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Researcher Publications

Alexander Ploss, PhD

Selected Publications

  1. Ploss A.*, Evans M.J.*, Gaysinskaya A., Panis M., You H., de Jong Y.P., Rice C.M. (2009) Human occludin is a hepatitis C virus entry factor required for infection of mouse cells, Nature, 457: 882-6. PMC2762424
  2. Dorner, M., Horwitz, J.A., Robbins, J., Barry, W.T., Mu, K., Jones, C.T., Schoggins, Catanese, M.T., J.W., Burton, D.R., Law, M., Rice, C.M., Ploss, A. (2011) A genetically humanized mouse model for hepatitis C virus infection, Nature, 474: 209-211. PMC3159410
  3. Klein F., Halper-Stromberg A., Horwitz J.A., Gruell H., Scheid J.F., Bournazos S., Mouquet H., Spatz L.A., Diskin R., Abadir A., Dorner M., Billerbeck E., Labitt R.N., Gaebler C., Marcovecchio P., Incesu R.B., Eisenreich T.R., Bieniasz P.D., Seaman M.S., Bjorkman P.J., Ravetch J.V., Ploss A., Nussenzweig M.C. (2012), HIV therapy by a combination of broadly neutralizing antibodies in humanized mice, Nature, 492: 118-22. PMC3809838
  4. Dorner M., Horwitz J.A.*, Donovan B.M.*, Labitt R.N., Budell W.C., Friling T., Vogt A., Catanese M.T., Satoh T., Kawai T., Akira S., Law M., Rice C.M., Ploss A. (2013) Completion of the entire hepatitis C virus life-cycle in genetically humanized mice, Nature, 501(7466):237-41, PMCID:PMC3858853
  5. de Jong, Y.P., Dorner, M., Mommersteeg, M.C., Xiao, J.W., Balazs, A.B., Robbins, J.B., Vega, K., Labitt, R.N., Donovan, B.M., Giang, E., Krishnan, A., Chiriboga, L., Charlton, M.R., Burton, D.R., Baltimore, D., Law, M., Rice, C.M., Ploss, A. (2014) Broadly neutralizing antibodies abrogate established hepatitis C virus infection, Science Translational Medicine, 6(254):254ra129, PMCID:PMC4312107
  6. Douam, F., Gaska, J., Winer, B.Y., Ding, Q., von Schaewen, M., Ploss, A. (2015) Genetic dissection of the host tropism of human tropic pathogens, Annual Reviews in Genetics, 2015; 49:21-45. doi: 10.1146/annurev-genet-112414-054823. PMCID: PMC5075990
  7. Ding, Q, Heller, B., Capucino, J.M.V., Song, B., Nimgaonkar, I., Hrebikova, G., Contreras, J.E, Ploss, A. (2017) Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles, Proc Natl Acad Sci U S A, 114(5):1147-1152. PMCID: PMC5293053
  8. Douam, F., Hrebikova, G., Soto Albrecht, Y.E., Sellau, J., Sharon, Y., Ding, Q., Ploss, A. (2017) Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome. Nature Communications, 8:14781. doi: 10.1038/ncomms14781. PMCID:PMC5424064
  9. Winer, B.Y., Huang, T.S., Pludwinski, E., Wojcik, F. Lipkowitz, G., Parekh, A., Cho, C., Shrirao, A., Muir, T., Novik, E., Ploss, A. (2017) Long-term persistent hepatitis B virus infection in a scalable micro-well primary hepatocyte coculture system, Nature Communications, PMCID:PMC5527081
  10. Nimgaonkar, I., Ding, Q., Schwartz, R.E., Ploss, A. (2018) Hepatitis E virus: Advances and Challenges, Nature Reviews Hepatology & Gastroenterology, 15(2):96-110
  11. Ding, Q., Gaska, J.M., Heller, B., Ploss, A. (2018) Species-specific disruption of the STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease, Proc Natl Acad Sci U S A. Pii: 201803406. doi: 10.1073/pnas.1803406115. PMID:29915078
  12. Dragovic SM, Agunbiade TA, Freudzon M, Yang J, Hastings AK, Schleicher TR, Zhou X, Craft S, Chuang YM, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, Ploss A, Dimopoulos G, Fikrig E (2018) Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice, Cell Host & Microbe, 23(4):523-535.e5, PMCID:PMC5998332
  13. Winer, B.Y., Shirvani-Dastgerdi, E., Bram, Y., Sellau, J., Low, B.E., Johnson, H., Huang, T., Hrebikova, G., Heller, B., Sharon, Y., Giersch, J., Gerges, S., Seneca, K., Pais, M.A., Frankel, A.S., Lipkowitz, G., Chiriboga, L., Cullen, J., Nahass, R.G., Lutgehetmann, M., Toettcher, J.E., Wiles, M.V., Schwartz, R.E., Ploss, A. (2018) Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for persistent hepatitis delta virus infection, Science Translational Medicine, 10(447). Pii: eaap9328. doi: 10.1126/scitranslmed.aap9328.
  14. Douam, F., Ziegler, C.G.K, Hrebikova, G., Fant, B., Leach, R., Parson, L., Wang, W., Gaska, J.M., Winer, B.Y., Heller, B., Shalek, A.K., Ploss, A. (2018) Selective expansion of myeloid and NK cells in humanized mice yields human-like host responses to vaccination, Nature Communications, 28;9(1):5031, PMCID:PMC6262001
  15. Wei, L., Ploss, A. (2020) Core components of DNA lagging strand synthesis machinery are essential for the reconstitution of hepatitis B virus cccDNA formation, Nature Microbiology, doi: 10.1038/s41564-020-0678-0. [Epub ahead of print]

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