guthrie S, Irvine KD, Francis-West PH. Regulation of neuronal migration by Dchs1-Fat4 planar cell polarity. Curr. Biol. 2014 Jul 21;24(14):1620-1627. PMID: 24998526; PMCID: PMC4193925. Irvine KD (CMG)
Wan L, Lu X, Yuan S, Wei Y, Guo F, Shen M, Yuan M, Chakrabarti R, Hua Y, Smith HA, Blanco MA, Chekmareva M, Wu H, Bronson RT, Haffty BG, Xing Y, Kang Y. MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors. Cancer Cell. 2014 Jul 14;26(1):92-105. PMID: 24981741; PMCID: PMC4101059. Haffty BG (CIPT), Kang Y (CMG)
Rauskolb C, Sun S, Sun G, Pan Y, Irvine KD. Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex. Cell. 2014 Jul 03;158(1):143-156. PMID: 24995985; PMCID: PMC4082802. Irvine KD (CMG)
Strohecker AM, White E. Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers. Cancer Discov. 2014 Jul;4(7):766-72. PMID: 24860158; PMCID: PMC4090279. White E (CMG)
Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD. Quantitative flux analysis reveals folate-dependent NADPH production. Nature. 2014 Jun 12;510(7504):298-302. PMID: 24805240; PMCID: PMC4104482. Rabinowitz JD (CMG)
Perekatt AO, Valdez MJ, Davila M, Hoffman A, Bonder EM, Gao N, Verzi MP. YY1 is indispensable for Lgr5+ intestinal stem cell renewal. Proc. Natl. Acad. Sci. U.S.A. 2014 May 27;111(21):7695-700. PMID: 24821761; PMCID: PMC4040551. Gao N (CMG), Verzi MP (GICG)
Devergne O, Tsung K, Barcelo G, Schüpbach T. Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A. 2014 May 27;111(21):7689-94. PMID: 24828534; PMCID: PMC4040573. Schüpbach T (CMG)
He B, Doubrovinski K, Polyakov O, Wieschaus E. Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation. Nature. 2014 Apr 17;508(7496):392-6. PMID: 24590071; PMCID: PMC4111109. Wieschaus E (CMG)
Laddha SV, Ganesan S, Chan CS, White E. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Mol. Cancer Res. 2014 Apr;12(4):485-90. PMID: 24478461; PMCID: PMC3989371. Ganesan S (CIPT), Chan CS (GICG), White E (CMG)
Park J, Schwarzbauer JE. Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition. Oncogene. 2014 Mar 27;33(13):1649-57. PMID: 23624917; PMCID: PMC3934944. Schwarzbauer JE (CMG)
Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson AB, Roberts AI, Wang Y, Shi Y. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res. 2014 Mar 01;74(5):1576-87. PMID: 24452999; PMCID: PMC3959857. Rabson AB (CMG), Shi Y (CMG)
Shao D, Oka S, Liu T, Zhai P, Ago T, Sciarretta S, Li H, Sadoshima J. A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. Cell Metab. 2014 Feb 04;19(2):232-45. PMID: 24506865; PMCID: PMC3937768. Li H (CP), Sadoshima J (CMG, CP)
Kimani SG, Geng K, Kasikara C, Kumar S, Sriram G, Wu Y, Birge RB. Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity. Front Immunol. 2014;5:566. PMID: 25426118; PMCID: PMC4226236. Birge RB (CMG)
Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell. 2013 Dec 05;155(6):1216-9. PMID: 24315093; PMCID: PMC3987898. Guo JY (CMG), Xia B (GICG), White E (CMG)
Fan J, Kamphorst JJ, Mathew R, Chung MK, White E, Shlomi T, Rabinowitz JD. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol. Syst. Biol. 2013 Dec 03;9:712. PMID: 24301801; PMCID: PMC3882799. White E (CMG), Rabinowitz JD (CMG)
Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov. 2013 Nov;3(11):1272-85. PMID: 23965987; PMCID: PMC3823822. White E (CMG)
