Adjuvant Gemcitabine and Capecitabine Chemotherapy in Resected Pancreatic Cancer Following Neoadjuvant Chemotherapy.
Primary Objectives:
To determine the disease free survival (DFS) for patients treated with post-operative adjuvant chemotherapy, as compared to neoadjuvant therapy alone.
Secondary Objectives:
1. To determine the clinical efficacy of the study treatment in terms of median overall survival (OS) and median disease free survival (DFS).
2. To assess the safety and tolerability of the study treatment regime as measured by the adverse events rates.
3. To assess the quality of life in patients receiving the study treatment.
GEMCITABINE
- Rutgers Cancer Institute of New Jersey
Inclusion Criteria
- Histologically and/or cytologically confirmed diagnosis of pancreatic ductal
adenocarcinoma
- Neoadjuvant chemotherapy (for at least three months) ± chemoradiation followed by R0
surgical resection
- Eastern Cooperative Oncology Group(ECOG) Performance status of PS 0 - 2
- At least 18 years of age
- Adequate bone marrow and organ functions as defined by:
- Absolute neutrophil count ≥ 1000 cells/ μL
- Hemoglobin ≥ 8 g/ dL
- Platelets > 75,000 / μL
- Creatinine ≤ 1.5 x ULN OR creatinine clearance ≥ 30 mL/min by Cockroft-Gault
- Total bilirubin ≤1.5 ULN
- AST/ ALT < 2.5 x ULN, unless with liver metastases and then must be <5 x ULN of
normal
- Women and men of childbearing potential must agree to use adequate contraception
(hormonal or barrier method of birth control or abstinence) prior to study entry and
for the duration of study participation. Should a woman become pregnant or suspect
pregnancy on study, she must notify her treating physician immediately
- Ability to understand the nature of this study protocol and give written informed
consent.
- Willingness and ability to comply with scheduled visits, treatment plans laboratory
tests and other study procedures
Exclusion Criteria
- Receipt of any investigational agents at the time of registration
- Known, untreated brain metastases
- Presence of metastatic disease or malignant ascites on diagnostic imaging
- Grade two or greater peripheral neuropathy
- Presence of any additional active malignancy within the past 3 years where the
malignancy is at least reasonably likely to later the course of therapy, require
systemic therapy or interfere with imaging assessments
- Uncontrolled intercurrent illness, including significant active infection, symptomatic
congestive heart failure (NYHA classification grade III or IV), unstable angina or
active arrhythmia
- Major surgery within the 4 weeks prior to initiation of study treatment
- A history of allergy or hypersensitivity to any of the study drugs
- Any additional significant medical condition, laboratory abnormality, or psychiatric
illness that would prevent the subject from fully participating in the study
- Pregnancy
- Severe hepatic impairment
- Participants with known malabsorption
Please note that we have obtained the inclusion and exclusion criteria information from the National Institutes of Health’s clinical trials web site ClinicalTrials.gov. The listed criteria may not necessarily reflect recent amendments to the protocol and the current criteria.
For further information about clinical trials, please contact us at 732-235-7356.