Markowitz Laboratory Select Publications

Complete list of Dr. Markowitz's publications

  1. Honigsberg R, Cruz T, Yoffe L, Tang MS, Dicle O, Markowitz G, Michael M, Singh A, Altorki NK, Elemento O, Villena-Vargas J. Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade. bioRxiv. 2025 Jun 1;. doi: 10.1101/2025.04.27.650862. PubMed PMID: 40501950; PubMed Central PMCID: PMC12154853.
  2. Yoffe L, Bhinder B, Kang SW, Zhang H, Singh A, Ravichandran H, Markowitz G, Martin M, Kim J, Zhang C, Elemento O, Tansey W, Bates S, McGraw TE, Borczuk A, Lee HS, Altorki NK, Mittal V. Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer. bioRxiv. 2025 Jan 1;. doi: 10.1101/2024.12.31.630523. PubMed PMID: 39803458; PubMed Central PMCID: PMC11722343.
  3. Markowitz GJ, Ban Y, Tavarez DA, Yoffe L, Podaza E, He Y, Martin MT, Crowley MJP, Sandoval TA, Gao D, Martin ML, Elemento O, Cubillos-Ruiz JR, McGraw TE, Altorki NK, Mittal V. Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1(+) progenitor CD8(+) T cells to improve immunotherapy. Nat Immunol. 2024 Oct;25(10):1884-1899. doi: 10.1038/s41590-024-01963-1. Epub 2024 Sep 26. PubMed PMID: 39327500.
  4. Crowley MJP, Bhinder B, Markowitz GJ, Martin M, Verma A, Sandoval TA, Chae CS, Yomtoubian S, Hu Y, Chopra S, Tavarez DA, Giovanelli P, Gao D, McGraw TE, Altorki NK, Elemento O, Cubillos-Ruiz JR, Mittal V. Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer. Nat Commun. 2023 Jan 9;14(1):120. doi: 10.1038/s41467-022-35584-9. PubMed PMID: 36624093.
  5. Wennerberg E, Mukherjee S, Spada S, Hung C, Agrusa CJ, Chen C, Valeta-Magara A, Rudqvist NP, Van Nest SJ, Kamel MK, Nasar A, Narula N, Mittal V, Markowitz GJ, Zhou XK, Adusumilli PS, Borczuk AC, White TE, Khan AG, Balderes PJ, Lorenz IC, Altorki N, Demaria S, McGraw TE, Stiles BM. Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Sci Transl Med. 2022 Mar 16;14(636):eabe8195. doi: 10.1126/scitranslmed.abe8195. Epub 2022 Mar 16. PubMed PMID: 35294260; PubMed Central PMCID: PMC9256502.
  6. Gao Y, You M, Fu J, Tian M, Zhong X, Du C, Hong Z, Zhu Z, Liu J, Markowitz GJ, Wang FS, Yang P. Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B. J Hepatol. 2022 Jan;76(1):148-159. doi: 10.1016/j.jhep.2021.08.029. Epub 2021 Sep 12. PubMed PMID: 34689996.
  7. Ban Y, Markowitz GJ, Zou Y, Ramchandani D, Kraynak J, Sheng J, Lee SB, Wong STC, Altorki NK, Gao D, Mittal V. Radiation-activated secretory proteins of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer. Nat Cancer. 2021 Sep;2(9):919-931. doi: 10.1038/s43018-021-00245-1. Epub 2021 Sep 20. PubMed PMID: 34917944; PubMed Central PMCID: PMC8670735.
  8. Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS, Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H, Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A, Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD, Rudin CM, Merghoub T. Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity. Cancer Cell. 2021 Jul 12;39(7):973-988.e9. doi: 10.1016/j.ccell.2021.05.006. Epub 2021 Jun 10. PubMed PMID: 34115989; PubMed Central PMCID: PMC9115604.
  9. Zhang C, Gao Y, Du C, Markowitz GJ, Fu J, Zhang Z, Liu C, Qin W, Wang H, Wang F, Yang P. Hepatitis B-Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation. Cancer Res. 2021 May 1;81(9):2386-2398. doi: 10.1158/0008-5472.CAN-20-3453. Epub 2021 Mar 2. PubMed PMID: 33653774.
  10. Gao Y, Fan X, Li N, Du C, Yang B, Qin W, Fu J, Markowitz GJ, Wang H, Ma J, Cheng S, Yang P. CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma. Pharmacol Res. 2020 Jul;157:104800. doi: 10.1016/j.phrs.2020.104800. Epub 2020 Apr 8. PubMed PMID: 32278046.
  11. Yomtoubian S, Lee SB, Verma A, Izzo F, Markowitz G, Choi H, Cerchietti L, Vahdat L, Brown KA, Andreopoulou E, Elemento O, Chang J, Inghirami G, Gao D, Ryu S, Mittal V. Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer. Cell Rep. 2020 Jan 21;30(3):755-770.e6. doi: 10.1016/j.celrep.2019.12.056. PubMed PMID: 31968251.
  12. Altorki NK, Markowitz GJ, Gao D, Port JL, Saxena A, Stiles B, McGraw T, Mittal V. The lung microenvironment: an important regulator of tumour growth and metastasis. Nat Rev Cancer. 2019 Jan;19(1):9-31. doi: 10.1038/s41568-018-0081-9. Review. PubMed PMID: 30532012; PubMed Central PMCID: PMC6749995.