She P, Bunpo P, Cundiff JK, Wek RC, Harris RA, Anthony TG. General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice. J. Biol. Chem. 2013 Oct 25;288(43):31250-60. PMID: 24019515; PMCID: PMC3829435. Anthony TG (CMG)
Ell B, Mercatali L, Ibrahim T, Campbell N, Schwarzenbach H, Pantel K, Amadori D, Kang Y. Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. Cancer Cell. 2013 Oct 14;24(4):542-56. PMID: 24135284; PMCID: PMC3832956. Kang Y (CMG)
Wu A, Loutherback K, Lambert G, Estévez-Salmerón L, Tlsty TD, Austin RH, Sturm JC. Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proc. Natl. Acad. Sci. U.S.A. 2013 Oct 01;110(40):16103-8. PMID: 24046372; PMCID: PMC3791735. Austin RH (CMG)
White E. Exploiting the bad eating habits of Ras-driven cancers. Genes Dev. 2013 Oct 01;27(19):2065-71. PMID: 24115766; PMCID: PMC3850091. White E (CMG)
Dorner M, Horwitz JA, Donovan BM, Labitt RN, Budell WC, Friling T, Vogt A, Catanese MT, Satoh T, Kawai T, Akira S, Law M, Rice CM, Ploss A. Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature. 2013 Sep 12;501(7466):237-41. PMID: 23903655; PMCID: PMC3858853. Ploss A (CMG)
Sun G, Irvine KD. Ajuba family proteins link JNK to Hippo signaling. Sci Signal. 2013 Sep 10;6(292):ra81. PMID: 24023255; PMCID: PMC3830546. Irvine KD (CMG)
Rabinowitz JD, Silhavy TJ. Systems biology: metabolite turns master regulator. Nature. 2013 Aug 15;500(7462):283-4. PMID: 23925111; PMCID: PMC4084598. Rabinowitz JD (CMG)
Reaves ML, Young BD, Hosios AM, Xu YF, Rabinowitz JD. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature. 2013 Aug 08;500(7461):237-41. PMID: 23903661; PMCID: PMC4470420. Rabinowitz JD (CMG)
Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E, Xia B. Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov. 2013 Aug;3(8):894-907. PMID: 23650262; PMCID: PMC3740014. Ganesan S (CIPT), Karantza V (CMG), White E (CMG), Xia B (GICG)
Ghosh A, Holland AM, Dogan Y, Yim NL, Rao UK, Young LF, West ML, Singer NV, Lee H, Na IK, Tsai JJ, Jenq RR, Penack O, Hanash AM, Lezcano C, Murphy GF, Liu C, Sadelain M, Sauer MG, Sant'angelo D, van den Brink MR. PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD. Cancer Res. 2013 Aug 01;73(15):4687-96. PMID: 23733752; PMCID: PMC3732814. Sant'angelo D (CMG)
Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, White E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 2013 Jul 01;27(13):1447-61. PMID: 23824538; PMCID: PMC3713426. Guo JY (CMG), Dipaola RS (CIPT), Rabinowitz JD (CMG), White E (CMG)
Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 2013 May 30;497(7451):633-7. PMID: 23665962; PMCID: PMC3810415. Rabinowitz JD (CMG)
Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc. Natl. Acad. Sci. U.S.A. 2013 May 28;110(22):8882-7. PMID: 23671091; PMCID: PMC3670379. White EP (CMG), Rabinowitz JD (CMG)
Xu YF, Létisse F, Absalan F, Lu W, Kuznetsova E, Brown G, Caudy AA, Yakunin AF, Broach JR, Rabinowitz JD. Nucleotide degradation and ribose salvage in yeast. Mol. Syst. Biol. 2013 May 14;9:665. PMID: 23670538; PMCID: PMC4039369. Rabinowitz JD (CMG)
Kang Y, Pantel K. Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell. 2013 May 13;23(5):573-81. PMID: 23680145; PMCID: PMC3667710. Kang Y (CMG)
Radisky DC, Nelson CM. Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion. Oncotarget. 2013 Apr;4(4):498-9. PMID: 23625757; PMCID: PMC3720598. Nelson CM (CMG)
Reddy BV, Irvine KD. Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins. Dev. Cell. 2013 Mar 11;24(5):459-71. PMID: 23484853; PMCID: PMC3624988. Irvine KD (CMG)
