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Researcher Publications

Megerditch (Mike) Kiledjian, PhD

Selected Publications

  1. Grudzien-Nogalska, E., Wu, Y., Jiao, X., Cui, H., Mateyak, M. K., Hart, R. P., Tong, L., and Kiledjian, M. (2019) Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Nat Chem Biol 15, 575-582
  2. Jiao, X., Doamekpor, S. K., Bird, J. G., Nickels, B. E., Tong, L., Hart, R. P., and Kiledjian, M. (2017) 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell 168, 1015-1027 e1010
  3. Mauer, J., Luo, X., Blanjoie, A., Jiao, X., Grozhik, A. V., Patil, D. P., Linder, B., Pickering, B. F., Vasseur, J. J., Chen, Q., Gross, S. S., Elemento, O., Debart, F., Kiledjian, M., and Jaffrey, S. R. (2017) Reversible methylation of m6Am in the 5' cap controls mRNA stability. Nature 541, 371-375
  4. Grudzien-Nogalska, E., Jiao, X., Song, M. G., Hart, R. P., and Kiledjian, M. (2016) Nudt3 is an mRNA decapping enzyme that modulates cell migration. RNA 22, 773-781
  5. Castellanos-Rubio, A., Fernandez-Jimenez, N., Kratchmarov, R., Luo, X., Bhagat, G., Green, P. H., Schneider, R., Kiledjian, M., Bilbao, J. R., and Ghosh, S. (2016) A long noncoding RNA associated with susceptibility to celiac disease. Science 352, 91-95
  6. Jiao, X., Chang, J. H., Kilic, T., Tong, L., and Kiledjian, M. (2013) A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol Cell 50, 104-115
  7. Jiao, X., Xiang, S., Oh, C., Martin, C. E., Tong, L., and Kiledjian, M. (2010) Identification of a quality-control mechanism for mRNA 5'-end capping. Nature 467, 608-611
  8. Bail, S., Swerdel, M., Liu, H., Jiao, X., Goff, L. A., Hart, R. P., and Kiledjian, M. (2010) Differential regulation of microRNA stability. RNA 16, 1032-1039
  9. Gu, M., Fabrega, C., Liu, S. W., Liu, H., Kiledjian, M., and Lima, C. D. (2004) Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. Mol Cell 14, 67-80
  10. Wang, Z., and Kiledjian, M. (2001) Functional Link between the Mammalian Exosome and mRNA Decapping. Cell 107, 751-762

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