Cole Laboratory - Publications

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  1. Burns MA, Flamand Y, Keating J, Koch V, Cronholm SM, Hunt SK, Cole PD, Gennarini LM, Hijiya N, Kahn JM, Kelly KM, Michon B, Neuberg DS, Place AE, Laverdière C, Tran TH, Théorêt Y, Welch JJG, Sallan SE, Silverman LB, Vrooman LM. Pegaspargase Rechallenge Following Grade 2 Hypersensitivity Reaction in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 16-001. Pediatr Blood Cancer. 2026 Aug 11:e70581. doi: 10.1002/1545-5017.70581. Online ahead of print. PMID: 42578524
  2. Heneghan MB, Renfro LA, Wu Y, Crisler KM, Marcotte E, Trippett T, Horton T, Hoppe BS, Keller FG, Forlenza C, Schwartz C, Kelly KM, Cole PD, Castellino SM, Kahn JM. Survival by Race and Ethnicity in Children and Adolescents/Young Adults With Relapsed/Refractory Hodgkin Lymphoma: A Pooled Analysis of Children's Oncology Group Trials. Pediatr Blood Cancer. 2026 Jul 24:e70522. doi: 10.1002/1545-5017.70522. Online ahead of print. PMID: 42496647
  3. Wong AYL, Myers JW, Prakash G, Ma A, Brook JR, Petrova B, Bulut B, White R 3rd, Merz C, de Souza M, Maynard AG, Wang P, Yu A, Pohl NK, Weitman M, Silverman LB, Stegmaier K, Churchman LS, Cole PD, Brady DC, Kanarek N. Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity. Nat Cancer. 2026 May 25. doi: 10.1038/s43018-026-01177-4. Online ahead of print. PMID: 42185479
  4. O'Dwyer K, Winestone LE, Cheung MC, Benitez L, Buldini B, Cole PD, Damlaj M, Dholaria B, Dias AL, Dils A, Fritsch M, Greer J, Hayes-Lattin B, Henry M, Jaffe A, Jamy O, Kebriaei P, Mehrtens I, Shah NN, Wilde L, Young PA, Mai HJ, Kanaan G, Sereda Y, Saldanha IJ, Balk EM, Gupta S. American Society of Hematology 2026 guidelines for management of relapsed/refractory acute lymphoblastic leukemia in adolescents and young adults. Blood Adv. 2026 Jul 14;10(13):4726-4756. doi: 10.1182/bloodadvances.2021006479. PMID: 41670624
  5. Diefenbach CS, Jegede O, Wang V, Ansell SM, Kostakoglu L, Steidl C, Natkunam Y, Scott DW, Ambinder RF, David KA, Advani RH, Bartlett NL, Robertson MJ, Thomas SP, Cohen J, Ibrahimi S, Goyal G, Mehta-Shah N, Amengual JE, Forlenza CJ, Cole PD, Duan F, Kelly K, Kahl BS. A randomized phase 2 study of ipilimumab, nivolumab, and brentuximab vedotin in patients with relapsed Hodgkin lymphoma. Blood. 2026 Apr 30;147(18):2041-2052. doi: 10.1182/blood.2025029546. PMID: 41662628
  6. Thrope A, Ramjan S, White C, Mauguen A, Silverman LB, Welch JJG, Kahn J, Kelly KM, Tran TH, Michon B, Gennarini L, Park Y, Cole PD, Sands SA. Trajectory of Neurocognitive Functioning in Children Treated for Acute Lymphoblastic Leukemia (ALL): Dana-Farber Cancer Institute ALL Consortium Study 16-001. Pediatr Blood Cancer. 2026 Apr;73(4):e70118. doi: 10.1002/1545-5017.70118. Epub 2026 Jan 10. PMID: 41518030
  7. Willekens J, Ramjan S, Sands SA, Park Y, K C N, Burns MA, Welch JJG, Kahn J, Kelly KM, Tran TH, Michon B, Gennarini L, Place A, Silverman LB, Cole PD. CSF metabolomic signature during therapy for childhood acute lymphoblastic leukemia predicts subsequent working memory impairment. Mol Med. 2025 Dec 30;32(1):12. doi: 10.1186/s10020-025-01414-z. PMID: 41469545
  8. Patel C, Diglio F, Durham BH, Cole PD. Influence of ApoE genotype on doxorubicin-induced cognitive impairment in juvenile rats. Sci Rep. 2025 Dec 24;15(1):44620. doi: 10.1038/s41598-025-33104-5. PMID: 41436539
  9. Patel C, Glytsou C, Jang MH, Cole PD. The effects of doxorubicin on blood-brain barrier integrity in hCMEC/D3. Neurotoxicology. 2025 Dec;111:103355. doi: 10.1016/j.neuro.2025.103355. Epub 2025 Nov 19. PMID: 41265652
  10. Park Y, K C N, Willekens J, Patel C, Savage BA, Lin H, Paneque A, Daly R, Thrope A, Burns MA, Welch JJG, Kahn JM, Kelly KM, Tran TH, Michon B, Gennarini L, Silverman LB, Sands SA, Cole PD. Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 2025 Nov 3;34(11):2015-2024. doi: 10.1158/1055-9965.EPI-25-1058. PMID: 40905823
