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Researcher Publications

Céline Gélinas, PhD

Selected Publications

  • Kobayashi Y, Gélinas C and Dougherty JP. (2017) Histone deacetylase inhibitors containing a benzamide functional group and a pyridyl cap are preferentially effective human immunodeficiency virus-1 latency-reversing agents in primary resting CD4+ T cells. J. Gen. Virol. 98: 799-809. PMID: 28113052
  • Gilmore TD and Gélinas C. (2015) Methods for Assessing the In Vitro Transforming Activity of NF-kB Transcription Factor c-Rel and Related Proteins. Methods in Molecular Biology. 1280:427-446. PMID: 25736765
  • Medina DJ, Goodell L, Glod J, Gélinas C, Rabson AB and Strair RK. (2012) Mesenchymal stromal cells protect mantle cell lymphoma cells from spontaneous and drug-induced apoptosis through secretion of B-cell activating factor and activation of the canonical and non-canonical nuclear factor kB pathways. Hematologica 97:1255-63. PMID: 22371181 PMCID: PMC3409825
  • Guo JY*, Chen H-Y*, Mathew R*, Fan J*, Strohecker AM, Kamphorst JJ, Chen G, Lemmons JMS, Karantza V, Coller HA, DiPaola RS, Gélinas C, Rabinowitz JD and White E. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes & Dev. 25: 460-470. PMID: 21317241 PMCID: PMC3049287
  • Fan G, Simmons MJ, Ge S, Dutta-Simmons J, Kucharczak J, Ron Y, Weissmann D, Chen CC, Mukherjee C, White E and Gélinas C. (2010) Defective ubiquitin-mediated degradation of anti-apoptotic Bfl-1 predisposes to lymphoma. Blood 115: 3559-3569. PMID: 20185581 PMCID: PMC2867266
  • Drawid A, Gupta N, Nagaraj VH, Gélinas C and Sengupta A. (2009) A Hidden Markov Model with position-dependent transition probabilities accurately predicts the occupancy of a transcription factor on self-overlapping binding motifs. BMC Bioinformatics 10: 208-234. PMID: 19583839 PMCID: PMC2718928
  • Mathew R, Karp C, Beaudoin B, Vuong N, Chen G, Chen H-Y, Bray K, Reddy A, Bhanot G, Gélinas C, DiPaola RS, Karantza-Wadsworth V, White E. (2009) Autophagy suppresses tumorigenesis through elimination of p62. Cell 137: 1062-1075. PMID: 19524509 PMCID: PMC2802318
  • Fan G, Fan Y, Gupta N, Matsuura I, Liu F, Zhen Zhou X, Lu KP and Gélinas C. (2009) Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the Rel proteins in the NF-kB family. Cancer Research 69: 4589-4597. PMID: 19458071 PMCID: PMC2741415
  • Dutta J, Fan G and Gélinas C. (2008) CAPERa is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kB oncoprotein v-Rel. J. Virol. 82: 10792-10802. PMID: 18753212 PMCID: PMC2573166
  • Simmons, M.J, Fan G, Zong, W.X., Degenhardt K, White E and Gélinas C. (2008) Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist. Oncogene 27: 1421-1428. PMID: 17724464 PMCID: PMC2880719
  • Gupta N, Delrow J, Drawid, A., Sengupta AM, Fan G and Gélinas C. (2008) Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by Rel proteins. Cancer Research 68: 808-814. PMID: 18245482 PMCID: PMC2267479
  • Fan, Y, Dutta J, Gupta N, Fan G and Gélinas C. (2008) Regulation of programmed cell death by NF-kB and its role in tumorigenesis and therapy. Adv Exp Med Biol. 615: 223-50. PMID: 18437897
  • Fan, Y. and Gélinas, C. (2007) An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation. Oncogene 26: 4038-4043. PMID: 17173064
  • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson A, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, Nelson D, Jin S and White E. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation and tumorigenesis. Cancer Cell 10: 51-64. PMID: 16843265 PMCID: PMC2857533
  • Dutta J, Fan, Y, Gupta N, Fan G and Gélinas C. (2006) Current insights into the regulation of programmed cell death by NF-kB. Oncogene 25: 6800-6816. PMID: 17072329
  • Gélinas, C. and White, E. (2005) BH3-only proteins in control: Specificity regulates MCL-1 and BAK-mediated apoptosis. Genes & Dev. 19: 1263-1268. PMID: 15937216
  • Kucharczak, J.F., Simmons, M.J., Duckett, C.S. and Gélinas, C. (2005) Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a pro-death factor. Cell Death & Differ. 12: 1225-1239. PMID: 16094403
  • Xu, C., Shen, G., Chen, C., Gélinas, C. and Kong, A.N.T. (2005) Suppression of NF-kB and NF-kB-regulated gene expression by sulforaphane and PEITC through IkBa, IKK pathway in human prostate cancer PC-3 cells. Oncogene 24: 4486-4495. PMID: 15856023

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