Oh H, Slattery M, Ma L, Crofts A, White KP, Mann RS, Irvine KD. Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes. Cell Rep. 2013 Feb 21;3(2):309-18. PMID: 23395637; PMCID: PMC3633442. Irvine KD (CMG)
Liu L, Duclos G, Sun B, Lee J, Wu A, Kam Y, Sontag ED, Stone HA, Sturm JC, Gatenby RA, Austin RH. Minimization of thermodynamic costs in cancer cell invasion. Proc. Natl. Acad. Sci. U.S.A. 2013 Jan 29;110(5):1686-91. PMID: 23319630; PMCID: PMC3562811. Sontag ED (CIPT), Austin RH (CMG)
Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol. Cell. 2012 Dec 28;48(6):875-87. PMID: 23142081; PMCID: PMC3534931. Jacinto E (CMG)
Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B, Wen T, Han Y, Rabson AB, Tischfield JA, Shao C, Shi Y. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell. 2012 Dec 07;11(6):812-24. PMID: 23168163; PMCID: PMC3518598. Rabson AB (CMG), Tischfield JA (GICG), Shi Y (CMG)
Boghaert E, Gleghorn JP, Lee K, Gjorevski N, Radisky DC, Nelson CM. Host epithelial geometry regulates breast cancer cell invasiveness. Proc. Natl. Acad. Sci. U.S.A. 2012 Nov 27;109(48):19632-7. PMID: 23150585; PMCID: PMC3511712. Nelson CM (CMG)
Chakrabarti R, Hwang J, Andres Blanco M, Wei Y, Lukačišin M, Romano RA, Smalley K, Liu S, Yang Q, Ibrahim T, Mercatali L, Amadori D, Haffty BG, Sinha S, Kang Y. Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat. Cell Biol. 2012 Nov;14(11):1212-22. PMID: 23086238; PMCID: PMC3500637. Haffty BG (CIPT), Kang Y (CMG)
Moore CR, Liu Y, Shao C, Covey LR, Morse HC, Xie P. Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice. Leukemia. 2012 May;26(5):1122-7. PMID: 22033491; PMCID: PMC3433763. Covey LR (CIPT), Xie P (CMG)
White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer. 2012 Apr 26;12(6):401-10. PMID: 22534666; PMCID: PMC3664381. White E (CMG)
Xu YF, Amador-Noguez D, Reaves ML, Feng XJ, Rabinowitz JD. Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase. Nat. Chem. Biol. 2012 Apr 22;8(6):562-8. PMID: 22522319; PMCID: PMC3433955. Rabinowitz JD (CMG)
Guan F, Li G, Liu AB, Lee MJ, Yang Z, Chen YK, Lin Y, Shih W, Yang CS. δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats. Cancer Prev Res (Phila). 2012 Apr;5(4):644-54. PMID: 22366914; PMCID: PMC3324634. Shih W (CIPT), Yang CS (CMG)
Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, Yan J, Hua Y, Tiede BJ, Lu X, Haffty BG, Pantel K, Massagué J, Kang Y. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell. 2011 Dec 13;20(6):701-14. PMID: 22137794; PMCID: PMC3241854. Haffty BG (CIPT), Kang Y (CMG)
Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celià-Terrassa T, Mercatali L, Khan Z, Goodarzi H, Hua Y, Wei Y, Hu G, Garcia BA, Ragoussis J, Amadori D, Harris AL, Kang Y. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat. Med. 2011 Aug 07;17(9):1101-8. PMID: 21822286; PMCID: PMC3169707. Garcia BA (GICG), Kang Y (CMG)
Mehnert JM, Tan AR, Moss R, Poplin E, Stein MN, Sovak M, Levinson K, Lin H, Kane M, Gounder M, Lin Y, Shih WJ, White E, Rubin EH, Karantza V. Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach. Mol. Cancer Ther. 2011 Aug;10(8):1509-19. PMID: 21680752; PMCID: PMC3155243. Mehnert JM (CIPT), Tan AR (CIPT), Moss R (CIPT), Poplin E (CIPT), Shih WJ (CIPT), White E (CMG), Karantza V (CMG)


Publications without PMCID

Cancer Institute Member(s) Credited