  11. Patel C, Willekens J, Diglio F, Cole PD. Doxorubicin causes cognitive impairment and alters gut microbiota in both male and female juvenile rats. Sci Rep. 2025 Jul 28;15(1):27448. doi: 10.1038/s41598-025-12352-5. PMID: 40721627
  12. Ladas EJ, Sheng H, Athale UH, Asselin BL, Clavell LA, Cole PD, Flamand Y, Leclerc JM, Laverdiere C, Michon B, Sallan SE, Silverman LB, Welch JJG, Yao S, Kelly KM. Overweight or Obesity and Outcomes in Children With Acute Lymphoblastic Leukemia. JAMA Netw Open. 2025 May 1;8(5):e259952. doi: 10.1001/jamanetworkopen.2025.9952. PMID: 40366657
  13. Ramjan S, Blair Thies M, Li Y, Thrope A, Silverman L, Welch JJG, Kahn J, Kelly KM, Tran TH, Michon B, Gennarini L, Bona K, Park Y, Cole PD, Sands SA. Baseline Neurocognitive Functioning Among Children Treated for Acute Lymphoblastic Leukemia (ALL): Dana Farber Cancer Institute ALL Consortium Study 16-001. Pediatr Blood Cancer. 2025 Aug;72(8):e31767. doi: 10.1002/pbc.31767. Epub 2025 May 13. PMID: 40361276
  14. Daw S, Cole PD, Hoppe BS, Hodgson D, Beishuizen A, Garnier N, Buffardi S, Mascarin M, Lissat A, Mauz-Körholz C, Krajewski J, Akyol A, Crowe R, Anderson B, Xu Y, Drachtman RA, Kelly KM, Leblanc T, Harker-Murray P. Transplant-Free Approach in Relapsed Hodgkin Lymphoma in Children, Adolescents, and Young Adults: A Nonrandomized Clinical Trial. JAMA Oncol. 2025 Mar 1;11(3):249-257. doi: 10.1001/jamaoncol.2024.5627. PMID: 39745739
  15. Ramjan S, Cole PD, Blair-Thies M, Silverman LB, Fredrickson A, Schembri A, Welch JJG, Kahn J, Kelly KM, Tran TH, Michon B, Gennarini L, Sands SA. Feasibility of Utilizing a Brief Neurocognitive Battery in 3-Year-Old Patients During Treatment for Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2025 Mar;72(3):e31469. doi: 10.1002/pbc.31469. Epub 2024 Dec 9. PMID: 39654084
  16. Janelsins MC, Van Dyk K, Hartman SJ, Koll TT, Cramer CK, Lesser GJ, Barton DL, Mustian KM, Wagner LI, Ganz PA, Cole PD, Bakos A, Root JC, Hardy K, Magnuson A, Ferguson RJ, McDonald BC, Saykin AJ, Gonzalez BD, Wefel JS, Morilak DA, Dahiya S, Heijnen CJ, Conley YP, Morgans AK, Mabbott D, Monje M, Rapp SR, Gondi V, Bender C, Embry L, McCaskill Stevens W, Hopkins JO, St Germain D, Dorsey SG. The National Cancer Institute clinical trials planning meeting to address gaps in observational and intervention trials for cancer-related cognitive impairment. J Natl Cancer Inst. 2025 Feb 1;117(2):217-228. doi: 10.1093/jnci/djae209. PMID: 39250738
  17. Zhu Q, Nambiar R, Schultz E, Gao X, Liang S, Flamand Y, Stevenson K, Cole PD, Gennarini L, Harris MH, Kahn JM, Ladas EJ, Athale UH, Hoa Tran T, Michon B, Welch JJG, Sallan SE, Silverman LB, Kelly KM, Yao S. Genome-wide study identifies novel genes associated with bone toxicities in children with acute lymphoblastic leukaemia. Br J Haematol. 2024 Nov;205(5):1889-1898. doi: 10.1111/bjh.19696. Epub 2024 Aug 14. PMID: 39143423
  18. Aziz-Bose R, Cernik C, Umaretiya PJ, Ilcisin L, Kelly CA, Valenzuela A, Bruce C, de Cuba SE, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Tran TH, Welch JJG, Silverman LB, Bona K. Supplemental Nutrition Assistance Program participation gaps within a pediatric leukemia clinical trial cohort. Pediatr Blood Cancer. 2024 Nov;71(11):e31274. doi: 10.1002/pbc.31274. Epub 2024 Aug 11. PMID: 39129149
  19. Park Y, Kc N, Paneque A, Cole PD. Tau, Glial Fibrillary Acidic Protein, and Neurofilament Light Chain as Brain Protein Biomarkers in Cerebrospinal Fluid and Blood for Diagnosis of Neurobiological Diseases. Int J Mol Sci. 2024 ;25(12):6295. doi: 10.3390/ijms25126295. PMID: 38928000
  20. Athale UH, Flamand Y, Blonquist T, Steveson KE, Spira M, Asselin BL, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc J-M, Michon B, Schorin MA, Welch JJG, Harris MH, Neuberg DS, Sallan SE, Silverman LB. Predictors of thrombosis in children receiving therapy for acute lymphoblastic leukemia (ALL): Results from Dana-Farber Cancer Institute (DFCI) ALL Consortium trial 05-001. Pediatric Blood & Cancer. 2022; 69: 00e29581.
