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In the 2018 – 2022 period, the IMFC SR supported approximately 110 publications of which 30 in high-Impact Factor Journals:
Newman JH, Chesson CB, Herzog NL, Bommareddy PK, Aspromonte SM, Pepe R, Estupinian R, Aboelatta MM, Buddhadev S, Tarabichi S, Lee M, Li S, Medina DJ, Giurini EF, Gupta KH, Guevara-Aleman G, Rossi M, Nowicki C, Abed A, Goldufsky JW, Broucek JR, Redondo RE, Rotter D, Jhawar SR, Wang SJ, Kohlhapp FJ, Kaufman HL, Thomas PG, Gupta V, Kuzel TM, et al. Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer. Proc Natl Acad Sci U S A. 2020;117(2):1119-28. doi: 10.1073/pnas.1904022116. PubMed PMID: 31888983; PMCID: PMC6969546.
Esposito M, Fang C, Cook KC, Park N, Wei Y, Spadazzi C, Bracha D, Gunaratna RT, Laevsky G, DeCoste CJ, Slabodkin H, Brangwynne CP, Cristea IM, Kang Y. TGF-beta-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis. Nat Cell Biol. 2021;23(3):257-67. doi: 10.1038/s41556-021-00641-w. PubMed PMID: 33723425; PMCID: PMC7970447.
Chakrabarti R, Celia-Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, Hwang J, Peng J, Nixon B, Grady JJ, DeCoste C, Gao J, van Es JH, Li MO, Aifantis I, Clevers H, Kang Y. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science. 2018;360(6396). doi: 10.1126/science.aan4153. PubMed PMID: 29773667; PMCID: PMC7881440.
Zhao EM, Zhang Y, Mehl J, Park H, Lalwani MA, Toettcher JE, Avalos JL. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature. 2018;555(7698):683-7. doi: 10.1038/nature26141. PubMed PMID: 29562237; PMCID: PMC5876151.
Zhao Y, Wu L, Yue X, Zhang C, Wang J, Li J, Sun X, Zhu Y, Feng Z, Hu W. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. Elife. 2018;7. doi: 10.7554/eLife.34701. PubMed PMID: 29557783; PMCID: PMC5906094.
Poillet-Perez L, Sharp DW, Yang Y, Laddha SV, Ibrahim M, Bommareddy PK, Hu ZS, Vieth J, Haas M, Bosenberg MW, Rabinowitz JD, Cao J, Guan JL, Ganesan S, Chan CS, Mehnert JM, Lattime EC, White E. Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nat Cancer. 2020;1(9):923-34. doi: 10.1038/s43018-020-00110-7. PubMed PMID: 34476408; PMCID: PMC8409526.
Mahdi AH, Huo Y, Tan Y, Simhadri S, Vincelli G, Gao J, Ganesan S, Xia B. Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-kappaB in Mice with Disengaged BRCA1-PALB2 Interaction. Cancer Res. 2018;78(14):3969-81. doi: 10.1158/0008-5472.CAN-18-0388. PubMed PMID: 29739757; PMCID: PMC6050088.Tsang CK, Chen M, Cheng X, Qi Y, Chen Y, Das I, Li X, Vallat B, Fu LW, Qian CN, Wang HY, White E, Burley SK, Zheng XFS. SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation. Mol Cell. 2018;70(3):502-15 e8. doi: 10.1016/j.molcel.2018.03.029. PubMed PMID: 29727620; PMCID: PMC6108545.
Douam F, Ziegler CGK, Hrebikova G, Fant B, Leach R, Parsons L, Wang W, Gaska JM, Winer BY, Heller B, Shalek AK, Ploss A. Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses. Nat Commun. 2018;9(1):5031. doi: 10.1038/s41467-018-07478-2. PubMed PMID: 30487575; PMCID: PMC6262001.
Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, Zheng H, Cheung C, Magnani JL, Lin SH, Cristea IM, Sackstein R, Kang Y. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019;21(5):627-39. doi: 10.1038/s41556-019-0309-2. PubMed PMID: 30988423; PMCID: PMC6556210.
Winer BY, Gaska JM, Lipkowitz G, Bram Y, Parekh A, Parsons L, Leach R, Jindal R, Cho CH, Shrirao A, Novik E, Schwartz RE, Ploss A. Analysis of Host Responses to Hepatitis B and Delta Viral Infections in a Micro-scalable Hepatic Co-culture System. Hepatology. 2020;71(1):14-30. doi: 10.1002/hep.30815. PubMed PMID: 31206195; PMCID: PMC6917996.
Garcia PD, Leach RW, Wadsworth GM, Choudhary K, Li H, Aviran S, Kim HD, Zakian VA. Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP. Nat Commun. 2020;11(1):2173. doi: 10.1038/s41467-020-15875-9. PubMed PMID: 32358529; PMCID: PMC7195438.
Ghergurovich JM, Garcia-Canaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731-9. doi: 10.1038/s41589-020-0533-x. PubMed PMID: 32393898; PMCID: PMC7311271.
Fan H, Wang X, Li W, Shen M, Wei Y, Zheng H, Kang Y. ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP. Genes Dev. 2020;34(19-20):1359-72. doi: 10.1101/gad.339796.120. PubMed PMID: 32943576; PMCID: PMC7528707.
