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Researcher Publications

Suzie Chen, PhD

Selected Publications

  1. Pollock, Pamela M., Cohen-Solal, Karine, Sood, Raman, Namkoong, Jin, Koganti, Aruna, Zhu, Hua, Robbins, Christianec, Makalowska, Izabela, Martino, Jeffrey J., Shin, Seung-Shick, Marin, Yari, Roberts, Kathleen G., Yudt, Laura M., Chen, Amy, Cheng, Jun, Incao, Arturo, Pinkett, Heather W., Graham, Christopher L., Dunn, Karen, Crespo-Carbone, Steven M., Mackason, Kerine R., Ryan, Kevin B., Sinsimer, Daniel, Goydos, James, Reuhl, Kenneth R., Eckhaus, Michael, Meltzer, Paul S., Pavan, William J., Trent, Jeffrey M. and Chen, Suzie. Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nature Genetics. 34: 108-112, 2003.
  2. Sood, Raman, Makalowska, Izabela, Galdzicki, Michael, Hu, Ping, Eddings, Erica, Robbins, Christiane M., Moses, Tracy, Namkoong, Jin, Chen, Suzie, and Trent, Jeffrey M. Cloning and characterization of a novel gene SHPRH encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from 6q24 region. Genomics 82:153-161, 2003.
  3. Cohen-Solal, Karine A., Sood, Raman, Marin, Yari, Crespo-Carbone, Steven M., Sinsimer, Daniel, Martino, Jeffrey J., Robbins, Chrisatiane, Makalowska, Izabela, Trent, Jeffrey M. and Chen, Suzie. Identification and characterization of mouse Rab32 by mRNA and protein expression analysis. Biochem. Biophys. Acta. 1651: 68-75, 2003.
  4. Marín, Y., Namkoong, J., Cohen-Solal, K., , Shin, S. S., Martino, J., Oka, M. and Chen, S. Stimulation of Oncogenic Metabotropic Glutamate Receptor 1 in Melanoma Cells Activates ERK1/2 via PKCe. Cell Signaling, 18: 1279-1286, 2006.
  5. Namkoong, J., Shin, S.S., Lee, H.J., Marín, Y.E., Wall, B.A., Goydos, J.S. and Chen, S. Metabotropic Glutamate Receptor 1 (GRM1) and Glutamate Signaling in Human Melanoma. Cancer Res. 67: 2298-2305, 2007.
  6. Shin, S. S., Namkoong, J., Lee, H. J., Wall, B., Gleason, R. and Chen, S. Oncogenic activities of Grm1 in melanocyte transformation. Pig. Cell and Mel. Res. 21: 368-378, 2008.
  7. Yip, D., Le, M., Chan, J., Lee, J., Mehnert, J., Yudd, A., Kempf, J., Shih, W., Chen, S. and Goydos, J. A phase 0 trial of Riluzole in patients with respectable stage III and IV melanoma. Clin. Can. Res. 15: 3896-3902, 2009.
  8. Shin, S. S., Wall, B. and Chen, S. AKT2 is a downstream target of metabotropic glutamate receptor 1 (mGlu1). Pig. Cell and Mel. Res. 23:103-111. 2010.
  9. Khan, A., Wall, B., Ahlawat, S., Green, C., Schiff, D., Mehnert, J., Goydos, J., Chen, S. and Haffty, B. Riluzole enhances ionizing radiation–induced cytotoxicity in human melanoma cells that ectopically express metabotropic glutamate receptor 1 in vitro and in vivo. Clin Can Res. 17:1807-1814, 2011.
  10. Lee, H. J., Wall, B., Wangari-Talbot, J., Shin, S. S., Rosenberg, S., Chan, J. L. K., Namkoong, Goydos, J. and Chen, S. Glutamatergic pathway targeting in melanoma; single agent and combinatorial therapies. Clin Can Res. 17:7080-7092, 2011.
  11. Lee, H.J., Wall, B. A., Wangari-Talbot, J. and Chen, S. Regulation of mGluR1 expression in human melanocytes and melanoma cells. Biochimica et Biophysic Acta 1819: 1123-1131, 2012.
  12. Wangari-Talbot, J., Wall, B. A., Goydos, J. S. and Chen, S. Functional effects of GRM1 suppression in human melanoma cells. Mol. Can. Res. 10: 1-11, 2012.
  13. Martino, J.J., Wall, B.A., Mastrantoni, E., Wilimczyk, B.J., La Cava, S.N., Degenhardt, K., White, E. and Chen, S. Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene, 32: 4366-4376, 2013.
  14. Goraczniak, R., Wall, B., Behlke, M., Lennox, K., Ho, E., Zaphiros, N., Jakubowski, C., Patel, N., Zhao, S., Magaway, C., Subbie, S., Yu, L., LaCava, S., Reuhl, K., Chen, S. and Gunderson, S. U1 Adaptor oligonucleotides targeting BCL2 and GRM1 suppress growth of human melanoma xenografts in vivo. Molecular Therapy and Nucleic Acids. Epub 2013 July 14;2:e92. doi: 10.1038/mtna.2013.24.
  15. Mehta, M., Dolfi, S., Bronfenbrener, R., Bilal, E., Chen, C., Moore, D., Lin, Y., Rahim, H., Aisner, S., Kersellius, R., The, J., Chen, S., Toppmeyer, D., Medina, D., Ganesan, S., Vazquez, A. and Hirshfield, K. Metabotropic glutamate receptor-1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS ONE. 8(7): doi:10.1371/journal.pone.0069851, 2013.
  16. Naczynski, D., Tan, M. Zevon, M., Wall, B., Kohl, J., Kulesa, A., Chen, S., Roth, C., Riman, R. and Moghe, P. Rare-earth-doped Biological composites as in vivo shortwave infrared reporters. Nature Communications. 4:2199 doi: 10.1038/ncomms3199, 2013.