  21. Wen J, Patel C, Diglio F, Baker K, Marshall G, Li S, Cole PD.  Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate. Neuropharmacology. 2022 Jan 2:108939. Available online January 2, 2022.
  22. Williams AM and Cole PD. Biomarkers of Cognitive Impairment in Pediatric Cancer Survivors. Journal of Clinical Oncology. 2021; Published online April 22, 2021. DOI: 10.1200/JCO.20.02436. PMID: 33886369.
  23. Song Y, Zhu Q, Cole PD, Stevenson K, Harris M, Schultz E, Kahn JM, Ladas EJ, Athale UH, Clavell L, Laverdiere C, Leclerc J-M, Michon B, Welch JJG, Sallan SE, Silverman LB, Kelly K. Genetic Ancestry and Skeletal Toxicities among Childhood Acute Lymphoblastic Leukemia Patients in the DFCI 05-001 Cohort. Blood Advances 2020; 5(2):451-8.
  24. Ladas EJ, Blonquist TM, Puligandla M, Orjuela M, Stevenson K, Cole PD, Athale UH, Clavell LA, Leclerc J-M, Laverdiere C, Michon B, Schorin MA, Welch JG, Asselin BL, Sallan SE, Silverman LB, Kelly KM. The protective effects of dietary intake of antioxidants and treatment-related toxicity in childhood leukemia: A Report from the DALLT Cohort. Journal of Clinical Oncology, 2020; 38(19): 2151-2159. PMID: 32330103
  25. Brace K, Lee W, Cole PD, Sussman E. (2019). Childhood leukemia survivors exhibit deficiencies in sensory and cognitive processes, as reflected by event-related brain potentials after completion of curative chemotherapy: A preliminary investigation. Journal of Clinical and Experimental Neuropsychology; 2019 Oct;41(8):814-831. DOI: 10.1080/13803395.2019.1623865. PMID: 31156064
  26. Ladas EJ, Orjuela M, Stevenson K, Cole PD, Lin M, Athale UH, Clavell LA, Leclerc JM, Laverdiere C, Michon B, Schorin MA. Fluctuations in Dietary Intake During Treatment for Childhood Leukemia: A Report from the DALLT Cohort. Clinical Nutrition. 2019;38(6):2866-2874
  27. Wen J, Maxwell RR, Wolf AJ, Spira M, Gulinello ME, Cole PD. Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model. Neuropharmacology. 2018; 139:76-84. PMID: 29990472
  28. Cole PD, McCarten KM, Pei Q, Spira M, Metzger ML, Drachtman RA, Horton TM, Bush R, Blaney SM, Weigel BJ, Kelly KM. Brentuximab vedotin with Gemcitabine for Pediatric and Young Adult Patients with Relapsed or Refractory Hodgkin Lymphoma: A Children’s Oncology Group, Single-arm, Phase 1 / 2 Trial. The Lancet
  29. Thomsen AM, Gulinello ME, Vijayanathan V, Wen J, Schmiegelow K, Cole PD. Liposomal Cytarabine Induces Less Neurocognitive Dysfunction than Intrathecal Methotrexate in an Animal Model. Journal of Pediatric Hematology / Oncology. 2018; 40 (2), e91-e96; published online July 17 2017. PMID: 28654460.