Kumar S, Lu B, Davra V, Hornbeck P, Machida K, Birge RB. Crk Tyrosine Phosphorylation Regulates PDGF-BB-inducible Src Activation and Breast Tumorigenicity and Metastasis. Mol. Cancer Res. 2018 Jan;16(1):173-183. PMID: 28974561. Birge RB (CMG)
Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. 2017 Dec 14;171(7):1545-1558.e18. PMID: 29153836. Rabinowitz JD (CMG)
Yang M, Bao W, Zhang X, Kang Y, Haffty B, Zhang L. Short-term and long-term clinical outcomes of uncommon types of invasive breast cancer. Histopathology. 2017 Dec;71(6):874-886. PMID: 28746732. Kang Y (CMG), Haffty B (CIPT)
Samavat H, Ursin G, Emory TH, Lee E, Wang R, Torkelson CJ, Dostal AM, Swenson K, Le CT, Yang CS, Yu MC, Yee D, Wu AH, Yuan JM, Kurzer MS. A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer. Cancer Prev Res (Phila). 2017 Dec;10(12):710-718. PMID: 28904061. Yang CS (CMG)
Das Gupta S, Patel M, Wahler J, Bak MJ, Wall B, Lee MJ, Lin Y, Shih WJ, Cai L, Yang CS, Suh N. Differential Gene Regulation and Tumor-Inhibitory Activities of Alpha-, Delta-, and Gamma-Tocopherols in Estrogen-Mediated Mammary Carcinogenesis. Cancer Prev Res (Phila). 2017 Dec;10(12):694-703. PMID: 28972008. Shih WJ (CIPT), Yang CS (CMG), Suh N (CIPT)
Irvine KD, Shraiman BI. Mechanical control of growth: ideas, facts and challenges. Development. 2017 Dec 01;144(23):4238-4248. PMID: 29183937. Irvine KD (CMG)
Feng S, Dai Z, Liu A, Wang H, Chen J, Luo Z, Yang CS. β-Sitosterol and stigmasterol ameliorate dextran sulfate sodium-induced colitis in mice fed a high fat Western-style diet. Food Funct. 2017 Nov 15;8(11):4179-4186. PMID: 29034917. Yang CS (CMG)
Panda A, Mehnert JM, Hirshfield KM, Riedlinger G, Damare S, Saunders T, Kane M, Sokol L, Stein MN, Poplin E, Rodriguez-Rodriguez L, Silk AW, Aisner J, Chan N, Malhotra J, Frankel M, Kaufman HL, Ali S, Ross JS, White EP, Bhanot G, Ganesan S. Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer. J. Natl. Cancer Inst. In process 2017 Nov 15. PMID: 29155997. Mehnert JM (CIPT), Hirshfield KM (GICG), Riedlinger G (CIPT), Poplin E (CIPT), Rodriguez-Rodriguez L (CIPT), Silk AW (CIPT), Aisner J (CIPT), Chan N (CIPT), Malhotra J (CIPT), Kaufman HL (CIPT), White EP (CMG), Bhanot G (GICG), Ganesan S (CIPT)
Wang H, Yang X, Liu A, Wang G, Bosland MC, Yang CS. δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice. Carcinogenesis. In process 2017 Nov 07. PMID: 29121168. Yang CS (CMG)
Esposito M, Guise T, Kang Y. The Biology of Bone Metastasis. Cold Spring Harb Perspect Med. In process 2017 Nov 03. PMID: 29101110. Kang Y (CMG)
Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Zhan , Yanxiang Guo J, White E, Rabinowitz JD. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017 Nov 02;551(7678):115-118. PMID: 29045397. White E (CMG), Rabinowitz JD (CMG)
Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 11;7(11):1266-1283. PMID: 28899863. Rabinowitz J (CMG)
Kumar S, Calianese D, Birge RB. Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment. Immunol. Rev. 2017 Nov;280(1):149-164. PMID: 29027226. Birge RB (CMG)
Espinosa V, Dutta O, McElrath C, Du P, Chang YJ, Cicciarelli B, Pitler A, Whitehead I, Obar JJ, Durbin JE, Kotenko SV, Rivera A. Type III interferon is a critical regulator of innate antifungal immunity. Sci Immunol. 2017 Oct 06;2(16). PMID: 28986419. Whitehead I (GICG), Kotenko SV (CMG)
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