  17. Wall, B., Wangari-Talbot, J., Shin, S., Schiff, D., Sierra, J., Yu, L. J., Khan, A., Haffty, B., Goydos, J. and Chen, S. Disruption of GRM1-mediated signaling using riluzole results I DNA damage in melanoma cells. Pigment Cell Melanoma Res. 27: 263-274, 2014.
  18. Wen, Y., Li, J., Koo, J., Shin, S. S., Lin, Y., Jeong, B. S., Cohen-Solal, K., Mehnert, J., Chen, S. and Goydos, J. Metabotropic glutamate receptor 1 activation leads to downstream pro-angiogenic signaling and enhanced angiogenesis in melanoma. Cancer Research, 74: 2499-2509, 2014.
  19. The, J., Shah, R., Shin, S. S., Wen, Y., Mehnert, J., Goydos, J. and Chen, S. Metabotropic glutamate receptor 1 (mGluR1) mediates melanocyte transformation via transactivation of IGF-1 Receptor. Pigment Cell Melanoma Res. 2014 doi:10.1111/pcmr12237.
  20. Wall, B., Khan, A., Goydos, J., Haffty, B. and Chen, S. Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells. Pigment Cell Melanoma Res. 28: 105-109, 2015.
  21. Teh, J., Shah, R., La Cava, S., Dolfi, S., Mehta, M., Kongara, S., Price, S., Ganesan, S., Reuhl, K., Hirshfield, K., Karantza, V. and Chen, S. Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells. Breast Cancer Research and Treatment. 151:57-73, 2015.
  22. Rosenberg, S., Niglio, S., Salehomoum, N., Chan, J., Jeong, B., Wen, Y., Li, J., Fukui, J., Chen, S., Shin, S. S., and Goydos, J. Targetng glutamatergic signaling and the PI3 kinase pathway to halt melanoma progression. Translational Oncology. 8:1-9, 2015.
  23. Mairhofer, D., Ortner, D., Tripp, C., Schaffenrath, S., Fleming, V., Heger, L., Komenda, K., Reider, D., Dudziak, D., Chen, S., Becker, J., Flacher, V., and Stoitzner, P. Impaired gp100-specific CD8+ T cell responses in the presence of myeloid-derived suppressor cells in a spontaneous mouse melanoma model. Invest. Derm. 135:2785-2793, 2015.
  24. Boregowda, R, K., Medina, D. J., Markert, E., Bryan, M. A., Chen, W., Chen, S., Rabkin, A., Vido, M. J., Gunderson, S. I., Chekmareva, M., Foran, D. J., Lasfar, A., Goydos, J. S. and Cohen-Solal, K. A. The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma. Oncotarget. 2016 Apr 18. doi: 10.18632/oncotarget.8822. [Epub ahead of print].
  25. Hirshfield, K. M., Tolkunov, D., Zhong, H., Ali, S. M., Stein, M. N., Murphy, S., Vig, H., Vazquez, A., Glod, J., Moss, R. A., Belyi, V., Chan, C. S., Chen, S., Goodell, L., Foran, D., Yelensky, R., Palma, N. A., Sun, J. X., Miller, V. A., Stephens, P. J., Ross, J. S., Kaufman, H., Poplin, E., Mehnert, J., Tan, A. R., Bertino, J. R., Aisner, J., DiPaola, R. S., Rodriguez-Rodriguez, L. and Ganesan, S. Clinical actionability of comprehensive genomic profiling for management of rare or refractory cancers. Oncologist, 2016 Aug 26. [Epub ahead of print].
  26. Dolfi, S., Medina, D., Kareddula, A., Paratala, B., Rose, A., Chen, S., Ganesan, S., Mackay, G., Vasquez, A. and Hirshfield, K. Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget, Jul 4;8(27):44639-44653. doi: 10.18632/oncotarget.17961, 2017.
  27. Yu, L. J., Wall, B., Wangari-Talbot, J. and Chen, S. Metabotropic glutamate receptors in cancer. Neuropharmacology, 115: 193-202, 2017.
  28. Kulkarni, A., Al-Hraishaw, H., Hirshfield, K., Chen, S., Pine, S., Jeyamohan, C., Sokol, L., Slrai, A., Lung, T., White, E., Rodriguez, L., Mehnert, J. and Ganesan, S. BRAF fusion as a novel mechanism of acquired resistance to vemurafenib in BRAFV600E mutant melanoma. Clin. Can. Res. 2017 May 24. doi: 10.1158/1078-0432.CCR-16-0758. [Epub ahead of print]
  29. Isola, A., Eddy, K., Zembrzuski, K., Goydos, J. and Chen, S. Exosomes released by metabotropic glutamate receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness. Oncotarget 9: 1187-1199, 2018.
  30. Chen, H. C., Sierra, J., Yu, L, J., Cerchio, R., Wall, B. Goydos, J. and Chen, S. Activation of Grm1 expression by mutated BRAF (V600E) in vitro and in vivo. Oncotarget, 9: 5861-5875, 2018.
  31. Mehnert, J. M., Silk, A. W., Wen, Y., Lee, J. H., Dudek, L., Seong, B. S., Li, J., Schenkel, J. M., Sadimin, E., Kane, M., Lin, H., Hong J. Shih, W. J., Zloza, A., Chen, S. and Goydos, J.S. A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma. Pig Cell and Mel Res. 31: 534-540, 2018.

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