Goglia AG, Wilson MZ, Jena SG, Silbert J, Basta LP, Devenport D, Toettcher JE. A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control. Cell Syst. 2020;10(3):240-53 e6. doi: 10.1016/j.cels.2020.02.005. PubMed PMID: 32191874; PMCID: PMC7540725.
Martin JK, 2nd, Sheehan JP, Bratton BP, Moore GM, Mateus A, Li SH, Kim H, Rabinowitz JD, Typas A, Savitski MM, Wilson MZ, Gitai Z. A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance. Cell. 2020;181(7):1518-32 e14. doi: 10.1016/j.cell.2020.05.005. PubMed PMID: 32497502; PMCID: PMC7780349.
Shen M, Xie S, Rowicki M, Michel S, Wei Y, Hang X, Wan L, Lu X, Yuan M, Jin JF, Jaschinski F, Zhou T, Klar R, Kang Y. Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis. Cancer Res. 2021;81(4):1014-25. doi: 10.1158/0008-5472.CAN-20-1876. PubMed PMID: 33239430; PMCID: PMC8026491.
Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12(1):2259. doi: 10.1038/s41467-021-22480-x. PubMed PMID: 33859191; PMCID: PMC8050259.
Chang CY, Wang J, Zhao Y, Liu J, Yang X, Yue X, Wang H, Zhou F, Inclan-Rico JM, Ponessa JJ, Xie P, Zhang L, Siracusa MC, Feng Z, Hu W. Tumor suppressor p53 regulates intestinal type 2 immunity. Nat Commun. 2021;12(1):3371. doi: 10.1038/s41467-021-23587-x. PubMed PMID: 34099671; PMCID: PMC8184793.
Kang Z, Fu P, Alcivar AL, Fu H, Redon C, Foo TK, Zuo Y, Ye C, Baxley R, Madireddy A, Buisson R, Bielinsky AK, Zou L, Shen Z, Aladjem MI, Xia B. BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage. Nat Commun. 2021;12(1):5966. doi: 10.1038/s41467-021-26227-6. PubMed PMID: 34645815; PMCID: PMC8514439.
Dai W, Li A, Yu NJ, Nguyen T, Leach RW, Wuhr M, Kleiner RE. Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation. Nat Chem Biol. 2021;17(11):1178-87. doi: 10.1038/s41589-021-00874-8. PubMed PMID: 34556860; PMCID: PMC8551019.
Kwon M, Rubio G, Nolan N, Auteri P, Volmar JA, Adem A, Javidian P, Zhou Z, Verzi MP, Pine SR, Libutti SK. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Cancer Res. 2021;81(21):5523-39. doi: 10.1158/0008-5472.CAN-21-0897. PubMed PMID: 34417201; PMCID: PMC8563430.
Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021;184(22):5635-52 e29. doi: 10.1016/j.cell.2021.09.018. PubMed PMID: 34653350; PMCID: PMC8584034.
Shen M, Wei Y, Kim H, Wan L, Jiang YZ, Hang X, Raba M, Remiszewski S, Rowicki M, Wu CG, Wu S, Zhang L, Lu X, Yuan M, Smith HA, Zheng A, Bertino J, Jin JF, Xing Y, Shao ZM, Kang Y. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer. 2022;3(1):43-59. doi: 10.1038/s43018-021-00279-5. PubMed PMID: 35121987; PMCID: PMC8818087.
Shen M, Smith HA, Wei Y, Jiang YZ, Zhao S, Wang N, Rowicki M, Tang Y, Hang X, Wu S, Wan L, Shao ZM, Kang Y. Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat Cancer. 2022;3(1):60-74. doi: 10.1038/s43018-021-00280-y. PubMed PMID: 35121988; PMCID: PMC8818088.
Zhang H, Su X, Burley SK, Zheng XFS. mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma. Theranostics. 2022;12(7):3518-33. doi: 10.7150/thno.72581. PubMed PMID: 35547764; PMCID: PMC9065186.
Hussmann JA, Ling J, Ravisankar P, Yan J, Cirincione A, Xu A, Simpson D, Yang D, Bothmer A, Cotta-Ramusino C, Weissman JS, Adamson B. Mapping the genetic landscape of DNA double-strand break repair. Cell. 2021;184(22):5653-69 e25. doi: 10.1016/j.cell.2021.10.002. PubMed PMID: 34672952; PMCID: PMC9074467.
Shen M, Jiang YZ, Wei Y, Ell B, Sheng X, Esposito M, Kang J, Hang X, Zheng H, Rowicki M, Zhang L, Shih WJ, Celia-Terrassa T, Liu Y, Cristea I, Shao ZM, Kang Y. Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling. Cancer Cell. 2019;35(1):64-80 e7. doi: 10.1016/j.ccell.2018.11.016. PubMed PMID: 30612941.
Wang J, Chang CY, Yang X, Zhou F, Liu J, Zhu S, Yu XZ, Liu C, O'Sullivan TE, Xie P, Feng Z, Hu W. Leukemia inhibitory factor protects against graft-versus-host disease while preserving graft-versus-leukemia activity. Blood. 2022;140(19):2076-90. doi: 10.1182/blood.2022015677. PubMed PMID: 35981499.
Xiao Q, Zhang X, Tu L, Cao J, Hinrichs CS, Su X. Size-dependent activation of CAR-T cells. Sci Immunol. 2022;7(74):eabl3995. doi: 10.1126/sciimmunol.abl3995. PubMed PMID: 35930653; PMCID: PMC9678385.