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Researcher Publications

Derek B. Sant'Angelo, PhD

Selected Publications

  • Darcy, P.W., Denzin, L.K., Sant'Angelo, D.B. YY1lo NKT cells are dedicated IL-10 producers. Nature Sci. Rep. 10(1):3897, 2020.
  • Newman JH et al Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer. Proc. Natl. Acad. Sci. USA 117(2):1119-1128, 2020
  • Sheng, H., Marrero, I., Maricic, I., Fanchiang, S.S., Zhang, S., Sant'Angelo, D.B. and Kumar, V. Distinct PLZF+CD8αα+ Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity. J. Immunology 203(8):2150-2162, 2019.
  • Zhang, S., Kryzanowska, A., Henry, E.K., Vieth, J.A., Denzin, L.K., Siracusa, M.C. and Sant’Angelo, D.B. The transcription factor PLZF is necessary for the development and function of mouse basophils. J. Immunology 203(5):1230-1241, 2019
  • Darcy, P.W., Jin, K. Osorio, L. Denzin, L.K. and Sant’Angelo, B. Co-expression of YY1 is required to elaborate the effector functions controlled by PLZF in NKT cells. J. Immunology 203(3):627-638, 2019
  • Vieth JA, Das J, Ranaivoson FM, Comoletti D, Denzin LK, Sant'Angelo DB. TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells. Nat Immunol. 2016 Nov 21;PubMed PMID: 27869818.
  • Zhang S, Laouar A, Denzin LK, Sant'Angelo DB. Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling. Sci Rep. 2015 Jul 16;5:12113. PubMed PMID: 26178856; PubMed Central PMCID: PMC4503983.
  • Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015 Jan;16(1):85-95. PubMed PMID: 25436972; PubMed Central PMCID: PMC4343194.
  • Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant'Angelo DB. The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol. 2008 Sep;9(9):1055-64. PubMed PMID: 18660811; PubMed Central PMCID: PMC2662733.
  • Denzin LK, Sant'Angelo DB, Hammond C, Surman MJ, Cresswell P. Negative regulation by HLA-DO of MHC class II-restricted antigen processing. Science. 1997 Oct 3;278(5335):106-9. PubMed PMID: 9311912.
  • Fallas JL, Tobin HM, Lou O, Guo D, Sant'Angelo DB, Denzin LK. Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. J Immunol. 2004 Aug 1;173(3):1549-60. PubMed PMID: 15265882.
  • Denzin LK, Sant'angelo DB. Dipping into the cytosol to broaden the MHC class II peptide repertoire. Immunity. 2005 May;22(5):536-7. PubMed PMID: 15894271.
  • Yi W, Seth NP, Martillotti T, Wucherpfennig KW, Sant'Angelo DB, Denzin LK. Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest. 2010 Apr;120(4):1324-36. PubMed PMID: 20200448; PubMed Central PMCID: PMC2846047.
  • Blander JM, Sant'Angelo DB, Metz D, Kim SW, Flavell RA, Bottomly K, Janeway CA Jr. A pool of central memory-like CD4 T cells contains effector memory precursors. J Immunol. 2003 Mar 15;170(6):2940-8. PubMed PMID: 12626545.
  • Kim HJ, Guo D, Sant'Angelo DB. Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7263-7. PubMed PMID: 15883386; PubMed Central PMCID: PMC1091755.
  • Stolzer AL, Sadelain M, Sant'Angelo DB. Fulminant experimental autoimmune encephalo-myelitis induced by retrovirally mediated TCR gene transfer. Eur J Immunol. 2005 Jun;35(6):1822-30. PubMed PMID: 15909313.
  • Papapetrou EP, Kovalovsky D, Beloeil L, Sant'angelo D, Sadelain M. Harnessing endogenous miR-181a to segregate transgenic antigen receptor expression in developing versus post-thymic T cells in murine hematopoietic chimeras. J Clin Invest. 2009 Jan;119(1):157-68. PubMed PMID: 19033646; PubMed Central PMCID: PMC2613472.
  • Sant'Angelo DB, Waterbury G, Preston-Hurlburt P, Yoon ST, Medzhitov R, Hong SC, Janeway CA Jr. The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity. 1996 Apr;4(4):367-76. PubMed PMID: 8612131.
  • Sant'Angelo DB, Waterbury PG, Cohen BE, Martin WD, Van Kaer L, Hayday AC, Janeway CA Jr. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity. 1997 Oct;7(4):517-24. PubMed PMID: 9354472.
  • Sant'Angelo DB, Lucas B, Waterbury PG, Cohen B, Brabb T, Goverman J, Germain RN, Janeway CA Jr. A molecular map of T cell development. Immunity. 1998 Aug;9(2):179-86. PubMed PMID: 9729038.
  • Sant'Angelo DB, Janeway CA Jr. Negative selection of thymocytes expressing the D10 TCR. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6931-6. PubMed PMID: 12011450; PubMed Central PMCID: PMC124506.

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