  13. Markowitz GJ, Havel LS, Crowley MJ, Ban Y, Lee SB, Thalappillil JS, Narula N, Bhinder B, Elemento O, Wong ST, Gao D, Altorki NK, Mittal V. Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival. JCI Insight. 2018 Jul 12;3(13). doi: 10.1172/jci.insight.96836. PubMed PMID: 29997286; PubMed Central PMCID: PMC6101707.
  14. Alexander PB, Chen R, Gong C, Yuan L, Jasper JS, Ding Y, Markowitz GJ, Yang P, Xu X, McDonnell DP, Song E, Wang XF. Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer. J Biol Chem. 2017 Jan 13;292(2):748-759. doi: 10.1074/jbc.M116.754960. Epub 2016 Nov 30. PubMed PMID: 27903634; PubMed Central PMCID: PMC5241747.
  15. Hu J, Markowitz GJ, Wang X. Noncoding RNAs Regulating Cancer Signaling Network. Adv Exp Med Biol. 2016;927:297-315. doi: 10.1007/978-981-10-1498-7_11. Review. PubMed PMID: 27376740.
  16. Hu J, Markowitz G, Wang XF. Isolation of Glioma-Initiating Cells for Biological Study. Adv Exp Med Biol. 2016;899:197-209. doi: 10.1007/978-3-319-26666-4_11. PubMed PMID: 27325268.
  17. Markowitz GJ, Yang P, Fu J, Michelotti GA, Chen R, Sui J, Yang B, Qin WH, Zhang Z, Wang FS, Diehl AM, Li QJ, Wang H, Wang XF. Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes. Cancer Res. 2016 Apr 15;76(8):2394-405. doi: 10.1158/0008-5472.CAN-15-1548. Epub 2016 Feb 18. PubMed PMID: 26893476; PubMed Central PMCID: PMC4873403.
  18. Xu X, Zhang Y, Jasper J, Lykken E, Alexander PB, Markowitz GJ, McDonnell DP, Li QJ, Wang XF. MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget. 2016 Apr 12;7(15):20381-94. doi: 10.18632/oncotarget.7953. PubMed PMID: 26967387; PubMed Central PMCID: PMC4991462.
  19. Yang P, Zhang Y, Markowitz GJ, Guo X, Wang XF. TGF-β-Regulated MicroRNAs and Their Function in Cancer Biology. Methods Mol Biol. 2016;1344:325-39. doi: 10.1007/978-1-4939-2966-5_21. PubMed PMID: 26520135.
  20. Kang SK, Markowitz GJ, Kim ST, Johnston MV, Kadam SD. Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters. Front Cell Neurosci. 2015;9:173. doi: 10.3389/fncel.2015.00173. eCollection 2015. PubMed PMID: 26029047; PubMed Central PMCID: PMC4429249.
  21. Markowitz GJ, Michelotti GA, Diehl AM, Wang XF. Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma. Sci Bull (Beijing). 2015 Apr 1;60(8):762-772. doi: 10.1007/s11434-015-0772-5. PubMed PMID: 26029472; PubMed Central PMCID: PMC4445464.
  22. Kadam SD, Chen H, Markowitz GJ, Raja S, George S, Verina T, Shotwell E, Loechelt B, Johnston MV, Kamani N, Fatemi A, Comi AM. Systemic injection of CD34(+)-enriched human cord blood cells modulates poststroke neural and glial response in a sex-dependent manner in CD1 mice. Stem Cells Dev. 2015 Jan 1;24(1):51-66. doi: 10.1089/scd.2014.0135. PubMed PMID: 25121827; PubMed Central PMCID: PMC4273202.
  23. Yang P*, Markowitz GJ*, Wang XF. The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma. Natl Sci Rev. 2014 Jul 14;1(3):396-412. doi: 10.1093/nsr/nwu038. PubMed PMID: 25741453; PubMed Central PMCID: PMC4346158. * equal contribution.
  24. George S, Kadam SD, Irving ND, Markowitz GJ, Raja S, Kwan A, Tu Y, Chen H, Rohde C, Smith DR, Comi AM. Impact of trichostatin A and sodium valproate treatment on post-stroke neurogenesis and behavioral outcomes in immature mice. Front Cell Neurosci. 2013;7:123. doi: 10.3389/fncel.2013.00123. eCollection 2013. PubMed PMID: 23966909; PubMed Central PMCID: PMC3746680.
  25. Yang P, Li QJ, Feng Y, Zhang Y, Markowitz GJ, Ning S, Deng Y, Zhao J, Jiang S, Yuan Y, Wang HY, Cheng SQ, Xie D, Wang XF. TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell. 2012 Sep 11;22(3):291-303. doi: 10.1016/j.ccr.2012.07.023. PubMed PMID: 22975373; PubMed Central PMCID: PMC3443566.
  26. Markowitz GJ, Kadam SD, Smith DR, Johnston MV, Comi AM. Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. Epilepsy Res. 2011 May;94(3):138-48. doi: 10.1016/j.eplepsyres.2011.01.002. Epub 2011 Apr 9. PubMed PMID: 21481568; PubMed Central PMCID: PMC3288256.
  27. Markowitz GJ, Kadam SD, Boothe DM, Irving ND, Comi AM. The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 mice. Neuroreport. 2010 Apr 21;21(6):452-6. doi: 10.1097/wnr.0b013e328338ba18. PubMed PMID: 20848732; PubMed Central PMCID: PMC3220279.