Characterization of Brain Dysfunction During Development in Survivors of Childhood Acute Lymphoblastic Leukemia.

1.1 Primary Objective
Our primary objective is to delineate effects of being treated for childhood leukemia on the developing brain. To that end, our aims are to:
1.1.1 Provide a complete and quantitative characterization of treatment-related effects of chemotherapy treatment on brain functions with electroencephalography (EEG), using well-established auditory cognitive paradigms (Aim 1),
1.2.1 Identify abnormal patterns of neural connectivity in these patients, using EEG and functional MRI, and advanced functional connectivity modeling (Aim 2),
1.3.1 Assess these pathways, and their changes over time in childhood survivors, as well as their relationship to the development of cognitive skills, at both one year and two years following successful cancer treatment chemotherapy treatment (Aim 3).

1.2 Secondary Objective
1.3.1 To assess cortical maturation among survivors and describe relationships between neurophysiologic endpoints and cognitive abilities as determined by neuropsychological testing.

For further information about clinical trials, please contact us at 732-235-7356.