  30. Finkelstein Y, Blonquist TM, Vijayanathan V, Stevenson KE, Neuberg DS, Silverman LB, Vrooman LM, Sallan SE, Cole PD. A Thymidylate Synthase Polymorphism is Associated with Increased Risk for Bone Toxicity Among Children Treated for Acute Lymphoblastic Leukemia. Pediatric Blood & Cancer. 2017; 64(7): e26393; Published online 13 Dec. 2016. PMID: 27957785
  31. Sands SA, Harel BT, Savone M, Kelly K, Vijayanathan V, Welch JG, Vrooman L, Silverman LB, Cole PD. Feasibility of Baseline Neurocognitive Assessment using Cogstate During the First Month of Therapy for Childhood Leukemia. Supportive Care in Cancer. 2016; published online October 12. PMID: 27726029
  32. Cole PD, Finkelstein Y, Stevenson KE, Blonquist TM, Vijayanathan V, Silverman LB, et al. Polymorphisms in Genes Related to Oxidative Stress Are Associated with Inferior Cognitive Function after Therapy for Childhood Acute Lymphoblastic Leukemia. Journal of Clinical Oncology. 2015; 33(19):2205-11. PMID: 25987702
  33. Kim S-E, Hinoue T, Kim MS, Sohn K-J, Cho RC, Cole PD, Weisberger DJ, Laird PW, Kim YI. g-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells. Genes and Nutrition, 2015; 10(1): 444. PMID: 25502219
  34. Kim S-E, Cole PD, Cho R, Ly A, Ishiguro L, Sohn K-J, Croxford R, Kamen B, Kim Y-I. γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate. British Journal of Cancer 2013; 109: 2175-88. PMID: 24045662
  35. Cole PD, Vijayanathan V, Ali NF, Wagshul ME, Tanenbaum EJ, Price J, Dalal V, Gulinello ME. “Memantine protects rats treated with intrathecal methotrexate from developing spatial memory deficits,” Clinical Cancer Research 2013: 19(16):4446-54. PMID: 23833301.
  36. Vijayanathan V, Ali N, Gulinello M, Cole PD. Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist. Behavioural Brain Research. 2011;225(2):491-7.
  37. Li Y, Vijayanathan V, Gulinello M, Cole PD. Intrathecal Methotrexate Induces Focal Cognitive Deficits and Increases Cerebrospinal Fluid Homocysteine. Pharmacology, Biochemistry and Behavior;2010; 95 (4): 428-33.
  38. Li Y, Vijayanathan V, Gulinello ME, Cole PD. Systemic Methotrexate Induces Spatial Memory Deficits and Depletes Cerebrospinal Fluid Folate in Rats. Pharmacology, Biochemistry and Behavior 2010: 94(3):454-63.
  39. Cole PD, Beckwith KA, Vijayanathan V, Roychowdhury S, Smith AK, Kamen BA. CSF Folate Homeostasis During Therapy for Acute Lymphoblastic Leukemia. Pediatric Neurology 2009; 40(1): 34-41.
  40. Wollack JB, Makori B, Ahlawat S, Koneru R, Picinich S, Smith AK, Goldman ID, Qiu A, Cole PD, Glod J, Kamen BA.  Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model. Journal of Neurochemistry, 2008; 104(6): 1494-503.
  41. Cho RC, Cole PD, Sohn KJ, Gaisano G, Croxford R, Kamen BA, Kim YI.  Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells.  Molecular Cancer Therapeutics, 2007; 6(11): 2909-20.
  42. Vijayanathan V. Smith AK, Zebala JA, Kamen BA, Cole PD. HPLC Separation of Aminopterin Polyglutamates Within Red Blood Cells of Children Treated for Acute Lymphoblastic Leukemia. Translational Research, 2007; 150(6) 367-73.
  43. Li WW, Su D, Mizobuchi H, Martin DS, Gu B, Gorlick R, Cole P, and Bertino JR. Status of methylthioadenosine phosphorylase and its impact on cellular response to l-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells. Oncology Research, 2004; 14: 373-379.
  44. Kaufman Y, Drori S, Cole PD, Kamen BA, Sirota J, Ifergan I, Ben Arush MW, Elhasid R, Sahar D, Kaspers GJL, Jansen G, Matherly LH, Rechavi G, Toren A, Assaraf YG.  Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia. Cancer. 2004; 100(4): 773-82.
  45. Cole PD, Smith AK, Kamen BA. Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.  Cancer Chemotherapy and Pharmacology 2002; 50(2): 111-6.
  46. Cole PD, Gorlick R, Banerjee D, Magill L, Smith A, Kamen BA, Bertino JR. Effects Of Overexpression Of g-Glutamyl Hydrolase (GGH) On Methotrexate Metabolism And Resistance.  Cancer Research, 2001; 61(11): 4599-4604.